Lavender Oil Research Articles

Carboxymethyl cellulose/poloxamer Gels Enriched With Essential Oil and Ag Nanoparticles: Promising Wound Dressings

Aim: Essential oils are promising antibacterial and wound-healing agents that should be explored for the design of wound dressings. Materials & methods: Topical gels prepared from a combination of carboxymethyl celluloseand poloxamer were incorporated with tea tree and lavender oil together with Ag nanoparticles. In vitro release, cytotoxicity, antibacterial, and wound healing studies were performed. Results: The gels displayed good spreadability with viscosity in the range of 210-1200cP. The gels displayed promising antibacterial activity against selected Gram-positive and Gram-negative bacteria used in the study. The % cell viability of the gels was more than 90.83%. Conclusion: The topical gels displayed excellent wound closure in vitro revealing that they are potential wound dressings for bacteria-infected wounds.

Spatial repellency effects of Taiwanese plant oils on the biting midge, Forcipomyia taiwana

The biting midge, Forcipomyia taiwana (Shiraki) (Diptera: Ceratopogonidae), can cause severe allergic reactions. It can pass through typical mosquito netting, so repellents are an important control measure against it. This project sought to identify spatial repellents from plants traditionally used by Taiwanese Aboriginal peoples as insect repellents. Fresh plant leaves were collected, frozen, and powdered, and essential oils extracted using hexane then ethyl acetate as solvents. Some commercial oils were also used. The extracts were tested against lab-reared F. taiwana using a Y-tube olfactometer. The composition of the extracts was identified using gas-chromatography mass-spectrometry (GC-MS). Commercial citronella, lavender, and Formosan cypress oils were effective repellents, as were lab-made capillary wormwood and camphor oils. Knockdown was detected in commercial clove leaf, rosemary, common wormwood, and cajuput oils. The oil composition data is the first for many of the Taiwanese plants, many of which contained repellent compounds like caryophyllene, α-pinene, and germacrene D. The results agreed with previous studies on the effects of some plants but differed on others, possibly due differences in plant chemotype, extraction method, and oil concentrations. Key Policy Highlights Botanical oils may have some effect as personal repellents against Forcipomyia taiwana. Commercially available oils show the most promise. Certain endangered trees show promise as sources of repellents, so their conservation should be prioritized.

Effects of sleep hygiene education and lavender oil inhalation on sleep quality, fatigue, and health-related quality of life in adults with an ostomy: a randomized controlled trial protocol

Background: It has been shown that the formation of an ostomy affects sleep quality, and sleep problems or insomnia cause fatigue in daily life, reducing the health-related quality of life. This trial aims to investigate the effects of sleep hygiene education and lavender oil inhalation alone and in combination on sleep quality, fatigue, and health-related quality of life in adults with an ostomy. Methods: This trial has been planned as a randomized controlled clinical trial and will use a 2×2 factor design in which an equal number of participants meeting the inclusion criteria will be randomly allocated to one of four groups. The study sample will comprise 120 adult patients who have undergone ostomy surgery in a city hospital in Turkey. Lavender oil inhalation together with sleep hygiene education will be applied in the first group (n=30), only sleep hygiene education in the second group (n=30), only lavender oil inhalation in the third group (n=30), and no intervention in the fourth group (n=30). The sleep quality of the groups will be evaluated using the Pittsburgh sleep quality index, their fatigue levels with the chalder fatigue scale, and their quality of life with the ostomy a quality-of-life scale. Conclusions: Non-pharmacological interventions are needed to prevent sleep and/or other problems that may develop due to insomnia in adults with ostomy. By evaluating the effects of these interventions, this trial will provide valuable evidence to guide clinical practice. Trial registration: This trial was registered in October 2022 (NCT05573256).

Comparison between the Chemical Composition of Essential Oil from Commercial Products and Biocultivated Lavandula angustifolia Mill.

The main aim of this study was to assess the differences in the chemical composition of essential oil from biocultivated Lavandula angustifolia in the Thracian Lowland floristic region, Bulgaria, and commercially available products from Bulgarian markets. Following the analytical results conducted with gas chromatography-mass spectrometry, we have established some differences in the chemical composition of the tested samples. The essential oil of biocultivated lavender contained 35 compounds, which represent 94.13% of the total oil. Samples from commercial products contained 28-42 compounds that represent 93.03-98.69% of the total oil. All the examined samples were rich in monoterpene hydrocarbons (1.68-12.77%), oxygenated monoterpenes (70.42-87.96%), sesquiterpene hydrocarbons (4.03-13.78%), and oxygenated sesquiterpenes (0.14-0.76%). The dominant components in all examined samples were linalool (20.0-45.0%) and linalyl acetate (20.79-39.91%). All the examined commercial samples contained linalool and linalyl acetate as was described in the European Pharmacopoeia, but in one of the samples, the quality of linalyl acetate is lower than that recommended in the European Pharmacopoeia.

In Vitro Metabolism and CYP-Modulating Activity of Lavender Oil and Its Major Constituents

The application of essential oils has historically been limited to topical (massage therapy) and inhalational (aromatherapy) routes of administration. More recently, however, evaluation of the therapeutic effects of essential oils has expanded to include the oral route of administration, which increases the herb-drug interaction potential. The purpose of this study was to evaluate the herb-drug interaction potential of lavender essential oil and two of its primary phytoactive constituents, namely linalool and linalyl acetate. The metabolic stability of linalool and linalyl acetate was determined in human liver microsomes (HLM) and S9 fractions by quantitative analysis using UPLC-MS/MS system. Linalool was metabolically unstable in HLM and S9 fractions with an intrinsic clearance of 31.28 mL·min-1·kg-1, and 7.64 mL·min-1·kg-1, respectively. Interestingly, it was observed that linalyl acetate converted to linalool both in HLM and S9 fractions. Lavender oil showed weak inhibitory effect on the catalytic activity of CYP3A4 and CYP1A2 enzymes (IC50 12.0 and 21.5 µg/mL). Linalyl acetate inhibited CYP3A4 (IC50 4.75 µg/mL) while linalool did not show any inhibitory effect on any of the enzymes. The lavender oil and its constituents did not activate PXR to a considerable extent, and no activation of AhR was observed, suggesting a lack of potential to modify the pharmacokinetic and pharmacodynamic properties of conventional medications if used concurrently.

THERAPEUTIC USE OF LAVENDER OIL

ABSTRACT PURPOSE To establish the scientific directions of lavender oil research and its therapeutic use. METHODS An analysis was made of the available methodological literature in the medical database PubMed related to Lavender oil. Known empirical therapeutic uses of lavender oil are Relaxation and stress relief. Lavender oil is known for its calming properties, which can help promote relaxation and reduce stress and anxiety; Pain relief: Lavender oil has analgesic properties, which means it can help relieve pain. Skincare: Lavender oil has antiseptic and anti-inflammatory properties, which can help soothe and heal minor skin irritations like acne, insect bites, and minor burns; Respiratory support: Digestive health: Lavender oil may also help support digestive health by reducing inflammation in the gut and promoting healthy digestion. RESULTS 501 scientific studies with Lavender oil were found in the medical database PubMed. This publication analyzes the directions of scientific studies. CONCLUSIONS Lavender oil is a popular essential oil that has been used for centuries for its therapeutic properties. A significant part of scientific research is aimed at proving empirically known therapeutic applications.

THERAPEUTIC USE OF LAVENDER OIL

PURPOSE To establish the scientific directions of lavender oil research and its therapeutic use. METHODS An analysis was made of the available methodological literature in the medical database PubMed related to Lavender oil. Known empirical therapeutic uses of lavender oil are Relaxation and stress relief. Lavender oil is known for its calming properties, which can help promote relaxation and reduce stress and anxiety; Pain relief: Lavender oil has analgesic properties, which means it can help relieve pain. Skincare: Lavender oil has antiseptic and anti-inflammatory properties, which can help soothe and heal minor skin irritations like acne, insect bites, and minor burns; Respiratory support: Digestive health: Lavender oil may also help support digestive health by reducing inflammation in the gut and promoting healthy digestion. RESULTS 501 scientific studies with Lavender oil were found in the medical database PubMed. This publication analyzes the directions of scientific studies. CONCLUSIONS Lavender oil is a popular essential oil that has been used for centuries for its therapeutic properties. A significant part of scientific research is aimed at proving empirically known therapeutic applications.

In vitro antibacterial effect of enrofloxacin combined with lavender essential oil on selected Salmonella serotypes isolated most commonly poultry

The present study investigated the antimicrobial activity of enrofloxacin in combination with lavender (Lavandula angustifolia) essential oil against three serotypes of Salmonella: Salmonella Enteritidis ATCC 13076, Salmonella Gallinarum biovar Pullorum ATCC 13036, Salmonella Typhimurium ATCC 14028 and Salmonella Typhimurium – a moderately sensitive monophasic strain. The analysis of the interaction of enrofloxacin with lavender essential oil was carried out using the checkerboard method. The obtained FICI values were interpreted as follows: synergistic when ≤ 0.5; additive when > 0.5 but ≤ 1; non-interactive when > 1 but ≤ 4; antagonistic when > 4. When analysing individual combinations of enrofloxacin with lavender oil, a positive additive effect was found in all cases (S. Enteritidis ATCC 13076 FICI – 0.85; S. Gallinarum biovar Pullorum ATCC 13036 FICI – 1.0; S. Typhimurium ATCC 14028 and S. Typhimurium – a moderately sensitive monophasic strain FICI – 0.7). Antagonistic interaction was not recorded in any case. When analysing individual combinations of enrofloxacin with lavender oil against the serotypes tested, an additive effect was demonstrated in all cases (FIC indices: 0.7-1.0). There was no antagonistic effect in any of the analysed combinations.

A Greener Facile Approach to Develop Durable Multifunctional Cellulosic Pigment Prints Using β-CD, ZnO-NPs and Several Bioactive Guest Molecules

In the present work, β-CD, ZnO-NPs, and several eco-friendly bioactive guests, namely, cinnamon oil, lemon oil, lavender oil, and vanillin along with environmentally benign pigment paste constituents were applied to cotton, viscose, cotton/viscose, and cotton/linen cellulosic substrates to develop durable multi-functional pigment prints in a single step using the pad-dry-thermofixation method. The developed one-step pigment coloration and multi-functionalization method resulted in a remarkable improvement in antibacterial efficacy, UV-protection ability, aroma property along with a noticeable increase in depth of the obtained pigment prints, making them very useful for a wide range of potential applications. The extent of enhancement in the above-mentioned functional and coloration properties is governed by type of cellulosic substrate, presence of β-CD/ZnO-NPs, type of bioactive agent as well as kind of pigment colorant. Among the used bioactive agents, lavender oil proved to be the best for attaining multi-functional and pigment coloration properties, keeping other parameters constant. The obtained results also demonstrated that increasing washing cycles up to 15 washes resulted in a slight decrease in the imparted functional and coloration properties, regardless of the used cellulosic substrate. Both SEM images and EDX spectra confirmed the surface modification and ZnO-NPs immobilization onto the selected fabric surfaces. Mode of interactions among the different printing paste constituents and the cellulosic substrates were also suggested.

Primena esencijalnih ulja lavande i nane za poboljšanje osobina semena lucerke (Medicago sativa L.)

Essential oils (EOs) are widely studied in agriculture. The study's objective was to examine the impact of EOs on alfalfa (Medicago sativa L.) seed dormancy. The four different varieties of alfalfa were used for the experiment (Zaječarka-83, Banatska-VS, K-28, Novosadska H-11). Two essential oils, lavender (Lavandula angustifolia Mill.) and peppermint (Mentha piperita L.) were applied at four concentrations:1%, 0.5%, 0.2%, and 0.02%, along with water as a control. Germination, dormant seeds and dead seeds were evaluated in a laboratory setting according to ISTA rules. The type of EOs had no discernible influence on germinated seeds, dormancy, and dead seeds. Both EOs in concentrations of 1% and 0.5% inhibited seed germination. The maximum germination of 91.66% was achieved with the Novosadska H-11 variety using lavender oil at a concentration of 0.02%, with reduced dormancy. Varieties Zaječarka-83 and Banatska-VS had the highest level of dead and dormant seeds when lavender and peppermint EOs were applied at a concentration of 0.2%. This study showed that both EOs at a concentration of 0.02% had a stimulatory effect on seed germination, simultaneously reducing seed dormancy, emphasizing their potential use for seed quality improvement in organic farming.

To Blend or Not to Blend? Anxiety Buffering Effects of Essential Oil Aromas

Essential oils of pure lavender and lavender blends have been employed as potential anxiolytic aromas in aromatherapy, but a direct comparison of their effectiveness is lacking. The current study investigated the effects of aroma on induced anxiety in non-clinical adults, comparing pure lavender, a commercially available blend and a no aroma control. An experimental, quantitative, mixed factorial design with an opportunity sample of 60 participants was employed. Participants were randomly allocated to three equal groups, one tested in a room infused with lavender aroma, the second with the doTerra Peace® blend, and the third free from any aroma. Participants’ state anxiety scores were measured before and after a novel video-based anxiety induction procedure. Data analysis revealed that the anxiety induction was successful and that both aromas delivered small to medium-sized buffering effects compared to no aroma. The findings add to a small body of research in an area where the practice is global yet has limited scientific evaluation. Future studies utilising brain imaging and blood serum analysis to investigate the anxiolytic mechanism of aromas would be beneficial to further our understanding.

<i>In silico</i> anti-inflammatory activity of lavender (<i>Lavandula officinalis</i>) essential oil bioactive compounds: Molecular docking analysis of COX-1 and COX-2, and ADMET prediction

<abstract> <p>Advanced investigations are in action worldwide to find medications with improved safety profiles. Natural resources are essential in the creation of innovative treatments and drugs that have fewer side effects. The essential oil (EO) of lavender (<italic>Lavandula officinalis</italic>) is well-known in alternative and complementary therapies for its use as wound-healing and antimicrobial ingredients. However, the exact pharmacological and anti-inflammatory aspects of naturally produced lavender essential oil (LEO) compounds are still unknown. As a consequence, it is essential to explain LEO drug molecular docking experiments with cyclo-oxygenase enzymes (COX-1 and COX-2). An attempt was developed in this study to discover the anti-inflammatory activity of LEO bioactive components. The online DockThor server was used for <italic>in silico</italic> molecule docking simulation. Interaction studies of LEO compound binding poses with COX were performed to get an understanding of the interacting amino acids and their inter-molecular bondings. Based on physicochemical attributes and toxicity, the docked compounds with the greatest binding affinities were also investigated for drug similarity utilizing the admetSAR tool and PASS platforms. Molecular docking studies exploring the bioactive principle targeted action revealed that electrostatic interactions and H-bonds make the main causative factor in inter-molecular connections associated with anti-inflammatory action. Seven top-ranked compounds were selected by virtual screening. Molecular docking revealed that limonene has the highest negative binding affinity (−8.536 kcal/mol) in complex with COX-1, followed by <italic>α</italic>-terpineol (−8.535 kcal/mol) and <italic>p</italic>-cymene (−8.515 kcal/mol), while two approved anti-inflammatory drugs (celecoxib and betamethasone) produced −8.191 and −8.041 kcal/mol respectively. Similarly, these terpenes can be documented as promising drug candidates based on qualifying Lipinski's rule five. The selected terpenes showed excellent drug-like properties and a percentage of human oral absorption. Besides, it was found to be safe for the human body in toxicological risk assessment. This work gives insight into the anti-inflammatory mechanism of action of LEO terpenes. LEO drugs' pharmacokinetic data and molecular docking patterns may open the way for the development of new COX inhibitors with anti-inflammatory capability and improved pharmacokinetic and pharmacodynamic properties.</p> </abstract>

Dual actions of certain essential oils in combating mosquito Culex pipiens (Diptera: Culicidae)

Author : Ahmed S. Hashem, Ahmed H. Abdelwahab, Mohamed A.M. Shahat, Marwa M. Ramadan Mosquitoes are one of the most annoying and potentially dangerous insects on the planet as they are infamous for transmitting diseases such as malaria, dengue fever, Zika virus, West Nile virus, and many others. In order to protect public health and stop the spread of diseases like dengue, zika, and malaria, mosquito control is essential. The current study attempts to evaluate the toxicity and repellant qualities of lavender camphor, and garlic, essential oils against Culex pipiens. After 72 hours, the essential oil demonstrated good larvicidal action in a lab setting against third-instar larvae (LC50 = 341.12, 430.79, and 624.15 ppm, respectively). At all dosages, lavender oil offers a comprehensive repellant that endures longer. In contrast, there were no appreciable variations in the repellents' duration of protection against C. pipiens. These findings provide insight into potential use of essential oils of garlic, camphor, and lavender for the management of mosquitoes.

EFEITOS DA AROMATERAPIA NOS SINTOMAS DE ANSIEDADE EM MULHERES COM CÂNCER DE MAMA: REVISÃO SISTEMÁTICA

ABSTRACT Objective: to assess the effect of aromatherapy on anxiety symptoms in women undergoing treatment for breast cancer. Method: a systematic review, carried out from the PEOT strategy: what are the effects of aromatherapy in reducing anxiety symptoms in women undergoing treatment for breast cancer? The research was conducted in six databases and in eight other data sources. Randomized clinical trials without date and language restrictions were included. Results: the sample consisted of seven studies. Aromatherapy was applied by inhalation (57.1%) and massage (42.8%), and was adopted alone or in conjunction with other interventions, demonstrating a reduction in anxiety symptoms in 71.4% of studies. The predominance of lavender, bergamot, frankincense and sandalwood essential oils is highlighted for their anxiolytic, relaxing, sedative, invigorating, antidepressant and muscle tension reducing effects. Conclusion: aromatherapy showed positive and significant results in reducing anxiety symptoms in women undergoing treatment for breast cancer.

The Role of Green Tea (Camellia sinensis) in the Management of Androgenetic Alopecia (AGA): A Review

Alopecia is a condition that impacts over 50% of the global population. The Food and Drug Administration (FDA) only approved topical minoxidil and oral finasteride for prevention of hair loss, and hair regrowth. Numerous in vitro and in vivo studies on active herbal ingredients suggest the herbal active ingredients may help control hair loss when used alone, together, and in combination with synthetic anti-hair loss medicines. For over 100 years, thyme, lavender, rosemary, and cedar wood essential oils have traditionally used to treat hair loss. According to current researches about topical green tea in the prevention and hair re-growth, this plant may be a suitable and relatively reliable alternative to chemical drugs such as minoxidil and finasteride. Green tea contains polyphenol compounds called catechins. Catechins have a significant anti-hair loss due to their effect on the dermal papillae cells (DPCs); DPCs are specialized fibroblasts that control the hair growth cycles. This article reviews the potential impact of green tea (Camellia sinensis) in reducing hair loss, hair re-growth, and its particular effect on dermal papillae.

Are Prepubertal Gynaecomastia and Premature Thelarche Linked to Topical Lavender and Tea Tree Oil Use?

Various studies, conducted since 2007, have reported a total of eight boys with prepubertal gynaecomastia and four girls with premature thelarche following exposure to lavender and/or tree tea oil. All patients experienced regression of the breast tissue after they stopped using these oils. Both of these essential oils, and several of their constituents, have oestrogenic and antiandrogenic activity in vitro. However, limited dermal penetration of some of the components means that the in vitro findings cannot be extrapolated to the in vivo situation. There are unanswered questions as to how much lavender or tea tree oil was actually present in the skincare products used by the children and a lack of information about exposure to other agents. Furthermore, since both prepubertal gynaecomastia and premature thelarche often spontaneously regress, it cannot be concluded that the use of lavender and/or tree tea oil is the cause of the gynaecomastia and thelarche in these children.

Role of Alternate Therapies to Improve the Quality of Life in Menopausal Women: A Systematic Review.

Middle aged women in majority undergoing menopausal symptoms are unaware of the physiological changes happening in their body, necessary lifestyle changes and alternate therapies to overcome the symptoms. All major electronic sources of relevant information were systematically searched and collected data were pooled under specific subheadings. From the reviewed papers, the awareness on symptoms and related complications of menopause in the middle aged women were consolidated. Studies helped to identify alternative therapies replacing or in parallel with the Hormone Replacement Therapy to overcome the menopausal symptoms. Reduced oestrogen and progesterone level causes physiological, psychological, and genitourinary symptoms. Prolonged consequences cause libido, osteoporosis, and cardio vascular diseases. Hypo-estrogenic status is well managed with alternative therapies including dietary intervention, acupuncture, aromatherapy, exercise, and yoga. Dietary interventions involving foods like Fennel, Soy, Black Cohash, St. John Wort, Red Clover and Date Pollen were found to be managing vasomotor symptoms and sexual dysfunction. Non-Hormonal and Non-Pharmacological impact behind acupuncture treatment was well accepted. Various studies proved inhaling and massaging with Lavender, Neroli oil, Fennel, Rose, and Geranium essential oils balance cortisol hormone and reduce stress and anxiety. Impact of yoga therapy on neurohormonal pathways reduce both psychological and physiological symptoms. Reviews summarizes various symptoms and complications during menopausal transition and alternate ways of better management with dietary intervention, yoga, exercise, aromatherapy, and acupuncture to improve the quality of menopausal women's life.

A new solution for control of respiratory infection by Streptococcus equi isolated from horses in northern Iran

Respiratory infections caused by Streptococcus equi are one of the most important diseases in the equine industry. The increasing rate of antibiotic resistance among this bacterial species necessitates new antimicrobial agents. In this research, nasopharyngeal samples were taken from horses (n=90) in some areas of the Golestan Province, Iran. After isolation and identification of S. equi strains, antibiotic resistance of the isolates was evaluated using the Kirby-Bauer method. The antibacterial effect of lavender essential oil was investigated by broth microdilution assay. The frequency of streptococcal strains was 27.8%. The most frequent isolates were S. equi subsp. equi (72%) and S. equi subsp. zooepidemicus (28%). The frequency of S. equi was highest in horses aged less than 2 years (69.3%) and thoroughbred Turkmen horses (61.5%). The highest rate of resistance was observed against amoxicillin, while the highest rate of sensitivity was to ceftriaxone. Furthermore, the essential oil of lavender inhibited 90% of the isolates at concentrations ≥2048 μL/mL. Our study revealed that the frequency of antibiotic-resistant S. equi isolates was relatively high in the studied population of horses in Iran. It was concluded that essential oil of lavender possessed more potent in vitro activity than the common antibiotics for treatment of infections caused by S. equi subspecies.

POTENTIAL USE OF ESSENTIAL OILS IN VETERINARY INDUSTRY: A REVIEW

Essential oil have been used for ages in religious ceremonies for offering Gods, as perfume, in food flavoring, as preservative substances and used ancient medicines. In modern days these essential oils are roots for pharmaceutical industries, main ingredients in food industry as a flavor, main sources for agarbatti industries, core materials in cosmetic industries, used in preparation of aromatic candles and they act as plant protecting agents un organic farming. Apart from these industries essential oils commercially used in veterinary industry. In veterinary industry these oils used as medicine, as nutrition as feed additives and to maintain the hygienity in animals. Essential oils mainly used in aromatherapy, the word aromatherapy was found by Rene mourice guttefoss during 1st world war. He accidently invented healing property of lavender oil and before using these oils on human beings, he tested on dogs and horses. This is first reference were the essential oils used in animals.

Evaluation of The Anti-Cancer Efficiency of Lavender Oil and Newcastle Disease Virus (NDV) Through Induction of Apoptosis

Evaluation of The Anti-Cancer Efficiency of Lavender Oil and Newcastle Disease Virus (NDV) Through Induction of Apoptosis