Three hybrids of canola were cultivated in Brazil submitted to three sowing dates in 2018: April 21 (early autumn), May 20 (mid-autumn), and June 24 (late autumn). The samples were harvested and the grain yields were measured. Thereafter, canola oil was extracted by Soxhlet with n-Hexane and by supercritical CO2 (SFE-CO2) following a completely randomized design. The following responses were evaluated: oil yields, oil composition, protein contents, and cost of manufacturing of oil. The highest grain yield was 2807 kg ha−1 and the highest oil yield was 34.7 wt.%. The main fatty acids identified in the oil were oleic acid (46.4–57.5 wt.%), linoleic acid (10.6–15.2 wt.%), and α-linolenic acid (5.8–8.1 wt.%). The highest protein content in the solid coproducts was 38.2 wt.%. Furthermore, the cost of manufacturing (COM) of oil was simulated for a pilot/industrial scale dedicated to processing 180 kg of seeds per batch. The COM of oil ranged from US$ 7.60 kg-1 to US$ 11.96 kg-1 (SFE-CO2) and from US$ 1.13 kg-1 to US$ 1.47 kg-1 (Soxhlet), respectively. After an integrated evaluation of technological and economic responses, the hybrid Hyola 61 sown on May 20 seems to be the most suitable condition for being cultivated by farmers and for being processed by food-related industries.
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