Abstract Hydro-generator unit is the core component of the hydropower station, and the stability of the shaft system directly determines the safety of the hydropower station. Thrust bearing is the only component to bear axial load, and working performance directly affects the stable operation and efficiency of the unit. In this study, a full 3D model of the shaft system of a 1000 MW hydro-generator unit is established, and the oil flow of thrust bearing oil film and oil in the oil tank considering the spray system and the overall model is analysed by means of the thermo-hydrodynamic method. The results show that the load increases with increasing inclination angle. Within certain limits, the pressure and temperature of the oil film increase with increasing inclination. And there are many vortices in the tank. Although the spray system reduces the oil churn, the lubricating oil flow between pads is chaotic. The loss is mainly caused by the chaotic flow between pads. Analyzing the effects of oil film thermal effects on bearing loads, lubricant flow, and bearing surface temperatures of tilting pads provides valuable insights for bearing design and maintenance guidance.