A two-dimensional basin and petroleum system modeling approach was applied to the Burano-Bolognano petroleum system (Central Italy) to constrain some factors (position, lateral extension and maturity of the source rock, the role of fractures and faults in hydrocarbon migration) which influenced its structural evolution and the related migration pathways. The petroleum system extends from the Majella Mountain to the northern Cigno, Vallecupa, Bonanno oil fields, intensively explored during the past century. Some features, such as the location and extension of the source rock and its maturity, and hydrocarbon pathways, are still undefined. Thus, we developed a 3D geological static model of the Cenozoic carbonate succession and then, we performed basin modeling along a 2D geological section, integrating the petrophysical properties of rocks measured in laboratory. Our results prove that the Burano source rock reached a low-middle maturity, and the best representation of the actual hydrocarbon occurrences is reached when the source rock is at north of the Majella Mountain with a minimum extension of 3 km. For the BBPS a strong lateral migration and a gradual oil biodegradation towards the Majella area must be considered. Moreover, modeling results highlight a minor control of the faults on the migration in this area. This basin modeling is relevance for investigations in similar settings since carbonate-ramp reservoir studies are usually very challenging to be correctly modeled due to their high heterogeneities.