Event Abstract Back to Event Three-Dimensional Mathematical Models of Active Signal Processing in Dendrites and Subcellular Calcium Signaling Konstantinos Xylouris1*, Gillian Queisser2 and Gabriel Wittum2 1 University of Frankfurt, Germany 2 University of Heidelberg, Germany Action potentials in neurons are generated on the plasma membrane through depolarization, i.e. exchange of charges through the membrane. Hodgkin and Huxley developed a mathematical model which describes the interaction of ions through an active plasma membrane. We combined a passive three-dimensional (3D) model for signal propagation in dendrites with a generalized Hodgkin-Huxley model to obtain a 3D-model that describes active signal processing on realistic cell morphologies. Time dependent changes of the neuron's intra- and extracellular potential is regulated by the Ohmic flux of charges. These fluxes are balanced in membrane-near areas, by the capacitory and Hodgkin-Huxley flux. The active model we present consists of five non-linear, coupled integro-differential equations which are solved numerically with a finite volume approach, implicit time stepping and Newton's method for solving the underlying non-linear system of equations with multigrid solver methods. We present numerical results as well as axon behavior in a biological setting. This model can be considered as a three-dimensional expansion of existing state of the art one-dimensional models, with the significant advantage of being able to investigate the morphological influence of neuron cell types on their specific signaling properties. On a subcellular level we investigated the influence of the nuclear morphology on calcium signals. There we find two main types of nuclei, infolded and spherical. While spherical nuclei are observed to be "signal-integrators", infolded nuclei are adept at resolving high-frequency signals. Calcium acts as a key regulator in the nucleus for biochemical events that trigger gene transcription and is involved in processes such as memory formation and information storage. Recent research showed that the morphology of hippocampal neuron nuclei is regulated by the cell's NMDA receptors, which led us to investigate the morphological influence in a modeling environment. Similar to nerve cells the nucleus is able to dynamically change its form in response to the cell's activity and therefore influences the way calcium signals are interpreted in the nucleus. Especially the concept of high-frequency calcium signaling could be introduced by this model and has been further investigated experimentally in recent work. Conference: Bernstein Symposium 2008, Munich, Germany, 8 Oct - 10 Oct, 2008. Presentation Type: Oral Presentation Topic: All Abstracts Citation: Xylouris K, Queisser G and Wittum G (2008). Three-Dimensional Mathematical Models of Active Signal Processing in Dendrites and Subcellular Calcium Signaling. Front. Comput. Neurosci. Conference Abstract: Bernstein Symposium 2008. doi: 10.3389/conf.neuro.10.2008.01.071 Copyright: The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers. They are made available through the Frontiers publishing platform as a service to conference organizers and presenters. The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated. Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed. For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions. Received: 17 Nov 2008; Published Online: 17 Nov 2008. * Correspondence: Konstantinos Xylouris, University of Frankfurt, Frankfurt, Germany, konstantinos.xylouris@gmail.com Login Required This action requires you to be registered with Frontiers and logged in. To register or login click here. Abstract Info Abstract The Authors in Frontiers Konstantinos Xylouris Gillian Queisser Gabriel Wittum Google Konstantinos Xylouris Gillian Queisser Gabriel Wittum Google Scholar Konstantinos Xylouris Gillian Queisser Gabriel Wittum PubMed Konstantinos Xylouris Gillian Queisser Gabriel Wittum Related Article in Frontiers Google Scholar PubMed Abstract Close Back to top Javascript is disabled. Please enable Javascript in your browser settings in order to see all the content on this page.
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