In this paper, we present a hierarchicity-based (self-similar) hybrid genetic algorithm for the solution of the grey pattern quadratic assignment problem. This is a novel hybrid genetic search-based heuristic algorithm with the original, hierarchical architecture and it is in connection with what is known as self-similarity—this means that an object (in our case, algorithm) is exactly or approximately similar to constituent parts of itself. The two main aspects of the proposed algorithm are the following: (1) the hierarchical (self-similar) structure of the genetic algorithm itself, and (2) the hierarchical (self-similar) form of the iterated tabu search algorithm, which is integrated into the genetic algorithm as an efficient local optimizer (local improvement algorithm) of the offspring solutions produced by the crossover operator of the genetic algorithm.