On the basis of coherent optical orthogonal frequency-division-multiplexing (CO-OFDM), CO-OFDM/ offset quadrature amplitude modulation (CO-OFDM/OQAM) improves the spectrum efficiency by utilizing specially designed filter banks to eliminate the cyclic prefix (CP) inserted between consecutive OFDM blocks and decreases the demanding of guard band between two channels, being a promising candidate for the next generation optical transmission link. Due to the relaxation of the orthogonal condition from the complex field to the real field, chromatic Dispersion (CD) and polarization mode dispersion (PMD) bring serious intrinsic imaginary interference (IMI) to an optical OFDM/OQAM system. Channel estimation schemes based on the interference approximation method (IAM) have been proved to be effective in suppressing the IMI with low complexity. For the IAMs, increasing the power of the pseudo pilot could decrease the effects of amplified spontaneous emission (ASE) noise and other frequency domain residual error on the channel estimation accuracy. In most of the previous reported IAM works, pilot blocks were designed according to the structure of the center pilot block loaded, while the two side pilots nulled for simplicity. However, the power of the pseudo pilot under this method did not reach the maximum, resulting in non-optimal channel estimation accuracy. In this paper, channel estimation method based on the combined phase offset (CMPO) is proposed and systematically discussed. For the proposed method, three consecutive full loaded blocks are treated as the pilot blocks and the optimal pilot structure have been obtained by utilizing the maximum likelihood algorithm. As validated by numerous Montel Carlo simulations results, system robustness against IMI, phase noised induced interference, and nonlinear effect have been improved significantly, thanks to CMPO.