Occurrences Research Articles

Mind-wandering increases in frequency over time during task performance: An individual-participant meta-analytic review.

Attention has a seemingly inevitable tendency to turn inward toward our thoughts. Mind-wandering refers to moments when this inward focus diverts attention away from the current task-at-hand. Mind-wandering is thought to be ubiquitous, having been estimated to occur between 30% and 50% of our waking moments. Yet, it is unclear whether this frequency is similar within-task performance contexts and unknown whether mind-wandering systematically increases with time-on-task for a broad range of tasks. We conducted a systematic literature search and individual participant data meta-analysis of rates of occurrence of mind-wandering during task performance. Our search located 68 research reports providing almost a half-million total responses to experience sampling mind-wandering probes from more than 10,000 unique individuals. Latent growth curve models estimated the initial occurrence of mind-wandering and linear change in mind-wandering over sequential probes for each study sample, and effects were summarized using multivariate meta-analysis. Our results confirm that mind-wandering increases in frequency over time during task performance, implicating mind-wandering in characteristic within-task psychological changes, such as increasing boredom and patterns of worsening behavioral performance with time-on-task. The systematic search and meta-analysis provide the most comprehensive assessment of normative rates of mind-wandering during task performance reported to date. (PsycInfo Database Record (c) 2024 APA, all rights reserved).

Neutrophil CD64 index as a new early predictive biomarker for infected pancreatic necrosis in acute pancreatitis

ObjectiveInfectious pancreatic necrosis (IPN) is a serious complication of acute pancreatitis, and early recognition and timely intervention are the keys to improving clinical outcomes. The purpose of this study was to investigate the predictive capacity of the neutrophil CD64 index (nCD64 index) on IPN in patients with acute pancreatitisMethodsThis study comprises two independent cohorts: the training cohort consisted of 202 patients from Hunan Provincial People's Hospital, and the validation cohort consisted of 100 patients from Changsha Central Hospital. Peripheral blood samples were collected on the day of admission and on the 3rd, 5th, 7th, and 10th days of hospitalization, and the nCD64 index was detected by flow cytometry. Additionally, relevant clinical characteristics and laboratory biomarkers were collected and analyzed.ResultsWe observed that nCD64 index on admission was significantly higher in the IPN group than Non-IPN group (p < 0.001). In the training cohort, a higher occurrence rate of IPN was observed in the high nCD64 index group compared to the moderate and low nCD64 index group (p < 0.001). Further analysis showed that nCD64 index was significant positive correlated with the incidence rate of IPN (p < 0.001, correlation coefficient = 0.972). Furthermore, logistic regression analysis showed that high expression of the nCD64 index on admission was a risk factor for the occurrence of IPN (OR = 2.971, p = 0.038). We further found that the nCD64 index of IPN patients was significantly higher than the Non-IPN patients on the days 1, 3, and 5 after admission, and the nCD64 index of IPN patients before and after the onset (p < 0.05). At the same time, this study revealed that the nCD64 index on admission showed good predictive efficacy for IPN (AUC = 0.859, sensitivity = 80.8%, specificity = 87.5%), which was comparable to APACHE II score. And this finding was further validated in an independent cohort of 100 participants (AUC = 0.919, Sensitivity = 100.0%, Specificity = 76.6%).ConclusionThis study demonstrated the clinical value of nCD64 index in patients with IPN patients for the first time through two independent cohort studies. The nCD64 index can be used as an early prediction and risk assessment tool for the occurrence of IPN, contributing to the improvement of patient outcomes and efficiency of medical resource allocation.

Prevalence of hospital acquired gastrointestinal protozoa parasites among in-patients of a missionary and private hospital in Awka, Southeastern Nigeria

Regardless of the efforts by health organizations and hospital personnel, research continues to report hospital acquired infections in admitted patients worldwide. This research was carried out to survey the prevalence of hospital acquired gastrointestinal protozoa parasites among admitted patients of Regina Caeli Specialist Hospital (missionary hospital) and Izunna Hospital and Maternity (private hospital) in Awka South LGA of Anambra State, Southeast Nigeria. Two samples each from 79 patients were collected and analyzed using direct wet mount and formol ether concentration technique. Other information concerning demography and risk factors were obtained with the aid of a structured questionnaire. Data obtained was analyzed using chi-square test and probability values ≤ 0.05 were considered significant. Out of the samples examined, 9(11.4%) were positive for hospital acquired gastrointestinal protozoa parasites. Hospital acquired gastrointestinal protozoa parasites were found to occur in all two hospitals with the missionary hospital having the highest occurrence rate of 66.7%. Males recorded the highest prevalence of 6(15.8%) compared to females 3(7.3%) while age group 50-59years had the highest prevalence of 28.6%. Patients from the male ward recorded a higher prevalence of 17.9%. Meanwhile patients whose occupation is farming had a higher prevalence of 25.0% while patients who only wash their vegetables/fruits sometimes before eating presented a higher prevalence of 18.2%. Prevalence of hospital acquired gastrointestinal protozoa parasite infection was strongly associated with duration of hospital stay (P˂ 0.000). Out of the four parasites identified, Entamoeba histolytica was the most prevalent with 5(55.6%). Consequently, regulation of patients’ hospital stay, sanitation and better hygiene practices should be adopted and encouraged to prevent the spread of hospital acquired infection.

The ground is the limit: epidemiology of skydiving accidents over 25 years and in 2.1 million jumps in the Netherlands with sub-analysis of injuries reported by medical professionals in the past five years

BackgroundSkydiving is the fastest nonmotorized sport; and consequently is not without risk. In the last decades, skydiving has become considerably safer but injuries and fatalities still occur. Incidents are reported to and administered by the Royal Netherlands Aeronautical Association (KNVvL). From 1995 to 2020, 2715 incidents were reported; of which 1503 resulted in injury and 26 in fatality. There is a need for more information available on the particular type, severity, and factors which contribute to skydiving-related injuries worldwide. This study aims to investigate patterns in occurrence rates, examine demographic and skydiving-related factors linked to injuries, and analyze the types and severity of injuries relating to these contributing factors.MethodsThe Dutch KNVvL database – covering more than 25 years of data – was examined for contributing factors. An analysis of the severity and types of injury resulting from incidents over the last five years were matched with a search of hospital databases.ResultsThe rate of injuries pattern increases starting from 2016, with novice jumpers having the highest risk of injury. Most injuries occur during the landing phase. The lower extremities and the spine are most affected, with fractures being the most prevalent type of injury. More than half of the patients were admitted to hospital, with 10% requiring surgery, resulting in months of rehabilitation.ConclusionThis study is the first in the Netherlands, and only the second worldwide to analyze technical incident databases in combination with data from medical information systems. Skydiving accidents of experienced jumpers should be considered as ‘high-energy trauma,’ therefore treatment should follow standard trauma guidelines. In less experienced skydivers, it is critical to conduct a secondary survey to assess the extremities adequately. Clinicians should also pay attention to friction burns that can arise due to friction between the skin and skydive equipment, a phenomenom that is already known in road traffic accidents.

Correlation between pose estimation features regarding movements towards the midline in early infancy.

In infants, spontaneous movement towards the midline (MTM) indicates the initiation of anti-gravity ability development. Markerless 2D pose estimation is a cost-effective, time-efficient, and quantifiable alternative to movement assessment. We aimed to establish correlations between pose estimation features and MTM in early-age infants. Ninety-four infant videos were analysed to calculate the percentage and rate of MTM occurrence. 2D Pose estimation processed the videos and determined the distances and areas using wrist and ankle landmark coordinates. We collected data using video recordings from 20 infants aged 8-16 weeks post-term age. Correlations between MTM observations and distance values were evaluated. Differences in areas between groups of videos showing MTM and no MTM in the total, lower-limb, and upper-limb categories were examined. MTM observations revealed common occurrences of hand-to-trunk and foot-to-foot movements. Weak correlations were noted between limb distances to the midbody imaginary line and MTM occurrence values. Lower MTM showed significant differences in the lower part (p = 0.003) and whole area (p = 0.001). Video recording by parents or guardians could extract features using 2D pose estimation, assisting in the early identification of MTM in infants. Further research is required to assess a larger sample size with the diversity of MTM motor behaviour, and later developmental skills, and collect data from at-risk infants.

Document Author Classification using Parsed Language Structure

Over the years there has been ongoing interest in detecting authorship of a text based on statistical properties of the text, such as by using occurrence rates of noncontextual words. In previous work, these techniques have been used, for example, to determine authorship of all of The Federalist Papers. Such methods may be useful in more modern times to detect fake or AI authorship. Progress in statistical natural language parsers introduces the possibility of using grammatical structure to detect authorship. In this paper we explore a new possibility for detecting authorship using grammatical structural information extracted using a statistical natural language parser. This paper provides a proof of concept, testing author classification based on grammatical structure on a set of “proof texts,” The Federalist Papers and Sanditon which have been as test cases in previous authorship detection studies. Several features extracted from the statistical natural language parser were explored: all sub trees of some depth from any level; rooted subtrees of some depth, part of speech, and part of speech by level in the parse tree. It was found to be helpful to project the features into a lower dimensional space. Statistical experiments on these documents demonstrate that information from a statistical parser can, in fact, assist in distinguishing authors.

A PANoptosis pattern to predict prognosis and immunotherapy response in head and neck squamous cell carcinoma

Individuals diagnosed with head and neck squamous cell carcinoma (HNSCC) experience a significant occurrence rate and are susceptible to premature spreading, resulting in a bleak outlook. Therapeutic approaches, such as chemotherapy, targeted therapy, and immunotherapy, may exhibit primary and acquired resistance during the advanced phases of HNSCC. There is currently no viable solution to tackle this issue. PANoptosis—a type of non-apoptotic cell death—is a recently identified mechanism of cellular demise that entails communication and synchronization among thermal apoptosis, apoptosis, and necrosis mechanisms. However, the extent to which PANoptosis-associated genes (PRG) contribute to the forecast and immune reaction of HNSCC remains mostly undisclosed. The present study aimed to thoroughly analyze the potential importance of PRG in HNSCC and report our discoveries. We systematically analyzed 19 PRG from previous studies and clinical data from HNSCC patients to establish a PAN-related signature and assess its prognostic, predictive potential. Afterward, the patient information was separated into two gene patterns that corresponded to each other, and the analysis focused on the connection between patient prognosis, immune status, and cancer immunotherapy. The PAN score was found to correlate with survival rates, immune systems, and cancer-related pathways. We then validated the malignant role of CD27 among them in HNSCC. In summary, we demonstrated the effectiveness of PAN.Score-based molecular clustering and prognostic features in predicting the outcome of HNSCC. The discovery we made could enhance our comprehension of the significance of PAN.Score in HNSCC and facilitate the development of more effective treatment approaches.

Probabilistic Analysis of Basic Causes of Vessel–Platform Allision Accidents

This paper proposes a methodology to estimate the probability of basic causes of allision accidents between vessels and offshore platforms that overcomes the problem of data scarcity required for causal analysis. The approach uses information derived from incidental data and expert elicitation, processed by a multiple attribute utility method and hierarchical Bayesian analysis. First, the methodology is detailed, briefly describing the adopted approaches. A dataset of allision incidents provided mainly by the UK Health and Safety Executive and other agencies is prepared. The features of the incidents’ causation in terms of the causal factors and basic causes are presented and discussed. A novel scheme is proposed to evaluate the annual occurrence rates of basic causes of accidents from the relative importance of each basic cause derived by the Deck of Cards method. Then, a hierarchical Bayesian analysis is conducted to predict the posterior distribution of the occurrence rate of each basic cause in the time frame under analysis. The proposed holistic methodology provides transparent estimates of allision causation probabilities from limited and heterogeneous datasets.

Evaluation of the factors associated with anemia in neonates admitted to the Neonatal Unit of Maiwand Teaching Hospital: A cross-sectional study

BackgroundWhile anemia has been associated with severe outcomes in neonates, there is a lack of scientific data regarding the associated factors of this problem in newborn babies of Afghanistan; hence, this study was undertaken to fill that gap. The objective of this study was to evaluate the factors associated with anemia in neonates who were admitted to the Neonatal Unit. MethodsThis analytic cross-sectional study with retrospective document review was conducted at the Neonatal Unit of the Maiwand Teaching Hospital in Kabul City, Afghanistan, in 2023. SPSS 26 and certain statistical methods were used to carry out the statistical analysis. ResultsOf the 220 newborns enrolled in this study, anemia occurred in 26.8% of them. Based on gestational age, the occurrence rates of neonatal anemia within groups of term and preterm neonates were 23% and 41.3%, respectively. The occurrence of neonatal anemia was found to be 60% in extremely low birth weight, 41.2% in very low birth weight, 27.2% in low-birth-weight neonates, and 23.9% in normal birth weight neonates. The neonates in the anemic group versus the non-anemic group had a mean birth weight of (2516.18 ± 898.79 vs 2749.62 ± 766.02 g, P = 0.03, 95%CI= -691_-9.9), a mean gestational age of (35.47 ± 3.7 vs 37.4 ± 2.5 w, P = 0.04, 95% CI= -1.6_ -0.9), a mean age of (11.41 ± 6.39 vs 9.9 ± 6.88 days, P = 0.35, 95%CI= -1.6_4.6), a mean CRP level of (13.6 ± 7.6 vs 9.8 ± 5.6 mg, P = 0.01, 95%CI= 0.8_7.8) and a mean hemoglobin level of (11.1 ± 1.7 vs 17.3 ± 2.5 g, P = 0.04, 95%CI=-7.4_-5.1). There was a significant association between neonatal anemia and preterm birth (OR=2.4, P = 0.04, 95%CI=0.08_0.5), male sex (OR=2.4, P = 0.04, 95%CI= 0.1_0.3), neonatal sepsis (OR=2.5, P = 0.01, 95%CI= 0.1_ 0.6), cesarean delivery (OR=3.4, P = 0.00, 95%CI=1.7_6.5), maternal age greater than 35 years (OR=2.9, P = 0.03, 95%CI=0.04_0.6), no iron intake by the mother during pregnancy (OR=1.9, P = 0.002, 95%CI=1.1_3.4), antepartum hemorrhage (OR=4.7, P = 0.00, 95%CI=1.3_10.3), and poor household income (OR=2.6, P = 0.03, 95%CI=0.03_0.2). ConclusionsNewborns admitted to the Neonatal Unit had a significant prevalence of neonatal anemia. The highest occurrence rates were seen within groups of preterm and extremely low-birth-weight newborn babies. Neonatal anemia was found to be associated with lower mean neonatal birth weight and gestational age, as well as with preterm birth, male sex, a higher CRP level, neonatal sepsis, older maternal age, cesarean delivery, no maternal iron consumption, antepartum hemorrhage, and a poor household income.

Effectiveness of adjuvant traditional Chinese medicine on macrovascular invasion in patients with hepatocellular carcinoma: a real-world propensity score-matched study.

The study aimed to investigate the potential of traditional Chinese medicine (TCM) in reducing the risk of macrovascular invasion (MVI) in Chinese patients with hepatocellular carcinoma (HCC). This retrospective analysis involved 2,267 HCC patients treated at our hospital. Propensity score (PS) matching was used to compare TCM users (n = 485) with non-users (n = 485) in terms of age, Barcelona Clinic Liver Cancer (BCLC) staging, type of treatment, and AFP. The impact of TCM on the hazard ratio (HR) of MVI was evaluated using a Cox multivariate regression model. The efficacy of TCM therapy on MVI was further examined using the log-rank test. The analysis revealed that TCM medication was a significant protective factor for MVI in HCC patients, as evidenced by the Cox analysis (adjusted HR = 0.496, 95% CI: 0.387-0.635, p < 0.001). After PS matching, the Kaplan-Meier curve demonstrated a lower occurrence rate of MVI in TCM users compared to non-users. The study findings suggest that TCM treatment has the potential to decrease the incidence of MVI in HCC patients, irrespective of etiology, BCLC staging, liver function, or treatment type. Notably, as the use of TCM increased, the percentage of MVI in patients showed a gradual decrease, indicating the potential of TCM therapy as a successful strategy for preventing MVI.

Характеристика генів інтегронів клінічних ізолятів Pseudomonas aeruginosa, які реалізують резистентність до антибіотиків та біоплівкоутворення цими штамами

Pseudomonas aeruginosa is a bacterium that holds significant clinical and epidemiological significance. It serves as the principal etiological cause of opportunistic infections in individuals with impaired immune systems. Integrons are known to have a notable impact on Gram-negative bacteria, particularly in the context of P. aeruginosa, a bacterium recognized for its ability to develop resistance to antimicrobial drugs. Aim. To systematically characterize and detect integron genes (intI, intII, intIII) with antibiotic-resistant and biofilm-forming capabilities in isolated P. aeruginosa. Methods. A total of 209 samples were collected from Al Yarmouk Teaching Hospital in Baghdad City, Iraq to isolate P. aeruginosa. The process of bacterial identification was carried out phenotypically and by biochemical tests. Antibiotic susceptibility was measured using the Vitek2 system. Biofilm quantification was done by the microtiter method. The PCR approach was employed to assess the presence of class 1, 2, and 3 integrons. Results. P. aeruginosa was identified in 83 isolates by using a combination of morphological and biochemical examinations where all isolates showed the ability to grow a selective medium on cetrimide agar for P. aeruginosa. The results also showed significant variances (p &lt; 0.05) among the percentage of a number of samples and isolated P. aeruginosa. The burn and wound infection scored the highest percentages (25% and 19%) based on the positivity of P. aeruginosa, whereas burn and ear sites scored the highest percentage (58% and 50%). Also, the isolates show the ability to form biofilm at a percentage of 68.7% with resistance to a high number of antibiotics. The multidrug-resistant and sensitive P. aeruginosa isolates scored high percentages (49.4% and 34.9%) whereas potentially pan drug-resistant and extensively drug-resistant isolates scored low percentages (2.4% and 13.3%). PCR results showed that integron I scored the highest percentage (100%) compared to integron 2 found in 3 (10%) isolates, and no intI3 gene was detected in any of the P. aeruginosa isolates. Conclusions. Overall, the findings of the present investigation indicate that integrons and biofilm development are recognized as significant factors contributing to antibiotic resistance in P. aeruginosa. The prevalence of class 1 integrons is shown to be significantly high in all bacterial isolates, with a complete occurrence rate of 100%. This high incidence of class 1 integrons is associated with the development of resistance to crucial antibiotics, including β-lactams, aminoglycosides, and cephalosporins.

Efficacy and Safety of High-power Short-duration Radio Frequency Ablation in the Treatment of Atrial Fibrillation: A Meta-analysis of Prospective Study

Background: Radiofrequency ablation is a critical therapeutic method used in the management of atrial fibrillation (AF). This study systematically evaluates the effectiveness and safety of two catheter radio frequency ablation approaches: high-power short-duration (HPSD) and traditional low-power long-duration (LPLD), in treating AF. Methods: Four databases were searched for prospective studies (eight cohort studies and three randomised controlled trials) that evaluated the effect of HPSD treatment on AF recurrence, occurrence rate of complications and procedural time in patients with AF from the establishment of the databases to March 2023. We utilised RevMan 5.20 and Stata 11.0 statistical software to conduct a meta-analysis, and publication bias was assessed using funnel plots and Egger's test. The effect estimates were synthesised as relative risks (RRs) or standardised mean differences (SMDs) along with their corresponding 95% confidence intervals (CIs). Results: A total of 536 relevant studies were retrieved, and 11 prospective studies were collected. The combined value of the estimated effect of HPSD versus LPLD treatment on AF recurrence in patients with AF had an RR of 0.59 (95% CI: 0.45–0.78; p &lt; 0.001), the effects of HPSD versus LPLD treatment on procedural time in patients with AF had an SMD of –1.17 (95% CI: –1.56– –0.77; p &lt; 0.001), and the effect of HPSD versus LPLD treatment on oesophageal thermal injury in patients with AF had an RR of 0.84 (95% CI: 0.22–3.28; p = 0.80). Notably, the estimated combined effects of HPSD and LPLD on other major complications (steam pop) in patients with AF had an RR of 0.57 (95% CI: 0.22–1.47; p = 0.24). Conclusions: HPSD is more effective than traditional LPLD and has a lower AF recurrence rate after surgery. Meanwhile, HPSD treatment can improve surgical efficiency and has a shorter procedural time than LPLD treatment.

An Improved Forest Smoke Detection Model Based on YOLOv8

This study centers on leveraging smoke detection for preemptive forest smoke detection. Owing to the inherent ambiguity and uncertainty in smoke characteristics, existing smoke detection algorithms suffer from reduced detection accuracy, elevated false alarm rates, and occurrences of omissions. To resolve these issues, this paper employs an efficient YOLOv8 network and integrates three novel detection modules for enhancement. These modules comprise the edge feature enhancement module, designed to identify smoke ambiguity features, alongside the multi-feature extraction module and the global feature enhancement module, targeting the detection of smoke uncertainty features. These modifications improve the accuracy of smoke area identification while notably lowering the rate of false alarms and omission phenomenon occurrences. Meanwhile, a large forest smoke dataset is created in this paper, which includes not only smoke images with normal forest backgrounds but also a considerable quantity of smoke images with complex backgrounds to enhance the algorithm’s robustness. The proposed algorithm in this paper achieves an AP of 79.1%, 79.2%, and 93.8% for the self-made dataset, XJTU-RS, and USTC-RF, respectively. These results surpass those obtained by the current state-of-the-art target detection-based and neural network-based improved smoke detection algorithms.

The Occurrence of Suids in the Post-Olduvai to Pre-Jaramillo Pleistocene of Europe and Implications for Late Villafranchian Biochronology and Faunal Dynamics

It has been proposed that suids were absent from Europe during the post-Olduvai to pre-Jaramillo Early Pleistocene (from less than 1.8 to more than 1.2 Ma) and that their “re-appearance” in the late Early Pleistocene would mark the end of the late Villafranchian and the beginning of the Epivillafranchian. Arguments enumerated in favor of this “suid gap” are the lack of suid remains from extensively sampled fossil localities of this age and the high reproductive potential (r-strategy) of suids, which would translate in a high commonness of their remains in the fossil record. However, here it shown that while suids’ reproductive potential is certainly exceptional within artiodactyls, there is no direct relationship between the reproductive strategy and preservation rate of a taxon in the fossil record. In Early Pleistocene localities of Europe and adjoining areas, where suids are present in a fossil assemblage, they are always rare. In terms of number of occurrences (frequency), suids range from being moderately common (~2.0–1.8 Ma) to moderately rare (~1.1–1.0 Ma). Suid material is also described herein from Peyrolles (Issoire, France; reference locality for MNQ 19), a site dated at 1.47 Ma, providing direct evidence for the presence of suids within the purported “suid gap”. The case of suids underlines an important source of caveat in inferring faunal dynamics of the late Early Pleistocene of western Europe—including the dispersal of hominins—i.e., the unequal geographical distribution of the paleontological sites of post-Olduvai to pre-Jaramillo age. Indeed, Peyrolles is the only large mammal site in western Europe located outside the Iberian and Italian Peninsulas reliably dated around 1.5 Ma. In the post-Olduvai to pre-Jaramillo period, there is a paucity of radiometric estimates (or they have too coarse a resolution) and of paleomagnetic excursions detectable in continental deposits. Basically, for this time span, there is a high dependence on biochronological correlations, although, at the same time, these correlations are less reliable—because these are based on a few sites not covering the entire spectrum of environments present in Europe and the sites are not independently dated with methods that outperform biochronology—than those for other periods.

G protein-coupled estrogen receptor activates PI3K/AKT/mTOR signaling to suppress ferroptosis via SREBP1/SCD1-mediated lipogenesis.

Lung cancer is the leading cause of cancer-related death worldwide. The sex differences in the occurrence and fatality rates of non-small cell lung cancer (NSCLC), along with its association with estrogen dependence, suggest that estrogen receptors (ERs) contribute to the development of NSCLC. However, the influence of G protein-coupled estrogen receptor (GPER1) on NSCLC remains to be determined. Escape from ferroptosis is one of the hallmarks of tumor discovered in recent years. In this context, the present study evaluated whether GPER1 promotes NSCLC progression by preventing ferroptosis, and the underlying mechanism through which GPER1 protects against ferroptosis was also explored. The effects of GPER1 on the cytotoxicity of H2O2, the ferroptosis inducer RSL3, and Erastin were assessed using the CCK8 assay and plate cloning. Lipid peroxidation levels were measured based on the levels of MDA and BODIPY™581/591C11. GPER1 overexpression and knockdown were performed and G1 was used, and the expression of SCD1 and PI3K/AKT/mTOR signaling factors was measured. Immunofluorescence analysis and immunohistochemistry were performed on paired specimens to measure the correlation between the expression of GPER1 and SCD1 in NSCLC tissues. The effect of GPER1 on the cytotoxicity of cisplatin was measured in vitro using the CCK8 assay and in vivo using xenograft tumor models. GPER1 and G1 alleviated the cytotoxicity of H2O2, reduced sensitivity to RSL3, and impaired lipid peroxidation in NSCLC tissues. In addition, GPER1 and G1 promoted the protein and mRNA expression of SCD1 and the activation of PI3K/AKT/mTOR signaling. GPER1 and SCD1 expression were elevated and positively correlated in NSCLC tissues, and high GPER1 expression predicted a poor prognosis. GPER1 knockdown enhanced the antitumor activity of cisplatin in vitro and in vivo. GPER1 prevents ferroptosis in NSCLC by promoting the activation of PI3K/AKT/mTOR signaling, thereby inducing SCD1 expression. Therefore, treatments targeting GPER1 combined with cisplatin would exhibit better antitumor effects.

The Assessment and Treatment of Post-traumatic Stress Disorder in Autistic People: A Systematic Review

AbstractAdverse life events and mental health conditions are unfortunately common amongst autistic adults and children; this may present a vulnerability to developing post-traumatic stress disorder (PTSD). This systematic review provides an update of Rumball’s (Review Journal of Autism and Developmental Disorders, 6, 294–324, 2019) systematic review of PTSD in autistic individuals and identifies 18 new studies published from 2017 to 2022, reflecting increased research interest in PTSD in autistic populations. Included literature suggests that autistic adults and children experience more severe PTSD symptoms compared to their non-autistic peers, with at least comparable rates of occurrence. We provide a comprehensive overview of this emerging field and identify the need for future research to validate PTSD symptom assessment tools and treatment strategies and investigate unique manifestations of trauma-related symptoms in autistic individuals.

Frailty Influence on Postoperative Surgical Site Infections After Surgery for Degenerative Spine Disease and Adult Spine Deformity. Can a Frailty Index be a Valuable Summary Risk Indicator? A Systematic Review and Metanalysis of the Current Literature.

Metanalysis. Surgical site infections (SSI) is one of the commonest postoperative adverse events after spine surgery. Frailty has been described as a valuable summary risk indicator for SSI in spine surgery. The aim of this metanalysis is to evaluate the influence of frailty on postoperative SSI in this cohort and provide hints on which index can predict the risk of SSI. Papers describing the postoperative SSI rate in adult degenerative spine disease or adult spine deformity patients with varying degrees of frailty were included in the analysis. The SSI rate in different grades of frailty was considered for outcome measure. Meta-analysis was performed on studies in whom data regarding patients with different levels of frailty and occurrence of postoperative SSI could be pooled. P < .05 was considered significant. 16 studies were included. The frailty prevalence measured using mFI-11 ranged from 3% to 17.9%, these values were inferior to those measured with mFI-5. Significant difference was found between frail and non-frail patients in postoperative SSI rate at metanalysis (z = 5.9547, P < .0001 for mFI-5 and z = 3.8334, P = .0001 for mFI-11). This is the first meta-analysis to specifically investigate the impact of frailty, on occurrence of SSI. We found a relevant statistical difference between frail and non-frail patients in SSI occurrence rate. This is a relevant finding, as the ageing of population increases alongside with spine surgery procedures, a better understanding of risk factors may advance our ability to treat patients while minimizing the occurrence of SSI.

Observations of polar mesospheric summer echoes resembling kilometer-scale varicose-mode flows

Abstract. The mesosphere and lower thermosphere (MLT) region represents a captivating yet challenging field of research. Remote sensing techniques, such as radar, have proven invaluable for investigating this domain. The Middle Atmosphere Alomar Radar System (MAARSY), located in northern Norway (69∘ N, 16∘ E), uses polar mesospheric summer echoes (PMSEs) as tracers to study MLT dynamics across multiple scales. Chau et al. (2021) recently discovered a spatiotemporally highly localized event showing a varicose mode (simultaneous upward and downward movements), which is characterized by extreme vertical velocities (|w|≥3σ) of up to 60 m s−1 in the vertical drafts. Motivated by this finding, our objective is to identify and quantify similar extreme events or comparable varicose structures, i.e., defined by quasi-simultaneous updrafts and downdrafts, that may have been previously overlooked or filtered out. To achieve this, we conducted a thorough manual search through a MAARSY dataset, considering the PMSE months (i.e., May, June, July, August) spanning from 2015 to 2021. This search has revealed that these structures do indeed occur relatively frequently with an occurrence rate of up to 2.5 % per month. Over the 7-year period, we observed and recorded more than 700 varicose-mode events with a total duration of about 265 h and documented their vertical extent, vertical velocity characteristics, duration, and their occurrence behavior. Remarkably, these events manifest throughout the entire PMSE season with pronounced occurrence rates in June and July, while the probability of their occurrence decreases towards the beginning and end of the PMSE seasons. Furthermore, their diurnal variability aligns with that of PMSEs. On average, the observed events persisted for 20 min, while the varicose mode caused an average expansion of the PMSE layer by a factor of 1.5, with a maximum vertical expansion averaging around 8 km. Notably, a careful examination of the vertical velocities associated with these events confirmed that approximately 17 % surpassed the 3σ threshold, highlighting their non-Gaussian velocity distribution and extreme nature.

Efficacy of Vaginal Progesterone for Maintenance Therapy after Arrested Preterm Labor: A Randomized Controlled Trial

Objective: To evaluate whether 400 milligrams of vaginal progesterone, as a maintenance tocolysis, could prolong the latency to delivery, prevent preterm birth, reduce adverse neonatal outcomes, and delay cervix shortening after arrested preterm labor. Materials and Methods: An open-label randomized controlled trial was conducted on 80 singleton pregnant women with symptomatic preterm labor, who were successfully arrested with Nifedipine as acute tocolysis, at gestational ages 24 to 33 weeks and 6 days, at Hatyai Hospital. Participants were then randomly allocated using a permuted block of four to either the vaginal progesterone group or the control group. Results: The vaginal progesterone group resulted in a longer mean latency to delivery at 47.3±17.1 versus 34.2±18.1 days (p&lt;0.001), a lower preterm birth rate at 12.5% versus 35.0% (p=0.036), a higher gestational age at delivery of 38.5±1.3 versus 36.7±2.5 weeks (p&lt;0.001), and improved birth weight of 2,932.6±309.9 versus 2,627.1±517.3 grams (p=0.002). There were no significant differences in the delay of cervical shortening at –3.2±2.8 versus –4.7±5.0 mm (p=0.192) or the rate of neonatal intensive care unit (NICU) admission of 4% versus 11% (p=0.086) or the rate of birth asphyxia of 5% versus 10% (p=0.675). Conclusion: Administering 400 milligrams of vaginal progesterone as a maintenance tocolysis in arrested preterm labor effectively prolongs latency to delivery, reduces the rate of preterm birth, and improves birth weight. However, it fails to delay cervical shortening and does not decrease the rate of NICU admission or occurrence of birth asphyxia. Keywords: Arrested preterm labor; Preterm birth; Vaginal progesterone; Maintenance therapy

The Prognostic Value of Somatic Mutations of Epigenetic Regulation Genes in Acute Myeloid Leukemias in Real-World Clinical Practice: Results of an Observational Non-Interventional Prospective Interregional Study

Aim. To assess the rate of DNMT3A, IDH1, IDH2, and ASXL1 gene mutations and their effect on the prognosis both as isolated findings and in combination with well-known chromosomal aberrations and gene mutations in newly diagnosed acute myeloid leukemia (AML) patients from some regions of the Russian Federation.&#x0D; Materials &amp; Methods. The study enrolled 83 patients with newly diagnosed AML from 22 regions of the Russian Federation, who underwent molecular genetic examination for detecting IDH1 (R132), IDH2 (R140), ASXL1, and DNMT3A gene mutations with droplet digital PCR and Sanger sequencing methods.&#x0D; Results. The mutation rate in DNMT3A was 16.7 %, in IDH1 (R132) it was 6 %, in IDH2 (R140) it was 9.6 %, and in ASXL1 it was 6 %. The R140 mutation in IDH2 correlated with the older age of patients. The mutations in IDH1 (R132), IDH2 (R140), and DNMT3A showed a significant association with mutated NPM1. The mutations in IDH1 (R132), IDH2 (R140) were reported to occur significantly more often in patients with normal karyotype. The IDH1 (R132) and IDH2 (R140) mutations appeared to have a favorable effect on AML prognosis, which is most likely to be associated with a high rate of their compatibility with NPM1 mutation. The mutated type of DNMT3A had a negative effect on overall survival of patients with NPM1 mutation. The mutation in ASXL1 also appeared to be an unfavorable prognostic factor for overall survival of patients with wild type NPM1.&#x0D; Conclusion. A high rate of mutation occurrence in epigenetic regulation genes as well as the prognostic potential of these mutations in AML necessitate the need for determining the mutation status of DNMT3A, IDH1, IDH2, and ASXL1 in the context of primary diagnosis in real-world clinical practice.