Preventive measures aimed at minimizing the occurrence of work-related musculoskeletal disorders of the upper limbs (WMSDs) associated with repetitive tasks can be divided into three categories: structural, organizational and educational. Whenever specific risk and injury assessments have shown the need for preventive action, this is most often implemented within the framework of a range of assorted measures. In particular, structural measures involve optimizing the layout of the work area and furnishings, and the 'ergonomic' properties of work tools and equipment. Such measures serve to alleviate the problems caused by the use of excessive force and awkward postures. The authors refer to the principles guiding such structural measures, in the light of the extensive literature that has been published on the subject. Organizational (or reorganizational) measures essentially relate to job design (i.e. distribution of tasks, speeds and pauses). They serve to alleviate problems connected with highly repetitive and frequent actions, excessively lengthy tasks and inadequate recovery periods. Very few relevant findings are available: the authors therefore illustrate in some detail a practical trial conducted in a major engineering firm. The objective was to lower to acceptable limits the frequency of certain repetitive tasks performed using the upper limbs. The trial made it possible to identify a suitable plan and schedule of measures taking into due consideration the impact of the plan on production levels (and costs). The fundamental principles guiding the adoption of specific educational and training programmes for the workers and their supervisors are presented and discussed.