Occurrence Of Outbreaks Research Articles

Reproducibility and Validity of a Self-Administered Food Safety Assessment Tool on Children and Adolescent's Risk Perception, Knowledge, and Practices.

The present study aimed to verify the instrument's reliability and validity for assessing children and adolescents' risk perception, knowledge, and food safety practices in the school context. Moreover, it aimed to test the hypothesis that both application methods (paper and pencil (PAPI) and online) are valid. The instrument comprised three questionnaires and followed a strict protocol to combine online and PAPI models, resulting in five application forms. The sample consisted of 439 Brazilian students from 10 to 14 years old (y/o). The results related to reliability and validity indicated that the knowledge questionnaire presented adequate stability and discriminant validity coefficients. The self-reported practices questionnaire obtained acceptable coefficients of stability and internal consistency. Regarding risk perception data, it was observed that students attribute a low probability of Foodborne Diseases (FBD) outbreaks occurrence and low severity of possible symptoms. In addition, students demonstrated insufficient knowledge and inadequate practices on issues related to failures associated with the time and temperature of preparation, storage, and exposure of food, contamination of food, and consumption of unsafe food. In this context, the reproducibility and validity indices need to be interpreted and discussed correctly, and young people in food safety actions are a priority in facing FBD.

Quantifying the potential impact of mass media campaigns on mitigating the spread of chikungunya virus during outbreaks in heterogeneous population

In recent decades, media campaigns have played an important role in assessing, preventing and controlling infectious diseases. However, little progress has been made in quantifying its impact during chikungunya epidemics. In order to address this critical gap, this paper develops and analyzes a climate-based model of chikungunya virus disease that incorporates mass media campaigns and heterogeneous biting exposures. We obtained the basic reproduction numbers associated with the proposed model and determined the results of the threshold dynamics. We calibrated our model based on literature data and validated it with monthly observed chikungunya cases in Madhya Pradesh, India (2016–2017). The results show that mass media campaigns can significantly reduce the spread of the disease. It can also limit the occurrence of future outbreaks in the next few years. We also observed that media fatigue may reduce the impact of media to mitigate the spread of chikungunya virus.

Environmental pollutants and their impact on COVID‐19 spread: Current problem and future resolutions

AbstractCOVID‐19 is the greatest crucial universal health issue of the century and the extreme challenge that came after the 2nd World War faced by humankind. In 2019, different strains of the coronavirus have emerged drastically, that as severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) which is the causative agent of corona disease. As far as human civilization history, there have been occurrences of severe diseases and outbreaks of various viruses. According to World Health Organization reports, throughout the world, the present outbreak of COVID‐19 has engulfed more than 200 countries affecting 241,471,559 individuals and more than 4,914,092 people lost their lives. SARS‐CoV‐2 outbreak is severely disturbing the worldwide economy at present. The urgent need of recent times is to understand the environmental aspect of COVID‐19 disease. Hence to fulfill this point, the present review article is compiled with a brief discussion about all the minute points of the COVID‐19 pandemic related to the environment: origin and present scenario, the occurrence of SARS‐CoV‐2 in environmental habitats, the effect of COVID‐19 on human health, and environment, environmental factors influencing the transmission and spreading of SARS‐CoV‐2. This review explains micro and macro pollutants in hospital and urban wastewater influencing COVID‐19, detection of SARS‐CoV‐2, current global drug strategies to control replication and spread of SARS‐CoV‐2 from the environment, future approaches, and guidelines to prevent and control upcoming pandemics. The SARS‐CoV‐2 structural details and their effect on humans have been already well presented but the research about environmental factors affecting COVID‐19 could be important points to fight present and future pandemics.

Epidemiological aspects of cattle tick fever in Brazil.

The present work reviews the epidemiologic situation of Anaplasma marginale and Babesia spp. infections and the occurrence of cattle tick fever outbreaks in Brazil. In areas of tick fever enzootic instability, environmental conditions interfere with the development of Rhipicephalus (Boophilus) microplus: chilly winter in the southern region, floods in the Pantanal, and low humidity in the Caatinga. In contrast, the climatic conditions of stable zones (Cerrado, Amazon and Atlantic Forest biomes) favor tick development. In enzootic areas, tick fever is uncommon because the animals are in frequent contact with the parasite, acquiring immunity naturally during the period of innate resistance; however, outbreaks may occur when calves become infested by considerable numbers of infected ticks during this period or in adults raised in tick-free environments that become infested for the first time when transporting to stable areas. It is necessary to better understand the disease's risk factors under stable conditions and the implications of the mechanical and other vector transmission of A. marginale. To prevent tick fever outbreaks in Brazil, it is important to develop and use anaplasmosis and babesiosis vaccines in cattle from enzootic unstable regions, especially when animals are moved to stable areas.

COVID-19 and all that this Pandemic Entails

The struggle between man and infectious diseases dates back to the very beginning of civilization. Throughout history, mankind has suffered the scourge of an infinite number of entities with varied etiological diversity (viral, bacterial, fungal and parasitic), which have spread death and disability among millions of the planet’s inhabitants. The increase of re-emerging and emerging diseases in recent decades has greatly complexified the epidemiological picture at the global level, where the occurrence of several epidemic and pandemic outbreaks has been evident, with marked repercussions on human health and that of the rest of the animals. The current situation that the planet is living, due to the new coronavirus, is one more effect, derived from the bad behavior of anthropogenic activity, accumulated during thousands of years.

Multicriteria analysis model for foot-and-mouth disease risk classification in the state of Goiás - Brazil

ABSTRACT: Foot-and-mouth disease (FMD) is a viral disease that affects several animal species, including domestic and wildlife ones. The occurrence of an FMD outbreak can potentially cause a large negative impact on countries or regions’ livestock production and economy. Performed over several decades, mass herd vaccination has been the main strategy to control the disease. However, countries are beginning the stage of eradicating FMD, which involves suspending vaccinations. The present study carried out a risk classification for FMD occurrence in Goiás State, Brazil by evaluating and combining multiple risk factors involved in FMD introduction and dissemination. Data from 126,345 rural properties were collected and categorized by municipality. The risk factors were grouped into two modules and then scores for each module were obtained by adding and weighting the risk factors. These combined scores resulted in the final FMD occurrence risk score. Most of the municipalities, as well as the herds were found in the lowest likelihood levels. Variables linked to herd density and animal movement played a key role in the score composition. We believed that this model can be a useful tool in the decision-making process regarding actions and strategies related to FMD eradication.

Five decades of infectious diseases outbreaks in the African region (1970–2018) a geographic snapshot

This paper is being written at a time when the recent pandemic, namely COVID-19, has shaken the entire world in a manner that has never been seen in modern history. The ecology, socio-economy and weak health systems make Africa an area favorable to the occurrence of various diseases and disease outbreaks. This paper explores forty-eight (48) years of disease outbreaks in the WHO African region of the World Health Organization (WHO). Twenty-five (25) Integrated Disease Surveillance and Response priority diseases were selected, and their outbreaks were described and analyzed. Using inferential spatial statistics, spatial clusters at the health district level, specifically hot spots of those outbreaks, were produced and analyzed. The Population at risk of those hot spots was estimated. Results show a consistent report of outbreaks during the selected period, with 52 outbreaks on average per year. Poliomyelitis, cholera, yellow fever, meningococcal disease and measles were the most reported outbreaks. Democratic Republic of the Congo (DRC) and Nigeria were the countries reporting the highest number of outbreaks (5 on average per year), with high number of people living in hot spots districts (85M). Despite efforts to limit their number, some disease outbreaks, such as cholera, malaria, and measles, continue to have a burden in terms of morbidity and mortality. In contrast, others, such as poliomyelitis, yellow fever and diarrhoeal disease, have shown a declining trend, and wild polio virus transmission has been eliminated in the region. Results suggest that concerted public health action may help reduce outbreaks in the region. Results can be used to inform preparedness and prevention activities. Priority public health actions should target DRC and Nigeria and identified hot spots and areas with existing risk factors within other countries.

Spatio-temporal distribution & seasonality of highly pathogenic avian influenza H5N1 & H5N8 outbreaks in India, 2006-2021.

The highly pathogenic avian influenza (HPAI) H5N1 and H5N8 viruses have been one of the leading causes of avian diseases worldwide, resulting in severe economic losses and posing potential zoonotic risk. There are no reports on the correlation of the seasonality of H5N1 and H5N8 viruses with the migratory bird season in India, along with the species affected. The present report describes the distribution and seasonality of HPAI outbreaks in India from 2006 to 2021. The data on the occurrence and locations of outbreaks in India and affected bird species were collated from the Food and Agriculture Organization of the United Nations database and grouped by month and year. The distribution and seasonality of HPAI H5N1 and H5N8 viruses were analyzed. A total of 284 H5N1 outbreaks were reported since 2006, with a surge in 2021. The initial outbreaks of H5N1 were predominantly in poultry. Since 2016, 57 outbreaks of H5N8 were also reported, predominantly in wild birds. Most of the outbreaks of HPAI were reported from post monsoon onwards till pre-summer season (i.e. between October and March) with their peak in winter, in January. Apart from poultry, the bird species such as owl, Indian peafowl, lesser adjutant, crows and wild migratory birds such as demoiselle crane, northern pintail and bar-headed goose were positive for HPAI. Such studies on the seasonality of HPAI outbreaks would help in the development of prevention and control strategies. The recent human infections of H5N1 and H9N2 viruses highlight the need to strengthen surveillance in wild, resident, migratory birds and in poultry along with One Health studies in India.

Efficacy of household methods for disinfecting water for human consumption: focus on the context of Santarém, state of Pará, Brazil

In the Amazon region, cities such as Santarém, in the state of Pará, Brazil, still lack Water Treatment Stations to serve the entire population. In these places, household methods of water disinfection are important to preserve potability and avoid undesirable health effects. Our study experimentally evaluated the effect of household methods for eliminating Escherichia coli in water samples. The techniques evaluated for this study were: (i) sodium hypochlorite 2.5%; (ii) boiling; (iii) ceramic filter, and (iv) sun exposure. Samples were tested, combining different concentrations of E. coli (from 3 to 100 colony forming units/100mL). The results showed that household disinfection methods were effective in eliminating E. coli; except for the ceramic filter, the water of which was still positive for their growth, even after filtration. Considering that the distribution of treated water does not reach most of the population living in Santarém and in peri-urban areas, such as the quilombola and riverside communities, the use of such methods as sodium hypochlorite 2.5%, boiling, and sun exposure may favor health promotion and reduce the occurrence of outbreaks of dysentery transmitted by water.

Monkeypox: A Review in Indian Context

Emerging and re-emerging zoonoses of diverse etiologies have caused significant morbidity and mortality recently. In the past two decades, several viral zoonoses, such as Bird flu, Ebola hemorrhagic fever, Hantavirus infection, Nipah virus disease, Rift Valley fever, Swine flu, West Nile fever, SARS, MERS, COVID-19 etc., have emerged from different parts of the world. The latest to the list is the “Monkey Pox”, which has recently been renamed as “Mpox” by WHO. The ongoing 2022 multi-country outbreak of monkeypox is the largest in history to occur outside of Africa. Monkeypox is an emerging zoonotic disease that for decades has been viewed as an infectious disease with significant epidemic potential because of the increasing occurrence of human outbreaks in recent years. With increasing case numbers being reported in the current outbreak, it is important for healthcare staff everywhere to update their knowledge of this zoonotic infection, including its prevention, clinical management, prophylaxis, and basics of infection control, to understand the broader implications of the current outbreak. We provide an overview of monkeypox virus infection to serve as a primer for healthcare staff who may encounter this condition in their practice.

1074. Surveillance of SARS-CoV-2 variants of concern (VOC) in hospital wastewater (WW) and its correlation with hospitalized cases of COVID-19 and the occurrence of outbreaks

Abstract Background WW surveillance enables real time monitoring of SARS-CoV-2 burden in defined sewer catchment areas. Here, we assessed the occurrence of total, Delta and Omicron SARS-CoV-2 RNA in sewage from three tertiary-care hospitals in Calgary, Canada. Methods Nucleic acid was extracted from hospital (H) WW using the 4S-silica column method. H-1 and H-2 were assessed via a single autosampler whereas H-3 required three separate monitoring devices (a-c). SARS-CoV-2 RNA was quantified using two RT-qPCR approaches targeting the nucleocapsid gene; N1 and N200 assays, and the R203K/G204R and R203M mutations. Assays were positive if Cq< 40. Cross-correlation function analyses (CCF) was performed to determine the time-lagged relationships between WW signal and clinical cases. SARS-CoV-2 RNA abundance was compared to total hospitalized cases, nosocomial-acquired cases, and outbreaks. Statistical analyses were conducted using R. Results Ninety-six percent (188/196) of WW samples collected between Aug/21-Jan/22 were positive for SARS-CoV-2. Omicron rapidly supplanted Delta by mid-December and this correlated with lack of Delta-associated H-transmissions during a period of frequent outbreaks. The CCF analysis showed a positive autocorrelation between the RNA concentration and total cases, where the most dominant cross correlations occurred between -3 and 0 lags (weeks) (Cross-correlation values: 0.75, 0.579, 0.608, 0.528 and 0.746 for H-1, H-2, H-3a, H-3b and H-3c; respectively). VOC-specific assessments showed this positive association only to hold true for Omicron across all hospitals (cross-correlation occurred at lags -2 and 0, CFF value range between 0.648 -0.984). We observed a significant difference in median copies/ml SARS-CoV-2 N-1 between outbreak-free periods vs outbreaks for H-1 (46 [IQR: 11-150] vs 742 [IQR: 162-1176], P< 0.0001), H-2 (24 [IQR: 6-167] vs 214 [IQR: 57-560], P=0.009) and H-3c (2.32 [IQR: 0-19] vs 129 [IQR: 14-274], P=0.001). Conclusion WW surveillance is a powerful tool for early detection and monitoring of circulating SARS-CoV-2 VOCs. Total SARS-CoV-2 and VOC-specific WW signal correlated with hospitalized prevalent cases of COVID-19 and outbreak occurrence. Disclosures All Authors: No reported disclosures.

Molecular characterization of circulating Dengue virus 2 during an outbreak in Northern Senegal's Saint-Louis region in 2018.

Globally, 390 million people are at risk of dengue infection and over the past 50 years, the virus incidence increased thirty-fold. In Senegal, an unprecedented occurrence of outbreaks and sporadic cases have been noticed since 2017. In October 2018, an outbreak of Dengue virus 2 (DENV-2) was reported in the north of Senegal affecting multiple areas including Saint-Louis, Richard Toll, and Rosso which are located at the border with Mauritania. Of these 173 blood specimen samples collected from patients, 27 were positive for dengue byquantitative reverse transcription PCR (qRT-PCR), and eight were serologically confirmed to be positive for DENV immunoglobulin M (IgM). Serotyping using qRT-PCR reveals that isolates were positive for DENV-2. A subset of DENV-2 positive samples was selected and subjected to whole-genome sequencing followed by phylogenetic analysis. Analysis of six nearly complete genome sequences revealed that the isolates belong to the cosmopolitan genotype and are closely related to the Mauritanian strains detected between 2017 and 2018 and those detected in many West African countries such as Burkina Faso or Cote d'Ivoire. Our results suggest a transboundary circulation of the DENV-2 cosmopolitan genotype between Senegal and Mauritania and call for a need for coordinated surveillance of arboviruses between these two countries. Interestingly, a high level of homology between West African isolates highlights endemicity and calls for the set-up of subregional viral genomic surveillance which will lead to a better understanding of viral dynamics, transmission, and spread across Africa.

Vaccine hesitancy among Ukrainian refugees.

On February 2022, Russia invaded Ukraine. Beyond Poland, Romania, Russia, several refugees reached Italy also. In the past, several factors contributed to low vaccination coverage in Ukraine and the occurrence of epidemic outbreaks. The purpose of our study was to analyze the main characteristics of Ukrainian refugees who accessed the Rozzano Vaccination Center (Italy), and the attitude towards proposed vaccinations. In March-July 2022, we conducted a cross-sectional study on Ukrainian refugees under the age of 18. On the basis of their vaccination certificates or antibody dosages, the doctor proposed to the parents (or legal guardians) any vaccinations to be carried out on the basis of the Italian childhood vaccination schedule. Refused or accepted vaccinations were registered and the data exported for statistical analysis. COVID-19 vaccination was excluded from the analysis. 27 refugees missed the appointment, so 79 Ukrainian refugees have been included in the study. Females represented the 51.90% of patients; the average age was 7.11 (sd 4.92) years. The most refused vaccinations were: HPV, MMR and men C. Significant differences due to age were found for Men C and Chickenpox acceptance. The efforts made to ensure complete care and to promote vaccination among refugees, offering them a complete evaluation of the vaccination status and the possibility of being vaccinated for free, seem to be insufficient to convince most refugees to get vaccinated.

Dengue Fever Outbreak Investigation in Werder Town, Dollo Zone, Somali Region, Ethiopia.

Dengue fever (DF) is a mosquito-borne disease caused by the dengue virus. DF is endemic to many tropical and subtropical countries around the world. In Ethiopia, DF emerged in 2013 and caused a serious public health problem. We investigated the outbreak to describe by time, place, person, and to identify risk factors associated with the outbreak in Werder town, Dollo Zone, Somali Region, Ethiopia. Descriptive and case-control studies (1:2 ratio) were conducted. We used the World Health Organization (WHO) case definition to identify cases in Werder town from December 10, 2020, to January 4, 2021. Controls were selected from the same town that did not suffer from DF. Serum samples were tested by reverse transcription polymerase chain reaction (RT-PCR) to detect the dengue virus and to identify serotypes. A structured questionnaire was used to collect socio-demographic, behavioural, and environmental characteristics. We identified a total of 57 cases and 114 controls. The overall attack rate was 334.41/100,000 with a zero case fatality rate. Six out of twenty serum samples tested positive for the DEN-3 serotype. In multivariate analysis, not hearing of DF (Adjusted odd ratio (AOR): 2.2, 95% CI: 1.015-4.701), not knowing the mode of transmission (AOR: 2.9, 95% CI: 1.338-6.831), not using long-lasting insecticidal net (LLITN) (AOR: 4.4, 95% CI: 1.592-12.330) and not spraying insecticide (AOR: 3.6, 95% CI: 1.591-8.098) were statistically significant risk factors associated with DF outbreak. However, wearing long sleeves (AOR: 0.435, 95% CI: 0.206-0.918) was a protective factor for the DF outbreak. DF outbreak in Werder town has been confirmed. The present study provides evidence-based information regarding the identified risk factors that have contributed to the occurrence of DF outbreaks. We recommended implementing vector control measures and strengthening dengue surveillance systems is strongly advised.

Monkeypox Infection 2022: An Updated Narrative Review Focusing on the Neonatal and Pediatric Population.

Monkeypox disease has been endemic in sub-Saharan Africa for decades, attracting remarkable attention only i23n 2022 through the occurrence of a multi-country outbreak. The latter has raised serious public health concerns and is considered a public health emergency by the World Health Organization. Although the disease is usually self-limiting, it can cause severe illness in individuals with compromised immune systems, in children, and/or the pregnant woman-fetus dyad. Patients generally present with fever, lymphadenopathy, and a vesicular rash suggestive of mild smallpox. Serious eye, lung and brain complications, and sepsis can occur. However, cases with subtler clinical presentations have been reported in the recent outbreak. A supportive care system is usually sufficient; otherwise, treatment options are needed in patients who are immunocompromised or with comorbidities. A replication-deficient modified and a live infectious vaccinia virus vaccine can be used both before and after exposure. Due to the persistent spread of monkeypox, it is necessary to focus on the pediatric population, pregnant women, and newborns, who represent fragile contagion groups. Here we assess and summarize the available up-to-date information, focusing on available therapeutic options, with insights into social and school management, breastfeeding, and prevention that will be useful for the scientific community and in particular neonatal and pediatric health professionals.

An analysis on the preliminary benefits of aquaculture smart aeration control

Aquaculture in Taiwan is characterised by high breeding densities of up to five times higher than the normal breeding densities. Pollution in the breeding environment and its adjacent waters have exacerbated the occurrence of disease outbreaks in fish, shrimp and shellfish, which greatly impacted the economy. Therefore, the parameters pertaining to water quality status, especially dissolved oxygen are particularly important. In addition to the rising cost of labour, land, infrastructure and other materials, the capital needed to engage in aquaculture has risen, whereas the profits have decreased. This limits the growth of aquaculture and fisheries. To overcome this problem, it is essential to shift towards efficient and ecologically precise smart aquaculture. The application of industrialised and smart systems in the vertical diffusion and in-depth integration of aquaculture facilitates decision-making, improves the level of intelligence in breeding, and enhance aquaculture's contribution to Taiwan's economy.

Worldwide poliomyelitis outbreaks: should mass gathering organizers be concerned?

The polio is the longest PHEIC and the continued occurrence of outbreaks of cVDPV would put further risks globally. The binary nature of PHEIC declarations would not support the continued polio PHEIC due to the requirement of tiered or graded strategies to combat such diseases.

Epidemiology of foot-and-mouth disease outbreaks in Thailand from 2011 to 2018.

Foot-and-mouth disease (FMD) is one of the most important animal diseases hindering livestock production in Thailand. In this study, a temporal and spatial analysis at the subdistrict level was performed on FMD outbreak reports in Thailand from 2011 to 2018. Risk factors associated with FMD outbreaks were furthermore investigated using generalized estimating equations. The results showed that the incidence of FMD outbreaks was the highest in 2016 and was affected by season, with a peak in FMD outbreaks occurring in the rainy-winter season, during October to December. FMDoutbreaks were mostly distributed in small clusters within a few subdistricts. Some high-risk areas with repeated outbreaks were detected in the central regions. Risk factors, including the increase of subdistrict's size of the dairy population, beef population or pig population, the low percentage of forest area, subdistricts in the provinces adjacent to Malaysia, the presence of a livestock market and the occurrence of an FMD outbreak in a neighbouring subdistrict in the previous month significantly increased the odds of having an FMD outbreak. The increase in proximity to the nearest subdistrict with an FMD outbreak in the previous month decreased the odds of having FMD outbreaks. This study helped to identify high-risk areas and periods of FMD outbreaks in Thailand. Together with the identified risk factors, its results can be used to optimize the FMD control programme in Thailand and in other countries having a similar livestock industry and FMD situation.

Food Safety Issues Related to Eating In and Eating Out.

Because of growing urbanization and lack of time to prepare meals at home, eating out or getting food delivered have become common trends for many people. The consumption of food from unknown sources may impose an increased chance of contamination with microbiological hazards, especially if sanitary conditions are not met. We evaluated data from health surveillance agencies and scientific articles on foodborne diseases (FBD) reported internationally according to the exposure sites. We observed that the data are influenced by cultural, political, and socioeconomic differences. For instance, in New Zealand, Australia, United States, Denmark and India, the occurrence of FBD outbreaks was greater from foods prepared in commercial establishments and street vendors than from households. Conversely, in China, countries of the European Union and Brazil, the results are the opposite. Additionally, the pandemic imposed new eating behavior patterns, increasing delivery services and foods prepared in so-called "Dark Kitchens". The underreporting and heterogeneity of data among countries prevented a precise conclusion to the question of whether homemade foods are inherently safer than foods prepared out. Nevertheless, a lower level of development in a country influences its sanitation conditions, as well as the number of street food vendors, the search for cheaper foods, and insufficient knowledge of the population on good hygiene practices, which can all increase the chances of FBD cases.

Effects of migration and vaccination on the spread and control of yellow fever in Latin American communities: a mathematical modelling study

BackgroundWith the COVID-19 pandemic, the stigmatisation of migrants as mere vectors of diseases has worsened. Our goal was to assess how migration rates could affect yellow fever dynamics in Latin American communities, one of those being in Necoclí, Colombia, with 70 000 inhabitants and another 70 000 migrants annually waiting to access central America. MethodsThis modelling study used a susceptible, exposed, infective, recovered, and vaccinated compartimental deterministic model for humans and vectors and numerical simulations applied to three scenarios: (1) migration from an endemic community to a disease-free host community; (2) migration from an endemic community located in a migratory route to a disease-free community; and (3) Necoclí as a case study, evaluating the effects of vaccinating migrants upon arrival. FindingsThe type of vector and vaccination coverage in the host community were more relevant for the occurrence of outbreaks than migration rates, and effective vaccinations were able to reduce 55·68% of cases and 54·54% of deaths, but not eliminate them entirely because of the influx of exogenous cases. In Necolcí, assuming the number of migrants equals the resident population, the loss of herd immunity reached 50% every year, and in the case of an outbreak, there were from 3500 to almost 8000 cases of yellow fever in the city. InterpretationAlthough migration brings a virus to a community, it does not cause the outbreak outcomes. Therefore, as our results showed, the focus should be on vaccinations and working on vector control rather than blaming migrants. Vaccination could prevent even more cases if any proportion of migrants are already immune, but there are no reliable data on the proportion of vaccinated migrants and no expectation that people on the move will have their personal vaccination documentation on hand. With the increase in the migration of children younger than 5 years, there are increasing concerns about their vaccination history. This model represents many communities in Latin America and suggests that safe migration corridors can substantially contribute to the control of vaccine preventable diseases. FundingCoordination for the Improvement of Higher Education Personnel.