Occurrence Of Neurological Symptoms Research Articles

NEUROLOGICAL SYMPTOMS AND MERCURY CONCENTRATION IN THE BRAIN OF MICE FED WITH METHYLMERCURY SALT

A hypothesis on the critical concentration of mercury in the brain, which is neces-sary to induce neurological symptoms, was tested again by feeding of methylmercury chloride to mice.As well as in the previous experiment; single or repeated peroral administration of methylmercury chloride to mice, death followed the occurrence of neurological symptoms, when the accumulated amount of mercury was more than 30 μg Hg/g.The most sensitive, namely earliest, symptom; the lessening of the head mainte-nance on horizontal position on being hung with the tail was noticed at a brain con-centration of 10 μg Hg/g.The lowest daily dose group of 10 μg Hg/g of diet did not show the loss of body weight and neurological symptoms during the observation period up to the 41st day of mercury feeding.

Polyneuritis in systemic lupus erythematosus; review of the literature and report of a case.

THE occurrence of neurologic symptoms and signs in the course of systemic lupus erythematosus is well known, but the majority of these are the result of involvement of the central nervous system. Only a few well studied cases of associated polyneuritis have been reported.1 , 2 The incidental finding of peripheral mononeuritis, usually preterminally, has been recorded in a few autopsied cases without any report of the autopsy protocol of the isolated clinical findings.3 , 4 Sedgwick and Von Hagen5 described the occurrence of polyneuritis in a case of systemic lupus erythematosus, but the data presented are insufficient to support the diagnosis. A second . . .

NEUROPATHY IN DIABETES MELLITUS

The frequent occurrence of neurologic symptoms and signs is one of the striking features noted in a clinic for the treatment of diabetes. Although the frequency of individual symptoms and signs varies, it is safe to say that about 50 per cent of diabetic patients show evidence of a disturbed nervous system. In 1884, Bouchard1noted absence of knee jerks in 28.8 per cent of diabetic patients, and in 1931 Sevringhaus2recorded pain in 49 per cent and reduced reflexes in 57.3 per cent of diabetic patients specially examined for these changes. Among 461 of our diabetic patients in whom the patellar and achilles reflexes were tested, we found decreased or absent reflexes in 45.3 per cent. Diabetic neuritis is not a new condition, yet little progress seems to have been made in its prevention or cure. Although previous to 1864 symptoms suggestive of the degeneration of nerves