As occupational therapists develop their roles in promoting the health of populations, it is important to understand the nature of population-based practice. Seventeen occupational therapists engaged in population-based practice participated in semi-structured interviews that explored major aspects of their practice. Qualitative descriptive analysis was used to summarize results. The population-based practice of participants was primarily at the community level and focused on health teaching and coaching, and collaboration and consultation. Four topic areas within population-based practice were identified (with respective themes): characteristics (bigger impact, respond to specific needs of communities, and emphasize prevention), preparation (community engagement within occupational therapy education, education beyond occupational therapy, and networking and leadership experiences), challenges (difficulty obtaining funding, resistance, and time consuming), and benefits (doing more within the scope of practice, and positive client impact). These themes can inform the work of occupational therapists engaged in population-based practice.