Background and Objectives: Occupational injuries are considered as one of the most important health, social and economic risk factors in industrial and developing societies. Therefore, the aim of the present study was to investigate the trend of mortality and Disability Adjusted Life Years rates due to occupational injuries in Hamedan province during 1990 to 2021. Methods: In this cross-sectional descriptive study, the trend of changes in the mortality and Disability Adjusted Life Years rates due to occupational injuries in Hamedan province in a period of 32 years was investigated using join point regression and Join Point Regression software version 5.1.0. Results: The Disability Adjusted Life Years (due to premature death and disability) from occupational injuries in Hamedan province decreased from 496.75 years per thousand population in 1990 to 229.98 years per thousand population in 2021 (the average annual percent changes (AAPC) was -2.40%). This decreasing trend in DALY caused by occupational injuries was also evident in men and women (the AAPC in men and women was -2.40% and -1.10%, respectively).On the other hand, the mortality rate due to injuries in both sexes had decreased from 7.55 cases per 100,000 population in 1990 to 3.46 cases per 100,000 population in 2021 (AAPC was -2.50%). Conclusion: Generally, the trend of mortality and Disability Adjusted Life Years rates due to occupational injuries in Hamedan province had a decreasing trend, which was consistent with other studies conducted in Iran and the world.