The purpose of the study was to analyze the occupational morbidity in the Dnieper Economic Region, its structure in dynamics for 2015-2019, identify the main causes that lead to the formation of occupational pathology, and suggest ways to solve the problem. Material and methods. Based on the processing of the medical documentation of the clinic, the Ukrainian Research Institute of Industrial Medicine, we conducted a comparative analysis of occupational morbidity indicators in the dynamics of 2015-2019 was carried out taking into account the main forms of pathology and regional distribution. Results and discussion. The level of occupational morbidity among workers of the Dnieper Economic Region in 2015-2019 varies from 354 to 10307 cases. The leadership in the formation of professional pathology remains with the Dnipropetrovsk region, where large enterprises of the leading branches of heavy industry are located, in dangerous and harmful conditions of which a significant number of people work. In the structure of occupational morbidity, the first place is occupied by chronic obstructive pulmonary diseases of occupational etiology (31.7%), the second is cochlear neuritis (27.3%), the third is radiculopathy (23.7%), and the fourth is vibration disease (7.6%). Indicators of occupational morbidity indicate only the detection of occupational pathology. The statistics do not reflect the true situation, which is due to the imperfection of labor protection legislation, the lack of legal and economic sanctions for concealing occupational diseases, and the shortcomings of medical diagnostic and preventive work among workers. The solution to this problem, in our opinion, may consist in enhancing coordination of the entire complex of scientific and practical activities for the development and substantiation of strategies, tactics and implementation of national policies from the most important areas of occupational medicine. Conclusion. It is necessary to formulate a systematic approach to the prevention of occupational morbidity of the population, taking into account the characteristics of the current situation in the region and in the country as a whole. Comprehensive solution of problems in the health of workers, taking into account the interagency coordination of the system of measures, in the future will ensure the preservation of labor potential, prolong working life, and reduce general and occupational diseases