Occlusion In Children Research Articles

Abnormal tooth maturation associated with port wine stains.

This study aims to evaluate the potential impact of port wine stains on the development of permanent teeth in mixed dentition and provide insights for managing tooth abnormalities in patients with port wine stains. A retrospective analysis was conducted on 21 patients with mixed dentition and unilateral maxillary port wine stains. Two researchers concurrently utilized Nolla Analysis to assess the developmental stage of bilateral maxillary and permanent mandibular teeth based on panoramic radiographs. The cumulative developmental values of upper and lower permanent teeth on both sides were calculated, and a comparison was made between the developmental stages of the upper and lower jaws. Port wine stains can influence the maturity of permanent upper teeth, within the unilateral maxillary port wine stains range, with an early developmental completion observed on the affected side compared to the unaffected side. While the developmental stages of the lower teeth on both sides showed similarities. Port wine stains can accelerate the maturity of teeth on the affected side, leading to alterations in the order of tooth eruption and subsequent abnormal occlusion in children with mixed dentition. These findings provide a basis for developing appropriate management strategies for addressing tooth abnormalities in patients with port wine stains.

How do children fare compared with adults? Comparing relative outcomes after thrombectomy for acute ischemic stroke due to large-vessel occlusion

ObjectiveSafety and efficacy data for endovascular thrombectomy for acute ischemic stroke secondary to large-vessel occlusion in children are lacking compared with those for adults. We undertook an updated systematic review and meta-analysis of endovascular thrombectomy in children and compared their outcomes with adult data. MethodsWe searched PubMed, Medline, and EMBASE databases to identify prospective and retrospective studies describing patients <18 years treated with endovascular thrombectomy for acute ischemic stroke due to large-vessel occlusion. ResultsEight pediatric studies were included (n = 192). Most patients were male (53.1 %), experienced anterior circulation large-vessel occlusion (81.8 %), and underwent endovascular thrombectomy by stent retreiver (70.7 %). The primary outcome was change in National Institutes of Health Stroke Scale score from presentation to 24 h after thrombectomy. Secondary outcomes included modified Rankin scale score improvement and 90-day score, recanalization rates, procedural complications, and mortality rates. After treatment, 88.5% of children had successful recanalization; the mean National Institutes of Health Stroke Scale score reduction was 7.37 (95 % CI 5.11–9.63, p < 0.01). The mean reduction of 6.87 (95 %CI 5.00–8.73, p < 0.01) for adults in 5 clinical trials (n = 634) was similar (Qb = 0.11; p = 0.74). Children experienced higher rates of good neurological outcome (76.1 % vs. 46.0 %, p < 0.01) and revascularization (88.5 % vs. 72.3 %, p < 0.01), fewer major periprocedural complications (3.6 % vs. 30.4 %, p < 0.01), and lower mortality (1.0 % vs. 12.9 %, p < 0.01). ConclusionsEndovascular thrombectomy may be safe and effective treatment for acute ischemic stroke due to large-vessel occlusion in children. The aggregated data demonstrated high rates of revascularization, favorable long-term neurological outcomes, and low complication rates.

Mechanical Thrombectomy in a 12-Month-Old Infant with Acute Ischemic Stroke Possibly due to Internal Carotid Artery Dissection: A Case Report.

Stroke in children is a rare but devastating disease. Although endovascular treatment has been reported to be safe and effective in the treatment of stroke with large vessel occlusion in this population, there are still limitations and controversies. In this case report, we describe a 12-month-old girl who was admitted to the hospital with acute onset of left-sided hemiplegia and confusion, which turned out to be due to a large infarct in the right middle cerebral artery territory, possibly caused by dissection of the right cervical internal carotid artery. Aspiration thrombectomy was successfully performed, and the patient was able to walk a few steps and raise her left upper extremity at the 12-month follow-up. The aspiration-only technique in thrombectomy may be safe and technically feasible to treat acute ischemic stroke with large vessel occlusion in children as young as 12 months, although large-volume prospective studies are needed.

The Impact of Benign Jawbone Tumors on the Temporomandibular Joint and Occlusion in Children: A Ten-Year Follow-Up Study

This study aimed to provide a complex analysis of the modifications in craniofacial skeleton development that may arise following the diagnosis of pediatric benign jaw tumors. A prospective study was undertaken involving 53 patients younger than 18 years of age, who presented for treatment at the Department of Maxillo-Facial Surgery, University of Medicine and Pharmacy, Cluj-Napoca, with a primary benign jaw lesion between 2012 and 2022. A total of 28 odontogenic cysts (OCs), 14 odontogenic tumors (OTs), and 11 non-OTs were identified. At follow-up, dental anomalies were identified in 26 patients, and overjet changes were found in 33 children; lateral crossbite, midline shift, and edge-to-edge bite were found in 49 cases; deep or open bite were found in 23 patients. Temporomandibular disorders (TMDs) were found in 51 children, with unilateral TMJ changes identified in 7 cases and bilateral modifications found in 44 patients. Degenerative changes in the TMJ were also diagnosed in 22 pediatric patients. Although benign lesions could be associated with dental malocclusions, a direct etiological factor could be not identified. The presence of jaw tumors or their surgical treatment could, however, be linked to a change of the occlusal relationships or the onset of a TMD.

Digital analysis of stomatognathic system morphofunctional condition in patients with distal occlusion before and after treatment with the Twin Block appliance

Relevance. For many years studies have evaluated the possibilities of modifying the growth of the maxillofacial complex during orthodontic treatment with functional appliances. Despite the large number of studies devoted to orthodontic treatment of distal occlusion in children and adolescents, there is no consensus among orthodontists on the appropriateness, timing and tactics of such treatment.Material and methods. The article presents the results of the treatment of distal occlusion in children and adolescents aged 7-18 years using the Twin Block appliance. The study included clinical, anthropometric, radiographic and functional research methods.Results. The course of treatment eliminated distal occlusion in all groups; in Group 1, the length of the mandibular body was 64.4 ± 2.8 mm before the treatment and 69.6 ± 2.4 mm after the treatment (p = 0.016); in Group 2, the length of the mandibular body was 69.7 ± 6.6 mm before the treatment and 72.5 ± 6.9 mm after the treatment (p = 0.019); in Group 3, the length of the mandibular body was 69.8 ± 5.6 mm before the treatment and 74.0 ± 4.3 mm after the treatment (p = 0.005). The temporomandibular joints did not show pathological changes; most patients (70%) did not demonstrate anterior position of the condyles after the treatment.Conclusion. Orthodontic treatment of patients aged 7-18 years with distal occlusion using the Twin Block appliance is an effective treatment method. The orthodontic treatment with functional appliances is most reasonable during the period of peak growth when significant skeletal changes are possible to obtain.

Results of nose breathing evaluation during orthodontic treatment in children

Relevance. In the modern practice of an orthodontist, distal occlusion caused by respiratory dysfunction is increasingly more common. It is especially evident in early mixed dentition, i.e., in 6-8-year-old children with diagnosed pathology of ENT organs, namely, adenoids.Objective. The study aimed to evaluate the relationship between respiratory dysfunction and distal occlusion in children with early mixed dentition.Materials and methods. The study performed conventional anterior and posterior rhinoscopy, endoscopic examination of ENT organs, anterior active rhinomanometry, and masticatory muscles’ electromyography. The orthodontic examination included an oral examination, impression-taking, occlusion assessment, morphometric analysis of the jaw models and lateral cephalometric image measurements.Conclusion. In modern medical practice, the pathology of ENT organs and maxillofacial anomalies are closely related. Therefore, the collaboration between an orthodontist and an ENT specialist is the key to the effective treatment of distal occlusion in early mixed dentition.

Comparison of Dental Occlusion in Children with Mouth Breathing and Different Types of Pharyngeal Lymphoid Tissue Obstruction

Background: The relationship between malocclusion and respiration has been debated for decades. Aim: The aim of this study is to assess dental occlusion in relation to mouth breathing and different types of pharyngeal lymphoid tissue obstruction in children. Settings and Design: This was a cross-sectional study of 200 children aged between 6 and 12 years who were clinically examined and divided into two groups: mouth breathers and nasal breathers. Materials and Methods: The children were subjected to otorhinolaryngologic examination to identify the type of pharyngeal obstruction. Dental interarch relationship and pharyngeal tissue obstruction were diagnosed and appropriate cross tabulations were done. Statistical Analysis Used: The data collected were statistically analyzed using the SPSS version 15.0 software. Results: Statistically significant association was found between type of breathing and pharyngeal lymphoid tissue obstruction (P = 0.001), dental occlusion and type of breathing (P = 0.001), and pharyngeal lymphoid tissue obstruction and dental occlusion (P = 0.001). Higher prevalence of crossbite, deep bite, and Class II malocclusion was seen in children with adenotonsillar hypertrophy as well as mouth breathing habit. Conclusion: Obstructive tonsils and adenoids are risk factors for the development of malocclusion. Early detection and correction of airway obstruction can help in proper growth of the dentofacial region.

Long-Term Efficacy of the Combination of Active Vision Therapy and Occlusion in Children with Strabismic and Anisometropic Amblyopia.

This retrospective study was conducted to evaluate the efficacy of the combined treatment of occlusion and active vision therapy in a total of 27 amblyopic children, including 14 strabismic and 13 anisometropic cases. For such purpose, changes in distance and near visual acuity as well as in the binocular function was evaluated during a two-year follow-up. In both amblyopia groups, significant improvements were found in distance and near visual acuity in the non-dominant eye (p < 0.001). In the strabismic amblyopia group, the percentage of patients with binocular function score (BF) > 3.3 decreased significantly from a baseline value of 64.3% to a two-year follow-up value of 7.1% (p < 0.001). In the anisometropic amblyopia group, this percentage also decreased significantly from a baseline value of 15.4% to a two-year follow-up value of 0.0% (p < 0.001). No recurrences were observed in the anisometropic amblyopia group, whereas recurrence occurred in two cases of the strabismic amblyopia group after finishing the vision rehabilitation process. In conclusion, the combined approach of the treatment evaluated is efficacious for providing an improvement in visual acuity and binocular function in both anisometropic and strabismic amblyopia, which was maintained over time.

Optimization of surgical treatment of mandibular fracture in children with a variable bite

Children aged 6 to 12 are characterized by increased activity, begin to engage in active sports and this increases the risk of traumatic injuries of the facial skeleton. Among such lesions, fractures of the mandible rank first. Using acrylic mandibular splints and mandibulomaxillary fixation are considered to be a traditional method of treating mandibular fractures in children. In the period of variable occlusion due to physiological changes of teeth, caries and its complications, loss of teeth due to traumatic injuries and unexpressed equatorial teeth, mandibulomaxillary fixation is difficult or impossible and using acrylic mandibular splints is ineffective when line of fracture goes out of dental arc. Due to these and other circumstances, there is a need for open reposition and internal fixation of fragments with miniplates. Children have a risk of damage to the rudiments and roots of permanent teeth or mandibular canal when miniplates are fixed with screws. In order to prevent complications in the surgical treatment of mandibular fractures during variable occlusion in children, we analyzed cone-beam computerized tomograms and identified areas for safe fixation of screws, established a safe depth of immersion of screws in bone tissue.

Efficacy of supplemental Occlu-pad therapy with partial occlusion in children with refractive anisometropic amblyopia.

Purpose:To study the efficacy of supplemental occlu-pad therapy with partial occlusion in children with refractive anisometropic amblyopia.Methods:Thirty-one children who did not improve after partial occlusion of 6 h for 6 months were supplemented with the use of occlu-pad for 1 h per day and three such sessions in a week.Results:The mean age was 6.8+/-1.4 years (range 5–9 years). A significant improvement of 3.2+/-1.3 lines in visual acuity was noticed at the end of 3 months of starting this supplemental therapy in children. Out of 31 children, 26 children improved at least 2 lines or more at the end of 3 months. All children (n = 9) having anisohyperopic amblyopia improved at the end of 3 monthsConclusion:Occlu-pad is useful in supplementing occlusion therapy in cases of refractive amblyopia and is more effective in anisohyperopic amblyopia.

Characteristics of dental arches and occlusion in children born prematurely. A case-control study.

To determine if there are differences between the dental arch dimensions and occlusal characteristics of children born prematurely and admitted into a Neonatal Intensive Care Unit (NICU) (study group) and children born at term (control group). The study group was analysed at the same time in order to find out if the parameters of the dental arches are related to specific perinatal variables. Study design: Out of a total of 504 children born between 2011 and 2014 in high-risk conditions at the clinic of the University Hospital "San Cecilio" in Granada (Spain), 78 children were selected. Of these 42 had been born prematurely and admitted to the NICU (study group) and 36 had been born at term (control group). The age of the sample was 5 to 8 years. The parameters of the dental arches, together with the occlusal characteristics, were examined using dental casts. Both the upper and lower arches were measured for a total of 156 dental casts with a FINO digital caliper. The data confirm the smaller size of the dental arch dimensions of children born prematurely and admitted to a NICU compared with children born at term. This fact should be taken into consideration with regard to future orthodontic and paediatric dentistry treatments.

Post-interventional Evaluation and Follow-Up in Children With Patent Ductus Arteriosus Complicated With Moderate to Severe Pulmonary Arterial Hypertension: A Retrospective Study.

Background: Transcatheter closure is an important treatment for patent ductus arteriosus (PDA) complicated with moderate and severe pulmonary arterial hypertension (PAH). This report presents our experience with transcatheter closure of PDA complicated with moderate and severe PAH.Methods: The 49 cases of PDA complicated with moderate and severe PAH were collected in the Second Affiliated Hospital and Yuying Children's Hospital from January 2014 to December 2019 with transcatheter closure of PDA and follow-up. All patients were invited for transthoracic echocardiography, electrocardiogram, and thoracic radiography check-up.Results: Device implantation was successful in 48 of 49 patients (98.0%). Among them, 30 cases were in the PAH after defect correction (CD) group, and 19 examples were in the Non-PAH after defect correction (NCD) group. Pulmonary systolic pressure, left atrial diameter, and left ventricular end-diastolic diameter immediately after interventional therapy and 6 months later were lower than the pre-operative levels (p < 0.05). The incidence of the immediate residual shunt (RS) in this study was 34.9%, most of which were minimal amount shunt. RS disappeared in all patients within 1 year of therapy. Four patients had thrombocytopenia and one patient had left pulmonary artery stenosis. No other serious adverse event occurred during the follow-up period. The pressure gradient tricuspid valve regurgitation (PGTI) and the right heart catheterization (RHC) consistency points were 93.75% (15/16) and were within the 95% consistency limit by the Bland-Altman method. The Logistic regression analysis concluded that the pre-operative Pp/Ps and the narrowest diameter of PDA are risk factors for post-operative PAH (p < 0.05). The cut-off point of the pre-operative Pp/Ps and the narrowest diameter of PDA were calculated to be 0.595 and 4.75 mm, respectively.Conclusion: Interventional occlusion in children with PDA complicated with moderate and severe PAH is safe, effective, and has few complications. Targeted drug therapy has a good clinical effect. The narrowest diameter of PDA and the pre-operative Pp/Ps may be one of the risk factors of residual PAH after interventional therapy.

Unfractionated Heparin (UFH) For Prevention of Central Venous Catheter Thrombotic Complications in Children: A systematic review and meta-analysis

Abstract Objective To determine the efficacy of unfractionated heparin in reducing central venous catheter-related deep venous thrombosis and/or catheter thrombotic occlusion in children by systematically searching the literature and conducting a meta-analysis study. Methods Four electronic databases (PubMed, Google Scholar, Elsevier’s thrombosis journal, and the Cochrane Central Register for Controlled Trials) were searched for journal peer-reviewed articles published in the period from Jan 2000 to Dec 2018. The search criteria included observational studies, and randomized controlled trials on patients aged 0–18 years with central venous catheters (CVC), which compare between the effect of UFH (flushes, lock solutions, continuous infusion, and heparin bonded catheter) and no prophylaxis (Normal saline flush or no treatment) for the prevention of CVC thrombotic complications (CVC-related deep venous thrombosis (DVT) and/or catheter thrombotic occlusion). Two authors independently reviewed and identified the eligible studies, which were assessed for study methodology including bias, and extraction of unadjusted data whenever available. To pool data from eligible studies, the meta-analysis was performed on RevMan version 5.3. Odds ratios were generated with the corresponding 95% CI through the random-effect model. Results Of the 413 articles identified, only eight studies were eligible with 1380 patients. Our results revealed that UFH was significantly superior on control group in reducing thrombotic occlusion and/or CVC-related DVT (odds ratio 0.39, 95% CI: 0.19:0.8) (p 0.01). Conclusion The published data support the hypothesis that using UFH as a thromboprophylaxis may significantly reduce catheter thrombotic complication in pediatric patients with CVC.

Intussusception caused by Burkitt's lymphoma - a clinical case.

Background: Intussusception is one of the most frequent causes of intestinal occlusion in children under 3 years of age, and it is mainly idiopathic. In adolescence and adulthood it is rare, but often presents a pre-existing pathology, such as Meckel's diverticulum, intestinal polyps, neurofibromas or malignant diseases.

Genetic influence on the curves of occlusion in children seeking orthodontic treatment

To examine the proportion of variability in the Curve of Wilson (COW) and the Curve of Spee (COS) that is explained by genetic factors in siblings seeking orthodontic treatment. Pre-treatment cone-beam computed tomography (CBCT) of 148 sibling patients were selected. The sample consisted of 79 females and 69 males with a mean age of 12 years 7 months. The COS was measured by creating a tangent line from the distobuccal cusp of the mandibular first molars and the highest incisal tip of the mandibular incisors. Measurements were taken from that tangent line to the deepest point on the premolars and canines. The COW was measured using the molar axis line to the perpendicular to WALA (Will Andrews Lawrence Andrews) points' axis line. The results indicate that these occlusal curves are generally moderate to highly heritable. Heritability of COW-maxilla was 78.3%, heritability of COW-mandible was 43.2% and heritability of COS was 100% (P-value<0.05). Most of the developmental variability in the curves of occlusion comes from genetic differences, with very little contribution from environmental factors. Therefore, siblings tend to show similar occlusal curves.

Association between speech and dental occlusion changes in children with cleft lip and palate and time of primary plastic surgeries

ABSTRACT Purpose: to describe the changes in speech and dental occlusion in children with cleft lip and palate and verify their association with each other and with the time of primary plastic surgeries. Methods: a cross-sectional study with collected data on the subjects’ identification, age at the time of primary surgeries, and clinical assessment of speech and dental occlusion. The chi-square test, Fisher's exact test, and t-test were used to verify the associations between the variables at the 5% significance level (p &lt; 0.05). Results: the sample comprised 11 children aged 6 to 10 years, most of whom were males, self-reported white, with trans-incisive foramen cleft, predominantly on the left side. The mean age at lip repair surgery was 6 months, and 13 months at palatoplasty. Among the main dental occlusion changes, posterior and anterior crossbite stood out. All the subjects presented changed speech, with a prevalence of cases with dentoalveolar and palatine deformities, followed by passive and active changes. Subjects with anterior crossbite tended to have undergone primary lip repair surgery at a mean of four months earlier than the subjects without anterior crossbite. Conclusions: the associations between speech and dental occlusion changes, and between these and the time of primary plastic surgeries were not statistically significant. Even though it is known that early lip repair surgery is ideal to favor oral functions and aesthetics, the results revealed a tendency towards anterior crossbite, in these subjects.

ANALYSIS OF HYGIENE AND PERIODONTAL INDEXES OF CHILDREN WITH I TYPE DIABETES MELLITUS

Gingivitis and periodontitis are two forms of periodontal disease that are well known as oral complications in diabetic patients. Particular attention should be paid to the diagnosis of periodontal disease at an early age among patients with this endocrinological pathology. The aim of this scientific work was to assess the gum bleeding and the state of the periodontium in children with type I diabetes mellitus during the periods of milk bite and period of mixed dentition.&#x0D; Scientific studies of gingivitis during milk and variable occlusion in children with diabetes are quite rare. In addition, the period limited by the age ranges is transitional for the dental-maxillary system. This fact will allow us to have a great opportunity to study the differences from deciduous and permanent teeth.&#x0D; 258 children aged from six to fourteen were examined for this scientific work, namely 129 children with type I diabetes mellitus and 129 children without somatic diseases. All patients were divided into appropriate subgroups: somatically healthy children without signs of gingivitis, somatically healthy children with signs of gingivitis, children with type I diabetes mellitus without signs of gingivitis, children with type I diabetes mellitus with signs of gingivitis.&#x0D; The hygiene index was determined according to Fedorov - Volodkina (1968) and OHI-S (Green, Vermillion, 1964). The periodontal condition was assessed by the PMA index (papillary-marginal-alveolar index) modified with Parma (1960). Bleeding index was determined according to Loe, Silness (1967), that is, the so-called gingival index (GI). We also calculated the bleeding index according to Muhleman H.R. (1971).&#x0D; There was no statistically significant difference in the values of the intensity of caries, its prevalence and hygiene indexes in the group with insulin-dependent diabetes mellitus compared with healthy children.&#x0D; Our studies showed a statistically significant difference between the control group and patients with type I diabetes mellitus regarding periodontal indexes and gingival bleeding, consistent with existing data in the literature. Inflammatory processes in the periodontium of children and adults with diabetes mellitus have been increased. It is also very important to recognize this process as soon as possible.&#x0D; The results of this research work determine that children with diabetes have a great risk of bleeding gums compared to children without diabetes.&#x0D; We cannot say that gingivitis in children always lead to destructive periodontal disease in adulthood, a number of Ukrainian and foreign authors point out that children with insulin-dependent diabetes are more prone to periodontal destruction, than healthy ones. This is important because the most common periodontal diseases can be prevented even in people with an increased susceptibility to them and the development of destruction can be stopped by early detection of the disease in the early stages. Moreover, there is evidence that the treatment of periodontal disease in adults with diabetes has a positive effect on the level of metabolic control of these individuals.&#x0D; Thus, in light of the current results, oral screening and preventive programs should emphasize the importance of timely diagnosis of periodontal disease even during the milk occlusion and period of mixed dentition, especially in children with insulin-dependent diabetes mellitus.

Influence of adenotomy/adenoidectomy on the respiration and occlusion in mouth-breathing children

Introduction: Difficult nasal breathing is a common problem, which may be a result of multiple factors, leading to physiological disturbance and/or anatomical disorders of the nose and paranasal sinuses. One of the most frequent reasons in childhood age is adenoid hypertrophy. Aim: The aim of the current article is to determine the influence of adenotomy and adenoidectomy on the respiration and occlusion of children with difficult nasal breathing Materials and Methods: A total of 412 children, diagnosed with difficult nasal breathing, took part in the study. Of them, 139 underwent a second clinical examination in the period of 1 to 3 months to determine the way of breathing after adenotomy/adenoidectomy. Results: In primary dentition, after removing the etiological factor for difficult nasal breathing, 68.00% of the children began to breathe spontaneously through the nose. In mixed dentition, there was a higher percentage of children, who maintained mouth breathing as a bad habit. In comparison to the dental class after adenotomy/adenectomy, there was a higher percentage of Angle class II. In the saggital plane there was an increase of the frequency of the overjet from 1 to 3mm, which led to preservation of mouth breathing. Conclusion: After adenotomy/adenectomy we have determined that in primary dentition a higher percent of children begin to breathe spontaneously through the nose, whereas in mixed dentition mouth breathing is preserved as a bad habit. In children with preserved mouth breathing, there is an increase in the degree of severity of orthodontic deformations and complications of the deformation.

Analysis of treatment methods for children with bilateral complete cleft of the lip and palate in mixed bite

Relevance. According to the World Health Organization, it was found that cleft lip and palate cases ranges from 0.6 to 1.6 cases per 1000 newborns. According to the severity of the lesion, bilateral cleft lip and palate takes the first place, however, it occurs much less common – 15-25%.Purpose – to analyze methods of treatment in children with bilateral cleft lip and palate during the period of the mixed dentition.Materials and methods. An analysis of 51 sources Russian and foreign articles for the period from 1951 to 2019 was carried out. The features of the development of occlusion in children with bilateral cleft lip and palate during the period of a changeable occlusion, as well as methods of treating this pathology, are considered.Results. It was found that the main anatomical features of the maxillofacial region in children with bilateral cleft lip and palate during the period of a changeable bite are -narrowing of the upper and lower jaws, the presence of soft tissue scars. The main methods of treatment for such children are reconstructive surgery, including the closure of a hard palate defect using a mucoperiosteal flap cut out in the lateral part of the hard palate, as well as orthodontic treatment methods, the main purpose of which is to expand and extend the dentition using single jaw removable plate apparatuses, fixed plate apparatuses.Conclusions. Taking everything into account, surgical reconstructive operations, as well as complex orthodontic treatment, the main purpose of which is to expand and extend the upper and lower jaws, are the integral methods of treating such children. Orthodontic treatment should be aimed at eliminating myofunctional disorders with the helpof orthodontic trainers and elastopositioners. Conducting a comprehensive surgical and orthodontic treatment can reduce the rehabilitation time of children with bilateral cleft lip and palate.

Anxiety and related factors after ventricular septal defect occlusion in children

Anxiety and related factors after ventricular septal defect occlusion in children