Obvious Effective Rate Research Articles

Efficacy and safety of Wuhu oral liquid in treating acute soft tissue injuries: a multicenter, randomized, double-blind, double-dummy, parallel-controlled trial.

Background: Wuhu Oral Liquid (WHOL) is a modified preparation derived from the famous Wuhu Powder, which has a long history of use in treating traumatic injuries. This preparation has anti-inflammatory and analgesic properties and accelerates recovery following acute soft tissue injuries. Aims: To evaluate the efficacy and safety of WHOL in treating acute soft tissue injury associated with qi stagnation and blood stasis syndrome and to provide a basis for applying for the protection of varieties of Chinese medicine for WHOL. Methods: This study was a randomized, controlled, double-blind, multicenter clinical trial in which Fufang Shang Tong Capsule (FFSTC) was selected as the control drug. A total of 480 subjects with acute soft tissue injury associated with qi stagnation and blood stasis syndrome were randomly divided into a test and control group in a 3:1 ratio. The duration of drug treatment was 10days. The primary outcome was Visual Analogue Scale (VAS) score for pain (including pain at rest and pain on activity). Secondary outcomes included the disappearance time of the pain at rest and on activity; the curative effect of TCM syndrome and improvement in the individual symptoms of TCM (swelling, ecchymosis, and dysfunction); and changes in C-reactive protein (CRP) and interleukin-6 (IL-6) levels. Safety was assessed using vital signs, laboratory examinations, electrocardiograms, and physical examinations. Results: Patient compliance was satisfactory in both groups (all between 80% and 120%). After 4days of treatment, the WHOL group was superior to the FFSTC group in decreasing the VAS scores for pain at rest (-1.88 ± 1.13 vs. -1.60 ± 0.93, p < 0.05) and on activity (-2.16 ± 1.18 vs. -1.80 ± 1.07, p < 0.05). After 7 days of treatment, the WHOL group was superior to the FFSTC group in decreasing the VAS scores for pain on activity (-3.87 ± 1.60 vs. -3.35 ± 1.30, p < 0.01) and improving swelling (cure rate: 60.4% vs. 46.2%, p < 0.05; obvious effective rate: 60.7% vs. 47.0%, p < 0.05). After 10 days of treatment, the WHOL group was superior to the FFSTC group in decreasing the levels of CRP (-0.13 ± 2.85 vs. 0.25 ± 2.09, p < 0.05) and improving the TCM syndrome (cure rate: 44.1% vs. 30.8%, p < 0.05) and swelling (cure rate: 75.6% vs. 67.5%, p < 0.01; obvious effective rate: 75.6% vs. 68.4%, p < 0.05; effective rate: 77.0% vs. 71.8%, p < 0.05). The disappearance time of pain at rest was 8days in both groups and 9days on activity in both groups. In addition, there was no statistical difference between the incidence of adverse events (4.5% vs. 2.6%, p > 0.05) and adverse reactions (0.3% vs. 0%, p > 0.05) between the WHOL group and the FFSTC group. No serious adverse events occurred in either group, and no subjects were withdrawn because of adverse events. Conclusion: WHOL relieves the symptoms caused by acute soft tissue injury associated with qi stagnation and blood stasis syndrome more rapidly than FFSTC, and it is effective and safe in the treatment of acute soft tissue injury. Future studies still need a larger sample size to verify its efficacy and safety. Clinical Trial Registration: https:// www.chictr.org.cn/showproj.html?proj=149531, Identifier ChiCTR2200056411.

Effect of Bloodletting Therapy on Patients with Spastic Wrist Dorsiflexion Dysfunction after Stroke

<sec><title>Objective</title> To observe the effect of bloodletting therapy on limb spasticity, wrist dorsiflexion function, surface electromyography, upper limb motor function of patients with spastic wrist dorsiflexion dysfunction after stroke. </sec><sec><title>Methods</title> A total of 70 patients with spastic wrist dorsiflexion dysfunction after stroke in the Peoples Hospital Affiliated to Fujian University of Traditional Chinese Medicine were randomly divided into the control group and the experimental group according to the random sequence was generated by SPSS 22.0 software, with 35 cases in each group. The control group received routine medical treatment, rehabilitation treatment and acupuncture therapy. Yangxi (LI 5), Yangchi (TE 4), Daling (PC 7) acupoint of the affected hand were selected for acupuncture treatment, Yangxi (LI 5) acupoint was straightly needled 0.5-0.8 inch, Yangchi (TE 4) and Daling (PC 7) acupoints were straightly needled 0.3-0.5 inch, 30 minutes each time, once a day, five times a week, continous treatment for four weeks. The experimental group was given bloodletting therapy on the basis of routine medical treatment and rehabilitation treatment in the control group. The operation acupoints of bloodletting therapy were the same as those of the control group, once every other day, three times a week, continous treatment for four weeks. Before treatment and after treatment for four weeks, the modified Ashworth scale (MAS) was used to evaluate limb spasticity; passive range of motion (PROM) of wrist dorsiflexion joint was used to evaluate wrist dorsiflexion function; the simplified Fugl-Meyer assessment upper extremity scale (FMA-UE) was used to evaluate upper limb motor function; surface electromyography such as integrated electromyogram (iEMG) and root-mean-square value (RMS) were used to evaluate the functional status of the neuromuscular system on the affected side; the clinical effects of the two groups were compared. </sec><sec><title>Results</title> There was no significant difference in MAS grade, PROM score, iEMG, RMS, and FMA-UE score between the two groups before treatment (<italic>P</italic>>0.05). Compared with before treatment, the MAS grade, iEMG and RMS of the two groups were significantly decreased after treatment, and the PROM score, FMA-UE score were significantly increased (<italic>P</italic><0.05). Compared with the control group, the MAS grade, iEMG and RMS of the experimental group were significantly lower, and the PROM score, FMA-UE score were significantly higher (<italic>P</italic><0.05). There was no significant difference in the total effective rate between two groups (<italic>P</italic>>0.05), while the obvious effective rate of the experimental group was significantly higher than the control group (<italic>P</italic><0.05). </sec><sec><title>Conclusion</title> Bloodletting therapy can improve the spasticity of wrist flexor muscle in patients with spastic wrist dorsiflexion dysfunction after stroke, reduce the abnormal muscle contraction, and improve the passive range of motion of wrist joint and limb motor function. It is worthy of clinical application and promotion. </sec>

Effect of para areola incision on the cosmetic surgery of multiple benign breast lumps

Objective To investigate the effect of para areola incision on the appearance of breast after excision of multiple benign breast lumps. Methods From February 2010 to November 2017, 60 females of multiple benign breast tumor underwent surgical resection in the Fifth People's Hospital of Datong were selected and randomly divided into study group (n=30) and control group (n=30), respectively received periareolar incision and traditional incision surgery.The operation time and operation effect were compared between the two groups.VSS was used to compare the postoperative scar score between the two groups.The satisfaction for breast shape was also compared between the two groups. Results The operation time of the study group [(25.36±7.69)min] had no statistically significant difference compared with that of the control group (t=0.264, P>0.05). The incision length and the amount of bleeding in the study group were (5.86±2.49)mm, (9.69±5.68)mL, respectively, which were significantly lower than those of the control group (t=8.621, P<0.05; t=2.549, P<0.05). The obvious effective rate(53.33% vs.43.33%), effective rate(40.00% vs.33.33%) and total effective rate(93.33% vs.76.67%) between the study group and control group had statistically significant differences (χ2=5.264, 7.127, 13.267, all P<0.05). The scar and breast shape scores of the study group were better than those of the control group[ VSS: (4.35±1.67)points vs.(7.92±2.51)points, breast appearance: (1.38±0.61)points vs.(4.92±1.67)points, t=7.264, 6.621, all P<0.05]. Conclusion The resection of breast multiple benign masses by parareone incision has less trauma, high resection rate, concealed incision and good cosmetic effect after operation, which meets the needs of the patients. Key words: Para areola incision; Breast tumor; Mammary gland; Beauty

Application value of cervical circular cutting technique in the treatment of cervical intraepithelial neoplasia

Objective To investigate the clinical effect of cervical circular cutting technique in the treatment of cervical intraepithelial neoplasia. Methods 120 patients with cervical intraepithelial neoplasia were selected.They were treated with cervical circular cutting technique, and the effect was analyzed. Results 120 patients after treatment, the obvious effective rate was 76.67%(92/120), the effective rate was 19.17%(23/120), the ineffective rate was 4.17%(5/120), the total effective rate was 95.83%.The LEEP operation time was controlled at (9.0±0.5)min, the intraoperative blood loss was (16.2±1.2)mL.The postoperative pathologic examination results compared with cervical multi-point biopsy under colposcope had no statistically significant difference(χ2=1.238, P>0.05). Conclusion The cervical circular cutting technique in the treatment of cervical intraepithelial neoplasia has good effect, can not only completely remove cervical lesions, and has less blood loss, fewer complications, it is worthy of widely use in clinic. Key words: Cervical intraepithelial neoplasia; Microwaves; Treatment outcome

Acupuncture with regulating mind and spleen for diarrhea irritable bowel syndrome and sleep quality:a randomized controlled trial

To compare the effects between acupuncture with regulating mind and spleen and wes-tern medication for diarrhea irritable bowel syndrome (IBS-D). Eighty-one patients were randomly at the ratio of 2 to 1 assigned into an acupuncture group (54 cases) and a western medication group (27 cases). Acupuncture with regulating mind and spleen was applied in the acupuncture group for 6 weeks at Baihui (GV 20), Yintang (GV 29), Tianshu (ST 25), Zusanli (ST 36), Shangjuxu (ST 37), Sanyinjiao (SP 6), and Taichong (LR 3), once every other day, 3 times a week. Pinaverium bromide tablet was used orally in the western medication group for 6 weeks, 50 mg a time, 3 times a day. IBS symptom severity score (IBS-SSS) were observed before and after 1-week, 6-week treatment. Pittsburgh sleep quality index (PSQI) was applied before and after 6-week treatment. Also, clinical efficacy was evaluated in the two groups. Three patients dropped out in the acupuncture group, and 1 in the western medication group. Except abdominal distension score after 1-week treatment in the western medication group, single scores and total scores of IBS-SSS apparently reduced in the two groups after 1-week and 6-week treatment (P<0.01, P<0.05). After 1-week treatment, the abdominal pain score of the acupuncture group was obviously lower than that of the western medication group (P<0.05). After 6-week treatment, with abdominal pain relief advantage, other results including the number of pain days, defecation satisfaction,life disturbance degree and total score of the acupuncture group were obviously lower than those of the wes-tern medication group (P<0.01,P<0.05). After 6-week treatment, the PSQI score and its change before and after treatment in the acupuncture group were superior to those in the western medication group (both P<0.05). The relief rate and relief plus obvious effective rate in the acupuncture group were higher than those in the western medication group[51.0% (26/51) vs 19.2% (5/26), P<0.01; 64.7% (33/51) vs 34.6% (9/26), P<0.05]. Acupuncture with regulating mind and spleen for diarrhea irritable bowel syndrome can more effectively relieve abdominal pain than pinaverium bromide tablet at the early stage. Its total effect and single effects are better at the later stage on abdominal pain, seizure frequency, defecation satisfaction, life disturbance, and sleep quality.

Application of extracorporeal cardiac shock wave therapy in treating coronary heart disease in the elderly

Objective To evaluate the efficacy and safety of cardiac shock wave therapy (CSWT) in coronary heart disease in elderly patients. Methods Eleven patients with refractory angina pectoris were enrolled. The ischemic area was determined by the 99mTechnetium-MIBI single-photon emission computed tomography (SPECT) and coronary angiography, and treated with CSWT. The CSWT were performed during treatment of 3 months, with 9 times totally. The clinical evaluations included the clinical symptoms, Canadian Cardiovascular Society (CCS) class scores, New York Heart Association class (NYHA), Seattle angina questionnaire (SAQ), 6-min walking distance and the use of dosage of nitroglycerin, left ventricular end diastolic diameter (LVEDD) and left ventricular ejection fraction (LVEF). The amelioration of ischemic myocardial was analyzed by SPECT. The safety of CSWT was evaluated by changes in clinical symptoms, ECG monitoring, blood pressure and oxygen saturation, blood levels of creatine kinase, creatine kinase myocardial band isoenzymes (CK-MB), troponin T (TnT), alanine transfer enzyme (ALT), creatinine (CR), brain natriuretic peptide and high sensitive C reactive protein (hs CRP). Results The CCS class scores, NYHA, 6-min walking distance and the dosage of nitroglycerin were significantly improved at 4 and 12 months after treatment as compared with pretreatment. The steady state of angina pectoris and the frequency score in SAQ were significantly improved. The 21 cardio-vessel segments were treated, and the improvement rate of resting myocardial perfusion was 46.2% (6/13), the effective rate was 38.5% (5/13), and the obvious effective rate was 7.8% (1/13) after treatment. The improvement rate of loaded myocardial perfusion was 57.1% (12/21), the effective rate was 47.6% (10/21), and the obvious effective rate after treatment was 9.5% (2/21). There were no significant changes in levels of CK, CK-MB, TNT, ALT, Cr, BNP and hs CRP, heart rate, systolic blood pressure, diastolic blood pressure and oxygen saturation after treatment as compared with pretreatment. Conclusions The CSWT is a safe and effective treatment for coronary heart disease in the elderly, and the curative effect could maintain at least one year. Key words: Coronary disease; Radionuclide imaging; Extracorporeal cardiac shock wave

Montelukast for Postinfectious Cough: A Systematic Review of Randomized Controlled Trials.

To systematically assess the efficacy and safety of montelukast for postinfectious cough (PIC) and to propose a recommendation via a systematic review of all available randomized controlled trials (RCTs). Electronic databases and relevant journals were searched for RCTs from inception to July 2014. In addition, some unpublished literature was also searched. All studies included in the systematic review met the same inclusion criteria. Methodological quality and evidence quality were examined according to Cochrane handbook. The data were extracted and trial quality was assessed independently by two reviewers. Fourteen RCTs involving 1372 patients were included in our review. The methodological quality of the included trials was poor because one or more biases were observed in these studies. The quality of evidence was low to moderate levels. All trials reported better effect favouring montelukast treatment. Findings suggested that compared with other Western medication and Chinese medicine, montelukast showed significant effects in shortening cough relief time, increasing the clinic obvious effective rate, decreasing coughing frequency and severity, and improving quality of life. Adverse events were mentioned in six studies, but no serious adverse effects were reported in any of them. Montelukast demonstrated potential positive efficacy and safety for PIC; however, we could not come to a firm conclusion on the efficacy and safety of montelukast for PIC. More high quality randomized controlled trials are required to confirm the efficacy and safety of montelukast for PIC.

Effect of Yupingfeng droppill in treatment of allergic rhinitis

To evaluate the efficacy of Yupingfeng droppill and western medicine in treatment of allergic rhinitis, 76 patients from Beijing Shijitan hospital during April 2011 to May 2012 were selected and randomly divided into the treatment group (n = 44) and control group (n = 32). The treatment group was treated with Yupingfeng droppill and cetirizine tablets, the control group was treated with cetirizine tablets, the effect of the two groups was observed after 28 days, after treatment, the symptoms and inferior turbinate volume contrast of the two groups were better than before. The obvious effective rate and total effective rate were 84.09%, 95.45% and 46.87%, 56.25% in the treatment group and and control group. The differences in the obvious effective rate and total effective rate were statistically significant between two groups (P < 0.05), Yupingfeng droppill has the curative effect on allergic rhinitis, which is better than simple oral cetirizine tablets.

Observation of the effect of butylphthalide combined with nimodipine in the treatment of vascular cognitive impairment

Objective To investigate the effect of butylphthalide combined with nimodipine in the treatment of vascular cognitive impairment.Methods 160 patients with vascular cognitive impairment were divided into the control group and the observation group according to treatment methods,80 cases in each group.The control group was treated with nimodipine,and the observation group was given butylphthalide combined with nimodipine treatment.The therapeutic effect and cognitive function were compared.Results The obvious effective rate of the observation group was 58.75 ％ (47/80),which was significantly higher than that of control group 45 ％ (36/80) (P =0.03).After treatment,MoCA score of the observation group was (24.83 ± 9.48),which was significantly higher than that of the control group(21.64 ±9.52) (P =0.04).ADL score of the observation group was(58.31 ± 11.27),which was significantly higher than(53.28 ± 10.32) of the control group (P =0.04).After treatment,directional force,visual spatial and executive function,delayed memory and attention of the observation group were higher than those of the control group (P =0.03,0.02,0.04,0.02).Conclusion Butylphthalide combined with nimodipine in the treatment of patients with vascular cognitive impairment has good effect. Key words: Cognitive function impairment ; Butylphthalide; Nimodipine

Observation of the curative effect of traditional Chinese medicine direction inductive therapeutical instrument combined with golden bifid in the treatment of infantile diarrhea

Objective To explore the effect of traditional Chinese medicine direction inductive therapeutical instrument combined with golden bifid in the treatment of infantile diarrhea .Methods 188 infants aged from 1 month to 3 years who suffered from acute diarrhea were randomly divided into the treatment group and the control group ,94 cases in each group .All the patients were treated with continued diet ,prevention and correct water and electrolyte bal-ance and other treatment ,the treatment group received traditional Chinese medicine direction inductive therapeutical instrument combined with oral golden bifid based on the above treatment .The time of temperature returned to normal , stop vomiting and diarrhea and stool frequency were recorded and analyzed .Results The time of symptoms disap-peared,obvious effective rate and total effective rate of the treatment group were better than those of the control group . Conclusion It is safe and effective to treat infantile diarrhea by traditional Chinese medicine direction inductive therapeutical instrument combined with golden bifid . Key words: Traditional Chinese medicine direction inductive therapeutical instrument; Golden bifid; Infantile diarrhea

Comparative study of intravenous medication and pelvic perfusion on patients with gynecological pelvic inflammatory disease

Objective To investigate the effects of intravenous medication and pelvic perfusion in the treatment of gynecological acute and chronic pelvic inflammatory disease.Methods 120 cases with pelvic inflammatory disease were randomly divided into two groups.The control group(60 cases) received intravenous drugs.The observation group(60 cases) were given pelvic infusion therapy.The treatment efficacy of the two groups was compared after treatment for 14 days.Results The obvious effective rate of the observation group was 80.00％,which was significantly higher than 50.00％ in the control group(x2 =11.58,P ＜ 0.05).The total effective rate in the observation group was 90.00％,which was significantly higher than 68.33％ in the the control group(x2 =13.72,P ＜ 0.05).The incidence rate of adverse reactions in the control group was 38.33％,that in the observation group was 20.00％,the difference between the two groups was significant(x2 =4.18,P ＜ 0.05).Conclusion Pelvic perfusion therapy can improve the clinical efficacy of pelvic inflammatory disease,improve the symptoms of patients,reduce side effects,which is worthy of clinical application. Key words: Pelvic inflammatory disease ; Perfusion; Route of administration

The clinical efficacy and safety of amiodarone in the treatment of elderly patients with ventricular arrhythmia

Objective To analyze the clinical efficacy and safety of amiodarone in the treatment of the elderly patients with ventricular arrhythmia.Methods 136 elderly patients with ventricular arrhythmia were randomly divided into the observation group (n =68cases) and control group (n =68cases).The observation group was given amiodarone by intravenous to treat the elderly ventricular arrhythmia,and patients in the control group were treated with combination therapy.After treatment for 4 weeks,the treatment outcomes were observed and compared.Results The obvious effective rate and total effective rate of the observation group was 51.47％,92.65％).which were significantly higher than those in the control group (51.47 ％,92.65 ％) (P ＜ 0.05).There was no significant difference in the incidence rate of adverse effect between the two groups (P ＞ 0.05).Conclusion Amiodarone has good clinical effect in treatment of elderly patients with ventricular arrhythmia,it is worthy of clinical use. Key words: Arrhythmia; Coronary disease; Amiodarone; Treatment outcome; Aged

Comparison of the efficacy of skin rehabilitation therapies between comprehensive treatment and simple Chinese medicine steam spray after deep facial burn

Objective To study the efficacy of simple Chinese medicine steam spray and comprehensive rehabilitation nursing after facial burn deep Ⅱ degree.Methods 80 patients were randomized into the treatment group (40 cases) and the control group (40 cases).The treatment group was given the treatment of Chinese medicine steam spray.The control group was given the treatment of Chinese medicine steam spray,pressure therapy,physical therapy,rehabilitation training and psychotherapy.The clinical efficacy of two groups was evaluated respectively after 3 months.Results After 3 months,the skins of most of patients in the treatment group were nearly normal with no pigmentation and scar hyperplasia.The cure rate was 72.5 ％,the obvious effective rate was 12.5 ％,and the effective rate was 7.5 ％.Some patients in the control group were lightly and inconspicuously pigmented,but the pigmentation area was reduced.The colour of their skins was not different from that of the normal skin.The cure rate was 42.5 ％,the obvious effective rate was 12.5 ％,and the effective rate was 25.0 ％.The effects of the two groups were significant differences (P＜0.05).Conclusions Comprehensive rehabilitation nursing after the facial burn can reduce the pigmentation and scar hyperplasia and improve the quality of life. Key words: Facial burn; Skin care; Comprehensive rehabilitation treatment; Chinese medicine steam spray

Clinical observation on sodium aescinate in the treatment of 87 patients with internal hemorrhoids

Objective To observe the clinical effect of sodium aescinate in the treatment of patients with stage Ⅰ - Ⅱ internal hemorrhoids.Methods 177 patients with stage Ⅰ - Ⅱ internal hemorrhoids were randomly divided into two groups,the treated group( n =87 ) and the control group( n =90).Patients in the control group were treated with external hemorrhoids suppositories ( 1 per time,bid),while patients in the treated group took sodium aescinate orally(2 per time,Bid).After the 7-day course of treatment,the efficacy of sodium aescinate was determined.Results There was significant difference between the two groups in the total obvious effective rate and the total effective rate(P ＜0.01 ).Compared with the control group,the symptoms of hematochezia and anal pain were more improved in the treated group( P ＜ 0.01 ).There was significant difference between the two groups in the hemorrhoidal mucosa,prolapse,the size of hemorrhoids and total score difference ( P ＜ 0.05 ).The total obvious effective rate and the total effective rate of the treated group were 87.4％ and 95.4％.Conclusion Sodium aescinate had better clinical effect in the treatment of patients with stage Ⅰ - Ⅱ internal hemorrhoids. Key words: Hemorrhoids; Sodium aescinate

Meta-analysis of effect on treatment of acute episode of asthma of infants with oxygen drived nebulizer

Objective To evaluate the clinical effect of the therapy of nebulized oxygen inhalation in infants with asthma. Methods According to the requirements of cochrane systematic review, a thorough literature search was performed among Chinese digital Hospital Library ( www. chkd. cnki. net ) and Chinese Biomedical Literature Disk Database (CBM disk). A-meta analysis was performed on a total of 741 patients involved in 9 papers which met the inclusion criteria. Results The obvious effective rate, total effective rate and clinical symptom were improved in study group. The difference between the two groups has reached significance (P ＜0. 0l ). Conclusions Oxygen-driven method inhalation was quick and effective in treating medium and heavy bronchial asthma, Oxygen atomized inhalation was superior to ultrasound inhalation in therapeutic effect. Key words: Oxygen atomized inhalation; Infants; Asthma; Meta-analysis

Clinical observation of Flunarizine combined with Duxil treating with vertebra basilar insufficiency

Objective To observe the therapeutic effects of Flunarizine combined with Duxil on patients with vertebra basilar insufficiency. Methods 138 patients with vertebra basilar insufficiency were randomly divided into two groups. 65 patients in control group were treated by Dextran 40 injection 500ml with Danshen injection 20ml was given once everyday. 73 patients in treatment group were treated by Flunarizine and Duxil on the basis of giving the same treatment as the control group, Flunarizine 5mg was taken before sleep everynight, Duxil 1 tablet was taken twice everyday. The therapeutic effects were observed 14 days later.Results The healing rate and the obvious effective rate in treatment group were 52% and 41%,The healing rate and the obvious effective rate in control group were 34% and 32%.There were significant difference between treatment group and control group in the healing rate and the obvious effective rate( P<0.01 and P< 0.05 ). We had found by check with TCD ( Trans-cranial Doppler ) the average velocity of blood in vertebral basilar artery was obviously additional after the treatment in treatment group and control group, but the addition was more significant in the treatment group ( P< 0.05 ).Conclusions Flunarizine and Duxil combined with Dextran 40 and Danshen injection have an obvious therapeutic effect on vertebra basilar insufficiency. And it is a good method and is worthy to popularizie clinically. Key words: Vertebra basilar insufficiency; Flunarizine; Duxil; United treatment

Application of closed thoracic drainage with micro-catheter in treatment of tuberculous pleural effusion

Objective To observe the effect and safety of pleural effusion treated by closed thoracic drainage with micro-catheter. Methods A total of 64 cases with pleural effusion were randomly divided into conventional therapy group ( control group ) and closed thoracic drainage with micro-catheter group ( treatment group) , each group including( 32 cases ). Control group were treated with drainage of thoracic puncture interruptedly while treatment group treated by closed thoracic drainage with micro-catheter. Results Both two therapeutic methods could reduce pleural effusion, but obvious effective rate of treatment group was higher than that of control group( P ＜ 0.05 ). Meanwhile, the rate of pleural reaction and treatment cost in treatment group were lower than that in control group. Conclusion Closed thoracic drainage with micro-catheter was effective, lower treatment cost and lower complications. Moreover, it could reduce medical risk. Key words: Micro-catheter; Closed thoracic drainage; Pleural effusion; Clinical effect

Comparative study on the clinical efficacy of triple needling and conventional acupuncture in the treatment of cervical spondylosis of vertebral artery type

Objective To compare the clinical efficacy of triple needling and conventional acupuncture in the treatment of cervical spondylosis of vertebral artery type. Methods 49 cases with cervical spondylosis of vertebral artery type were randomly divided into two groups ,24 patients of control group treated with conventional acupuncture,25 patients of observation group treated with triple needling,the clinical results of two groups were compared. Results The obvious effective rate of the observation group was significantly higher than the control group, there were significant differences between two groups( x2 =4. 69 ,P < 0. 05). The improvement of average flow velocity(Vm) of the observation group was better than the control group, there was significant difference between two groups ( P < 0. 05 ).Conclusion Triple needling in the treatment of cervical spondylosis of vertebral artery type had better clinical results, and it was worthy of concern. Key words: Cervical spondylosis of vertebral artery type; Acupuncture therapy

Observation on the treatment of recurrent oral ulcer with the combination of vitamin B2 and Zhibaidihuangwan

Objective To study the effect of combined vitamin therapy of B2 and Zhibai-Dihuang Wan on recurrent oral ulcer.Methods A total of 178 patients with recurrent oral ulcer were randomly recruited into a control group and a treatment group.The control group was treated with vitamin B2,0.2g/time,3 times/day;while the treatment group WaS treated with Zhibai-Dihuang Wan,9g/time,twice/day,on the basis of the control group.The therapeutic effects were observed in both groups after 14 days.Results The obvious effective rate in the treatment group was significantly higher than the control group(P=0.0083).while total effective rate did not show significant difierence between the two groups(P=0.0712).The relapse rate in the treatment group was significant lower than the control group.Conclusion It is effective to treat recurrent oral ulcer with the combination of vitamin B2 and Zhibai-Dihuang Wan. Key words: Zhibai-Dihuang Wan; Recurrent oral ulcer

Efficacy and tolerability of oxycodone in moderate-severe cancer-related pain: A meta-analysis of randomized controlled trials

In order to evaluate the efficacy and tolerability of oxycodone in moderate-severe cancer-related pain, we conducted a systematic review of randomized controlled trials (RCTs). Publications addressing the efficacy and tolerability of oxycodone in moderate-severe cancer-related pain were selected from the Cochrane library, PubMed, Embase and CBM databases. Data were extracted from the studies by two independent reviewers. The meta-analysis was performed by RevMan 5.0.25 and STATA 9.2 software. From these data, odds ratios (ORs) or the standard mean difference (SMD) with 95% confidence intervals (CIs) were calculated. Finally, only seven RCTs were retrieved with a total of 613 cancer patients with moderate-severe pain. The meta-analysis results showed that oxycodone was statistically superior to other strong opioids based on pain intensity scores following intervention [weighted mean difference (WMD), 0.25; 95% CI, 0.05-0.45; P=0.01; WMD, -1.30; 95% CI, -1.55-1.05; P<0.001, respectively]. In addition, there were statistically significant differences between oxycodone and other strong opioids in cancer-related pain on the obvious effective rate and the overall effective rate (OR, 2.03; 95% CI, 1.40-2.95; P=0.0002; OR, 1.94; 95% CI, 1.09-3.44; P=0.02, respectively). Compared with other strong opioids, nausea and constipation occurred significantly less frequently with the use of oxycodone for cancer-related pain (OR=0.52, 95% CI=0.32-0.85, P=0.009; OR= 0.55, 95% CI= 0.35-0.87, P= 0.01; respectively). In conclusion, this meta-analysis confirms that the efficacy and tolerability of oxycodone are superior to those of other strong opioids, including morphine sulfate, codeine and tramadol, supporting its use as an opioid for cancer-related pain.