Background: Chronic apical periodontitis is potential infection with poor symptoms that are easily overlooked. Disease progession can lead to cellulitis, osteomyelitis, sinusitis, endocarditis, nephritis, arthritis, persistent fever and sepsis. In recent times, thanks to advances in endodontic in improving instruments, root canal antiseptics, techniques for shaping, obturation canals, endodontic treatment has achieved remarkable success rate. BioRootTM RCS is born from Active Biosilicate technology, is the lasted generation biomaterial, with the main ingredient being Tricalcium silicate and recommended for root canal obturation. Materials and Methods: 33 tooth with diagnosis of chronic apical periodontitis of 33 patients with inclusion criterias were selected in study sample, carried out endodontis treatment and obturation canals with BioRootTM RCS and cone Gutta Percha. Evaluating treatment results after 3 months, 6 months and factors associated with treatment results. Results: About treatment result after 3 months, 6 months: very good accounted for 87.9% and 90.9%, good were 12.1% and 9.1%, no poor cases; there was a relationship between the periapical index, lesion size, lesion boudaries with treatment results. Conclusion: BioRootTM RCS was a reliable material in the treatment of chronic apical periodontitis. Key words: Chronic apical periodontitis, Tricalcium Silicate, BioRootTM RC