Obstetric Pathology Research Articles

New approaches in assessing the clinical and pathomorphological aspects of obstetric pathology in the structure of the mother-placenta-fetus using atomic force microscopy

New approaches in assessing the clinical and pathomorphological aspects of obstetric pathology in the structure of the mother-placenta-fetus using atomic force microscopy

The Role of Oxidative Stress during Pregnancy on Obstetric Pathology Development in High-Yielding Dairy Cows

The study aimed to examine the processes of oxidative stress and their intensity depending on the state of the antioxidant system in dairy cows. The study was conducted in 2018-2019 on the territory of the Druzhba breeding factory (Voronezh region, Russia) and involved 154 cows divided into 4 groups. Group 1 consisted of healthy animals (n = 83). Group 2 contained animals with afterbirth retention (n = 6). Group 3 included animals with uterine subinvolution (n = 49). Group 4 comprised animals with postpartum catarrhal-purulent endometritis (n = 16). The blood samples were taken from the animals to estimate the content of vitamin E, lipids, malonic aldehyde and enzymes-catalases, reductase and ferroxidase. The concentration of vitamin E in groups 1 and 4 were found to decrease (by 3.9-23.2%; 30.7±2.16-25.9±2.16 compared to 31.9±1.68 μM/L) within two months. The level of malonic aldehyde in group 4 was higher than in other groups after the first month. In one month, its level increased by 20.6% (1.11±0.09 μM/L) by 35.4, 19.4 and 6.7%, respectively (P<0.01-0.001). The exhibited differences indicate the strong significance of functional insufficiency of the antioxidant protection system during the development of oxidative stress during pregnancy and, as a result, the etiology and pathogenesis of parturient and postpartum complications in cows.

PERINATAL ASPECTS OF PREGNANCY AND CHILDBIRTH ON THE BACKGROUND OF VITAMIN D LACK IN PREGNANT WOMEN

The aim: To study the features of the course of gestation and perinatal outcomes of delivery in women with vitamin D lack. Materials and methods: The article presents the results of studies of the characteristics of the course of pregnancy and delivery outcomes in 50 patients with vitamin D lack compared with a group of 50 somatically healthy pregnant women with normal level of 25 (OH) D. In order to establish a lack of vitamin D in pregnant women in the 10-12, 20-22, 30-32 weeks of gestation electrochemiluminiscence method by using a test system EURIMMUN (Germany) in the blood serum level of 25-hydroxycalciferol (25 (OH) D) in pregnant women. Results: When analyzing the structure of complications in women with vitamin D lack during pregnancy and childbirth we found out that risk of premature birth and premature births dominated among all the complications, respectively (58.0% and 36.0%) against (12.0% and 16.0%), p &lt;0.05. Vitamin D lack in pregnant women is often associated with a wide range of obstetric and perinatal complications, namely: preeclampsia, gestational diabetes, bacterial vaginosis , premature rupture of membranes, placental abruption, abnormal labor activity, fetal distress that required delivery by Caesarean section. Conclusions: An analysis of the course of pregnancy and childbirth in women of thematic groups proved the expediency of an individual approach to the therapy of obstetric pathology among women with vitamin D lack. Despite the level of 25 (OH) D in the blood serum of a pregnant woman of 30 ng / ml and below, it is advisable to prescribe vitamin D for prophylaxes and treatment of Vitamin D deficiency in mother and fetus.

Urogenital disorders in women of reproductive age after radical surgeries about uterine myoma – optimization of diagnostic algorithm

The article presents an assessment and analysis of the most important medical and social risk factors for long-term postoperative urogenital disorders in women of reproductive age after radical surgical treatment for uterine fibroids. Radical operations for uterine fibroids cause an increase in the proportion of urogenital disorders, the clinical manifestations of which have a negative impact on the physical, psycho-emotional form and social significance of women in society. A survey of 80 women aged 40 to 50 years, the main group included 40 patients who underwent vaginal hysterectomy, the comparison group consisted of 40 patients with hysterectomy performed by abdominal access. Data on the assessment of pelvic floor condition and urogenital dysfunction using a standardized POP-Q system, both at the stage of preoperative observation and for 3 and 5 years after surgery. Сonducted surveys, filling diaries of pain, urination, physical examination and bimanual examination, determination of the pH of the vaginal contents, colposcopy, evaluated the index of the vaginal condition, the state of the microbiota of the mucous membranes, a comprehensive urodynamic examination, cystometry, ultrasound examination of the pelvic organs and assessment of ovarian structure.The most important risk factors are identified, which would allow to form groups of patients that require individualized approaches in the choice of surgical techniques and rehabilitation program. These included obstetric and gynecological history (birth of large fetuses, episiotomies, birth injuries, high birth parity); ovarian surgery, the use of gonadotropin-releasing hormone agonists. chronic diseases of the respiratory system and gastrointestinal tract, accompanied by increased intra-abdominal pressure; the presence of stigmas of undifferentiated connective tissue dysplasia; clinical manifestations of pelvic floor failure and functional disorders of the urethral sphincter. When choosing a method and access in case of surgical treatment for uterine fibroids, it is advisable to take into account the presence of pelvic prolapse and initial dysuric manifestations in women, the functional state of the sphincter apparatus and urethral hypermobility, obstetric and gynecological pathology and previous surgery on the organs of the uterus. the patient, her awareness of possible complications, the surgeon’s experience and his choice of surgical techniques.

Pregestational obesity, maternal morbidity and risk of caesarean delivery in a country in an advanced stage of obstetric transition

ObjectiveTo evaluate whether pregestational obesity is associated with the risk of caesarean section in pregnant women living in a country in an advanced stage of the obstetric transition. MethodsRetrospective cohort study. Data were collected from prenatal and hospital records. Pregestational obesity was defined as: body mass index, [weight(k)/height (m2)] ≥30, and caesarean sections were categorized as elective, emergency, or non-emergency/medically necessary. Biodemographic and sociodemographic characteristics, obstetric and perinatal pathologies, and maternal anthropometric variables were assessed. Chi-square and t-tests were used to compare qualitative and quantitative variables, respectively. Simple and adjusted generalized linear models were used to evaluate the association between pregestational obesity and caesarean delivery. Finally, population attributable risk was calculated. Data analysis was performed using STATA.v.14.0. Participants2309 pregnant women with a singleton pregnancy who gave birth at a public hospital in the Metropolitan Region of Santiago, Chile in 2015. ResultsThe prevalence of pregestational obesity was 21.4%, and the incidence of caesarean deliveries was 34.8% (33% of which corresponded to elective, 46% to emergency, and 21% to non-emergency/medically necessary caesarean deliveries). Pregestational obesity increased the risk of caesarean delivery (aRR = 1.46; 95%CI. [1.19–1.79] as well as the risk of elective (aRR = 1.74; 95%CI. [1.23–2.45]) and emergency caesarean delivery (aRR = 1.44; 95%CI. [1.03–2.00]). The population attributable risk of pregestational obesity for caesarean section was 32%. ConclusionGiven the significant association between pregestational obesity and caesarean delivery, it is necessary to develop strategies to decrease obesity among women of childbearing age in order to decrease obstetric intervention.

Гостра жирова дистрофія печінки вагітних, ускладнена абдомінальним компартмент- і ДВЗ-синдромами (Випадок із практики)

The problem of late preeclampsia still remains its relevance today, considering the variety of possible severe complications of this obstetric pathology. In this context, acute fatty liver of pregnancy (AFLP) is considered as one of the most challenging complications of severe preeclampsia (or as a separate nosology) [frequency: 1 case per 7–16 thousand deliveries], which can possibly lead to the development of abdominal compartment syndrome (ACS) and coagulopathic changes. This complications combination is currently potentially fatal for the pregnant woman or those in labor and remains an urgent call for perinatologists. The article presents modern ideas about the etiology, diagnosis, treatment and delivery in case of this obstetric pathology on the example of an experienced clinical case. The aim of the study is to research the potential algorithm for AFLP diagnosis and treatment with analysis of the effectiveness of measures proposed. At the first stage, a retrospective review of publications on this issue was conducted with further analysis of the case of AFLP complicated by ACS and DIC syndrome, which was successfully conducted at the Department of Obstetrics and Gynecology №1. Successful outcome and recovery of a patient in a very serious condition was achieved with to the use of a basic algorithm of actions with delivery of a pregnant woman with AFLP, complex post-syndrome therapy of multiple organ failure, ACS surgical treatment, extraordinary approach to generalized fibrinolysis treatment, therapy with transfusion of whole single-group donor blood. Keywords: preeclampsia, acute fatty liver of pregnancy, abdominal compartment syndrome, DIC syndrome, hepato-renal dysfunction.

Functional Evaluation of STOX1 (STORKHEAD-BOX PROTEIN 1) in Placentation, Preeclampsia, and Preterm Birth.

Revaluation of the association of the STOX1 (STORKHEAD_BOX1 PROTEIN 1) transcription factor mutation (Y153H, C allele) with the early utero-vascular origins of placental pathology is warranted. To investigate if placental STOX1 Y153H genotype affects utero-vascular remodeling-compromised in both preterm birth and preeclampsia-we utilized extravillous trophoblast (EVT) explant and placental decidual coculture models, transfection of STOX1 wild-type and mutant plasmids into EVT-like trophoblast cell lines, and a cohort of 75 placentas from obstetric pathologies. Primary EVT and HTR8/SVneo cells carrying STOX1 Y153H secreted lower levels of IL (interleukin) 6, and IL-8, and higher CXCL16 (chemokine [C-X-C motif] ligand 16) and TRAIL (tumor necrosis factor-related apoptosis-inducing ligand) than wild-type EVT and Swan71 cells. Media from wild-type EVT or Swan71 cells transfected with wild-type STOX1 stimulated: endothelial chemokine expression, angiogenesis, and decidual natural killer cell and monocyte migration. In contrast, Y153H EVT conditioned medium, Swan71 transfected with the Y153H plasmid, or HTR8/SVneo media had no effect. Genotyping of placental decidual cocultures demonstrated association of the placental STOX1 CC allele with failed vascular remodeling. Decidual GG NODAL R165H increased in failed cocultures carrying the placental CC alleles of STOX1. Multivariate analysis of the placental cohort showed that the STOX1 C allele correlated with premature birth, with or without severe early-onset preeclampsia, and small for gestational age babies. In conclusion, placental STOX1 Y153H is a precipitating factor in preterm birth and placental preeclampsia due to defects in early utero-placental development.

Diagnostic stage of obstetric dispensary of cows in the conditions of PAE “Shpanivske” of Rivne district of Rivne region

The problem of obstetric pathology of cows is one of the first non-communicable diseases of animals. To eliminate it, a system of medical examination of cows has been developed, which includes a set of diagnostic, treatment and preventive measures aimed at reproduction of herds and obtaining healthy animals. The aim of the work was to study the prevalence of obstetric pathology, to determine the toxic and biochemical parameters and inorganic elements in the serum of cows in the period before launch and after calving in PSP “Shpanivske” Rivne district of Rivne region. Taken 15 blood samples from cows from different physiological groups (1 group – cows after calving, 2 – cows before start). The research was carried out by conventional methods on ImmunoChem-2100 – multifunctional microplate photometer and Immunochem-2200-2 – thermoshaker on 2 tablets using a set of reagents from “Philisit-Diagnostics” and “Vector-Best” and the content of inorganic elements. absorption spectrophotometer C-115M1. According to the results of obstetric examination of cows, conducted in the dry period, revealed: ketosis – 12.4 %, fatty hepatodystrophy – 11.7 %, udder edema – 8.8 % and subclinical mastitis – 23.6 % of animals. In 67.8 % of cows in the dry period with ketosis, the level of ketone bodies was at the level of 2.2 ± 0.01 mmol/l, and after birth they developed postpartum paresis – 18.3 %, postpartum endometritis – 27.9 % and delay manure – 26.7 %. Dry cows were diagnosed with a decrease in total cholesterol by 23.9 % relative to the lower reference value, and in cows after start – recorded an increase in total protein by 1.7 %, total globulin by 0.5 %, urea content by 23.3 % relative to the upper reference level and a decrease in glucose of 36.0 % relative to the lower reference level. There was also a decrease in the content of Zinc after childbirth by 22.0 % and in the period of dryness by 21.7 % and inorganic Phosphorus after childbirth by 28.2 % and in the period of dryness by 18.6 % relative to the lower reference level. In the future, further research will determine the quality of feed and develop schemes for immunocorrection of cows during the dry season and after calving.

Changes in physicobiochemical properties of nasopharyngeal aspirate in newborns with congenital cytomegalovirus infection

Aim . To study the change in the physico-biochemical properties of the nasopharyngeal aspirate in newborns with congenital cytomegalovirus infection (CMVI). Materials and methods . The pH, the concentration of medium molecular weight peptides, seromucoid, total cholesterol, triglycerides, and the activity of lactate dehydrogenase in the nasopharyngeal aspirate in 59 full-term infants with intrauterine development, uncomplicated and complicated by congenital CMVI, who died at 2-5 days of life, were studied. The first group included 25 children of early neonatal age (control group), whose mothers did not have moderate and severe obstetric and somatic pathologies during pregnancy, as well as respiratory viral infections and sexually transmitted infections. The second group was represented by 18 newborns (comparison group) from mothers with exacerbation of CMVI in the second trimester of gestation, which does not lead to antenatal infection of their offspring. The third group consisted of 16 newborns (main group) with diagnosed intrauterine CMVI. Results . In the nasopharyngeal aspirate in the newborns of the second group, in comparison with the first one, there were no statistically significant differences in pH (7.02±0.016 and 7.05±0.016, respectively, p&gt;0.05). At the same time, there was a decrease in the concentration of total cholesterol (0.196±0.006 and 0.238±0.003 mmol/L, respectively, p&lt;0.001), an increase in the concentration of medium molecular weight peptides (0.595±0.032 and 0.345±0.005 mmol/L, respectively, p&lt;0.001), seromucoid (0.112±0.002 and 0.098±0.001 optical density units, respectively, p&lt;0.001), triglycerides (0.160±0.005 and 0.145±0.004 mmol/L, respectively, p&lt;0.05) and lactate dehydrogenase activity (345,0±14.16 and 287.6±10.23 IU/L, respectively, p&lt;0.01). In the third group, in comparison with the second one, a decrease in pH by 1.01 times (p&lt;0.01) and in total cholesterol by 1.35 times (p&lt;0.001), an increase in the concentration of medium molecular weight peptides by 1.32 times (p&lt;0,05), seromucoid – 1.13 times (p&lt;0.001), triglycerides – 1.24 times (p&lt;0.001) and the level of lactate dehydrogenase – 1.15 times (p&lt;0.05). Conclusion . In dead newborns with intrauterine CMVI, a change in the physico-biochemical properties of the nasopharyngeal aspirate in the first minutes after birth indicates an antenatal direct and indirect negative effect of the infection on the state of the amniotic membrane, placenta and organs of the intrauterine fetus.

Role of CD146 (MCAM) in Physiological and Pathological Angiogenesis-Contribution of New Antibodies for Therapy.

The fundamental role of cell adhesion molecules in mediating various biological processes as angiogenesis has been well-documented. CD146, an adhesion molecule of the immunoglobulin superfamily, and its soluble form, constitute major players in both physiological and pathological angiogenesis. A growing body of evidence shows soluble CD146 to be significantly elevated in the serum or interstitial fluid of patients with pathologies related to deregulated angiogenesis, as autoimmune diseases, obstetric and ocular pathologies, and cancers. To block the undesirable effects of this molecule, therapeutic antibodies have been developed. Herein, we review the multifaceted functions of CD146 in physiological and pathological angiogenesis and summarize the interest of using monoclonal antibodies for therapeutic purposes.

Особливості перебігу вагітності та характеристика акушерської патології у жінок з ожирінням різного ступеня та фізіологічною масою тіла

The medical and social significance of obesity in pregnant women lies in the high frequency of obstetric complications: miscarriage, preeclampsia, placental dysfunction, abnormal labor, obstetric hemorrhages, infectious and extragenital diseases in offspring that are programmed in utero. The purpose of the research was to analyze the course of pregnancy and to characterize obstetric pathology in women with obesity of various degrees and physiological body weight. Material and methods. To achieve this goal, we surveyed 369 pregnant women. Pregnant women with obesity were divided into three experimental groups: the first one consisted of 149 women with obesity of the 1st degree; the second group included 73 women with the 2nd degree obesity; the third group had 46 women with the 3rd degree obesity. The control group consisted of 101 women with physiological body weight (BMI = 18.5-25 kg/m2). Results and discussion. In the early term of pregnancy, the risk of miscarriage in women with obesity of different degrees was reliably higher by 2.1-2.9 times compared to the control group (p˂0.05). The risk of late miscarriage in groups of women with obesity of different degrees was 1.7-2.4 times higher than in the control group, although these differences were unreliable. There was also a clear tendency for the risk of preterm labor to increase by 1.4-1.7 times (p˃0.05) in obese women. There was a significant increase in the frequency of placental dysfunction in pregnant women with obesity of varying degrees, which was 1.3-1.8 times higher than the control values. An increase in the incidence of placental dysfunction in obese pregnant women manifested as an increase in the number of cases of fetal distress during pregnancy, the frequency of which increased in accordance with the severity of obesity. There was an increase in the incidence of early preeclampsia without statistical significance in women with the 2nd and 3rd degree obesity. Regarding preeclampsia, a significant increase in its frequency should be noted in obese pregnant women depending on the severity. Only women with 2nd and 3rd degree obesity had obstetric hemorrhage caused by premature detachment of the normally situated placenta. This complication was not observed in pregnant women of the control group and with the I degree obesity. Anemia of pregnancy was 1.5 times more common in women with I degree obesity and 1.4 times in women with the 2nd degree obesity, compared to the control group. In obese pregnant women, the frequency of asymptomatic bacteriuria increased in the 1st degree obesity by 1.6 times, in the 2nd and 3rd degrees by 1.2 and 1.4 times respectively compared to the control group. Conclusion. Thus, obesity is an aggravating factor of pregnancy, as evidenced by the increasing frequency of the most threatening complications for the mother and fetus such as miscarriage, placental dysfunction, preeclampsia, and obstetric hemorrhage compared to pregnant women with physiological body weight

Abridged Abstracts From the Medical Literature.

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POLYMORPHISMS OF ENDOTHELIAL DYSFUNCTION GENES NOS3 AND CYBA IN YAKUT POPULATION

Polymorphisms of different genes can predispose people to various diseases. They can influence the body's physiological response to exogenous risk factors. Polymorphisms of the endothelial dysfunction genes NOS3 and CYBA contribute to the development of socially significant diseases, such as acute coronary syndrome, stroke, as well as diseases accompanied by fibrotic changes (cirrhosis of the liver, pulmonary fibrosis, etc.). Therefore, the study of these genes in the Yakut population seems relevant. The present study involved 124 healthy volunteers, their ethnicity is Yakuts (including Yakuts in the third generation, living in the Republic of Sakha (Yakutia)). Genetic analysis of polymorphisms was performed by the method of polymerase chain reaction of restriction fragment length polymorphisms (PCR-RFLP). The study found that healthy Yakuts have GG homozygote of rs1799983 of the NOS3 gene in 83.87%, GT - 15.32%, TT - 0.81%. The frequency of the G allele was 91.53%, the T allele - 8.47%. The study found that healthy Yakuts have CC homozygote of rs4673 of the CYBA gene in 75.0%, CT - 21.77%, TT - 3.23%. The frequency of C allele was 91.44%, T - 8.56%. These results are consistent with the literature data. Thus, the research of the polymorphism rs1799983 of the NOS3 gene and rs4673 of the CYBA gene in various ethnic groups could have encouraging prospects in the personalized medicine for predicting pathological conditions associated with endothelial dysfunction: liver fibrosis, cardiovascular diseases, obstetric and gynecological pathologies, dysfunctions of various organs and systems.

Abstract Author Index

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Incidence of Hip Fracture is Decreasing.

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Adolescent Health: Think, Act, Grow

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Addiction Medicine Allergy & Clinical Immunology Anesthesiology Audiology & Speech-Language Pathology Cardiology Cardiothoracic Surgery Critical Care Medicine Dentistry, Oral Surgery & Medicine Dermatology Dermatologic Surgery Emergency Medicine Endocrinology & Metabolism Family or General Practice Gastroenterology & Hepatology Genetic Medicine Geriatrics & Gerontology Hematology Hospitalist Immunology Infectious Diseases Internal Medicine Legal/Forensic Medicine Nephrology Neurology Neurosurgery Nursing Nutrition & Dietetics Obstetrics & Gynecology Oncology Ophthalmology Orthopedics Otorhinolaryngology Pain Management Pathology Pediatrics Plastic/ Reconstructive Sugery Pharmacology & Pharmacy Physiology Psychiatry Psychology Public, Environmental & Occupational Health Radiology, Nuclear Medicine & Medical Imaging Physical Medicine and Rehabilitation Respiratory/Pulmonary Medicine Rheumatology Sport Medicine/Science Surgery (General) Trauma Surgery Toxicology Transplantation Surgery Urology Vascular Surgery Virology I don't have a medical specialty What's your work setting? Hospital Under 250 Beds Hospital Over 250 Beds Eldercare or Hospice Facility Psychiatric or Rehabilitative Facility Private Practice Group Practice Corporation (Pharmaceutical, Biotechnology, Engineering, etc.) Doctoral University or Medical School Masters or 4-Year Academic University Community College Government Other I have read & acknowledge the End User License Agreement. I have read & accept the terms of the Privacy Policy. Subscribe to journalSubscribe Get new issue alertsGet alerts Enter your Email address: Wolters Kluwer Health may email you for journal alerts and information, but is committed to maintaining your privacy and will not share your personal information without your express consent. For more information, please refer to our Privacy Policy. Subscribe to eTOC Secondary Logo Journal Logo All Articles Images Videos Podcasts Blogs Advanced Search Toggle navigation Subscribe Register Login Articles & Issues Current IssueArchivesePub Ahead-of-Print Collections Acute/Critical CareArt of Nursing Back to BasicsCase ReportsContinuing EducationDisaster and Emergency PreparednessEnvironmental Health and IssuesEthics Evidence-Based Practice, Step by StepFamily CaregiversGeriatric NursingHolistic NursingIn The CommunityInfectious DiseaseInfluenza Classics from the AJN ArchivesInternational TopicsLegal ClinicMental HealthMilitary and Veterans Health Care New to NursingNurse's Week 2019Nursing Research, Step By StepNursing ResourcesPalliative CarePatient SafetyPatient Safety-Safety MonitorPolicy and PoliticsProfessional Development, Leadership and ScholarshipProfessional Partners Supporting Diverse Family Caregivers Across SettingsProfilesPutting Patients First – The Planetree CollectionQI: Quality ImprovementResearchSocial Media and Information TechnologySpecial SupplementsSupporting Family Caregivers: No Longer Home AloneSystematic Reviews Step by StepTeaching For PracticeTransforming Care at the Bedside (TCAB)Uniforms (Nursing)Uniting States, Sharing StrategiesWomen's HealthWriting Resources Multimedia PodcastsVideosHow to Try This VideosNew Look at the Old VideosSupporting Family CaregiversWebinars CE/NCPDFor Authors Submit a ManuscriptInformation for AuthorsLanguage Editing ServicesAuthor Permissions Journal Info About the JournalAdvertising and BusinessAJN Photo Exhibit: Faces of CaringAuthor Guidelines - ReflectionsAward WinnersBook of the Year AwardsContact InfoEditorial BoardInformation for FacultyInformation for MediaInformation for Peer ReviewersLetters to the EditorNurse Faculty Scholars / AJN Mentored Writing AwardOpen AccessReprintsRights and PermissionsSubscription ServicesNurses: Submit Your Photos! All Articles Images Videos Podcasts Blogs Advanced Search

2020 Peer Reviewers

The American Journal of Nursing is a peer-reviewed journal. Nurses and other practitioners serve as peer reviewers, sharing with us their expertise in health care, research, and all aspects of nursing practice. They are essential to ensure the quality of the manuscripts we publish. We are pleased to acknowledge and thank the following individuals who reviewed manuscripts in 2020.

Strengthening New Nurse Manager Leadership Skills Through a Transition-to-Practice Program.

The nurse manager role is increasingly complex, and oftentimes, leadership competencies are learned through experience rather than an effective role transition. The need for a transition-to-practice program for new nurse managers is frequently cited in the literature. This evidence-based practice project resulted in significant improvement in leadership competencies and was used in the development of an American Organization for Nursing Leadership nurse manager transition-to-practice program to be offered in 2021.

What is in the Myopathy Literature?

This update begins with muscle manifestations of coronavirus 2019. They may include myalgias and elevations in serum creatine kinase. It is unknown whether there is direct muscle invasion and how often the critically ill have muscle sequelae. Regarding autoimmune myopathies, a retrospective study of statin-induced necrotizing myopathy is covered. A relatively large proportion of patients had normal strength at presentation. Examples of dermatomyositis associated with immune checkpoint inhibitors are provided including one with cytokine storm. A report of juvenile dermatomyositis with severe abdominal complications is noteworthy. Two articles address unusual associations with inclusion body myositis, namely, spinocerebellar ataxias and granuloma myositis. In the category of muscular dystrophies, a relatively large single center study of the outcome of scapulothoracic arthrodesis for facioscapulohumeral muscular dystrophy is discussed and a article on anoctaminopathies with pauci- or asymptomatic hyperCKemia.

PSVII-17 Program Chair Poster Pick: Reproductive function of cows depending on lipid metabolism

Abstract The aim of the study was to determine the etiopathogenesis of reproductive dysfunction in highly productive cows. Studies were conducted on cows of black-motley breed, aged 3–5 lactations, with a live weight of 480–520 kg. Cows were divided into two groups. The first group included 20 cows effective inseminated after the first insemination. The second group included 17 cows that did not fertilize after the first insemination. Blood samples (n = 253) were taken from 4–7; 14–17; 24–34; 35–50; 88–95; 195–210 days of pregnancy; during the beginning of dry period (DP); 1–4 days before calving and on the first day after calving. The content of total serum lipids in pregnant animals was 15.8% higher compared to unfertilized animals. In non-pregnant cows, a decrease in free cholesterol (by 28.65%), especially in its ether-bound fraction (14.91%), indicates a lower synthetic function of the liver, which is confirmed by the low serum levels of vitamins A and E (a difference of 11.3 and 23.65%). The DP was characterized by a significant increase in the products of lipid peroxidation - malondialdehyde by 12–17%, diene and triene conjugates - by 10–15 and 8–15%, respectively, and 1–4 days before calving in cows, which subsequently had a pathological calving, in particular - retention of placenta (5 cows), were characterized by an increased content in the blood plasma of lipid peroxidation products. Thus, the difference in the number of dienes, trienes, and malondialdehyde products was 14.0, 12.0, and 23.5%, compared with animals without obstetric pathology. On the first day after calving, this difference increased even more. Cows with retention of placenta had a significantly higher level of lipid peroxidation products and were characterized by a predominance of oxidized products over the antiradical thiol disulfide and ascorbate systems restored in the antioxidant balance.