Observed Gender Differences Research Articles

Gender-specific pathway differences in the human serum metabolome.

The susceptibility for various diseases as well as the response to treatments differ considerably between men and women. As a basis for a gender-specific personalized healthcare, an extensive characterization of the molecular differences between the two genders is required. In the present study, we conducted a large-scale metabolomics analysis of 507 metabolic markers measured in serum of 1756 participants from the German KORA F4 study (903 females and 853 males). One-third of the metabolites show significant differences between males and females. A pathway analysis revealed strong differences in steroid metabolism, fatty acids and further lipids, a large fraction of amino acids, oxidative phosphorylation, purine metabolism and gamma-glutamyl dipeptides. We then extended this analysis by a network-based clustering approach. Metabolite interactions were estimated using Gaussian graphical models to get an unbiased, fully data-driven metabolic network representation. This approach is not limited to possibly arbitrary pathway boundaries and can even include poorly or uncharacterized metabolites. The network analysis revealed several strongly gender-regulated submodules across different pathways. Finally, a gender-stratified genome-wide association study was performed to determine whether the observed gender differences are caused by dimorphisms in the effects of genetic polymorphisms on the metabolome. With only a single genome-wide significant hit, our results suggest that this scenario is not the case. In summary, we report an extensive characterization and interpretation of gender-specific differences of the human serum metabolome, providing a broad basis for future analyses.Electronic supplementary materialThe online version of this article (doi:10.1007/s11306-015-0829-0) contains supplementary material, which is available to authorized users.

The Sex Effect on the Perceived Significance of Functional Loss Due to Spinal Cord Injury

Objective: This study aimed to assess the gender effect on the perceived significance of functional loss in patients enduring spinal cord injury (SCI). Methods: Questions related to fecal incontinence, sexual dysfunction, urinary incontinence, and walking disorder have been directed to 50 patients with SCI. Patients were asked to list these disabilities in the order of the significance they placed on each disability, first being the most significant and fourth being the least, and accordingly each disability was scored from 1 to 4. Results: Twenty-nine (58%) male and 21 (42%) female patients were included in the study. Ten (35%) male and 7 (33%) female patients were married. Ten (20%) had tetraplegia, and 40 (80%) had paraplegia. Twenty-five male (86%) and 18 female (86%) subjects had urinary incontinence and the corresponding figures for fecal incontinence were 23 (80%) and 16 (76%), respectively. All participants had at least impaired walking, with complete inability to walk in a certain proportion of patients. Eleven male (38%) and 12 female (57%) patients required walking-aids for walking. All male patients and 16 female patients (76%) reported sexual dysfunction. The significance placed on different functional disabilities in the decreasing order was as follows for male patients: (1) walking disorder, (2) sexual dysfunction, (3) fecal incontinence, and (4) urinary dysfunction. The corresponding order for females was as follows: (1) walking disorder, (2) urinary incontinence, (3) fecal incontinence, and (4) sexual dysfunction. Conclusions: The observed gender difference in the perceived significance of dysfunction because of SCI may be due to anatomical, cultural and social factors.

Gender differences in brain structure and resting-state functional connectivity related to narcissistic personality.

Although cognitive and personality studies have observed gender differences in narcissism, the neural bases of these differences remain unknown. The current study combined the voxel-based morphometry and resting state functional connectivity (rsFC) analyses to explore the sex-specific neural basis of narcissistic personality. The VBM results showed that the relationship between narcissistic personality and regional gray matter volume (rGMV) differed between sexes. Narcissistic scores had a significant positive correlation with the rGMV of the right SPL in females, but not in males. Further analyses were conducted to investigate the sex-specific relationship between rsFC and narcissism, using right SPL/frontal eye fields (FEF) as the seed regions (key nodes of the dorsal attention network, DAN). Interestingly, decreased anticorrelations between the right SPL/FEF and areas of the precuneus and middle frontal gyrus (key nodes of the the default mode network, DMN) were associated with higher narcissistic personality scores in males, whereas females showed the opposite tendency. The findings indicate that gender differences in narcissism may be associated with differences in the intrinsic and dynamic interplay between the internally-directed DMN and the externally-directed TPN. Morphometry and functional connectivity analyses can enhance our understanding of the neural basis of sex-specific narcissism.

How gender and financial self‐efficacy influence investment risk taking

AbstractEvidence shows alarming numbers of US workers nearing retirement insufficiently save for this next life stage. Moreover, many women invest too conservatively. This finding is of particular concern as women typically live longer than men do, and thus, rely on accumulated savings for longer periods of time. This study extends work in the psychology of investing by examining the relationship between gender and investment risk and the role financial self‐efficacy (FSE) plays. Data collected from 182 US student subjects tested the hypotheses that women make less risky investments than men do and that FSE is positively related to the level of risk taken within investment portfolios. The results not only supported the hypotheses but also the analysis shows that FSE might account for the frequently observed gender difference associated with greater financial risk taking.

Gender differences on general knowledge tests: Are they due to Differential Item Functioning?

Gender differences on knowledge tests favoring men are among the most stable gender differences found in cognitive ability measures. Even though several attempts have been made to explain this finding, most studies have not sufficiently considered methodological aspects such as Differential Item Functioning (DIF). The present study investigated whether a German general knowledge test would show gender differences and whether these gender differences could be explained by DIF. To this end, we administered a knowledge test to a sample of N=977 German high-school students. We observed a large gender difference in the total score of the general knowledge test (|d|=0.78). On the basis of a nonparametric DIF-detection approach, we found that 40 of the 84 items showed a substantial amount of DIF. Eliminating those items from the overall knowledge test score reduced the observed gender difference to |d|=0.32. Results are discussed with regard to gender differences on knowledge tests in general and methodological considerations.

All else being equal, men and women are still not the same: using risk models to understand gender disparities in care.

Despite growing awareness of the burden of cardiovascular disease (CVD) in women over the past 2 decades, reports of disparities in the delivery of health care for these diseases have persisted over time.1 Under-treatment of women as compared with men has been described for primary prevention, stable coronary artery disease (CAD) and suspected or diagnosed acute coronary syndromes in both observational studies and controlled experiments.2–6 However, because men and women are nonidentical in many ways that might be relevant for treatment decisions, a critical question for policy makers and clinicians is whether these gender-based variations in treatment correspond to lower quality care. A demonstration of clinical inequity (unequal treatment despite equal clinical need) rather than strict inequality (unequal treatment regardless of need or condition) has been proposed as a framework to identify inappropriate variations in healthcare utilization.7 Following this model, it is important to consider whether observed gender differences correspond to inequities or may reflect appropriate variations explained by differences in treatment indications and contraindications or patient preferences.7 In a well-known study published over a decade ago, investigators devised a clever experiment to address just this question of identifying inappropriate healthcare variations.8 Using actors posing as patients with chest pain, primary care physicians were less likely to refer women for cardiac catheterization than men. Because these patients were carefully designed to be identical in age, cardiac risk factors, and symptoms, followed a script standardizing patient communication, and only differed by gender (and race), it seemed obvious that biased decision-making must account for treatment differences. In this commentary, we illustrate why analyses that attempt to control for all known cardiac risk factors that affect treatment decisions might still yield misleading findings about the presence, magnitude, and causes of gender disparities. This residual bias occurs …

A potential gender bias in assessing quality of life - a standard gamble experiment among university students.

BackgroundThere are several methodologies that can be used for evaluating patients’ perception of their quality of life. Most commonly, utilities are directly elicited by means of either the time-trade-off or the standard-gamble method. In both methods, risk attitudes determine the quality of life values.MethodsQuality of life values among 31 Austrian undergraduate students were elicited by means of the standard gamble approach. The impact of several variables such as gender, side job, length of study, and living arrangements on the quality of life were identified using different types of regression techniques (ordinary least squares, generalized linear model, Betafit).ResultsSignificant evidence was found that females are associated with a higher quality of life in all specifications of our estimations.DiscussionThe observed gender differences in quality of life can be attributed to a higher degree of risk aversion of women. A higher risk aversion leads to a higher valuation of given health states and a potential gender bias in health economic evaluations. This result could have implications for health policy planners when it comes to budget allocation decisions.

Long-Term Outcomes following the MEND 7-13 Child Weight Management Program.

In the current study, we report outcomes 2.4 years from baseline in a random subsample of overweight and obese children who attended MEND 7-13 programs delivered in UK community settings under service level conditions. The study employed an uncontrolled pre-follow-up design. A total of 165 children were measured. Outcomes included anthropometry, parental perception of emotional distress, body esteem, and self-esteem. Overall, there were significant improvements in all outcomes apart from BMI z-score. In boys, BMI z-score, waist circumference z-score, and psychometrics all improved. In girls, there were no statistically significant differences at 2.4 years, except for body esteem. In real-world settings, the MEND intervention, when delivered by nonspecialists, may result in modest, yet positive, long-term outcomes. Subsequent research should focus on improving the outcome effect size, providing effective behavior change maintenance strategies, and further investigating the reasons behind the observed gender differences.

Do risk and time preferences have biological roots?

We revisit the claims about the biological underpinnings of economic behavior by specifically exploring if observed gender differences in risk/time preferences can be explained by natural fluctuations in progesterone/estradiol levels during the menstrual cycle and by prenatal exposure to testosterone levels. Results suggest that natural fluctuations in progesterone levels have a direct effect on discount rates and that estradiol/progesterone levels can indirectly affect time preferences by changing the curvature of the utility function. Using measured D2:D4 digit ratio, results imply that subjects with low digit ratio exhibit higher discount rates and risk loving preferences.

Gender differences in narcissism: a meta-analytic review.

Despite the widely held belief that men are more narcissistic than women, there has been no systematic review to establish the magnitude, variability across measures and settings, and stability over time of this gender difference. Drawing on the biosocial approach to social role theory, a meta-analysis performed for Study 1 found that men tended to be more narcissistic than women (d = .26; k = 355 studies; N = 470,846). This gender difference remained stable in U.S. college student cohorts over time (from 1990 to 2013) and across different age groups. Study 1 also investigated gender differences in three facets of the Narcissistic Personality Inventory (NPI) to reveal that the narcissism gender difference is driven by the Exploitative/Entitlement facet (d = .29; k = 44 studies; N = 44,108) and Leadership/Authority facet (d = .20; k = 40 studies; N = 44,739); whereas the gender difference in Grandiose/Exhibitionism (d = .04; k = 39 studies; N = 42,460) was much smaller. We further investigated a less-studied form of narcissism called vulnerable narcissism-which is marked by low self-esteem, neuroticism, and introversion-to find that (in contrast to the more commonly studied form of narcissism found in the DSM and the NPI) men and women did not differ on vulnerable narcissism (d = -.04; k = 42 studies; N = 46,735). Study 2 used item response theory to rule out the possibility that measurement bias accounts for observed gender differences in the three facets of the NPI (N = 19,001). Results revealed that observed gender differences were not explained by measurement bias and thus can be interpreted as true sex differences. Discussion focuses on the implications for the biosocial construction model of gender differences, for the etiology of narcissism, for clinical applications, and for the role of narcissism in helping to explain gender differences in leadership and aggressive behavior. Readers are warned against overapplying small effect sizes to perpetuate gender stereotypes.

Gender, Sleep Problems, and Obesity in Taiwan: A Propensity-Score-Matching Approach

Obesity has become a major health risk in industrialized countries, with disturbed sleep identified as a correlate. This study used data drawn from Taiwan’s 2005 Social Development Trend Survey on Health and Safety and the propensity-score-matching method to shed light on gender-specific associations between sleep problems and obesity among 24,113 adults aged 20–64 years. The average increase in obesity prevalence among respondents with disrupted sleep was 1.85%, as compared to those who did not report disrupted sleep, with similar psycho-social attributes. Similarly, the prevalence of obesity among those who reported restless sleep was increased by an average of 1.40% compared to those who did not report restless sleep with similar psycho-social attributes. We also found gender-specific vulnerability to different types of sleep problems. Among men who reported disrupted sleep, we found a 3.12% increase in the prevalence of obesity. Among women exposed to restless sleep, the increase in obesity prevalence was 1.84%. The observed gender difference in the prevalence of increases in obesity may be attributed to gender-specific behavioral responses to poor sleep. With poor sleep, men may respond to hunger by overeating; women may respond by physical inactivity. Both can contribute to an elevated risk of obesity.

Gender differences in portfolio risk across birth cohort and marital status

AbstractThis paper investigates gender differences in portfolio risk among Canadian men and women and finds that, controlling for a variety of personal and household characteristics, never married men, born post‐1966, hold significantly higher risk portfolios relative to single women and married couples. Conversely, observed gender differences among pre‐1943 birth cohorts are primarily driven by disparities in characteristics rather than gender or marital status. Previously married women, born 1955–1966, have remarkably high predicted portfolio risk relative to other women and men in the same cohort.

High serum uric acid is associated with increased cardio-ankle vascular index (CAVI) in healthy Japanese subjects: A cross-sectional study

ObjectiveTo investigate the association of serum uric acid (SUA) with arterial stiffness assessed by cardio-ankle vascular index (CAVI). MethodsWe analyzed the cross-sectional data from 27,360 healthy Japanese subjects (12,910 males and 14,450 females) aged between 20 and 74 years without a past history of heart disease, stroke, hypertension, diabetes, nephritis or gout. We investigated whether SUA was independently associated with CAVI in a gender-specific manner. ResultsBMI, CAVI, systolic/diastolic BP, GOT, GPT, γ-GTP, triglyceride (TG), creatinine and SUA were higher and HDL-C was lower in males than in females. Next, they were stratified by SUA into 3 groups: lower tertile (T1), middle tertile (T2) and upper tertile (T3) and by gender. CAVI increased progressive with increasing SUA tertile, after adjusting for age, BMI and systolic BP (sBP) identified in multiple regression analysis for CAVI. Multivariate analysis showed that the odds ratios (95% CI) relative to T1 for high CAVI (≥90th percentile) were 1.233 (0.928–1.638) in T2 and 1.352 (1.031–1.773) in T3 for males, and 1.133 (0.984–1.303) in T2 and 1.361 (1.098–1.687) in T3 for females, after adjusting for confounders. Furthermore, increase in adjusted CAVI was observed in a lower SUA range in females compared to that observed in males. ConclusionWe demonstrated an independent correlation between SUA and CAVI, and observed gender difference in the SUA range for increase in CAVI. These results may suggest the need to set different target SUA levels for men and women in anti-hyperuricemic treatment for atherosclerosis prevention.

Gender differences in occupational injury incidence.

To describe the frequency and distribution of workplace injury claims by gender, and quantify the extent to which observed gender differences in injury claim rates are attributable to differential exposure to work-related factors. WorkSafe Victoria (Australia) workers' compensation data (254,704 claims with affliction onset 2004-2011) were analysed. Claim rates were calculated by combining compensation data with state-wide employment data. Mental disorder claim rates were 1.9 times higher among women; physical injury claim rates were 1.4 times higher among men. Adjusting for occupational group reversed the gender difference in musculoskeletal and tendon injury claim rates, i.e., these were more common in women than men after adjusting for occupational exposure. Men had higher rates of physical injury claims than women, but this was mostly attributable to occupational factors. Women had higher rates of mental disorder claims than men; this was not fully explained by industry or occupation.

Gender Orientation and the Cost of Caring for Others

The “cost-of-caring” thesis asserts that observed gender differences in psychological distress are largely a consequence of women’s greater emotional investment in the lives of their loved ones. Research on this topic has supported this thesis by showing that network events result in higher levels of depressive symptoms for women compared to men. However, other evidence challenges this claim. In light of these divergent findings, this paper elaborates this topic in three ways. First, susceptibility to network events is assessed in terms of two dimensions of psychological distress, depressive symptomatology and problem drinking. Second, within-gender analyses are conducted to examine the possibility that masculine and feminine personality traits condition the relationship between network events and psychological distress. Finally, this paper assesses age variation in the cost of caring. Data collected from 1,393 respondents ages 18 to 55 who participated in a Toronto-based community study are employed to address these issues. Findings reveal that the cost of caring for others extends to women and men, and that gender orientation modifies the relationship between network events and psychological distress. These results underscore the need to critically assess the social factors that differentiate risk and well-being for men and women.

Gender, work orientations and job satisfaction

This article studies the gender gap in job satisfaction and argues that the observed gender difference is a consequence of the heterogeneity in work orientations between men and women. Using data from the 2006 Skills Survey, the analysis yields three major findings. The first shows that women, either in full-time or part-time employment, report significantly higher levels of job satisfaction than men. Secondly, work orientations are closely associated with one’s job satisfaction and their relationships vary significantly across men, women full-time and part-time workers. Finally and most importantly, the observed gender satisfaction differential is eliminated once work orientations are taken into consideration.

Gender and Dynamic Agency: Theory and Evidence on the Compensation of Top Executives

Survey and experimental evidence point to the existence of a pervasive set of culturally-related barriers. These include lack of mentoring and role models, exclusion from informal networks, gender based stereotyping, display of style different than the organizational norms, difficulties in engaging in negotiations and inhospitable corporate culture. Based on this evidence, we consider two alternative hypotheses regarding possible determinants of gender differences in the structure of compensation. The first hypothesis is that female executives have lower impact. Specifically, we allow for a lower effect of effort on the probability of high profits for female executives (probability-impact). Alternatively, we consider the case where for given effort, female executives give rise to higher volatility in firm profits (productivity-impact). The second hypothesis is that female executives have lower effectiveness - that is, they have a smaller role in the determination of a firm's profits, for a given impact of their effort. We find that the version of the model in which female executives have lower effectiveness is consistent with the observed gender differences in the structure of executive compensation. The version with lower impact fails to replicate, among the other things, the lower fraction of performance pay earned by female executives.

Androgens and esophageal cancer: What do we know?

Significant disparities exist between genders for the development and progression of several gastro-intestinal (GI) diseases including cancer. Differences in incidence between men vs women for colon, gastric and hepatocellular cancers suggest a role for steroid sex hormones in regulation of GI carcinogenesis. Involvement of intrinsic gender-linked mechanisms is also possible for esophageal adenocarcinoma as its incidence is disproportionally high among men. However, the cause of the observed gender differences and the potential role of androgens in esophageal carcinogenesis remains unclear, even though the cancer-promoting role of androgen receptors (AR) shown in other cancers such as prostate and bladder suggests this aspect warrants exploration. Several studies have demonstrated expression of ARs in esophageal cancer. However, only one study has suggested a potential link between AR signaling and outcome - poorer prognosis. Two groups have analyzed data from cohorts with prostate cancer and one of these found a decreased incidence of esophageal squamous and adenocarcinoma after androgen deprivation therapy. However, very limited information is available about the effects of androgen and AR-initiated signaling on esophageal cancer cell growth in vitro and in vivo. Possible mechanisms for androgens/AR involvement in the regulation of esophageal cancer growth are considered, and the potential use of AR as a prognostic factor and clinical target is highlighted, although insufficient evidence is available to support clinical trials of novel therapies. As esophageal adenocarcinoma is a gender linked cancer with a large male predominance further studies are warranted to clarify the role of androgens and ARs in shaping intracellular signaling and genomic responses in esophageal cancer.

Differential levels of soluble inflammatory markers by human immunodeficiency virus controller status and demographics.

Background. Human immunodeficiency virus (HIV)-1 elite controllers (ECs) represent an ideal population to study the effects of HIV persistence on chronic inflammation in the absence of antiretroviral therapy (ART).Methods. Twenty inflammatory markers measured in cohorts of ECs, HIV suppressed noncontrollers, and HIV-uninfected controls were compared using rank-based tests and partial least squares discriminant analysis (PLSDA). Spearman correlations were determined among the inflammatory markers, residual viremia by the single-copy assay, and CD4+ T cell slope.Results. Significant differences were seen between cohorts in 15 of the soluble inflammatory markers. Human immunodeficiency virus-1 ECs were found to have the highest levels for all of the markers with the exception of RANTES. In particular, median levels of 7 inflammatory markers (soluble CD14 [sCD14], interferon [IFN]-γ, IFN-γ-inducible protein [IP]-10, interleukin [IL]-4, IL-10, sCD40L, and granulocyte-macrophage colony-stimulating factor) were twice as high in the HIV-1 ECs compared with either of the HIV-suppressed or uninfected groups. Multivariate PLSDA analysis of inflammatory markers improved differentiation between the patient cohorts, discerning gender differences in inflammatory profile amongst individuals on suppressive ART. Soluble markers of inflammation in ECs were not associated with either levels of residual HIV-1 viremia or CD4+ T cell decline.Conclusions. Despite maintaining relatively low levels of viremia, HIV-1 ECs had elevated levels of a set of key inflammatory markers. Additional studies are needed to determine whether ECs may benefit from ART and to further evaluate the observed gender differences.

Dechlorane Plus in paired hair and serum samples from e-waste workers: Correlation and differences

Dechlorane Plus (DP) and a dechlorinated product of DP were measured in 34 matched human hair and serum samples (19 males and 15 females) collected from e-waste recycling workers in South China. The DP (sum of syn- and anti-DP) concentrations in hair and serum samples ranged from 6.3 to 1100ngg−1 dry weight and from 22 to 1400ngg−1 lipid weight (lw). The levels of anti-Cl11-DP ranged from 0.02 to 1.8ngg−1 in hair and from not detected to 7.9ngg−1 lw in serum. Significant positive correlations for both DP and anti-Cl11-DP concentrations between hair and serum samples were found (p<0.05), indicating hair to be a suitable matrix for human DP exposure. However, a significant difference was found in the DP isomer composition between hair and serum, suggesting stereoselective bioaccumulation during the absorption of DP into hair. A sharp gender difference was found in the levels of DP in hair. Moreover, syn-DP, anti-DP and anti-Cl11-DP in hair significantly correlated with those in serum for male samples, but not for female samples. The observed gender differences in the present study may be, in part, ascribed to the much longer hair exposure time for females than males due to the difference in sampling distance from the scalp.