Observational Study Research Articles

Establishment and validation of a predictive model for lower extremity deep vein thrombosis in patients with traumatic pelvic fractures

BackgroundPatients with traumatic pelvic fracture (TPF) are at high risk for developing deep vein thrombosis (DVT). However, there is still no unified standard on how to distinguish high-risk groups for DVT in patients with TPF and how to accurately use anticoagulants at present.ObjectivesThis observational study aimed to establish a DVT risk nomogram score (DRNS) model for TPF patients, and to explore the value of the DRNS model as a clinical guideline in the prevention of DVT with low molecular weight heparin (LMWH).MethodsIndependent risk factors of lower extremity DVT were screened through Lasso regression and logistic regression. A DRNS model was established per this.ResultsThe independent risk factors of DVT included combined femoral fractures, age ≥ 40 years old, BMI (body mass index) ≥ 24 kg/m2, ISS score, fibrinogen concentration, and the minimum concentration of ionized calcium within 48 h after admission. The optimal cutoff value for DRNS was 78.5. In the low-risk population of DVT (DRNS < 78.5), there was no statistical significance of variation about the incidence of DVT progression between the LMWH once a day (qd) group and the LMWH once every 12 h (q12h) group, with P = 0.323. In the high-risk population of DVT (DRNS ≥ 78.5), the incidence of DVT progression in the LMWH qd group was significantly higher than that in the LMWH q12h group, with P = 0.002.ConclusionsThe DRNS model based on independent risk factors of DVT could stratify the risk of DVT for TPF patients, and it was able to provide more precise DVT drug prevention plans for clinicians.

Automated Assessment of Reporting Completeness in Orthodontic Research Using LLMs: An Observational Study

This study evaluated the usability of Large Language Models (LLMs), specifically ChatGPT, in assessing the completeness of reporting in orthodontic research abstracts. We focused on two key areas: randomized controlled trials (RCTs) and systematic reviews, using the CONSORT-A and PRISMA guidelines for evaluation. Twenty RCTs and twenty systematic reviews published between 2018 and 2022 in leading orthodontic journals were analyzed. The results indicated that ChatGPT achieved perfect agreement with human reviewers on several fundamental reporting items; however, significant discrepancies were noted in more complex areas, such as randomization and eligibility criteria. These findings suggest that while LLMs can enhance the efficiency of literature appraisal, they should be used in conjunction with human expertise to ensure a comprehensive evaluation. This study underscores the need for further refinement of LLMs to improve their performance in assessing research quality in orthodontics and other fields.

An Observational Study of Patients Presenting in Hypotension and Shock to Emergency Room by Applying RUSH Protocol

Introduction: Care of the patient with shock can be one of the most challenging issues in emergency medicine. The early use of ultrasound at the bedside in such emergency is a very valuable tool to determine the type of shock. Rapid Ultrasound in SHock (RUSH) protocol done by emergency physicians is one such protocol which is being underused. Hence, we conducted this study to assess the effectiveness of the RUSH protocol for patients presenting with undifferentiated hypotension and shock. Materials and methods: This was prospective observational study done on a total of 100 patients presented with hypotension and shock. We performed an early bedside sonographic examination for participants based on RUSH protocol and type of shock was determined. Then the definitive interventions were performed as per the type of shock. The outcome measures were determined either till the survival to discharge from the hospital or till the in-hospital death of the patient. The data was analysed using SPSS version25. Results: In this study, the type of shock most commonly found overall was hypovolemic shock (40%) followed by cardiogenic shock (27%) and distributive shock (17%). Contractility of left ventricle, size of right ventricle, inferior venacava caliber, hemoperitoneum, pneumothorax, hemothorax, pulmonary edema, pleural effusion and lungs consolidation were statistically significant in determining the type of shock except cardiac tamponade, abdominal aortic aneurysm/dissection and deep vein thombosis. Majority of the interventions performed were fluid resuscitation (41%), vasopressors and inotropes (28%) and laparotomy (9%) and were statistically significant (p=0.001). Among all patients, 73% survived and 27% died. The outcome was statistically significant (p=0.002). Conclusion: RUSH protocol used for undifferentiated hypotension and shock is an effective tool at the bedside as an early approach to diagnose the type of shock. It will also help in determining early definitive interventions in shock states and thereby having better patient outcomes.

Usage of table salt and risk of all-cause and cardiovascular disease mortality among patients with diabetes: a national population-based cohort study

BackgroundA lower dietary sodium intake has been associated with a reduced risk of cardiovascular disease (CVD) mortality in the general population. However, the evidence is less clear in diabetic patients. The study aims to investigate whether the usage of table salt is associated with all-cause and CVD mortality among individuals with diabetes.MethodsIn this prospective cohort study, participants with diabetes from the U.S. National Health and Nutritional Examination Survey (NHANES) 2003–2018 were included. Weighted linear regression models were employed to assess the association between the usage of table salt and dietary sodium intake. Weighted Cox proportional hazards regression models were used to assess the association between the usage of table salt and all-cause and CVD mortality.ResultsThis cohort study included data from 6,258 participants in analysis. During 44,035 person-years of follow-up, 1,504 deaths from all-causes and 427 from CVD were documented. Not using table salt was significantly associated with lower dietary sodium intake, with a β of -192.60 (95% CI, -297.01 to -88.18) mg. A higher risk of all-cause and CVD mortality was observed in the group of participants not using table salt among patients with diabetes. Compared with participants using table salt, the hazard ratios for all-cause mortality were 1.18 (95% CI, 1.03 to 1.35), and for CVD were 1.48 (95 CI, 1.16 to 1.90) for participants not using table salt. The subgroup analysis revealed a significantly stronger link between the usage of table salt and all-cause mortality in participants with CVD (P for interaction = 0.004).ConclusionsThis study indicated that not using table salt was associated with a lower dietary sodium intake, and an increased risk of all-cause and CVD mortality among individuals with diabetes. Interventional studies are needed to determine more beneficial relevant approaches to dietary management in diabetes care.

Investigating the Association of Computer Vision Syndrome with Forward-Headed and Kyphotic Posture Among Undergraduate Information Technology Student

Introduction: Computers and visual display devices have become indispensable in our daily lives. The frequent use of these devices has led to the emergence of computer vision syndrome (CVS). Coupled with poor ergonomics, musculoskeletal diseases are on the rise due to excessive computer use. Accordingly, this study investigates the association between CVS and forward-headed and kyphotic posture in undergraduate IT students. Materials and Methods: We conducted an observational cross-sectional study involving 300 undergraduate IT students. We used a modified CVS questionnaire to assess CVS and the Kinovea software to diagnose forward head posture. We also used the occiput wall distance test to assess kyphosis. Results: In this study, a majority of undergraduate students (88%, 264 out of 300) exhibited CVS, resulting in forward head posture and kyphosis. There was a significant association between CVS, forward head posture, and kyphosis. Conclusion: Computer vision syndrome is strongly associated with forward head posture and kyphosis. Prolonged computer device usage leads to changes in body posture, affecting the neck, shoulders, elbows, wrists/hands, upper back, and lower back.

Feasibility, Acceptability, and Preliminary Effectiveness of a Reflective Supervision Professional Development Series Within Early Care and Education

ABSTRACT The positive impacts of Reflective Supervision (RS) are becoming increasingly evident. This approach may be especially important for early childhood teachers, who must deliver academic curricula and attend to children’s social-emotional development while maintaining high-quality program standards in increasingly challenging environmental contexts. However, to effectively provide RS to early childhood teachers, supervisors must first be trained in this approach. This paper describes the results of one such innovative training effort using data from a statewide, community-based program evaluation and a pilot open trial in the United States. Participants (N = 83 supervisors) were offered foundational training in RS followed by monthly skill-building sessions. We used a concurrent mixed methods approach, integrating observational, survey, and interview data collected simultaneously to assess feasibility, acceptability, and preliminary effectiveness of the RS professional development series. Data integration was achieved through contiguous narrative and joint display approaches. Research Findings: The RS series was feasible to implement, acceptable to participants, and led to improved reflective supervisory competencies. Practice or Policy: The RS series may represent an opportunity to effectively support the early care and education workforce, and in turn, benefit children. We discuss some differences between samples that may be useful for future implementation efforts across early care and education settings.

Association between changes in adherence to the 24-hour movement guidelines with depression and anxiety symptoms among Chinese adolescents: a prospective population-based study

BackgroundThe 24-hour movement guidelines (24-HMG) include screen time (ST), sleep duration, and physical activity. Previous studies have explored the associations of adherence to the 24-HMG with depression and anxiety symptoms among adolescents, ignoring changes in behaviors. This study aimed to examine whether changes in adherence to the 24-HMG were associated with depression and anxiety symptoms among adolescents.MethodsWe recruited adolescents from Shenzhen, China in 2021 and followed them up 1 year later. Changes in adherence to the individual 24-HMG were categorized into four groups: persistent non-adherence, adherence to non-adherence, non-adherence to adherence, and persistent adherence. Changes in the numbers of adherence to the overall 24-HMG were obtained by subtracting the number of guidelines adhered to in wave 2 from that in wave 1.ResultsWe included 12,570 participants aged 9–18 years with 52.2% boys. Compared with persistent non-adherence for the ST/sleep duration guideline, non-adherence to adherence and persistent adherence were associated with lower depression and anxiety symptoms, but adherence to non-adherence was not. Changes in adherence to the physical activity guideline were not related to outcomes. The β coefficients (95% CIs) for each point increase in changes in the numbers of adherence to guidelines were − 0.58 (− 0.69, − 0.47) and − 0.43 (− 0.53, − 0.33) for depression and anxiety symptoms, respectively. The association of persistently adhering to sleep guideline with anxiety symptoms and the associations of changes in the numbers of adherence to the 24-HMG had sex differences.ConclusionsMaintaining and strengthening healthy movement behaviors to meet more guidelines of the 24-HMG, especially sleep and ST, may be beneficial for preventing depression and anxiety symptoms in adolescents.

Association of Flat Feet with Knee Moments and Western Ontario and McMaster Universities Arthritis Index in Knee Osteoarthritis

Introduction: Flat feet are prevalent among individuals with medial compartment knee osteoarthritis (KOA), showing a correlation with elevated knee pain and cartilage degeneration. This study investigates the relationship between calcaneal eversion angle (CEA) and medial longitudinal arch angle (MLAA) with knee kinetics and pain. Materials and Methods: This analytical observational study included 30 volunteers with moderate KOA. The Vicon motion analysis system and two synchronized force plates were employed to capture level walking and the static standing position to measure CEA and MLAA. The study assessed the first and second peaks of the knee adduction moment, knee adduction moment impulse, peak knee flexion moment, and the peak knee flexion angle at heel strike (PKFA-HS). The Western Ontario and McMaster Universities arthritis index (WOMAC) pain and physical function were evaluated. Results: A significant positive correlation was found between CEA and the knee pain sub-score (Pearson correlation [PC]=0.446, P=0.011) and WOMAC total score (PC=0.363, P=0.049). Additionally, a significant negative correlation was observed between CEA and peak knee flexion moment/PKFA-HS (PC=-0.418, P=0.022, and PC=-0.479, P=0.001, respectively). The results also indicated a negative significant correlation between MLAA and WOMAC pain sub-score (PC=-0.389, P=0.034). Conclusion: Increased CEA and decreased MLAA are associated with elevated WOMAC pain sub-score and decreased PKFA-HS in individuals with moderate KOA. Addressing flat feet should be considered in KOA management to enhance pain relief and functional outcomes

Transcranial Ultrasound Guided Assessment of Brain Midline Shift in Neuro Intensive Care Unit

Background: Neuro Intensive Care Unit (Neuro-ICU) handles neurological emergencies that involve intracranial (IC) hemorrhages. It can be challenging to manage elevated intracranial pressure (ICP) and midline shift (MLS), as they requires constant monitoring and frequent imaging. Trans-cranial Color Coded Sonography (TCCS), a bedside monitoring tool, may be helpful in monitoring MLS under such conditions. Objectives: To correlate MLS of the third ventricle in the brain measured by TCCS with CT midline shift. Method: A prospective observational study was conducted on patients with IC bleed who were mechanically ventilated and had a head CT done to rule out MLS. Within an hour of doing a CT brain, TCCS-MLS was identified. Data was collected and analyzed. Results: A total of fifty patients studied, the MLS (mean ±SD) was 5.3mm ± 3.1 mm using TCCS and 6.7±4.4 mm using CT brain. The calculated midline shift between TCCS and CT brain demonstrated a Pearson's correlation of 0.78 (P&lt;0.001). With TCCS, the area under the ROC curve to identify a significant MLS was 0.91 (95%CI=0.8-1). TCCS-MLS of 3.9mm as a cut-off, predicted the occurrence of &gt;5mm MLS on CT scan with a sensitivity of 95% and specificity of 90%. Conclusions: This study suggests that TCCS could serve as an alternative bedside monitoring tool in patients whose transportation is risky, in predicting the transcranial MLS &gt;5mm with reasonable accuracy.

Prevalence and Impact of Stress in the Indian Population: A Retrospective Survey Analysis

Post-COVID-19 pandemic, individuals are experiencing various forms of stress. This study assessed the prevalence of stress among Indian adults, examined its physical and psychological impacts, and investigated stress management strategies, aiming to fill existing gaps in research. This retrospective observational study utilized an online survey from March 16, 2023, to July 30, 2023, using snowball sampling to target the Indian population. Respondents aged ≥18 years participated in the study. The survey collected data on demographic information, self-reported stress levels, and Perceived Stress Scale (PSS) scores. The chi-square test was applied for statistical analysis, and results with a p-value under 0.05 were considered significant. Among 1,479 respondents (638 males, 841 females; mean age: 23.7±7.7 years), 76.0% of respondents resided in Karnataka. Out of 1,479 respondents, 9.6% experienced mild stress, 84.9% experienced moderate stress, and 5.5% experienced severe stress according to the PSS. Females experienced significantly higher stress levels when compared with males (p=0.047), but both experienced moderate stress levels. Financial problems (20.7%) and studies (36.4%) were the most common stressors among respondents. They most frequently manage stress through personal strategies, such as sleeping and listening to music. The present study's findings indicate that, following the COVID-19 health crisis, moderate levels of stress are significantly prevalent in the Indian population, primarily due to academic and job-related pressures.

Diuretics and mortality reduction in incident dialysis patients: a two-year observational study

Fluid overload predicts morbidity and mortality in dialysis patients. Diuretics can reduce fluid overload, but their effects on morbi-mortality following inception remain ill-defined. To determine whether diuretics reduce mortality and hospitalization rates in incident dialysis patients in the first 2 years after inception. Adult patients starting dialysis between 2009 and 2015 in the REIN registry were matched with the SNDS database and divided into four subgroups according to loop diuretics exposure: < 5%, 5–50%, 50–80% or > 80% over the observation period of each patient. The incidence of hospitalization was described based on the primary diagnoses of the discharge summaries and codes. In this study, which included 67,736 patients, 53,829 (79.5%) who had varying degrees of diuretic exposure exhibited a significantly lower mortality rate at 2 years compared to those without diuretic exposure (24.8% [95% CI 24.4–25.2], vs 37.5% [95% CI 36.7–38.3] respectively). However, the duration of diuretic exposure significantly impacted outcomes. The all-cause mortality rate at two years was highest in the group with ≥ 80% exposure (68.2% [95% CI 67.3–69.1]), followed by those with 50–80% exposure (15.7% [95% CI 15.0–16.4]), and those with 5–50% exposure (6.6% [95% CI 6.3–7.0]). An inverse probability weighting (IPW) propensity score analysis supported these findings. Stratified analyses showed consistent results regardless of a history of congestive heart failure and were similar for both hemodialysis and peritoneal dialysis patients. Additionally, the number of hospitalizations and length of stay were generally higher in the group with the longest exposure to loop diuretics. Diuretic exposure was generally associated with a lower mortality rate in dialysis patients. However, prolonged exposure (≥ 80%) was linked to an increased risk of mortality and hospitalization. This prolonged exposure may indicate residual diuresis at the cost of chronic fluid overload.

The Vertical Structure of Turbulence Kinetic Energy Near the Arctic Sea‐Ice Surface

AbstractAtmospheric turbulence over the Arctic sea‐ice surface has been understudied due to the lack of observational data. In this study, we focus on the turbulence kinetic energy (TKE) over sea ice and distinguish its two different vertical structures, the “Surface” type and the “Elevated” type, using observations during the Multidisciplinary drifting Observatory for the Study of Arctic Climate expedition (MOSAiC). The “Surface” type has the maximum TKE near the surface (at 2 m), while the “Elevated” type has the maximum TKE at a higher level (6 m). The TKE budget analysis indicates that the “Elevated” type is caused by the increased shear production of TKE at 6 m. In addition, spectral analysis reveals that the contribution to TKE by horizontal large eddies is enhanced in the “Elevated” type. Finally, how the vertical structure of TKE affects the parameterization of turbulent momentum flux is discussed.

Association of the distance travelled, and the call to hospital arrival time with early neonatal mortality in neonates born to mothers using emergency medical services at term gestation: a retrospective observational study

BackgroundMost neonatal deaths in India occur due to a lack of timely and proper care just before and during delivery. Timely availability of an ambulance for institutional delivery has led...

Incidence of post-intensive care syndrome among patients admitted to post-ICU multidisciplinary consultations: the retrospective observational PICS-MIR study

To determine the prevalence of functional, respiratory and renal impairments and of post-intensive-care-syndrome (PICS) among patients who had attended a post-ICU multidisciplinary consultation (post-ICU-MC) around 3 months after ICU discharge, we performed a retrospective, monocentric observational study, at Clermont Ferrand University hospital, France. We included patients who had attended a post-ICU-MC. Their characteristics during ICU stay and at the post-ICU-MC were collected. Functional status was assessed by the 6-min-walking test, handgrip test and peak inspiratory pressure, respiratory function by exploratory functional outcomes, mental status by SF-36 score, and quality of life by SF-36 score and European Quality of Life 5 Dimensions questionnaire. Overall, we enrolled 67 patients, of whom 70%, 74%, and 68% had functional, respiratory, and renal impairments, respectively, at the post-ICU-MC. Additionally, 40%, 28%, 19%, and 2.5% had three, two, one, and none of these impairments, respectively. All patients experienced mental disorders and a decline in quality of life. Functional impairment correlated with frailty score and sex, and respiratory function with age. To conclude, the prevalence of PICS in our cohort was high, as was that of functional, respiratory and renal failure.

Factors Associated With Delayed Hospital Arrival After Stroke Onset: An Observational Study in Thanh Hoa Province, Vietnam

Factors Associated With Delayed Hospital Arrival After Stroke Onset: An Observational Study in Thanh Hoa Province, Vietnam

Assessing Radiative Feedbacks and Their Contribution to the Arctic Amplification Measured by Various Metrics

AbstractArctic amplification (AA), characterized by a more rapid surface air temperature (SAT) warming in the Arctic than the global average, is a major feature of global climate warming. Various metrics have been used to quantify AA based on SAT anomalies, trends, or variability, and they can yield quite different conclusions regarding the magnitude and temporal patterns of AA. This study examines and compares various AA metrics for their temporal consistency in the region north of 70°N from the early twentieth to the early 21st century using observational data and reanalysis products. We also quantify contributions of different radiative feedback mechanisms to AA based on short‐term climate variability in reanalysis and model data using the Kernel‐Gregory approach. Albedo and lapse rate feedbacks are positive and comparable, with albedo feedback being the leading contributor for all AA metrics. The net cloud feedback, which has large uncertainties, depends strongly on the data sets and AA metrics used. By quantifying the influence of internal variability on AA and related feedbacks based on global climate model ensemble simulations, we find that water vapor and cloud feedbacks are most heavily affected by internal variability.

Knowledge and awareness of emergency department residents and physicians regarding the management of dentofacial traumatic injuries: a cross-sectional study

BackgroundMajority of patients with Dento-Facial Traumatic Injuries (DFTI) seek initial care at an Emergency Department (ED). The timely management of DFTI is of utmost importance in determining long-term prognosis of the tooth and the patient’s overall quality of life. Thus, knowledge and awareness of ED residents & physicians regarding the management of DFTI is crucial for better patient outcomes. Numerous studies have investigated the knowledge of ED specialists regarding initial management of dental trauma, however, scientific evidence in this domain is scarce in our region.ObjectiveThe aim of this study was to evaluate the knowledge and awareness of ED residents and physicians regarding diagnosis and management of DFTI using a web-based survey on REDCap.MethodsAn observational cross-sectional study was conducted among the ED residents and physicians of private and public hospitals in Karachi, Pakistan. Data was collected through a web-based questionnaire, sent via email to the participants. The survey comprised of questions assessing their knowledge regarding the diagnosis and management of various dental and maxillofacial injuries. Responses from the participants were graded as low, moderate or high knowledge levels according to a pre-determined criteria. Pearson’s chi-square test was applied to determine the association between knowledge scores.ResultsThe total response rate was 47.6%. Out of 116 participants, 49 (42%) responses were received from physicians and 67 (58%) from residents. The overall knowledge level of participants was low (46.6%) and there was no significant difference in the knowledge level between residents and physicians (p = 0.157). Participants who had received formal training in dental trauma (p = 0.038) and those with more years of clinical experience (p = 0.004) had higher knowledge scores, that were statistically significant.ConclusionsThe knowledge and awareness of ED residents and physicians in dental trauma management was generally low. Specialized training courses are required to provide timely and adequate management of traumatic dental injuries in order to improve patient-related outcomes.

Is a rising cesarean delivery rate explained by late birth trend? A decomposition analysis of health insurance claims data (2013–2022) from South Korea

AbstractObjectiveTo analyze the factors influencing the increase in the cesarean delivery (CD) rate in South Korea and test the hypothesis on advanced maternal age driving the trend.MethodThe present study is a population‐based retrospective observational study utilizing administrative data from the Korean National Health Insurance Service. We analyzed a total 3 416 517 births from 2013 to 2022 covered by the national health insurance. The CD rate and contribution of demographic variables to changes in CD rates were calculated using Das Gupta's decomposition method.ResultsThe CD rate increased from 37.8% in 2013 to 61.6% in 2022. The decomposition analysis revealed that changes in maternal age structure contributed only 8.7% to the increase in the CD rate. When parity was added to maternal age, the explained proportion increased to 17.8%. When other factors were added to the model, such as multiple births, residential area, and income level, it did not contribute significantly to the increase in the CD rates, accounting for 19.0%, 18.6%, and 18.0%, respectively.ConclusionsAccording to our analysis, less than one‐fifth of the increase in CD rate was explained by the change in maternal age. The rising CD rate in Korea should not be considered an unavoidable consequence of demographic change. Much more diverse factors, including increased risk of medical lawsuits, changes in childbirth culture, and other health system determinants, may be driving the trend.

Effects of repetitive transcranial magnetic stimulation therapy on weight and lipid metabolism in patients with treatment‐resistant depression: A preliminary single‐center retrospective cohort study

AbstractAimThis study aimed to elucidate the effects of repetitive transcranial magnetic stimulation (rTMS) on weight, body mass index (BMI), and lipid metabolism in patients with treatment‐resistant depression (TRD).MethodsThis retrospective observational study included patients with TRD who received rTMS treatment at the Jikei University Hospital from September 2018 to August 2021. The patients were diagnosed based on the DSM‐5 and ICD‐10 criteria and treated using the NeuroStar TMS System. For 3–6 weeks, 10‐Hz rTMS was administered to the left dorsolateral prefrontal cortex at 120% motor threshold. The primary outcomes were changes in weight and BMI, whereas the secondary outcomes included changes in total, high‐density lipoprotein (HDL), and low‐density lipoprotein (LDL) cholesterol levels, thyroid function indicators, as well as HAMD‐17, HAMD‐24, and Montgomery–Åsberg Depression Rating Scale (MADRS) scores. Statistical analysis was conducted using paired t‐tests and repeated measures ANOVA.ResultsAmong the 34 patients (20 men and 14 women) included, no significant changes were observed in weight or BMI after rTMS treatment (average weight reduction: −0.50 kg, 95% CI: −0.14 to 0.56, p = 0.24; average BMI reduction: −0.21, 95% CI: −0.10 to 0.61, p = 0.15). However, significant reductions in total, HDL, and LDL cholesterol levels and FT4 were observed. Furthermore, the HAMD‐17, HAMD‐24, and MADRS scores significantly increased post‐treatment.ConclusionrTMS treatment did not affect weight or BMI in patients with TRD but is believed to improve lipid metabolism.

Knowledge Gaps Regarding Allergic Rhinitis among the Patients Visiting Community Pharmacies of Lahore, Pakistan

Introduction: Allergic rhinitis is a varied disorder characterized by symptoms such as sneezing, nasal blockage, nasal itching, and a runny nose. This study assessed the knowledge of patients about Allergic rhinitis and to identify knowledge gaps in patient’s understanding along with the factors that may impact knowledge regarding the disease. Methods: A cross-sectional observational study design was implemented to collect data from patients visiting community pharmacies of Lahore on a structured questionnaire (self-developed) containing 12 items related to knowledge. The questionnaire was distributed to physician diagnosed Allergic rhinitis patients. The questionnaire with closed-ended questions was completed by 240 participants of both genders as sampled through random sampling procedure. The study spanned over a period of eight months. Results: Among 240 respondents, 81.3% were students and majority were female (58.3%). It revealed that only 33.3% of respondents demonstrated adequate knowledge about Allergic rhinitis, while 66.7% demonstrated inadequate knowledge. Among demographic variables, female respondents presented better knowledge compared to the male population. Moreover, education status was positively associated with knowledge of respondents. Low education status of study subjects was observed to be the reason for knowledge gap among respondents. The p-values&lt;0.05 were considered statistically significant. Conclusion: This study highlights a significant gap in respondent’s knowledge, emphasizing the need for targeted education and intervention. Low literacy rate was the major factor negatively associated with respondents’ knowledge of Allergic rhinitis. Improved knowledge is crucial to promoting good practices and achieving desired outcomes. Educational interventions and seminars should be conducted at public health sectors to enhance awareness in the general population.