Distal Research Articles

Preoperative tibiofemoral contact point on standing lateral radiograph predicts anteroposterior knee kinematics in total knee arthroplasty

AbstractPurposeThis study investigated the tibiofemoral contact point (CP) on standing lateral radiographs in knee osteoarthritis and assessed the relationship between CP and pre‐ and postoperative knee kinematics in total knee arthroplasty (TKA).MethodsThe intraoperative knee status of 46 knees with varus deformity that underwent bicruciate stabilized TKA using a navigation system was investigated. The intraoperative anteroposterior (AP) position of the femur relative to the tibia at maximum extension, 15°, 30°, 45°, 60° and 90° was evaluated by the navigation system before and after TKA. The CP, defined as the CP between the femur and tibia, was assessed on standing lateral radiographs at the maximum extension of the knee before and 1 year after TKA. CP was expressed as the ratio of tibial plateau distance on a scale of 0–1, with 0 indicating the most anterior position of the femur relative to the tibia.ResultsThe mean CP on standing lateral radiographs was 0.54 ± 0.12 and 0.46 ± 0.08 before and after TKA, respectively. The postoperative CP was significantly more anterior than the preoperative CP (p = 0.0002). The mean AP position of the femur relative to the tibia moved anteriorly during early knee flexion both before and after TKA, representing nonanatomical AP movement. The preoperative posterior CP group (CP > 0.54) showed more nonanatomical AP movement from 15° to 60° before and after TKA compared with the preoperative anterior CP group (CP < 0.54).ConclusionPreoperative posterior deviation of the femur relative to the tibia in the standing position was a predictive factor for nonanatomical AP knee kinematics. Biomechanical analysis of postoperative knees will be necessary; however, surgeons should focus on preoperative tibiofemoral CP on standing lateral radiographs to predict knee kinematics.Level of EvidenceLevel Ⅲ.

Short humeral stem in total shoulder arthroplasty does not jeopardize primary implant stability

BackgroundThe trend of the modern humeral components in total shoulder arthroplasty (TSA) is towards shorter and shorter humeral stems. However, the question remains whether short uncemented stems can provide the same implant stability as long stems. This study aimed to evaluate and compare the torsional primary stability, and the pull-out extraction force of both a long and a short version of the same stem. Materials and MethodsTen humeral components (five long-stem and five short-stem) were press-fitted into ten synthetic composite humeri. A torsional load was applied to generate the most critical loading condition. The specimens were loaded with 100 cycles between 2 Nm and 10 Nm, at 1 Hz. A 3D Digital Image Correlation system was used to measure the relative displacement between the prosthesis and the host bone during the test. After completing the torsional test, the pull-out force was measured. Differences between the long and short-stem on the biomechanical parameters (permanent migrations, inducible micromotion, and extraction force) were tested with the non-parametric Mann-Whitney test (p<0.05). ResultsThe main rotational inducible micromotion was around the craniocaudal axis. No significant differences were found between the rotational permanent migrations of the long- and short-stem around the craniocaudal (p=0.421), anteroposterior (p=0.841), and mediolateral axes (p=0.452). No significant differences were found between the rotational inducible micromotions of the long- and short-stem around the craniocaudal (p=0.222), anteroposterior (p=0.420), and mediolateral axes (p=0.655). No significant differences were found between the permanent translations of the long- and short-stem the along craniocaudal (p=0.341), anteroposterior (p=0.420), and mediolateral (p=0.429) directions. No significant differences were found between the translations of the long- and short-stem in terms of inducible translation in the craniocaudal (p=0.547), anteroposterior (p=0.999), and mediolateral axis (p=0.285). Similar extraction force (p=0.35) was found. Discussion and ConclusionNo statistically significant difference was found between the long-stem and short-stem implants. These results show that short uncemented stems can provide adequate primary mechanical stability. As the long-stem version of this stem is already clinically used, the present findings suggest that the short-version can be reasonably expected to deliver similar outcomes in terms of implant stability.

Structural Analysis for Qazzaz Metamorphic Core Complex, Northwestern Arabian Shield, Saudi Arabia

AbstractIdentifying deformational mechanisms and associated structures at various scales, ranging from regional‐scale structures to microscopic fabric, is crucial for the assessment of tectonic development. Thirty‐three samples were taken from the Qazzaz metamorphic core complex to estimate the finite strain for felsic and mafic minerals. These samples included gneisses rocks, monzogranite, and metavolcano–sedimentary rocks for both the Thalbah and Bayda groups. Using the Rf/j and Fry methods, the axial ratios (XZ) range about 2.20 to 7.10 and 1.90 to 9.10, respectively. For various rock units, the strain measurements show moderate to highly deformation. Most of the observed samples show shallow WNW dipping along a N to WNW trend of finite strain (X). The short axes (Z) based to be subvertical foliation related with a subhorizontal foliation. The results demonstrate that contacts generated at semi‐brittle to ductile deformation and that the strain of magnitude has the same value for different lithologic units. It concluded that nappe generation in orogens results from pure shear deformation.

Ultrasound Shear Wave Elastography of the Arch-Supporting Structures in Symptomatic Flatfoot: A Pilot Study.

The posterior tibial tendon (PTT), deltoid ligament, and spring ligament are often torn or attenuated in patients with progressive collapsing foot deformity. The goal of this pilot study was to measure the ultrasound shear wave velocity (SWV) of these arch-supporting structures in feet with varying degrees of deformity to improve our understanding of their role in the progression of deformity. Two observers measured the SWV of the supramalleolar and inframalleolar PTT in long and short axes, in the tibiospring portion of the deltoid ligament, and in the superomedial band of the spring ligament in 8 neutrally aligned feet, 5 asymptomatic flatfeet, and 7 symptomatic flatfeet. Each measurement was repeated 3 times both with and without an applied eversion stress. Average SWV was lower at all locations in the symptomatic flatfeet compared with normal feet, but these differences were statistically significant only for the inframalleolar PTT and the spring ligament. Externally applied stress led to an increase in the SWV of the ligaments but a paradoxical decrease in the SWV in the supramalleolar PTT. The SWV of the PTT was lower along the short axis compared with the long axis. SWV may be useful in evaluating the severity of degenerative disease of arch-supporting structures, but further study is needed before this technique can be applied clinically. Level III, case-control study.

Ultrasound-guided core needle biopsy of deep fascia: A cadaveric study evaluating feasibility, accuracy and reliability.

Over the past few decades, researchers and clinicians have dedicated significant attention to fascial tissues. Current interest focuses on their anatomical and pathophysiological features. Breakthroughs in ultrasound (US) and magnetic resonance imaging (MRI) have enhanced our ability to study the dynamics and alterations of the tissue structures. However, a microscopic perspective is also essential for a comprehensive understanding of some pathologies of the fasciae. The aim of this study was to investigate, using a cadaveric study: (1) the ease of visualization of the landmarks used for the US-guided fascial core needle biopsy (CNB); (2) the consistency and accuracy of needle placement inside fascial layers using US guidance and confirmed by histological examination; (3) inter-rater reliability. We assessed the feasibility of US-guided CNB in different topographical regions of human cadavers: the thoracolumbar fascia (TLF), fascia lata (FL), and crural fascia (CF). The results, confirmed by histological examination, revealed no significant difference in needle placements between the in-plane approaches in the long and short axes for all locations and fasciae studied (long axis: 91.88%; short axis: 96.22%); p > 0.05. US-guided core needle biopsy with the in-plane approach is feasible, consistent and reliable. It could provide most or all of high-quality fascial tissue samples required for pathological examination. It could also reveal changes in fascial pathologies, capturing the exact site of pathology thanks to US guidance, in particular in patchy diseases such as eosinophilic fasciitis.

Medial center of rotation and 90-degree lateral laxity improve patient-reported outcomes in posterior cruciate retaining total knee arthroplasty

ObjectivesPhysiologic knee kinematics are crucial for successful total knee arthroplasty (TKA) but are often not replicated. Using a medial stabilizing technique (MST) minimizes bone resection but results in lateral laxity. This study aimed to investigate the effects of lateral laxity on knee kinematics and symptoms after TKA. MethodsMobile-bearing cruciate-retaining MST-TKA was performed on 40 knees using a navigation system. In the kinematic analysis, the anteroposterior (AP) translations of the medial femoral condyle (MFC) and lateral femoral condyle (LFC), femoral rotation angles, and medial and lateral component gaps were recorded every 0.1 s. These data were extracted from the software from 0° to 120° flexion in 10° increments. Kinematics were classified as the medial center of rotation (MCR) or non-MCR between 0° to 90° of flexion. Lateral laxity was calculated by subtracting the medial component gap from the lateral component gap. The final follow-up Knee Injury and Osteoarthritis Outcome Scores (KOOS) were evaluated. The relationships between the pre and postoperative kinematics and between postoperative lateral laxity and kinematics were assessed using Spearman’s correlation coefficients. Finally, the correlation between postoperative lateral laxity and KOOS symptoms was evaluated using linear regression analysis. ResultsPreoperative kinematics, including AP translation of the MFC and LFC and femoral rotation, correlated with postoperative kinematics (all P < 0.001). Additionally, postoperative lateral laxity correlated with postoperative AP translation of the MFC, LFC, and femoral rotation (all P < 0.001). Furthermore, the receiver operating characteristic analysis indicated a cutoff value of 0.9 mm on postoperative lateral laxity at 90° flexion for postoperative MCR (P < 0.001). Postoperative lateral laxity at 90° flexion was significantly correlated with KOOS symptoms (β = 0.465, P = 0.025). ConclusionPreoperative kinematics and postoperative lateral laxity correlated with postoperative kinematics after MST-TKA. Postoperative lateral laxity greater than 0.9mm at 90° flexion was associated with physiological kinematic motion, leading to fewer knee symptoms in the PROMs. The key to successful TKA was considered to be keeping the asymmetric gap balance with physiological lateral laxity, rather than the conventional symmetrical gap balance. Level of Evidence Level IIIRetrospective study.

Risk Factors for High Repair Tension During Rotator Cuff Repair

Background: Excessively high repair tension, especially tension ≥10 N, can lead to unsuccessful rotator cuff repair. Purpose/Hypothesis: The purpose of this study was to identify the preoperative risk factors for high repair tension in rotator cuff repair. It was hypothesized was that older age, longer symptom duration, nontraumatic (ie, degenerative) tear onset, progressive fatty degeneration, and larger tear size would be among the risk factors. Study Design: Cross-sectional study; Level of evidence, 3. Methods: This retrospective study involved 80 patients (80 shoulders) diagnosed with rotator cuff tears by magnetic resonance imaging between July 2018 and August 2020. Repair tension was measured intraoperatively using a digital tension meter. Risk factors for high repair tension (≥10 N) were evaluated. The t test was used to assess the relationship of repair tension with patient characteristics and surgical parameters. Parameters with a P value of &lt;.05 in the univariate analysis were entered into a multivariate logistic regression model to determine their relationship with repair tension ≥10 N. Results: Symptom duration of ≥4 months, nontraumatic tear onset, large/massive tears, mediolateral (ML) tear length of ≥20 mm, and anteroposterior (AP) tear length of ≥18 mm were associated with high odds of repair tension ≥10 N ( P≤ .013 for all). Multivariate analysis showed that nontraumatic onset, ML tear length of ≥20 mm, and AP tear length of ≥18 mm were independent risk factors for repair tension ≥10 N ( P≤ .035 for all). Conclusion: The independent risk factors for high repair tension (≥10 N) during rotator cuff repair were nontraumatic tear onset, ML tear length of ≥20 mm, and AP tear length of ≥18 mm. Symptom duration of ≥4 months and large/massive tears were associated with high odds of repair tension ≥10 N, although they were not considered independent risk factors. Prospective cohort studies with larger sample sizes are needed to confirm the clinical value of the risk factors identified in this study.

The Effects and Risk Factors of Femoral Neck Shortening after Internal Fixation of Femoral Neck Fractures.

Internal fixation has been established as a treatment of choice in relatively young patients with femoral neck fractures. Due to the characteristics of femoral neck anatomy and blood supply, complications such as malunion, nonunion, avascular necrosis, and femoral neck shortening can occur after internal fixation of femoral neck fractures. Unlike other complications such as avascular necrosis or nonunion, femoral neck shortening has not been relatively well studied. This study aimed to investigate the risk factors and clinical outcomes of femoral neck shortening after internal fixation of femoral neck fractures. From June 2012 to July 2022, among 102 patients who underwent internal fixation of femoral neck fractures, 94 patients who met inclusion and exclusion criteria were retrospectively analyzed. Internal fixation of the femoral neck was done with cannulated compression screws or a femoral neck system. Patients were divided into 2 groups; femoral neck shortening (≥ 5 mm) and no shortening (< 5 mm) according to measurement on follow-up hip anteroposterior (AP) simple radiographs compared with postoperative hip AP simple radiographs. Demographic and radiographic data were compared between the 2 groups. The modified Harris Hip Score (mHHS) and a visual analog scale (VAS) were used to evaluate the clinical outcomes. Among 94 patients, femoral neck shortening was observed in 33 (35.1%). In chi-square test, Pauwels angle, Garden type III or IV (displacement), and cortical comminution were significantly correlated with neck shortening (p < 0.05). In the multifactorial logistic regression test, cortical comminution was significantly correlated with femoral neck shortening (p < 0.01). The shortening group showed significantly lower clinical scores in terms of mHHS and VAS (p < 0.01). The femoral neck shortening group showed significantly lower clinical scores of mHHS and VAS than the no-shortening group. The presence of cortical comminution in preoperative hip computed tomography is a risk factor of femoral neck shortening after internal fixation of femoral neck fractures.

Comparative Analysis of Critical Shoulder Angle and Acromion Index in Patients with or without Rotator Cuff Tear

Background: Recent evidence suggests that a high value of radiographic acromial indices such as critical shoulder angle (CSA) and acromial index (AI) may be associated with a higher incidence of rotator cuff tears (RCTs). The objective of this observational study was to evaluate the relationship between RCTs, CSA, and AI. Materials and Methods: We divided 68 patients with shoulder pain into two groups: Group 1, RCT and Group 2, normal cuff. Patients were evaluated with standard true anteroposterior (AP) radiographs. CSA and AI were calculated on true AP X-ray. Twenty-four males and 10 females were selected for Group 1 whereas 23 males and 11 females for Group 2. Results: The mean age for Group 1 was 53.23 years and for Group 2 was 47.53 years. CSA findings (mean ± standard deviation [SD]) were 37.5 ± 4.37 for Group 1 and 32.23 ± 3.19 for Group 2. Mean ± SD for AI were 0.72 ± 0.07 and 0.66 ± 0.09 for Groups 1 and 2, respectively. CSA and AI revealed a statistically significant P &lt; 0.0001 for both groups. Logistic regression confirmed CSA and AI to be strong predictors of an RCT. Conclusions: Higher CSA and AI are associated with degenerative RCT. Level of Study: Level III.

An analysis of radiologic and anatomical parameters associated with medial osteochondral lesions of the talus in non-traumatic cases

The study aimed to provide a comprehensive analysis of radiological and anatomical measurements in patients with medial osteochondral lesions of the talus (OLT), particularly those without a history of trauma. The retrospective cross sectional study evaluated 23 medial OLT individuals aged 18–45 with no history of trauma who were identified by magnetic resonance imaging (MRI) between 2016 and 2020. The control group consisted of 27 individuals between the ages of 18 and 45 who did not have OLT and applied for other reasons. Measurements were performed with 16 parameters from anteroposterior (AP) and lateral weight-bearing ankle conventional radiographs (CR). All individuals' demographic data were assessed. A total of 50 patients aged 18–45 years, including 26 males and 24 females with a mean age of 30.28±4.46 years, were evaluated in the study. No significant differences in age or gender were found between the groups (P>0.05). Analysis of both the OLT and control groups revealed a significant association of decreased talar declination angle (P<0.001) and Meary-Tomeno's angle (P = 0.003) with medial OLT. There was no relationship between other radiological parameters and medial OLT development. In conclusion, a decreased talar declination angle and a decreased Meary-Tomeno's angle appear to have significant relationship with development of medial OLT in individuals without a history of trauma. These findings also indicate that a possible cause of medial OLT is a lower-angled positioning of the talus relative to the ground and the first metatarsus in the sagittal plane.Level of Clinical Evidence: Level 3 cross sectional study

Does the resistive index of the radial artery change after arterial cannulation in patients undergoing abdominal surgery? A prospective observational study.

To evaluate the flow at the cannulation site in the radial artery, the resistive indices (RIs) before cannula insertion and 6 h after decannulation were measured (primary outcome). The secondary outcomes were measurement of the artery size by anteroposterior (AP) diameter at the insertion site, RI and AP diameter at a point 4 cm proximal and in the ipsilateral ulnar artery before insertion and 6 h after cannula removal. In 96 patients requiring an arterial line during surgery, peak systolic velocity (PSV) and end-diastolic velocity (EDV) were measured to derive RI using a linear ultrasound transducer. The RI was measured at R1 (insertion point), R2, 4 cm proximal to R1, and U1 on the ipsilateral ulnar artery. The AP diameter of the arteries at baseline R10, R20 and U10 was measured and repeated 6 h after removal of the cannula, R16, R26 and U16. RI or AP diameter in R1 or R2 did not differ pre- and post-cannulation. Mean R10 1.143 [standard deviation (SD: 0.239)] versus R16 1.181 (SD: 0.260) m/sec [mean difference (MD): -0.0372 (95% confidence interval (CI): -0.098, 0.023), P = 0.230]. Mean AP diameter at baseline versus 6 h decannulation 0.177 (SD: 0.042) versus 0.172 (SD: 0.045) cm [MD: 0.005 (95% CI: 0.003, 0.013), P = 0.222] was also similar. The mean PSV in U10 versus U16 was higher: 0.480 (SD: 0.178) versus 0.528 (SD: 0.316) m/sec [MD: 0.120 (95% CI: -0.185, -0.054), P = 0.002] and AP diameter was also higher than baseline (P = 0.001). The flow in the radial artery did not change following cannulation. The PSV and AP diameter in the ulnar artery increased after decannulation, suggesting a compensatory increase in flow.

Design and aerodynamic performance study of subsonic Y-shaped inlet

Abstract A Y-shaped inlet with a quadrate import was designed by the super-ellipse method in this paper, and according to the variation pattern of the cross-section of the inlet, the variation pattern of the short and long axis of the super-ellipse was deduced. For many different flight situations, the numerical simulations of the Y-shaped inlet were made. The result shows (1) If 0.2≤Ma≤0.8, the total pressure recovery coefficient exceeds 0.96, and the total pressure distortion coefficient is close to 0.1, meeting the criterion of the design; (2) When Ma=0.8, for many different attack angle α=-4°∼22°, the total pressure recovery coefficient is close to 0.97, reaching the level of practical application, and it has little impact on total pressure recovery coefficient and the distortion coefficient. (3) These results demonstrate high total pressure recovery and low distortion coefficients across various flight conditions, indicating its potential for practical applications and future inlet designs.

Transhumeral prosthesis use and disuse affects whole-body angular momentum

BackgroundIndividuals with transhumeral limb loss have an increased risk of falling, potentially resulting from altered upper-body kinematics during gait. The purpose of this study was to investigate whole-body angular momentum as a measure of movement control, to gain an understanding of how these upper-body kinematics contribute to dynamic balance. MethodsEight participants with transhumeral limb loss and eight able-bodied control participants completed three gait trials at self-selected speeds. The participants with transhumeral limb loss performed trials with and without their prosthesis. Coefficient of cancellation and whole-body angular momentum about all anatomical axes of rotation were calculated. Means and variance were compared across the conditions over the gait cycle via statistical parametric mapping, and ranges were compared using a one-way ANOVA. FindingsCoefficient of cancellation was decreased between the upper/lower extremities in the transverse plane and between the upper extremities/trunk in the sagittal plane for both transhumeral walking conditions compared to the control group. Whole-body angular momentum was statistically different in the sagittal plane and decreased in the transverse plane when walking with the prosthesis compared to the control group. Walking without the prosthesis resulted in increased variability of whole-body angular momentum. InterpretationIndividuals with transhumeral limb loss had dysregulated whole-body angular momentum compared to the control group. This dysregulation was related to decreased segment-to-segment cancellation from the upper extremities and increased variance throughout the gait cycle. Based on these findings, individuals should be encouraged to wear their transhumeral prosthesis while walking as it may reduce fall risk and fatigue.

SLMAP3 is crucial for organogenesis through mechanisms involving primary cilia formation.

SLMAP3 is a constituent of the centrosome and is known to assemble with the striatin-interacting phosphatase and kinase (STRIPAK) complex, where it has been reported to repress Hippo signalling. The global knockout of SLMAP3 in mice results in embryonic/perinatal lethality and stunted growth without changes in the phosphorylation status of YAP. Diverse phenotypes present in the SLMAP3-/- embryos include reduced body axis, small and abnormal organs resembling defects in planar cell polarity (PCP) signalling, while also displaying the notable polycystic kidneys, a known manifestation of ciliopathies. Analysis of cell polarity in primary mouse embryonic fibroblasts (MEFs) including cell migration, orientation and mitotic spindle angle did not reveal any changes due to SLMAP3 loss in these cells, although the expression of DVL3 was significantly reduced. Furthermore, MEFs lacking FGFR1OP2 or STRN3, two other STRIPAK members, did not reveal any significant changes in any of these parameters either. Significant changes in the number of ciliated cells and primary cilium length in SLMAP3 and FGFR1OP2 deficient MEFs were evident, while a reduced primary cilium length was notable in chondrocytes of SLMAP3 deficient embryos. Our findings suggest that SLMAP3 is essential for mouse embryogenesis through novel mechanisms involving the primary cilium/PCP and protein stability independent of Hippo signalling.

Postural analysis of adolescent young athletes in different sports branches

The effects of posture on athletic performance have been the focus of attention of many researchers and the importance of body posture in achieving success has become undeniable. This study aimed to perform the postural evaluation of adolescent youth athletes who are trained in basketball, soccer, volleyball, and swimming branches. A total of 88 adolescent athletes (32 boys and 56 girls) with an average age of ±12.37 years, an average height of ±1.58 cm, an average body weight of ±48.2 kg, an average BMI of ±18.19 and an average training age of ±2.06 years from football, volleyball, and swimming branches actively active in Manisa and Bursa provinces participated in the study. Posture analysis of the athletes was performed using the Apecs-AI Posture Evaluation and Correction System® mobile posture application. The data obtained from the athletes were evaluated with the NewYork Posture Assessment Test (NYPD). The data obtained from the study were analyzed using the SPSS 22.0 package program. One-way Analysis of Variance (ANOVA) was used for independent samples. According to the results of the analysis, there was a significant difference between training age and NYPD scores according to branches (p&lt;.05). Significance was found between NYPD and body axis scores in volleyball and soccer athletes (p&lt;.05). There was no difference between NYPD and other variables in swimming and basketball. As a result, it is thought that the effect of the training age variable on posture structures differs specifically according to the branches, and posture is negatively affected as the training age increases in volleyball and soccer players.

Establishing Joint Orientation Angles of the Limbs in Korean Raccoon Dogs (Nyctereutes procyonoides koreensis) Using Computed Tomographic Imaging

Studies are being conducted on the anatomical structures of various wild animals. Despite the ecological importance of the Korean raccoon dog (Nyctereutes procyonoides koreensis), limited research has been conducted on its anatomical structure. This study is the first to establish a reference range for joint orientation angles in the limbs of the Korean raccoon dog. Joint orientation angles are an unexplored concept not only in Korean raccoon dogs but also in other wildlife. However, they are important in the examination of the skeletal anatomy of humans and companion animals, such as dogs and cats. Because this type of measurement is still emerging in wildlife research, we applied the methodology used in the domestic dog (Canis lupus familiaris). Angles were measured between the mechanical or anatomical axis and the joint orientation lines in the thoracic and pelvic limbs of Korean raccoon dogs. No significant differences were observed between the sexes or between the left and right sides. These findings are consistent with those observed in domestic dogs. Based on this study, a reference range of joint orientation angles could be established for Korean raccoon dogs.

Development of a Gait Analysis Application for Assessing Upper and Lower Limb Movements to Detect Pathological Gait.

Pathological gait in patients with Hakim's disease (HD, synonymous with idiopathic normal-pressure hydrocephalus; iNPH), Parkinson's disease (PD), and cervical myelopathy (CM) has been subjectively evaluated in this study. We quantified the characteristics of upper and lower limb movements in patients with pathological gait. We analyzed 1491 measurements of 1 m diameter circular walking from 122, 12, and 93 patients with HD, PD, and CM, respectively, and 200 healthy volunteers using the Three-Dimensional Pose Tracker for Gait Test. Upper and lower limb movements of 2D coordinates projected onto body axis sections were derived from estimated 3D relative coordinates. The hip and knee joint angle ranges on the sagittal plane were significantly smaller in the following order: healthy > CM > PD > HD, whereas the shoulder and elbow joint angle ranges were significantly smaller, as follows: healthy > CM > HD > PD. The outward shift of the leg on the axial plane was significantly greater, as follows: healthy < CM < PD < HD, whereas the outward shift of the upper limb followed the order of healthy > CM > HD > PD. The strongest correlation between the upper and lower limb movements was identified in the angle ranges of the hip and elbow joints on the sagittal plane. The lower and upper limb movements during circular walking were correlated. Patients with HD and PD exhibited reduced back-and-forth swings of the upper and lower limbs.

Morphological CBCT parameters for an accurate differentiation between nasopalatine duct cyst and the normal nasopalatine canal

BackgroundThe incisive foramen width was a traditional imaging criterion for diagnosing nasopalatine duct (NPD) cysts. Recent CBCT studies demonstrated significant dimensional variations of the nasopalatine canal, which raised questions about the accuracy of this criterion. This study investigated whether nasopalatine canal diameters assessed on CBCT images can accurately differentiate NPD cysts from normal nasopalatine canals.MethodsThe study included 19 patients with NPD cysts (12 (63.2%) males, 7 (36.8%) females, mean age 44.7 ± 13.3), and a control group of 164 patients (72 (43.9%) males, 92 (56.1%) females, mean age 47.25 ± 17.74). CBCT images were retrospectively evaluated. The following nasopalatine canal diameters were measured on reference sagittal, coronal, and axial reformation images: nasal opening anteroposterior (AP) and mediolateral (ML) diameter, oral opening AP (APOO) and ML (MLOO) diameter, nasopalatine canal length, minimum ML (minML) diameter, anterior wall expansion (AWE), nasopalatine canal angle, and the mid-level AP diameter (midAP). All parameters were compared between groups. Discriminant functional analysis (DFA) was applied to detect CBCT parameters that best differentiate the NPD cyst from the normal canal.ResultsPatients with NPD cyst had significantly greater values of APOO (7.06 ± 2.09 vs. 5.61 ± 1.70), MLOO (6.89 ± 2.95 vs. 3.48 ± 1.24), minML (2.88 ± 1.53 vs. 2.25 ± 1.09), AWE (2.15 ± 0.65 vs. 0.41 ± 0.67), and midAP (4.58 ± 1.61 vs. 2.48 ± 0.96). DFA showed MLOO, AWE, and midAP as the most accurate in distinguishing NPD cyst from the normal canal. When combined in the discriminant function equation X = 0.390·MLOO + 1.010·AWE + 0.288·midAP (cut score 1.669), the differentiation can be performed with a sensitivity and specificity of 98.8% and 76.9%, respectively.ConclusionNPD cysts can be accurately distinguished from the normal nasopalatine canal by measuring MLOO, AWE, and midAP diameter on CBCT images.

Prediction of non-sentinel lymph node metastases in T1–2 sentinel lymph node-positive breast cancer patients undergoing mastectomy following neoadjuvant therapy

BackgroundAxillary lymph node dissection (ALND) is the standard axillary management for breast cancer patients with positive sentinel lymph node biopsy (SLNB) after neoadjuvant therapy. Nevertheless, when that happens, the frequency of additional positive nodes is not properly evaluated. We aim to develop a prediction model to assess the frequency of additional nodal disease after a positive sentinel lymph node following neoadjuvant therapy.MethodsWe retrospectively analyzed the ultrasound and clinicopathological characteristics of breast cancer patients with 1–3 positive sentinel lymph nodes (SLN) undergoing mastectomy after neoadjuvant therapy (NAT) at our institution, and performed univariate and multivariate logistic analyses to confirm the factors affecting non-SLN metastasis. These factors were included to establish a nomogram, and the area under receiver operating characteristic curve (AUC) and decision curve analysis (DCA) were utilized to assess the validity of this model.ResultsA total of 126 breast cancer patients were ultimately included in our study, 38 (53.5%) patients were diagnosed with non-SLN metastases of all 71 patients in training set. The results of multifactorial logistic analysis suggested that lymph node metastasis ratio (LNR), short axis of lymph node and progesterone receptor (PR) were strongly associated with non-SLN metastasis. We established a nomogram using the above three variables as predictors, which yielded an area under the curve of 0.795, and validated with a favorable AUC of 0.876.ConclusionThe nomogram we constructed can accurately predict the likelihood of non-SLN metastasis in our patients with 1–3 positive SLN after NAT, which may help guide decision making regarding axillary management.

A multi-slice attention fusion and multi-view personalized fusion lightweight network for Alzheimer’s disease diagnosis

ObjectiveAlzheimer’s disease (AD) is a type of neurological illness that significantly impacts individuals’ daily lives. In the intelligent diagnosis of AD, 3D networks require larger computational resources and storage space for training the models, leading to increased model complexity and training time. On the other hand, 2D slices analysis may overlook the 3D structural information of MRI and can result in information loss.ApproachWe propose a multi-slice attention fusion and multi-view personalized fusion lightweight network for automated AD diagnosis. It incorporates a multi-branch lightweight backbone to extract features from sagittal, axial, and coronal view of MRI, respectively. In addition, we introduce a novel multi-slice attention fusion module, which utilizes a combination of global and local channel attention mechanism to ensure consistent classification across multiple slices. Additionally, a multi-view personalized fusion module is tailored to assign appropriate weights to the three views, taking into account the varying significance of each view in achieving accurate classification results. To enhance the performance of the multi-view personalized fusion module, we utilize a label consistency loss to guide the model’s learning process. This encourages the acquisition of more consistent and stable representations across all three views.Main resultsThe suggested strategy is efficient in lowering the number of parameters and FLOPs, with only 3.75M and 4.45G respectively, and accuracy improved by 10.5% to 14% in three tasks. Moreover, in the classification tasks of AD vs. CN, AD vs. MCI and MCI vs. CN, the accuracy of the proposed method is 95.63%, 86.88% and 85.00%, respectively, which is superior to the existing methods.ConclusionsThe results show that the proposed approach not only excels in resource utilization, but also significantly outperforms the four comparison methods in terms of accuracy and sensitivity, particularly in detecting early-stage AD lesions. It can precisely capture and accurately identify subtle brain lesions, providing crucial technical support for early intervention and treatment.