What are the indications for unilateral inferior oblique surgery in the face of asymmetrical primary overaction of the inferior oblique pre-operatively? First, in established acquired cases of superior oblique paralysis, one may proceed without concern with unilateral inferior oblique weakening. However, if the cases are congenital in origin, one must be wary of an effect on the unoperated inferior oblique. Secondly, in the monocular horizontal-vertical squint with amblyopia and the primary overacting inferior oblique is in the amblyopic eye, unilateral inferior oblique weakening may be considered, since it is not likely that fixation will be shifted to the operated eye post-operatively, and the surgery is basically for cosmetic reasons. In the latter cases, one must rule out the unusual situation in which there is simultaneous overaction of both the inferior oblique and superior oblique in the same eye. In such cases, unilateral inferior oblique weakening may produce a dramatic hypotropia. In such cases, weakening of both inferior and superior oblique muscles is recommended.