Prevalence Rates Of Obesity Research Articles

Airway immune response in the mouse models of obesity-related asthma.

The prevalence rates of obesity and its complications have increased dramatically worldwide. Obesity can lead to low-grade chronic systemic inflammation, which predisposes individuals to an increased risk of morbidity and mortality. Although obesity has received considerable interest in recent years, the essential role of obesity in asthma development has not been explored. Asthma is a common chronic inflammatory airway disease caused by various environmental allergens. Obesity is a critical risk factor for asthma exacerbation due to systemic inflammation, and obesity-related asthma is listed as an asthma phenotype. A suitable model can contribute to the understanding of the in-depth mechanisms of obese asthma. However, stable models for simulating clinical phenotypes and the impact of modeling on immune response vary across studies. Given that inflammation is one of the central mechanisms in asthma pathogenesis, this review will discuss immune responses in the airways of obese asthmatic mice on the basis of diverse modeling protocols.

Small-area estimation for public health surveillance using electronic health record data: reducing the impact of underrepresentation

BackgroundElectronic Health Record (EHR) data are increasingly being used to monitor population health on account of their timeliness, granularity, and large sample sizes. While EHR data are often sufficient to estimate disease prevalence and trends for large geographic areas, the same accuracy and precision may not carry over for smaller areas that are sparsely represented by non-random samples.MethodsWe developed small-area estimation models using a combination of EHR data drawn from MDPHnet, an EHR-based public health surveillance network in Massachusetts, the American Community Survey, and state hospitalization data. We estimated municipality-specific prevalence rates of asthma, diabetes, hypertension, obesity, and smoking in each of the 351 municipalities in Massachusetts in 2016. Models were compared against Behavioral Risk Factor Surveillance System (BRFSS) state and small area estimates for 2016.ResultsIntegrating progressively more variables into prediction models generally reduced mean absolute error (MAE) relative to municipality-level BRFSS small area estimates: asthma (2.24% MAE crude, 1.02% MAE modeled), diabetes (3.13% MAE crude, 3.48% MAE modeled), hypertension (2.60% MAE crude, 1.48% MAE modeled), obesity (4.92% MAE crude, 4.07% MAE modeled), and smoking (5.33% MAE crude, 2.99% MAE modeled). Correlation between modeled estimates and BRFSS estimates for the 13 municipalities in Massachusetts covered by BRFSS’s 500 Cities ranged from 81.9% (obesity) to 96.7% (diabetes).ConclusionsSmall-area estimation using EHR data is feasible and generates estimates comparable to BRFSS state and small-area estimates. Integrating EHR data with survey data can provide timely and accurate disease monitoring tools for areas with sparse data coverage.

An insight into the prevalence rates of obesity and its related risk factors among the Saudi community in the Hai'l Region.

Obesity/overweight is a major preventable cause of morbidity responsible for various health disorders. Thus, the present investigation aimed to estimate the prevalence rates of obesity and its related risk factors among the Saudi community in the Hai'l Region. In this study, 2,438 participants were randomly recruited in the Hai'l region during a cross-sectional survey. Participants were included based on their body mass index (BMI). Only those with BMI >25 weight (kg)/height (m)2 were included. The overall prevalence rates of overweight and obesity were 61% and 39%. The prevalence rates of males' overweight, obesity, and morbid obesity were 69%, 19%, and 12%, respectively. The prevalence rates of overweight, obesity and morbid obesity among females were 50%, 28%, and 22%, respectively. Overweight, obesity, and morbid obesity are prevalent in Hai'l region, Northern Saudi Arabia. Overweight/obesity is more prevalent among women, rural inhabitants, less educated people, and adults aged 26-40 years. Hypertension, type 2 diabetes mellitus (T2DM), and deep vein thrombosis (DVT) are significantly obesity-associated risk factors in Saudi Arabia.

Geographical disparities in obesity prevalence: small-area analysis of the Chilean National Health Surveys

BackgroundPrevious representative health surveys conducted in Chile evidenced a high obesity prevalence rate among adults, especially in female and urban areas. Nevertheless, these have limited utility for targeted interventions and local source allocation for prevention. This study analyzes the increments in obesity prevalence rates in populations ≥15 years of age and the geographic variation at the regional level. We also assessed whether the obesity rates have different patterns on a smaller geographic level than national and regional ones.MethodsThis ecological study analyzed data from two representative national samples of adolescents and adults ≥15 years old, who participated in the last Chilean health surveys, 2009 (n = 5412) and 2016 (n = 6233). Obesity (body mass index≥30 kg/m2) rates were calculated on the national, regional, and Health service (HS) levels, being HS the smallest unit of analysis available. Obesity rates and relative increase to early identify target populations and geographic areas, with 95% confidence intervals (95% CI), were calculated using the sampling design of the national surveys, at the national and regional level, and by gender, age groups, and socioeconomic status. The Fay-Herriot (FH) models, using auxiliary data, were fitted for obesity rate estimates at the HS level.ResultsThe relative increase in obesity rate was 37.1% (95%CI 23.3–52.9) at the national level, with a heterogeneous geographic distribution at the regional one. Southern regions had the highest obesity rates in both surveys (Aysén: 35.2, 95%CI 26.9–43.5 in 2009, 44.3 95%CI 37–51.7 in 2016), but higher increases were predominantly in the northern and central areas of the country (relative increase 91.1 95%CI 39.6–110.1 in Valparaiso and 81.6 95%CI 14.4–196.2 in Tarapacá). Obesity rates were higher in females, older age, and lower socioeconomic groups; nevertheless, relative increases were higher in the opposite ones. The FH estimates showed an obesity rates variation at the HS level, where higher rates tend to converge to specific HS areas of each region.ConclusionObesity rates and relative increase are diverse across subnational levels and substantially differ from the national estimates, highlighting a pattern that converges to areas with low-middle income households. Our results emphasize geographical disparities in obesity prevalence among adults and adolescents.

Prevalence and determinants of underweight, overweight, and obesity among adolescent secondary school students in Dongola City, Northern Sudan in 2019

Background: Adolescents comprise 1.2 billion of the world population. There is a worldwide increase in the prevalence of obesity and overweight among adolescents. This study aimed to determine the prevalence of underweight, overweight, and obesity among secondary school adolescents in Dongola city, North Sudan.Methods: A cross-sectional, school-based study was conducted among adolescents from 7 out of 11 schools in Dongola city in November 2019. Multistage sampling method was used besides ethical approval and informed consent were taken. Data was collected through questionnaire, weight and height of each participant were measured, body mass index was calculated and the World Health Organization (WHO) (5-19 years) reference chart was used to determine underweight, overweight, and obesity. Chi-square test and multinomial logistic regression were performed to determine factors associated with underweight, overweight, and obesity.Results: The study included 695 students with 397 (57.1%) males. The prevalence rates of underweight, overweight, and obesity were 12.2%, 15.7% and 5.2% respectively. Male students had more than twice times (OR=2.37; 95%CI=1.29-4.37) likely to be underweight. Students with family history of obesity had almost twice and two and half times (OR=1.78; 95% CI: 1.15-2.76) and (OR=2.46; 95% CI: 1.21-4.98) more likely to have overweight and obesity respectively. Students living in urban areas had thirteen times (OR=13.0; 95% CI: 1.76-0.96.7) more likely to be obese.Conclusions: The prevalence rates of underweight, overweight, and obesity are high compared to primary school children in Northern State. There is a need to strengthen the school health program and further studies involving rural and urban schools are recommended.

Anti-inflammatory diets reduce the risk of excessive gestational weight gain in urban South Africans from the Soweto First 1000-Day Study (S1000).

PurposeTo (i): examine whether maternal dietary inflammation assessed using the dietary inflammatory index (DII) is associated with gestational weight gain (GWG) and delivery outcomes in urban South African women from the Soweto First 1000-Day Study (S1000); and (ii): explore whether serum high-sensitivity c-reactive protein (hs-CRP) levels mediate these associations.MethodsEnergy-adjusted-DII (E-DII™) scores were calculated for 478 pregnant women using a quantitative food frequency questionnaire. GWG (kg/week) was assessed via anthropometry and hs-CRP concentrations were assessed in a sub-sample at < 14 (n = 263) and at 24–28 (n = 270) weeks gestational age. Multivariable linear and logistic regression models were used to examine associations between maternal E-DII scores, GWG, hs-CRP concentrations, and delivery outcomes.ResultsPositive vs. negative E-DII scores were associated with an increased odds of excessive weight gain (OR (95% CI): 2.23 (1.20; 4.14); P = 0.01) during pregnancy. Higher hs-CRP concentrations in the first trimester were associated with lower weight-for-length z-score (β (95% CI): −0.06 (−0.11; −0.01) per 1 mg/l hs-CRP; P = 0.02) and a reduction in odds of a large-for-gestational age delivery (OR (95% CI): 0.66 (0.47; 0.94); P = 0.02). Higher hs-CRP concentrations in the second trimester were associated with an increased odds of delivering preterm (OR (95% CI): 1.16 (1.01; 1.32); P = 0.03).ConclusionsConsumption of an anti-inflammatory diet during pregnancy reduced the risk of excessive GWG in a rapidly urbanising setting (Soweto, South Africa), where obesity prevalence rates are high. Further research is needed to better understand how maternal diet may ameliorate the effects of maternal adiposity on inflammatory milieu and fetal programming.Supplementary InformationThe online version contains supplementary material available at 10.1007/s00394-022-02931-x.

Body Mass Index of selected Overweight and Obese Indian Adolescents in Madurai district, Tamil Nadu, India

Childhood obesity is an important predisposing factor for most non-communicable diseases. Irrespective of the age and gender, the prevalence rates of overweight and obesity has attained alarming levels not only in developed countries but also in developing countries among all socio-economic groups. The prevalence of overweight and obesity has reached alarming levels, affecting virtually both developed and developing countries of all socio-economic groups, irrespective of their age and gender. Hence, the present study was aimed to identify the anthropometric measurements of selected overweight and obese school-going adolescents from different schools from Madurai district Tamil Nadu, India. A total of 514 adolescents (312 Girls and 202 Boys) aged 13-18 years participated from government and private schools. Mean height, weight and BMI were calculated and compared with (National centre for Health Statistics) NCHS standard references. The mean height, weight and BMI were found to be increasing as the age increases of both genders. Body Mass Index of Girls (34.18 – 35.24)was found to be higher than boys (33.49 – 32.89) of the same age group. The School-going adolescents of both genders, in general, have short stature at all ages as compared to NCHS reference data. The prevalence of Overweight 95 (18.48%) and obese 315 (61.28%) was found to be higher in Nuclear families, but there was no statistical association between family type and BMI (X2 = 2.575, p &gt; .05). A significant relationship was found between the Body Mass Index of the adolescents and Father’s Educational qualification (p=.00) and Mother’s Occupation (p=.008). Nutrition education can play an important part in reducing the incidence of overweight/obesity and its associated complications.Extensive trials with a healthy school environment as an intervention may pave the way for developing new strategies to reduce the overweight and obesity in school-going adolescents.

MAT PILATES EXERCISE IMPROVES STATIC BALACE OF YOUNG ADULTS WITH OBESITY

Background: The prevalence of obesity in women in Semarang at the age over 18 is 29.93%. This high prevalence rate of obesity can have a negative impact on individual health. The condition of obesity is closely related to its complications that can occur in various aspects of the body's physiology, in the example it can reduce functional abilities such as static balance which can interfere with activities and decrease quality of life. One of the methods that can be used to improve static balance is mat pilates. Mat pilates prioritizes stretching and strengthening core muscles with controlled and precise movements so that mat pilates exercises can improve static balance. However, no studies have yet discussed the effect of mat pilates exercise on static balance in obese young adults Aim: To prove that mat pilates exercise can increase static balance of female aged 18-23 years old with obesity. Methods: This study used quasi experimental pre and post-test design and was done in August-October 2020. The subjects were 33 female students of Medical Faculty of Diponegoro University aged 18-23 years with BMI over 27 kg/m², divided in 2 groups. Treatment group (n=15) was instructed to do 8 weeks of mat pilates exercise (3 times a week) and control group (n=18) was instructed to not do any exercise. Static balace was measured with Flamingo Balance Test (FBT). Data’s significance was analyzed with paired t test and independent t test. Results : There’s a significant decrease (p&lt;0,001; paired t test) in FBT score before and after of the mat pilates treatment group from 12,31 ± 5,15 to 10,09 ± 5,59. An insignificant increase (p=0,798; paired t test) found in FBT score before and after of the control group from 12,74 ± 4,65 to 12,93 ± 6,29. The score difference of FBT test of the mat pilates treatment group and control group shows significant result (p=0,013). Conclusion: There is an improvement of static balance after mat pilates exercise intervention on female aged 18-23 years old with obesity

Out-of-home eating frequency, causal attribution of obesity and support to healthy eating policies from a cross-European survey

&#x0D; Background: The relation between the increased out-of-home food consumption and the rising of overweight and obesity prevalence rates has been widely assessed, and the a key role played by the catering sector in ensuring healthy food choices has been recognised. Governments’ healthy eating policies have a wide range of action, influencing consumer behavior, and the socioeconomic and food environments, with specific actions for the catering sector. Information on the public support for these policies could help policy makers in planning decisions. This study aims to investigate the relationship of out-of-home eating frequency with beliefs about obesity causes, support to healthy eating policies, and with socio-demographic factors.&#x0D; Methods: Data on 3003 individuals from Belgium, Denmark, Italy, Poland and United Kingdom, of both sexes, aged ≥16 years, were employed, from the European survey on policy preferences (Eatwell). Data were analysed through Chi-square test and logistic regression analysis.&#x0D; Results: Out-of-home eating varied with gender, age, marital status, education, BMI, and by country. Convenience food consumption was positively associated with obesity attribution to genetics, and inversely associated with attribution to lack of willpower. Attributions of obesity to lack of time, and to lack of self-control were associated with increased likelihood to consume fast-food and ready-prepared food respectively. Out-of-home eating people expressed higher support for information-based prevention, and actions aimed at healthier out-of-home eating, and lower support for restrictions and regulations of the food supply environment.&#x0D; Conclusion: Future research on out-of-home food consumers and their support towards public interventions for the catering sector, could have important implications for effective strategies to promote healthy eating.&#x0D;

Body Composition in Preschool Children and the Association With Prepregnancy Weight and Gestational Weight Gain: An Ambispective Cohort Study.

ObjectiveTo describe the body composition in preschool children and to evaluate the association with prepregnancy BMI and gestational weight gain (GWG).MethodsChildren were recruited in their first year in kindergarten (3 years old) and followed up for the next 2 years. Information during pregnancy and birth was retrieved from medical records. Height, weight, fat mass, fat-free mass, and percentage of body fat (FM%) were measured through a bioelectrical impedance analysis for each child visit, and BMI, fat mass index (FMI), and fat-free mass index (FFMI) were calculated. Generalized linear mixed models (GLMMs) were used to evaluate the associations between prepregnancy weight, GWG, and adiposity indicators.ResultsA total of 3,329 single-birth 3-year-old children were recruited as the baseline population and were followed at 4 and 5 years old. During the 3 years of follow-up, the mean (±SD) values of BMI, FMI, FFMI, and FM% of the children were 15.6 (±1.6) kg/m2, 2.8 (±1.3) kg/m2, 12.8 (±0.7) kg/m2, and 17.2% (±5.8%), respectively. The prevalence rates of overweight and obesity in mothers before pregnancy were 16.6 and 3.2%, respectively. Mothers were divided into three groups based on GWG: appropriate (1,233, 37.0%), excessive (767, 23.0%), and insufficient (1,329, 39.9%). GLMMs analyses showed that the preschool children’s BMI, FMI, FFMI, and FM% were all significantly positively related to maternal prepregnancy BMI and GWG (all P < 0.001); the children of mothers who were overweight/obese before pregnancy were more likely to be overweight/obese, high FMI, high FFMI, and high FM% at preschool age (all P < 0.001); although maternal excessive GWG was not correlated with offspring’s overweight/obese (P = 0.156), the children of mothers with excessive GWG are more likely to have higher FMI, but not to be with a higher FFMI status than the children of mothers with appropriate GWG. For prepregnancy overweight/obese women, compared with the GWG-appropriate group, maternal excessive GWG was related to the risk of high FMI (coefficient = 0.388, 95% CI: 0.129–0.647) and high FM% (coefficient = 0.352, 95% CI: 0.097–0.607), but was not related to the risk of overweight/obese or high FFMI of the offspring at preschool age.ConclusionFat mass index decreased with age, while FFMI increased with age among 3- to 5-year-old children. It is necessary to optimize maternal weight prior to conception and GWG management to improve the health outcomes of the offspring.

Tasas de prevalencia de sobrepeso y obesidad y sus asociaciones con factores cardiometabólicos y renales. Estudio SIMETAP-OB

IntroductionExcess weight is a major health problem. Aims of this study were to determine the prevalence rates of overweight and obesity, and to compare their associations with cardiometabolic and renal risk factors between obese and non-obese populations, and between overweight and non-overweight populations. MethodsCross-sectional observational study conducted in Primary Care. Population-based random sample: 6,588 study subjects between 18 and 102 years of age (response rate: 66%). Crude and sex- and age-adjusted prevalence rates of overweight and obesity were calculated, and their associations with cardiometabolic and renal variables were assessed by bivariate and multivariate analysis. ResultsThe age- and sex-adjusted prevalence rates of overweight and obesity were 36.0% (42.1% in men; 33.1% in women) and 25.0% (26.2% in men; 24.5% in women), respectively. These prevalences increased with age, and were higher in men than in women. Fifty-two percent (95%CI: 50.0-53.9) of the overweight population and 62.3% (95%CI: 60.1-64.5) of the obese population had a high or very high cardiovascular risk. Abdominal obesity, physical inactivity, prediabetes, hypertension, hypertriglyceridemia, and low HDL-C were independently associated with both entities. Furthermore, diabetes was independently associated with overweight and hypercholesterolemia with obesity. ConclusionsThe prevalence of overweight and obesity was 61.0% (68.4% in men and 59.0% in women). More than half of the overweight population and nearly two-thirds of the obese population had a high cardiovascular risk. Hyperglycemia, physical inactivity, hypertension, hypercholesterolemia, low HDL-C, and hypertriglyceridemia were independently associated with overweight and obesity.

Self-Reported Sedentary Behavior and Metabolic Syndrome among Children Aged 6-14 Years in Beijing, China.

(1) Objective: This study aimed to examine the prevalence of metabolic syndrome (MetS) in children aged 6–14 years in Beijing, and to determine whether sedentary behavior is a risk factor. (2) Methods: Using a multistage stratified cluster random sampling method, 3460 students were selected for the Nutrition and Health Surveillance in Schoolchildren of Beijing (NHSSB). Data on children’s sedentary behavior time and MetS indicators were collected using the questionnaires, physical measurements, and laboratory tests. MetS was defined according to the CHN2012 criteria, and logistic regression analysis was used to compare the effects of different sedentary time on MetS and its components. (3) Results: The overall prevalence of MetS among children aged 6–14 in Beijing was 2.4%, and boys, suburban children, and older age were associated with a higher prevalence (χ2 values were 3.947, 9.982, and 27.463, respectively; p < 0.05). In boys, the prevalence rates of abdominal obesity, hyperglycemia, high triglycerides (TG), and low high-density lipoprotein cholesterol (HDL-C) were higher in the high-level sedentary behavior group than those in the low-level sedentary behavior group (p < 0.05); and in girls, the prevalence rates of high TG, low HDL-C, and MetS were higher in the high-level sedentary behavior group than those in the low-level sedentary behavior group (p < 0.05). After adjusting for confounding factors, the multivariate logistic regression results showed that compared with children with low-level sedentary behavior, the risks of abdominal obesity and low HDL-C were higher in boys with high-level sedentary behavior (odds ratio (OR) 1.51, 95% confidence interval (CI) 1.10–2.07, p = 0.011; OR 2.25, 95% CI 1.06–4.76, p = 0.034, respectively); while the risk of abdominal obesity was higher in girls with medium and high-level sedentary behavior (OR 1.52, 95% CI 1.01–2.27, p = 0.043; OR 1.59, 95% CI 1.04–2.43, p = 0.032, respectively). (4) Conclusions: Higher sedentary behavior time was related to the higher risk of MetS components among children aged 6–14 in Beijing. Reducing sedentary behavior may be an important method for preventing metabolic diseases.

Nutrition-Related Information Shared by Latine Influencers: A YouTube Content Analysis.

Latines are the fastest growing populace in the United States. Latine is a new, inclusive term for Hispanic and Latino populations regardless of gender identity. When compared with non-Latine counterparts, Latines have higher prevalence rates of obesity, diabetes, chronic liver disease, and kidney disease, which are associated with poor dietary behaviors. More research is warranted into the factors behind Latines' understanding of nutrition and potential sources of health information that influence dietary behaviors. This study describes the nutrition-related health information shared through YouTube by English-speaking Latine individuals between the ages of 18 and 49. For this content analysis, a cross-sectional study design was used. A four-step search strategy identified eligible YouTube channels and their corresponding video blogs (vlogs): discovery, screening, eligibility, and included. NVivo 1.0 was used to qualitatively code the nutrition-related information. A total of 68 vlogs were identified and reviewed. Five main themes emerged from the data (what vloggers discussed): Nutrition Philosophies, Inaccurate Information, Product Promotion, Recommendations based on the 2020-2025 Dietary Guidelines for Americans (DGA), and Recommendations not based on the 2020-2025 DGA. Although some of the nutrition-related information shared followed the 2020-2025 DGA, not all information were in line with these guidelines. Misinformation can undermine the scientific work done by health professionals and can threaten the health and lives of the citizenry by creating barriers for accessing, understanding, and utilizing evidenced-informed guidance in making health decisions. This study revealed that more research is warranted into specific aspects of social media and how they influence health behavior.

Forecasting chronic diseases in Africans – Evidence from an immigrant population cohort experience

Background: Many African countries have seen a decline in communicable diseases and infant mortality with a concomitant emergence of Western-type, resource-draining, chronic diseases in a growing mid-aged population. This poses a threat to countries with very limited resources and points to the urgent need for data to predict the impact of this emerging trend on health and economy.Methods: A cohort of 76,356 unselected immigrants to Israel, from the Gondar area in Ethiopia, was studied for patterns of non-communicable diseases emergence following their move to a Western environment. Age-specific prevalence rates of cardiovascular disease, cancer, and important risk factors (hypertension, diabetes, hyperlipidemia, BMI and smoking) were calculated by time since immigration and compared to those of 767,082 same period immigrants from the Former Soviet Union (FSU) and to the Israeli Jewish population, using the Clalit Chronic Disease Registry.Results: Prevalence rates of diabetes, hypertension, hyperlipidemia, obesity and smoking all increased significantly in every age-group among the Ethiopian immigrants. The increase started within 5 years of immigration and sometimes exceeded the rate in the local Israeli population, most notably with diabetes. Disease rates among the FSU immigrants were lower in magnitude and different in trend. Rates of malignancies changed differentially by type and etiology of disease.Conclusion: Major temporal increases of chronic diseases morbidity were documented in immigrants from semi-rural Ethiopia to a Western environment. African countries undergoing gradual Westernization need to take immediate preventive measures to tackle the emerging problem. These can involve health education measures or the use of risk reducing drugs as possible approaches.

Threats Posed by Social Media and Computer and Video Games from the Perspective of Sport Education

Sedentary behaviors are increasingly common, exerting a heavy financial burden on society and becoming a risk factor for chronic diseases and mor-tality. Taiwan has one of the highest obesity prevalence rates among Asian countries. This cross-sectional study investigated the correlation of socio-demographic characteristics and PE enrollment with the time spent on vari-ous sedentary behaviors. The valid responses of 1,195 Taiwanese university students on a survey were analyzed. They were recruited between May and June 2019 using cluster sampling. The survey inquired into demographic characteristics and the self-reported time spent on various sedentary behav-iors. Descriptive statistics, one-way analysis of variance, a t test, and effect size analysis were used to analyze the data. The results indicated that univer-sity students in Taiwan were sedentary for an average of 474 minutes per day, with use of social media being the most prevalent sedentary activity at 123 minutes per day. The severely overweight group was most sedentary, and female students and students that were not enrolled in a PE class tended to spend more time on video games and social media.

Comparative evaluation of efficacy of Gomaya Mashi Udvartana with Petiswedana and Rodhradi Gana Udvartana with Petiswedana in the management of Sthoulya (Obesity)

Obesity is a metabolic condition associated with the abnormal accumulation of fat in the body, resulting in multiple adverse effects on health. Generally, it occurs due to an imbalance between the intake of calories and its utilization in the body. Patients with a body mass index (BMI) of more than 25–30 kg/m are considered obese2. The prevalence rate of Obesity is 11.8% to 31.3% as per observations of ICMR-INDIAB in 2015. It can be correlated with Sthoulyamentionedin Ayurveda that occurred due to vitiated Kapha and Meda. Sthoulya is one of the major diseases under Santarpanottha Vyadhi (Nutritional Disorders) caused due to Dushtiof Medovaha Srotasa. It is an abnormal and excessive accumulation of Meda Dhatu in the body. According to Acharya Charaka, Udvartana has Kaphhar and Medohar properties. It is of 2 types, i.e. Snigdha Udvartana and Ruksha Udvartana. Among them, Ruksha Udvartana is used in the management of Sthoulya. To evaluate the comparative efficacy of Rodhradi Gana Udvartana with Petiswedana and Gomaya Mashi Udvartana with Petiswedana in the management of Sthoulya (Obesity). A total of 60 patients will be enrolled and divided randomly into two equal groups.

Analysis of Influencing Factors for Chronic Diseases: A Large Sample Epidemiological Survey from Liaoyang.

Purpose Northeast China is a region with a serious aging population. There are fewer articles on epidemiological surveys on the prevalence of chronic diseases in aging areas of China. The study is aimed at understanding the prevalence of chronic noncommunicable diseases such as hypertension and diabetes mellitus (DM) in Liaoning Province, northeast China, and analyzing the risk factors for these chronic diseases. Methods A questionnaire survey and physical examination were conducted in 5008 permanent residents in 2 streets (Henan Street and Hebei Street) covered by Liuerbao Central Health Center in Liaoyang and 4 villages (Miaogou Village, Wangjia Village, Heyan Village, and Shuiquan Village) covered by Shuiquan Health Center in Tianshui Town of Liaoyang from January 2020 to December 2020. Results A total of 4990 patients were included. The prevalence rates of hypertension, DM, dyslipidemia, and obesity in residents in Liaoyang were 54.13%, 12.30%, 43.31%, and 20.52%, respectively. The prevalence of hypertension and DM was highest in both male and female patients aged 40-60 years, which was higher than that in the other age groups (P < 0.05). The prevalence of dyslipidemia was highest in men over 60 years old and women 18 − <40 years old. Obesity was most common in men aged over 60 and in women 40 − <60 years old. The proportion of male smokers in all age groups was significantly higher than that of female smokers. Smoking, dyslipidemia, and significant overweight or obesity are common risk factors for hypertension and DM. Conclusion In Liaoyang, northeast China, the prevalence of noninfectious chronic diseases was high, and the prevalence rate in people over 40 years old was significantly higher than that in people under 40 years old. The prevalence and progression of chronic diseases were obviously related to local living and eating habits; thus, health education needs to be improved.

Paradoxical Obesity and Overweight Disparities Among Sexual Minority Men: A Meta-Analysis.

This study aims to analyze the prevalence and likelihood of overweight, obesity, and elevated body mass index (BMI) among sexual minority men (i.e., men who have sex with men [MSM], men who have sex with men and women [MSMW], and all sexual minority men), using men who have sex with women (MSW) as the reference group. Studies reporting mean BMIs or prevalence or likelihood of obesity, overweight, or elevated BMI categorized by sexual orientation were included. Data were pooled and analyzed to report mean differences (MDs) of BMIs, prevalence rates, odds ratios (ORs), and their respective 95% confidence intervals (CIs). Forty-three studies were included, with a median of 26,507 participants (median 3.37% sexual minority men). The respective mean overweight, obesity, and elevated BMI prevalence rates among MSM (36%, 23%, and 39%) and MSMW (33%, 27%, and 47%) were lower than those of MSW (44%, 26%, and 55%). This finding was consistent with a significantly lower BMI (MD −1.50 [−1.93, −1.08] kg/m2) and a decreased likelihood of overweight (OR 0.75 [0.64, 0.88]) and obesity (OR 0.84 [0.78, 0.90]). Sexual minority men present with a lower prevalence and likelihood of obesity and overweight than their heterosexual counterparts. The obesity paradox—a sustained catabolic state presenting with lower BMI—is a feasible explanation for this phenomenon, although further research exploring paradoxical cardiovascular findings is granted.

Exploring an algorithm to harmonize International Obesity Task Force and World Health Organization child overweight and obesity prevalence rates.

SummaryBackgroundThe International Obesity Task Force (IOTF) and World Health Organization (WHO) body mass index (BMI) cut‐offs are widely used to assess child overweight, obesity and thinness prevalence, but the two references applied to the same children lead to different prevalence rates.ObjectivesTo develop an algorithm to harmonize prevalence rates based on the IOTF and WHO cut‐offs, to make them comparable.MethodsThe cut‐offs are defined as age‐sex‐specific BMI z‐scores, for example, WHO +1 SD for overweight. To convert an age‐sex‐specific prevalence rate based on reference cut‐off A to the corresponding prevalence based on reference cut‐off B, first back‐transform the z‐score cut‐offs zA and zB to age‐sex‐specific BMI cut‐offs, then transform the BMIs to z‐scores zB,A and zA,B using the opposite reference. These z‐scores together define the distance between the two cut‐offs as the z‐score difference dzA,B=12zB−zA+zA,B−zB,A. Prevalence in the target group based on cut‐off A is then transformed to a z‐score, adjusted up or down according to dzA,B and back‐transformed, and this predicts prevalence based on cut‐off B. The algorithm's performance was tested on 74 groups of children from 14 European countries.ResultsThe algorithm performed well. The standard deviation (SD) of the difference between pairs of prevalence rates was 6.6% (n = 604), while the residual SD, the difference between observed and predicted prevalence, was 2.3%, meaning that the algorithm explained 88% of the baseline variance.ConclusionsThe algorithm goes some way to addressing the problem of harmonizing overweight and obesity prevalence rates for children aged 2–18.

Therapeutic Peptides to Treat Myocardial Ischemia-Reperfusion Injury.

Cardiovascular diseases (CVD) including acute myocardial infarction (AMI) rank first in worldwide mortality and according to the World Health Organization (WHO), they will stay at this rank until 2030. Prompt revascularization of the occluded artery to reperfuse the myocardium is the only recommended treatment (by angioplasty or thrombolysis) to decrease infarct size (IS). However, despite beneficial effects on ischemic lesions, reperfusion leads to ischemia-reperfusion (IR) injury related mainly to apoptosis. Improvement of revascularization techniques and patient care has decreased myocardial infarction (MI) mortality however heart failure (HF) morbidity is increasing, contributing to the cost-intense worldwide HF epidemic. Currently, there is no treatment for reperfusion injury despite promising results in animal models. There is now an obvious need to develop new cardioprotective strategies to decrease morbidity/mortality of CVD, which is increasing due to the aging of the population and the rising prevalence rates of diabetes and obesity. In this review, we will summarize the different therapeutic peptides developed or used focused on the treatment of myocardial IR injury (MIRI). Therapeutic peptides will be presented depending on their interacting mechanisms (apoptosis, necroptosis, and inflammation) reported as playing an important role in reperfusion injury following myocardial ischemia. The search and development of therapeutic peptides have become very active, with increasing numbers of candidates entering clinical trials. Their optimization and their potential application in the treatment of patients with AMI will be discussed.