The prevalence of central obesity in Indonesia, especially in women aged 45-54 years, has increased according to the results of the Basic Health Research (Riskesdas, Riset Kesehatan Dasar). Central obesity is associated with a higher risk of diseases such as diabetes, cardiovascular disease, dyslipidemia, and hypertension. This study aimed to identify factors associated with the incidence of central obesity in women aged 45-54 years in Indonesia using the 2018 Riskesdas data with a cross-sectional study design. The study sample consisted of 60,557 individuals, with 64.54% having central obesity. Marital status (PR=1.12; 95%CI 1.09-1.15), low physical activity (PR=1.18; 95%CI 1.14-1.21), and consumption of high-risk foods (PR=1.03; 95%CI 1.01-1.05) were found to be associated with an increased risk of central obesity. In contrast, primary education (PR=0.86; 95%CI 0.83-0.89), employment status (PR=0.91; 95%CI 0.90-0.93), and smoking status (PR=0.89; 95%CI 0.84-0.95) acted as protective factors against central obesity. The results of this study suggest the need for increased nutrition education and physical activity in women aged 45-54 years as well as health support programs for married women.