Obese Body Mass Index Groups Research Articles

Does an obese prepregnancy body mass index influence outcome in pregnancies complicated by mild gestational hypertension remote from term?

This study was undertaken to determine the influence of increased prepregnancy body mass index (BMI) on pregnancy outcome in women with mild gestational hypertension remote from term. A matched cohort design was used. A total of 365 pregnant women with mild gestational hypertension and a normal prepregnancy BMI (20-25 kg/m2) were matched 1:1 for gestational age at diagnosis, race and parity to 365 women with mild gestational hypertension, but an obese prepregnancy BMI (> or = 30 kg/m2). Matched characteristics were distributed as follows: gestational age at diagnosis 32.2 +/- 2.4 weeks; race 80.8% white; parity 59.7% nulliparous. The rate of progression to preeclampsia was the primary endpoint of the study and was similar between the prepregnancy normal and obese BMI groups (37.8% vs 41.1%, P = .352). Birth weight at delivery (3033 +/- 747 g vs 2833 +/- 659 g, P < .001) and cesarean delivery rate (56.7% vs 40.3%, P < .001) were greater in the obese prepregnancy BMI group. In patients with mild gestational hypertension remote from term, an obese prepregnancy BMI was associated with similar rates of progression to preeclampsia. Secondarily, an obese prepregnancy BMI was associated with higher birth weights and an increased incidence of cesarean delivery.

Variations in percentage of body fat within different BMI groups in young, middle-aged and old women.

The objective of the present study was to characterize age-dependent variations in percentage of body fat within different body mass index (BMI) classes in healthy Danish women. Cross-sectional analysis. The study was done at the Center for Clinical and Basic Research, Ballerup, Denmark. Four hundred and four healthy women aged 18-75 years were included in the present study. Fat tissue mass was estimated using dual-energy X-ray absorptiometry. Menopausal status and physical characteristics were also registered. Mean values of percentage of body fat calculated in the normal and overweight BMI groups were higher in middle-aged and old women compared with young women. No significant differences were seen in the underweight and obese BMI groups. The cut-off levels between normal and overweight and between overweight and obesity were 35-43% and 40-50%, respectively. The percentage of body fat is dependent on both age and menopausal status within each of the following BMI classes: from 20 to 25 and from 25 to 30, further emphasizing that BMI has limitations when used generally as an indicator of body fatness, and argues for defining BMI cut-off values age-specifically.

Impact of Body Mass Index on Outcomes Following Critical Care

To determine the impact of body mass index (BMI) on outcomes in critically ill patients. Retrospective analysis of a large multi-institutional ICU database. The influence of BMI classification (underweight, < 20 kg/m(2); normal [control subjects], 20 to 25 kg/m(2); overweight, 25 to 30 kg/m(2); obese, 30 to 40 kg/m(2); severe obesity, > 40 kg/m(2)) on hospital survival, functional status at hospital discharge, and ICU/hospital length of stay (LOS) was analyzed via multivariate analysis, adjusting for age, gender, type of hospital admission, and severity score (ie, simplified acute physiologic score [SAPS] II and mortality prediction model [MPM] at time zero). Univariate analysis also was performed according to the quartile of the severity score. All comparisons were to the normal BMI group. Of 63,646 patient datasets, 41,011 were complete for height, weight, and at least one of the two severity scores. We found increased mortality in underweight patients (odds ratio [OR] of death: SAPS group, 1.19; MPM group, 1.26) but not in overweight, obese, or severely obese patients. ICU and hospital LOS were increased in both the severely obese (OR of discharge: ICU, 0.81 and 0.84, respectively; hospital, 0.83 and 0.87, respectively) and underweight groups (OR of discharge: ICU, 0.96 and 0.94, respectively; hospital, 0.91 and 0.90, respectively). Only in the SAPS group did the obese group have increased ICU LOS (OR, 0.96) and hospital LOS (OR, 0.96). Functional status at discharge was impaired in underweight patients (OR of disability: ICU, 1.11; hospital, 1.19). Overweight patients had decreased discharge disability (OR of disability: SAPS, 0.93; MPM, 0.94), while the results in the obese group were discordant between the two severity score groups (SAPS, not significant; MPM, 0.91; p < 0.05 for all ORs). Low BMI, but not high BMI, is associated with increased mortality and worsened hospital discharge functional status. LOS is increased in severely obese patients and, to a lesser extent, in underweight patients. Patients in the overweight and obese BMI groups may have improved mortality and discharge functional status.

Expression of polo like kinase (PLK) in the murine placenta, endometrium and ovary

Genetic, lifestyle, and environmental factors contribute to the etiology of polycystic ovary syndrome (PCOS). Increased body mass index (BMI) exacerbates the reproductive and metabolic parameters and reduces the fecundity of women with PCOS. This is a secondary analysis of a large-sample, multicenter, randomized controlled trial conducted at 21 sites in Chinese mainland. A total of 1000 women diagnosed with PCOS were enrolled in this trial. Of these, 998 women with PCOS were included in the analysis. Increased BMI was associated with more severe menstrual irregularities, elevated testosterone level, higher prevalence of metabolic syndrome, and poorer quality of life. The rates of ovulation per woman for the normal, overweight, and obese BMI groups were 83.0%, 78.2%, and 63.6%, respectively (P < 0.001), and the rates of live birth were 23.6%, 18.1%, and 15.3% (P = 0.030). Northern PCOS patients showed more severe reproductive, glucose, and lipid profiles; less exercise; and lower total ovulation rates compared with PCOS patients from Southern China (74.8% vs 81.2%, absolute difference 6.4%, 95% confidence interval 1.2%–11.5%). The results show the typical phenotypic features of Han women with PCOS in Northern and Southern China. The women living in Northern China showed a higher BMI, more severe glycolipid metabolism profiles, and subsequently worse clinical outcomes by the same interventions than those living in Southern China. The difference in phenotypic features can be explained mostly by differences in BMI and the resulting difference in ovulation.