Abstract. We describe and evaluate a high-resolution real-time air quality forecast system over the Eastern Mediterranean, based on a regional, online coupled atmospheric chemistry and aerosol model. The Weather Research and Forecasting model coupled with Chemistry (WRF-Chem) is used to perform daily, 3 d forecasts of regulated pollutants (NO2, O3, PM2.5) over the Eastern Mediterranean, applying three nested domains with horizontal resolutions of 50, 10 and 2 km, the latter focusing on Cyprus. Natural (dust, sea-salt, biogenic) emissions are calculated online, while anthropogenic emissions are based on the Emissions Database for Global Atmospheric Research – Hemispheric Transport of Air Pollution (EDGAR-HTAP) global emission inventory. A high spatial (1 km) and temporal (hourly) anthropogenic emission inventory is used for the island of Cyprus in the innermost domain. The model skill in forecasting the concentrations of atmospheric pollutants is evaluated using measurements from a network of nine ground stations in Cyprus and compared with the forecasting skill of the EU Copernicus Atmosphere Monitoring Service (CAMS). The forecast of surface temperature, pressure, and wind speed is found to be accurate, with minor discrepancies between the modelled and observed 10 m wind speed at mountainous and coastal sites attributed to the limited representation of the complex topography of Cyprus. Compared to CAMS, the WRF-Chem model predicts with higher accuracy the NO2 mixing ratios at the residential site with a normalized mean bias (NMB) of 7 % during winter and −44 % during summer, whereas the corresponding biases for CAMS are −81 % and −84 %. Due to the high temporal resolution of the anthropogenic emission inventory, the WRF-Chem model captures more accurately the diurnal profiles of NO2 and O3 mixing ratios at the residential site. Background PM2.5 concentrations influenced by long-range transport are overestimated by the WRF-Chem model during winter (NMB = 54 %), whereas the corresponding NMB for CAMS is 11 %. Our results support the adoption of regional, online coupled air quality models over chemical transport models for real-time air quality forecasts.