Various nutritional evaluation tools have been proposed over the years. A good tool should involve simple and easy-to-detect measures and should be applicable to a large number of patients. In the home setting it is even more difficult to collect useful data for nutritional evaluation. Our unit carries out the evaluations and prescriptions for the HEN in patients discharged from the same presidium and for patients discharged from other structures but afferent to the territory of the AUSL. During the 1st evaluation, the anthropometric parameters (height weight or, where not available, arm and calf circumference plus ulna lenght) and nutritional indices are required. A clinical-laboratory follow-up is provided at fixed intervals. From January 2018 to August 2018, 50 patients initiated HEN (19 M and 31 F, average age 76 ± 22 years). 20 patients were carriers of PEG and 30 of SNG. At the 1st evaluation the average weight was 59 kg and the average BMI was 22.5 ± 4.2, not indicative of malnutrition, but the mean values of Albumin (2.6 ± 0.6 g/L) Prealbumin (12 ± 8 mg/dl) Total Protein (5.6 ± 1.1 g/dl) Transferrin (141 ± 75 mg/dl) and Lymphocytes (1312 ± 640) were all indicative of moderate malnutrition. Follow-up data collection is in progress. Our results show that weight and BMI in HEN setting are not really indicative of the nutritional status of patients, but it is necessary to use more specific tools such as the dosage of biochemical nutritional indices.