Influence Of Nutrition Research Articles

The influence of nutrition on brain aging: A Comprehensive Review

Purpose: Aging is characterized by a progressive decline in physiological functions, including those of the brain. As individuals age, cognitive and emotional functionalities are subject to change, Consequently, it is essential to consider both cognitive abilities and emotional functioning when examining the effects of aging on the brain. Objectives: The objective is to synthesize current scientific evidence on the relationship between nutrition and brain aging, with a specific focus on cognitive abilities as a measure of brain function. Methodology: A systematic review was conducted on nine studies. The PRISMA statement standards were adhered to in this systematic review. Findings: The findings showed how important it is for people to change their diets to prevent the onset and progression of various comorbidities and to encourage healthy aging. The findings of the study included in this Comprehensive review indicate that good aging and a higher quality of life may be achieved by abstaining from bad behaviors, particularly those related to food. Conclusions: The current body of study indicates a relationship between nutrition and brain aging, but additional studies are necessary to expand our understanding of these complex interactions and to develop clear dietary recommendations to support cognitive health across the lifespan.

Influence of Nutrition on Growth and Development of Metabolic Syndrome in Children

Obesity is currently an increasing public health burden due to its related metabolic and cardiovascular complications. In Western countries, a significant number of people are overweight or obese, and this trend is, unfortunately, becoming increasingly common even among the pediatric population. In this narrative review, we analyzed the role of nutrition during growth and its impact on the risk of developing metabolic syndrome and cardiovascular complications later in life. An impactful role in determining the phenotypic characteristics of the offspring is the parental diet carried out before conception. During intrauterine growth, the main risk factors are represented by an unbalanced maternal diet, excessive gestational weight gain, and impaired glycemic status. Breastfeeding, on the other hand, has many beneficial effects, but at the same time the quality of breast milk may be modified if maternal overweight or obesity subsists. Complementary feeding is likewise pivotal because an early introduction before 4 months of age and a high protein intake contribute to weight gain later. Knowledge of these mechanisms may allow early modification of risk factors by implementing targeted preventive strategies.

Comparing tooth development timing between ethnic groups, excluding nutritional and environmental influences.

The timing of dental development in ethnic Finns and Somalis, who were born and living in Finland, was compared, with efforts to minimize environmental bias. The developmental status of seven lower left permanent teeth were staged according to Demirjian et al., using panoramic radiographs from 2,100 Finnish and 808 Somali females and males, aged 2 to 23 years. For each tooth, a continuation-ratio model was constructed to analyze the allocated stages as a function of sex and ethnic origin. Several statistically significant differences in mean age of certain tooth developmental stage transitions were revealed. While Somalis generally displayed stage transitions at younger age, none of the seven teeth consistently showed earlier stage transitions in Somalis compared to Finns. Within each tooth, the lowest (or highest) mean age of stage transition varied without any discernible pattern between the two ethnic groups. Overall, the observed differences in mean age of stage transition between the groups was minimal, suggesting a low impact on clinical and forensic age assessment practice. In conclusion, the studied ethnic Finn and Somali groups with equal nutritional and /or environmental conditions exhibit similar timing in the development of all lower left permanent teeth.

Linking summer nutrition to behavior and performance of black‐tailed deer

AbstractMany large‐herbivore populations are regulated at least in part by bottom‐up forces, and thus relationships between herbivores and their habitat are of fundamental importance to wildlife managers. Variation in nutritional resources—and how herbivores respond to that variation—influences rates of nutrient intake, which directly affect nutritional condition, pregnancy rates, timing of parturition, offspring birth mass, and survival. Accordingly, nutrition‐focused research holds great potential for uncovering the mechanisms that govern population performance of large herbivores and for assessing the nature and magnitude of bottom‐up limitations. We quantified relationships between the foodscape (i.e., spatiotemporal variation in forage quality and abundance) in southwestern Oregon, USA, and black‐tailed deer (Odocoileus hemionus columbianus) behavior and performance, with a focus on the influence of maternal nutrition on fawn survival. We hypothesized that black‐tailed deer performance (i.e., fawn birth mass and survival) is influenced by the availability of high‐quality forage during spring and summer and patterns of foodscape use exhibited by individual deer. From 2016–2023 we monitored movement and survival of adult female black‐tailed deer and their offspring. We also conducted intensive vegetation sampling and used generalized additive modeling to map the foodscape available to deer in spring and summer. Suitable forage biomass (i.e., maximum biomass of forage that together exceeded quality thresholds for supporting one fawn) was highly variable across space and time, and our top foodscape model explained 70% of the variation in suitable biomass (adjusted R2 = 0.70). We observed a strong, positive relationship between use of the foodscape by maternal females prior to parturition and fawn birth mass. Although maternal foodscape use after parturition did not influence the probability of fawn survival, survival increased with increasing birth mass. These results suggest that the effects of nutrition on fawn survival in our study system are indirectly mediated by maternal behavior (i.e., use of the foodscape) and the corresponding effects on birth mass of fawns. Our study adds to a growing body of literature supporting a fundamental link between foodscape use and population performance of large herbivores. Wildlife managers can use the dynamic models we developed to assess habitat quality and to make quantitative predictions about how different management actions (e.g., forest thinning) are likely to influence habitat quality and performance of black‐tailed deer.

Значение предшественников и минерального питания в формировании урожайности и качества ярового ячменя в Пермском крае

Abstract. The purpose is to evaluate the influence of previous culture and mineral nutrition on the yield and quality of grain and seeds of spring barley in the conditions of the Middle Urals. Methods. The research was conducted at the Perm Agricultural Research Institute (a branch of the Perm Federal Research Center of the Ural Branch of the Russian Academy of Sciences) over the period 2021–2023 on sod-podzolic heavy loam soil. A two-factor field experiment with different previous culture and mineral nutrition backgrounds was carried out. Data were processed using B. A. Dospekhov’s methods, and grain quality was determined using standard techniques. Results. The limiting factor affecting plant growth and productivity is soil moisture, which influences both the size and quality of crops. Studies have shown that the soil under vetch-oat mixtures had the highest level of productive moisture at the start of the growing season. However, by the end of the season, the highest level was found under clover. During the research period, the most significant decrease in soil moisture was observed after barley, possibly due to the smaller surface area covered by this crop. The study of barley seed germination showed that they met the required standards. Seeds grown after vetch-oat had the best germination rate (95 %), while those preceding barley had the worst (92 %). This suggests that choosing the right precursor and providing optimal nutrition can lead to increased yield and improved grain quality. The yield of barley can vary widely, ranging from 1.06 to 3.77 tons per hectare. The study results show that using vetch-oat as a precursor can provide the best indicators for barley yield and quality. The optimal combination of precursor and mineral nutrient background can significantly improve the efficiency of barley production in agriculture. Scientific novelty: The complex effect of fertilizers and precursor substances on the formation of barley productivity and quality is being studied in the Perm region for the first time. The methods of barley management and quality control studied allow for obtaining highly productive seeds and achieving the planned yield.

The Effects of Nutrition, Health, Psychological and Socio-Economic Factors on Precocious Puberty in Girls

Early puberty or precocious puberty in girls, characterized by the beginning of puberty before turning 8, is a growing concern worldwide. This research paper explores the multifactorial influences of nutrition, health, psychological stressors, and socio-economic factors on the incidence of early puberty in girls. By examining existing literature, the paper highlights the complex interactions among these elements and provides insights into potential interventions. An understanding of these factors is crucial for developing effective preventive and therapeutic strategies. Recommendations are made to promote balanced diets, improve healthcare access, provide psychological support, and address socio-economic disparities to mitigate the risk of precocious puberty and its associated health consequences.

Influence of Nutrition, Lifestyle Habits, and Socio-Demographic Determinants on Eating Disorder Symptoms in the Spanish Young Adult Population: A Cross-Sectional Nationwide Survey.

Eating disorders represent a complex and multifaceted public health challenge, highly prevalent among young people. Background and Objectives: To examine the prevalence of eating disorders in the Spanish young adult population aged 18-30 years, and their correlation with various eating habits and lifestyle factors. Materials and Methods: A descriptive, cross-sectional survey was carried out using a non-probabilistic snowball sample. The valid and reliable NutSo-HH Scale was employed to collect data on nutrition, lifestyle, and health habits. Results: Data were collected from 9692 Spanish young adults, of which 101 (1.04%) were diagnosed with anorexia nervosa and 71 (0.73%) with bulimia nervosa. The prevalence of anorexia and bulimia was significantly higher (p < 0.001) in women than in men, regardless of socio-demographic variables such as educational level, income, region, and size of city of residence. A considerable percentage of participants showed possible symptoms of eating disorders. Nutritionally, individuals with eating disorders consumed less fast food and fried or ultra-processed food but tended to consume coffee and energy drinks more frequently. Additionally, sleep quality and duration were more adversely affected in individuals with eating disorders compared to the general population. Sedentary lifestyles did not significantly differ between those with eating disorders and healthy individuals, though physical activity increased in people with bulimia. Conclusions: The interplay between young adults' dietary habits, lifestyle factors, and mental health underscores the urgent need for targeted interventions to effectively address these complex public health challenges.

The Effects of Nutrition, Health, Psychological and Socio Economic Factors on Precocious Puberty in Girls

Early puberty or precocious puberty in girls, characterized by the beginning of puberty before turning 8, is a growing concern worldwide. This research paper explores the multifactorial influences of nutrition, health, psychological stressors, and socio-economic factors on the incidence of early puberty in girls. By examining existing literature, the paper highlights the complex interactions among these elements and provides insights into potential interventions. An understanding of these factors is crucial for developing effective preventive and therapeutic strategies. Recommendations are made to promote balanced diets, improve healthcare access, provide psychological support, and address socio-economic disparities to mitigate the risk of precocious puberty and its associated health consequences.

Unravelling the impact of epigenetic mechanisms on offspring growth, production, reproduction and disease susceptibility.

Epigenetic mechanisms, such as DNA methylation, histone modifications and non-coding RNA molecules, play a critical role in gene expression and regulation in livestock species, influencing development, reproduction and disease resistance. DNA methylation patterns silence gene expression by blocking transcription factor binding, while histone modifications alter chromatin structure and affect DNA accessibility. Livestock-specific histone modifications contribute to gene expression and genome stability. Non-coding RNAs, including miRNAs, piRNAs, siRNAs, snoRNAs, lncRNAs and circRNAs, regulate gene expression post-transcriptionally. Transgenerational epigenetic inheritance occurs in livestock, with environmental factors impacting epigenetic modifications and phenotypic traits across generations. Epigenetic regulation revealed significant effect on gene expression profiling that can be exploited for various targeted traits like muscle hypertrophy, puberty onset, growth, metabolism, disease resistance and milk production in livestock and poultry breeds. Epigenetic regulation of imprinted genes affects cattle growth and metabolism while epigenetic modifications play a role in disease resistance and mastitis in dairy cattle, as well as milk protein gene regulation during lactation. Nutri-epigenomics research also reveals the influence of maternal nutrition on offspring's epigenetic regulation of metabolic homeostasis in cattle, sheep, goat and poultry. Integrating cyto-genomics approaches enhances understanding of epigenetic mechanisms in livestock breeding, providing insights into chromosomal structure, rearrangements and their impact on gene regulation and phenotypic traits. This review presents potential research areas to enhance production potential and deepen our understanding of epigenetic changes in livestock, offering opportunities for genetic improvement, reproductive management, disease control and milk production in diverse livestock species.

Nutrition and Periodontitis: A Cross-Sectional Study from a Practice-Based Research Network.

Despite clinical interventional studies on the influence of diet on periodontal inflammatory parameters, there has been no practice-based cross-sectional study from a German population to date that has conducted both a comprehensive dental and periodontal examination and a thorough validated assessment of dietary behavior. Therefore, the aim of this pilot study was to evaluate, in a proof of concept, whether there is a correlation between the overall periodontal inflammatory surface area (PISA), periodontal clinical parameters (pocket probing depths (PPD), clinical attachment loss (CAL), bleeding on probing (BOP), furcation involvement (FI), tooth mobility (TM)), and the dietary behavior of patients with periodontal disease when utilizing a practice-based research network. The primary outcome was the correlation between the periodontal inflammatory surface (PISA) and the dietary assessment data. The practice-based research network, consisting of eight Master's graduates, recruited patients who met the inclusion and exclusion criteria and performed a periodontal examination together with the assessment of dietary behavior using a digital version of the validated retrospective dietary recall (DEGS/RKI). Statistical analyses included linear regression models adjusted for age and smoking and unpaired t-tests, conducted using STATA 17.0 with a significance level of 5%. In addition, the data obtained were classified according to the currently recommended amounts of daily intake. A total of 1283 teeth were analyzed, with 60.25% (773 teeth) requiring treatment. The average PISA was 753.16 mm2 (SD ± 535.75 mm). Based on dietary guidelines, the studied population consumed excessive amounts of extrinsic sugars and fats, while their fiber and legume intake was insufficient. The intake of certain nutrients, including water-soluble fibers, specific fatty acids, vitamins (D, B1, B2, B6, and B12), iron, and zinc, was associated with reduced PISA, PPD, CAL, and BOP. Within the limits of the current study, including its cross-sectional design and cohort size, the outcomes demonstrated the influence of nutrition on periodontal health.

34 The influence and interaction of nutrition with the immune system in companion animal models

Abstract Understanding the impacts of nutrients in a species-specific manner has both practical and academic benefits for improving animal health. Therefore, species-specific animal models and research reagents are crucial to understanding molecular and physiological pathways. However, limitations in repeatable, descriptive models, sample size, and the ethics of companion animal research result in often needing to make inferences from human, murine, and other related immunology and nutrition research models. Recent companion animal work has focused on the impact of key nutrients in animal diets, including fat-soluble vitamins D, and E, omega-3 polyunsaturated fatty acids (PUFA), overall amino acid and energy balance over the lifespan, minerals including zinc and selenium, and feed additives such as probiotics and beta glucans. The selected research model, samples able to be collected, and available reagents for sample analysis will impact potential outcomes and inferences made from the data, including both acute to chronic impacts. From a theoretical standpoint, the balance between nutrient supplementation and impact includes understanding nutrients and responses of a model system in both deficiency and therapeutic level settings. For example, when supplementing Vitamin D, Vitamin E, or omega-3 polyunsaturated fatty acids, inclusion above currently recommended levels may optimize immune function, such as pathogen clearance, improved vaccine titer responses, or reduce inflammation. For other nutrients associated with immunomodulation such as zinc, additional chronic pharmacological supplementation may inhibit certain aspects of immune function, much like a deficiency scenario. Overstimulation of the immune system through nutrient supplementation may also impact the necessary modulation and repair roles that immune cells such as macrophages play in wound healing and anti-inflammatory responses. Continued work in nutritional immunology will further enhance our understanding of the power of nutrition and diet to improve health in companion animals.

Influences of Maternal Nutrition and Lifestyle Factors on Early Childhood Oral Health: A Systematic Review of Mechanisms and Intervention Strategies.

This systematic review and meta-analysis examined the impact of maternal nutrition and lifestyle factors on early childhood oral health. The review focused on the effects of maternal vitamin D levels and smoking during pregnancy on children's dental health outcomes. A comprehensive literature search was conducted across PubMed, Scopus, and Web of Science, yielding 23 that were included for analysis. The quality of the studies was assessed using the Newcastle-Ottawa Scale. The effect estimates were pooled through a random effect model. All analyses were carried out using the R program. Most studies in our systematic review showed a significant association between maternal vitamin D and smoking during pregnancy and childhood dental health outcomes. Meta-analysis revealed a significant association between maternal vitamin D levels and children's dental health (OR = 1.30, 95% CI: 0.49 to 3.45, p < 0.001). Maternal smoking during pregnancy was strongly linked to an increased risk of childhood dental caries (OR = 0.3290, 95% CI: 0.2089-0.4491, p < 0.0001). These findings underscore the crucial role of maternal health behaviors in shaping children's oral health trajectories. This study emphasizes the need for integrated public health interventions promoting healthier maternal behaviors and early preventive dental care.

To Study the Correlation of Maternal Serum Vitamin D Levels and Infant Serum Vitamin D Levels With Infant Birth Weight: A Single-Centre Experience From the Bundelkhand Region, India.

Vitamin D deficiency during pregnancy can have severe effects on both the mother and the newborn child. The main aim of this study was to assess the impact of maternal vitamin D levels on the birth weight of the newborn by analysing the vitamin D levels in pregnant women at full term and their newborn. The cross-sectional, hospital-based study was conducted with 150 consecutive women in labour presenting with a singleton term pregnancy at a large tertiary centre in the Bundelkhand region, India. Maternal and infant blood samples were obtained at the time of delivery. Umbilical cord blood was collected from infants, while maternal venous blood was drawn simultaneously. All relevant data were gathered, including the assessment of 25-hydroxy vitamin D3 levels in both mother and infant. The birth weight of the infant was measured, and statistical analysis was performed to find an association between maternal vitamin D level to birth weight and vitamin D level of the infant. Most pregnant women had low vitamin D levels in this study. The results revealed a significant positive correlation between maternal serum vitamin D levels and infant birth weight (p < 0.001), suggesting that lower maternal vitamin D levels were associated with low birth weight in infants. Additionally, infant serum vitamin D levels showed a positive correlation with maternal vitamin D levels (p < 0.001), indicating that higher maternal vitamin D levels tend to have infants with higher vitamin D levels at birth. These findings suggest a potential correlation of maternal vitamin D status to birth weight and vitamin D level of newborns, and further research is needed to confirm and better understand this relationship. Additionally, other factors such as maternal nutrition, genetics, lifestyle factors, and environmental influences may contribute to birth weight outcomes.

The Effect of Nutrition and Diet on the Causes of Kidney Failure in Minors in Indonesia

Renal failure among minors in Indonesia has become a growing public health concern, with increasing evidence suggesting that dietary habits play a significant role in its development. This study investigates the influence of nutrition and diet on the causes of renal failure in minors, utilizing a quantitative analysis of 80 samples. Data were collected using a Likert scale (1 to 5) and analyzed with SPSS version 26. The results indicate significant positive correlations between the consumption of processed foods, sugary drinks, and the incidence of renal failure. Conversely, higher intake of fruits and vegetables was associated with a reduced risk of renal failure. Multiple regression analysis further confirmed the predictive power of these dietary factors, with processed foods and sugary drinks emerging as significant contributors to renal failure. The findings emphasize the need for targeted nutritional interventions and public health strategies to promote healthier eating habits among minors in Indonesia, aiming to reduce the incidence of renal failure and improve long-term health outcomes.

Prenatal Nutritional Factors and Neurodevelopmental Disorders: A Narrative Review.

According to the DSM-5, neurodevelopmental disorders represent a group of heterogeneous conditions, with onset during the developmental period, characterized by an alteration of communication and social skills, learning, adaptive behavior, executive functions, and psychomotor skills. These deficits determine an impairment of personal, social, scholastic, or occupational functioning. Neurodevelopmental disorders are characterized by an increased incidence and a multifactorial etiology, including genetic and environmental components. Data largely explain the role of genetic and environmental factors, also through epigenetic modifications such as DNA methylation and miRNA. Despite genetic factors, nutritional factors also play a significant role in the pathophysiology of these disorders, both in the prenatal and postnatal period, underscoring that the control of modifiable factors could decrease the incidence of neurodevelopmental disorders. The preventive role of nutrition is widely studied as regards many chronic diseases, such as diabetes, hypertension, and cancer, but actually we also know the effects of nutrition on embryonic brain development and the influence of prenatal and preconceptional nutrition in predisposition to various pathologies. These factors are not limited only to a correct caloric intake and a good BMI, but rather to an adequate and balanced intake of macro and micronutrients, the type of diet, and other elements such as exposure to heavy metals. This review represents an analysis of the literature as regards the physiopathological mechanisms by which food influences our state of health, especially in the age of development (from birth to adolescence), through prenatal and preconceptional changes, underlying how controlling these nutritional factors should improve mothers' nutritional state to significantly reduce the risk of neurodevelopmental disorders in offspring. We searched key words such as "maternal nutrition and neurodevelopmental disorders" on Pubmed and Google Scholar, selecting the main reviews and excluding individual cases. Therefore, nutrigenetics and nutrigenomics teach us the importance of personalized nutrition for good health. So future perspectives may include well-established reference values in order to determine the correct nutritional intake of mothers through food and integration.

Fecal Microbiota of Transbaikal Camels (Camelus bactrianus) under Different Systems of Grazing Management

Microbial diversity in the fecal samples of Bactrian camels in Transbaikalia under various grazing management (free grazing (group I), mixed (group II) and stall housing (group III)) was revealed using high-throughput sequencing of the 16S rRNA gene variable regions. The microbial community of the fecal microbiota was found to be diverse and to depend on the camel grazing management. The most common phyla of the camel fecal microbiota were Bacillota and Bacteroidota. The phylum Verrucomicrobiota was a codominant in the fecal microbiota of groups I and II of animals, and Actinomycetota, in the feces of camels of group III. Changes in the fecal microbiota structure and taxonomic diversity occurred as camel grazing management and feeding conditions changed. Free grazing resulted in high diversity of the prokaryotic community in the fecal microbiota. In addition, differences in taxonomic composition depending on sex were found, which were in the abundance of taxa rather than in their presence or absence. The results contribute to the current understanding of the fecal microbiota of camels under different management conditions and provide evidence of the influence of nutrition on the fecal microbiota under different management conditions. Our results may be useful for addressing the issues of reproduction and conservation of the Transbaikal camel (Camelus bactrianus).

Microbiome-Immune Dynamics: Insights into Infectious Diseases

Infectious diseases and infections continue to be a leading cause of death in low-income countries and pose a significant risk to vulnerable populations, such as infants and the elderly. The immune system is crucial in determining susceptibility, persistence, and resolution of these infections. With 70-80% of immune cells located in the gut, there is a complex interaction between the intestinal microbiota, the intestinal epithelial layer, and the local immune system. Beyond the local immune responses in the gut, it is increasingly acknowledged that the gut microbiome also influences systemic immunity. Clinicians are increasingly leveraging the growing understanding of these complex interactions between the immune system, the gut microbiome, and human pathogens. The now well-established influence of nutrition on the gut microbiota composition and the immune system underscores the role that nutrition can play in enhancing health. This review explores the mechanisms that maintain the intricate balance between the microbiota, gut health, the local immune response, and systemic immunity, linking this to infectious diseases throughout life, and emphasizes the impact of nutrition in the prevention and treatment of infectious diseases.

Influence of smoking, nutrition and other modifiable environmental factors on rheumatoid arthritis

Numerous reports in recent years have focused on the influence of environmental factors on rheumatoid arthritis. This article provides an overview of the current study situation on the influence of modifiable environmental factors on the development and course of rheumatoid arthritis. Lifestyle factors, such as cigarette smoking, diet, exercise and body weight can be individually influenced. Factors such as air pollution and socioeconomic status can be influenced by environmental and sociopolitical measures at apublic level. Epidemiological studies have identified nicotine abuse, an unhealthy diet and obesity as well as alow level of education and social status as risk factors for the development of rheumatoid arthritis. Numerous factors are also associated with apoorer response to treatment and aworse prognosis. As randomized interventional studies on most environmental factors are hardly feasible, the causal relationship of the individual factors to the incidence and progression of rheumatoid arthritis is difficult to quantify. Nevertheless, the current evidence already enables the provision of appropriate counselling to patients with rheumatoid arthritis with respect to ahealthy lifestyle including abstaining from cigarette smoking, maintaining ahealthy diet, physical activity and avoiding obesity.

The Influence of Nutrition Intervention on the P1NP and CTX-1 Response to an Acute Exercise Bout: A Systematic Review with Meta-Analysis.

Although nutrition and exercise both influence bone metabolism, little is currently known abouttheir interaction, or whether nutritional intervention can modulate the bone biomarker response to acute exercise. Improved understanding of the relationships between nutrition, exercise and bone metabolism may have substantial potential to inform nutritional interventions to protect the bone health of exercising individuals, and to elucidate mechanisms by which exercise and nutrition influence bone. The aim was to synthesise available evidence related to the influence of nutrition on the response of the bone biomarkers procollagen type 1 N-terminal propeptide (P1NP) and C-terminal telopeptide of type 1 collagen (CTX-1) to acute exercise, using a systematic review and meta-analytic approach. Studies evaluating the influence of nutritional status or intervention on the bone biomarker response to an acute exercise bout were included and separated into four categories: (1) feeding status and energy availability, (2) macronutrients, (3) micronutrients and (4) other. Studies conducted on healthy human populations of any age or training status were included. Meta-analysis was conducted when data from at least five studies with independent datasets were available. In the case of insufficient data to warrant meta-analysis, results from individual studies were narratively synthesised and standardised mean effect sizes visually represented. Twenty-two articles were included. Of these, three investigated feeding status or energy availability, eight macronutrients, eight micronutrients (all calcium) and six other interventions including dairy products or collagen supplementation. Three studies had more than one intervention and were included in all relevant outcomes. The largest and most commonly reported effects were for the bone resorption marker CTX-1. Meta-analysis indicated that calcium intake, whether provided via supplements, diet or infusion, reduced exercise-induced increases in CTX-1 (effect size - 1.1; 95% credible interval [CrI] - 2.2 to - 0.05), with substantially larger effects observed in studies that delivered calcium via direct infusion versus in supplements or foods. Narrative synthesis suggests that carbohydrate supplementation may support bone during acute exercise, via reducing exercise-induced increases in CTX-1. Conversely, a low-carbohydrate/high-fat diet appears to induce the opposite effect, as evidenced by an increased exercise associated CTX-1 response, and reduced P1NP response. Low energy availability may amplify the CTX-1 response to exercise, but it is unclear whether this is directly attributable to energy availability or to the lack of specific nutrients, such as carbohydrate. Nutritional intervention can modulate the acute bone biomarker response to exercise, which primarily manifests as an increase in bone resorption. Ensuring adequate attention to nutritional factors may be important to protect bone health of exercising individuals, with energy, carbohydrate and calcium availability particularly important to consider. Although a wide breadth of data were availablefor this evidence synthesis, there was substantial heterogeneity in relation to design and intervention characteristics. Direct and indirect replication is required to confirm key findings and to generate better estimates of true effect sizes.

PENINGKATAN PENGETAHUAN MENGENAI PERAN NUTRISI DALAM SISTEM IMUN

The pandemic began with the emergence of a new coronavirus in Wuhan, China. One way to prevent the transmission of this virus is by consuming nutritious foods that can boost the body's immunity. The immune system or the body's defense system is the body's ability to fight infections against bacteria or virulent factors. Consuming food rich in nutrients such as vitamins and minerals is important for enhancing the immune system. This community service aims to provide education to the community about food that can help improve the immune system. The youth of Nyamplung village have diverse educational backgrounds. Most have worked in several factories located in Yogyakarta. High interaction allows for exposure to bacteria and viruses, so it is necessary to boost immunity by consuming foods rich in minerals and vitamins. This community service activity is carried out with a community-based approach through directed discussion forums. The target is the youth in Nyamplung Village, Srimulyo Village, Piyungan District, Bantul Regency, Yogyakarta. The initial stage involves giving a pre-test to measure the level of knowledge. The expected outcome of the activity is an increase in the youth's knowledge about the influence of nutrition on the immune system, scientific articles, and activity reports.