Nutritional Recommendations Research Articles

Nutrition and Glycemic Control in Children and Adolescents with Type 1 Diabetes Mellitus Attending Diabetes Camps.

Background/Objectives: Diabetes camps for children and adolescents with Type 1 Diabetes mellitus (T1DM) offer the opportunity to have a camping experience in a safe and supportive environment where they can receive diabetes skills education, such as glucose self-monitoring, insulin injections, management of hypoglycemia/hyperglycemia, and nutritional recommendations, including meal planning and carbohydrate counting. The ultimate goal of diabetes camps is to educate children to manage their condition independently, without parental involvement. Additionally, attending a diabetes camp is an excellent opportunity to meet peers and share their experiences and concerns about their condition, enhancing their confidence and reducing diabetes-related emotional distress. The aim of this review was to assess whether the nutritional planning and education offered at diabetes camps has a favorable effect on the glycemic control of attending children and adolescents. Methods: A literature search in PubMed and Scopus databases was performed. Eligible for inclusion were studies evaluating the effect of nutritional education offered in diabetes camps on glycemic control of children and adolescents with T1DM. Results: The majority of identified eligible studies supported the beneficial impact of the nutritional education offered in diabetes camps on glycemic control during and after the camp sessions. The favorable effect, though, seemed to be temporarily sustained (<6 months). Conclusions: Continuous nutritional education is required to prolong the duration of these beneficial outcomes. Further interventional studies are required to evaluate the direct effect of nutritional education provided at diabetes camps on glycemic control of children and adolescents with T1DM and the actual duration of favorable outcomes.

Culinary properties, nutritional quality, and in vitro starch digestibility of innovative gluten-free and climate smart cowpea-based pasta

This study investigates the processability, culinary and rheological properties, biochemical composition and in-vitro starch digestibility of new gluten-free pasta formulated with whole cowpea flour alone or combined with teff and/or amaranth leaf flour(s). These pasta are compared with three wheat-based pasta with fiber content increasing from 4% to 16% g/100g, 16% g/100g being the average fiber content of cowpea-based pasta. The pasta were processed using low temperature extrusion and drying. The antioxidant properties of amaranth leaf flour facilitated extrusion by limiting excessive aggregation of the dough during hydration/mixing that is attributed to lipoxygenase activity of cowpea flour. The optimal cooking time and cooking losses of cowpea-based pasta were similar to wheat-based pasta with comparable fiber content, highlighting fiber as a key factor influencing culinary properties. Adding teff to cowpea-based pasta reduced cooking losses and firmness. Although some micronutrients were lost during pasta processing and cooking, the consumption of a cooked portion of 100 g of dry cowpea-based pasta still covered FAO nutritional recommendations for protein, fiber, iron, zinc, and vitamin B9 targeting adult women. Adding amaranth leaves helped meet recommended beta-carotene levels. The in vitro slowly digestible starch content of cowpea-based pasta is similar to or higher than that of wheat-based pasta.

Diet and sleep quality in chilean university students.

To evaluate an association between eating patterns and sleep quality in Chilean university students. A cross-sectional analytical study was conducted. Participants included students from 4 Chilean universities. Each student was administered survey Questionnaire on the frequency of healthy and unhealthy eating habits and Pittsburgh Sleep Quality Index and their weight and height were taken to obtain the Body Mass Index (BMI). A total of 1,079 young university students, 80.26 % were women and the average age was 21.7 years. The 73.68 % have inadequate sleep quality. There is a significant differences in frequency between sleep quality and the intake of breakfast (p<0.001), fish (p<0.05) and dinner (p<0.05), that is, university students who reported optimal sleep consume breakfast and dinner on a daily basis and their fish intake is in line with nutritional recommendations. With respect to the association between sleep quality and healthy dietary patterns, it is observed a significant association (p<0.01) between optimal sleep and daily breakfast consumption in model 3 (Odds Ratio (OR): 0.61 (0.46-0.82)). Regarding unhealthy dietary patterns, a significant association (p<0.05) is observed in model 3 between sleep quality and alcohol consumption (OR: 1.42 (1.02-1.96)). Furthermore, a significant association between optimal sleep and salt consumption is observed in both model 2 (OR: 0.73 (0.54-0.99)) and model 3 (OR: 0.72 (0.53-0.97)). Finally, a significant relationship between not tobacco use and optimal sleep is observed (OR: 0.68 (0.48-0.96)). A positive relationship between healthy diet and sleep quality was observed in university students, which certain dietary patterns, such as the consumption of breakfast and low salt consumption and alcohol, are crucial to talk about a good sleep quality in this population group.

Food consumption and adherence to dietary guidelines among Jordanian children and adolescents

Background Early-life food consumption patterns may affect children’s health by increasing susceptibility to developing non-communicable chronic diseases (NCDs) in adulthood. Aims To evaluate Jordanian children and adolescents’ energy and macronutrient intake and how closely they adhere to dietary recommendations. Methods This cross-sectional study used data from Jordan’s Population-based Food Consumption Survey, a household population-based study conducted in Jordan between 2021 and 2022 (561 children and adolescents 8-19 years). Dietary intake was assessed using the two non-consecutive 24-hour dietary recall methods (24-h DR). The estimated food group and nutrient intakes were compared to nutritional recommendations, including MyPlate dietary guidelines. Results The prevalence of overweight/obese individuals based on body mass index (BMI) was 44%, and the average waist-to-height ratio (WHtR) was 24.7%. Compared to MyPlate dietary guidelines, children and adolescents had a higher added sugar intake (57g/day). Also, consuming vegetables, fruits, and dairy fell short of MyPlate dietary guidelines. The total discretionary calorie intake in children and adolescents was approximately one-third of the total energy intake. Conclusion The food consumption of Jordanian children and adolescents includes high intakes of discretionary calories, with a low intake of fruits, vegetables, and dairy products. The prevalence of overweight/obesity was elevated compared to international norms.

Non-alcoholic fatty liver disease: The importance of physical activity and nutrition education-A randomized controlled study.

Non-alcoholic fatty liver disease (NAFLD) is characterized by the accumulation of excess fat in the liver, causing liver cell damage, increased inflammation, and weight gain. Despite its high prevalence, diagnosis and follow-up of the disease is difficult. Irisin, a slimming myokine produced in response to physical activity (PA), exhibits anti-inflammatory and anti-obesity effects. This study aimed to investigate changes in irisin levels, inflammation markers (tumor necrosis factor-α [TNF-α] and interleukin-6 [IL-6]), and myeloid differentiation factor-2 (MD2) levels in NAFLD, as well as anthropometric and routine biochemical parameters, by providing PA recommendations and nutrition education (NE) to individuals diagnosed with NAFLD over a period of 12weeks. The study included 62 patients diagnosed with NAFLD who did not use alcohol. They were divided into groups: PA, NE, both (NE+PA), and untreated (control) patients. Patients receiving NE were provided with 1-h NE sessions every 4weeks for 12weeks, and their personal information, nutritional status, 24-h retrospective food consumption record, and anthropometric measurements were recorded at the beginning (day 0) and end (week 12) of the study. The PA group was recommended aerobic walking for 30min, 5days a week. At the beginning (day 0) and end (week 12) of the study, patients' anthropometric and routine biochemical tests were conducted, and irisin, MD2, TNF-α, and IL-6 levels were measured using the ELISA method. All groups were similar in demographic characteristics and dietary habits. After 12weeks, there were no significant differences in biochemical parameters among the groups. Glucose levels increased in the untreated group but decreased in the PA and PA+NE groups compared to baseline, with a significant decrease in the PA group. Insulin levels significantly decreased in the NE group. The PA+NE group showed decreased aspartate aminotransferase (AST), gamma-glutamyl transferase, alkaline phosphatase, total cholesterol, low-density lipoprotein, and triglyceride levels and significant decrease in ALT levels. AST decreased significantly in the PA group while high-density lipoprotein increased significantly. There were no statistically significant differences between the groups in irisin, MD2, IL-6, and TNF-α levels. After 12weeks, irisin levels significantly increased in nutrition and PA groups except the untreated group. There were no statistically significant differences in IL-6 and MD2 levels compared with baseline after 12weeks. PA recommendations alone were not effective in observing significant changes in anthropometric measurements in individuals with NAFLD. It was detected that only nutritional recommendations provided a significant decrease in body fat ratio but were insufficient for the change in other anthropometric measurements. In the group where NE and PA were recommended together, a significant decrease in anthropometric measurements was found. The NE group significantly reduced their energy and carbohydrates (%EI) intake after 12weeks of intervention compared with the baseline. NE and PA recommendations led to improvements in liver-related biochemical parameters and significant reductions in anthropometric measurements among individuals with NAFLD. Moreover, patients receiving NE experienced a decrease in energy and carbohydrates intake as a percentage of total energy intake (%EI). Increased irisin levels in NE, PA, and NE+PA groups may have contributed to the decrease in body fat percentage.

Adherence to the nutritional recommendations according to diabetes status in Korean adults: a cross-sectional study

BackgroundNutritional therapy plays a crucial role in diabetes management. Assessing adherence to nutritional recommendations is critical for evaluating whether the current status of nutrition education is appropriate. This study aimed to evaluate adherence to nutritional recommendations according to diabetes status using data from the Korean National Health and Nutrition Examination Survey from 2016 to 2019.MethodsA total of 2,793 participants (55.4% male) were evaluated regarding their adherence to nutritional recommendations. The “aware” group comprised people who had been clinically diagnosed by a physician. The “treated” group comprised people receiving anti-diabetic medications. The “control” group comprised people who achieved an HbA1c level < 6.5%. The “educated” group comprised people who had received nutrition education or counseling at various locations.ResultsAmong the 1,918 individuals in the “aware” group, only 243 (8.7%) had received nutrition education. Adherence to nutritional recommendations was generally low, with people with diabetes showing slightly higher adherence to total energy intake (59.6% vs. 55.3%) and total sugar intake (88.0% vs. 84.5%) than people without diabetes. However, adherence to total carbohydrate intake was poor in both the treated and educated groups (34.3% and 26.0%, respectively) compared to the untreated and non-educated groups (44.4% and 36.0%, respectively).ConclusionsThese findings indicate inadequate nutritional management for people with diabetes in Korea. Nutrition education should be effectively strengthened to achieve nutritional goals.

An Update of the Promise of Glycine Supplementation for Enhancing Physical Performance and Recovery.

Glycine, the simple amino acid, is a key component of muscle metabolism with proven cytoprotective effects and hypothetical benefits as a therapeutic nutrient. Cell, in vitro, and animal studies suggest that glycine enhances protection against muscle wasting by activating anabolic pathways and inhibiting proteolytic gene expression. Some evidence indicates that glycine supplementation may enhance peak power output, reduce lactic acid accumulation during high-intensity exercise, and improve sleep quality and recovery. This literature review critically explores glycine's potential as an ergogenic aid and its relevance to muscle regeneration, muscle strength, endurance exercise performance, and sleep quality. It also underscores key areas for future research. It is concluded that more randomized controlled clinical trials in humans are needed to confirm glycine's potential as a dietary supplement to support muscle function, recovery, and overall athletic performance as an ergogenic aid and to establish nutritional recommendations for athletic performance. Also, it is essential to consider that high doses (>500 mg/kg of body mass) could induce cytotoxic effects and contribute to acute glutamate toxicity.

Results of the Italian cross-sectional web-based survey "Nutrition and breast cancer, what would you like to know?" An attempt to collect and respond to patients' information needs, through social media.

Several studies have demonstrated that, following a breast cancer (BC) diagnosis, patients are eager to obtain information on cancer and nutrition, in order to ameliorate both their quality of life (QoL) and disease outcome. To avoid BC survivors to get wrong information from unreliable sources, healthcare providers need to be aware of patients' needs, to guide them toward optimal nutrition recommendations, aimed at preventing tumor recurrence and increasing survival rates. The cross-sectional web-based survey "Nutrition and breast cancer, what would you like to know?" has been conceived and conducted, in Italy, between the 2nd and the 25th of June 2023. The link to the 19-items questionnaire, structured in 6 sections, was distributed via social media (Facebook and Instagram), newsletter, institutional websites, and printed flyers. Patients' responses were collected and analyzed, reporting absolute and relative frequencies. A total of 1616 participants (98.9% female and 1.1% male), with an average age of 47.5 years, answered the survey. Only subjects who declared having previously received a BC diagnosis (N=1159, 71.7%) were included in the present analysis. Overall, the respondents showed a wide interest in understanding whether nutrition might help to manage therapy side effects, as well as knowing how specific diets, foods, nutrients, and supplements could affect disease onset, progression and prognosis. Importantly, the need to receive evidence-based information from the "referring physician/specialist" and "nutritionist/dietitian" was expressed by 95.8% and 88.8% of them, respectively. In this study, we primarily aimed at intercepting nutrition information needs and sources of an Italian BC survivors' group. Based on that, we first organized a proactive digital intervention, to respond via Instagram live broadcasts to patients' "cancer and nutrition"-related questions. Secondly, we arranged a healthcare providers dedicated-workshop focused on the latest evidence-based knowledge on nutrition and BC. It is crucial, in fact, that once healthcare professionals capture patients' information needs, they can respond with appropriate nutritional guidance, counseling and education programs, while counteracting misleading and incorrect messages.

A review of nutritional recommendations for scuba divers.

Scuba diving is an increasingly popular activity that involves the use of specialized equipment and compressed air to breathe underwater. Scuba divers are subject to the physiological consequences of being immersed in a high-pressure environment, including, but not limited to, increased work of breathing and kinetic energy expenditure, decreased fluid absorption, and alteration of metabolism. Individual response to these environmental stressors may result in a differential risk of decompression sickness, a condition thought to result from excess nitrogen bubbles forming in a diver's tissues. While the mechanisms of decompression sickness are still largely unknown, it has been postulated that this response may further be influenced by the diver's health status. Nutritional intake has direct relevancy to inflammation status and oxidative stress resistance, both of which have been associated with increased decompression stress. While nutritional recommendations have been determined for saturation divers, these recommendations are likely overly robust for recreational divers, considering that the differences in time spent under pressure and the maximum depth could result nonequivalent energetic demands. Specific recommendations for recreational divers remain largely undefined. This narrative review will summarize existing nutritional recommendations and their justification for recreational divers, as well as identify gaps in research regarding connections between nutritional intake and the health and safety of divers. Following recommendations made by the Institute of Medicine and the Naval Medical Research Institute of Bethesda, recreational divers are advised to consume ~170-210 kJ·kg-1 (40-50 kcal·kg-1) body mass, depending on their workload underwater, in a day consisting of 3 hours' worth of diving above 46 msw. Recommendations for macronutrient distribution for divers are to derive 50% of joules from carbohydrates and less than 30% of joules from fat. Protein consumption is recommended to reach a minimum of 1 g of protein·kg-1 of body mass a day to mitigate loss of appetite while meeting energetic requirements. All divers should take special care to hydrate themselves with an absolute minimum of 500 ml of fluid per hour for any dive longer than 3 hours, with more recent studies finding 0.69 liters of water two hours prior to diving is most effective to minimize bubble loads. While there is evidence that specialized diets may have specific applications in commercial or military diving, they are not advisable for the general recreational diving population considering the often extreme nature of these diets, and the lack of research on their effectiveness on a recreational diving population. Established recommendations do not account for changes in temperature, scuba equipment, depth, dive time, work of breathing, breathing gas mix, or individual variation in metabolism. Individual recommendations may be more accurate when accounting for basal metabolic rate and physical activity outside of diving. However, more research is needed to validate these estimates against variation in dive profile and diver demographics.

Tele-Pulmonary Rehabilitation and Mediterranean-like Lifestyle, Adjunctively to Continuous Positive Airway Pressure in Obstructive Sleep Apnea Patients: Effects in Fitness and Oxidative Indicators

Obstructive sleep apnea (OSA), often overlooked by clinicians, may lead to negative outcomes if left untreated. In this study, we examined the efficacy and efficiency of a 12-week unsupervised tele-rehabilitation program in OSA patients and focused on the potential changes in their fitness indicators and oxidative status. Forty OSA patients were allocated into two groups: the CPAPgroup (AHI 52.0 ± 31.5 events/h; age, 49.7 ± 9.4 years; BMI, 32.1 ± 7.6 kg/m2; control group) versus the non-CPAPgroup (AHI 38.2 ± 21.5 events/h; age, 49.3 ± 10.7 years; BMI, 32.3 ± 5.1 kg/m2; intervention group; personalized recommendations for nutrition—based on the Mediterranean diet—and exercise programs). Measurements included anthropometric characteristics and body composition through whole-body bioelectrical impedance analysis. In addition, participants underwent blood sampling for reactive oxygen metabolites’ levels (d-ROM), plasma antioxidant capacity (PAT), and Lipoprotein (a) (Lp(a)), as well as a 6 min walk test (6MWT). Statistically significant differences were detected in both groups (CPAPgroup versus non-CPAPgroup) after 12 weeks between Lp(a) (−32.2 ± 25.5%, p = 0.021 versus −17.7 ± 16.3%, p = 0.034) and 6MWT (16.6 ± 9.3%, p &lt; 0.001 versus 7.5 ± 6.6%, p = 0.002). ΔNRO2 (oxygen saturation difference between nadir during sleep and resting awake) was significantly associated with d-ROMs levels (p = 0.045), resting mean arterial pressure (p = 0.024), and chest circumference in maximal inhalation and exhalation (Δchest, p &lt; 0.001). To conclude, lifestyle interventions with unsupervised tele-exercise-rehabilitation pulmonary programs and Mediterranean-like diet may serve as adjunctive-to-CPAP therapeutic elements.

Fueling the Heart: What Are the Optimal Dietary Strategies in Heart Failure?

Heart failure (HF) is a global health concern with rising incidence and poor prognosis. While the essential role of nutritional and dietary strategies in HF patients is acknowledged in the existing scientific guidelines and clinical practice, there are no comprehensive nutritional recommendations for optimal dietary management of HF. In this review, we discuss results from recent studies on the obesity paradox and the effects of calorie restriction and weight loss, intermittent fasting, the Western diet, the Mediterranean diet, the ketogenic diet, and the DASH diet on HF progression. Many of these strategies remain under clinical and basic investigation for their safety and efficacy, and there is considerable heterogeneity in the observed response, presumably because of heterogeneity in the pathogenesis of different types of HF. In addition, while specific aspects of cardiac metabolism, such as changes in ketone body utilization, might underlie the effects of certain dietary strategies on the heart, there is a critical divide between supplement strategies (i.e., with ketones) and dietary strategies that impact ketogenesis. This review aims to highlight this gap by exploring emerging evidence supporting the importance of personalized dietary strategies in preventing progression and improving outcomes in the context of HF.

A nutrition-focused review of the interventions in US-living Latino communities with type II diabetes.

Type 2 diabetes (T2D) is a chronic, debilitating disease that disproportionally affects the Hispanic/Latino community residing in the United States. Optimal nutrition therapy is fundamental to the proper management of T2D and must be culturally adapted to facilitate permanent behavior change in this population. This review selected and assessed the nutrition components of interventions aimed to improve T2D outcomes in US-based Latinos/Hispanics, published from 2002 to 2023. An overview of the participant characteristics, nutrition intervention, and dietary assessment and outcomes is included. Nutrition interventions in this community benefit from the inclusion of bicultural registered dietitian nutritionist (RDNs) to assure the counseling team promotes culturally tailored nutrition recommendations based on current dietary guidelines. Nutrition assessment and outcomes should be captured with the use of validated dietary assessment tools and dietary quality indices appropriate to their target population. Standardizing these practices will facilitate intervention comparability and replicability and ultimately better target the needs of this community.

Scientific Achievements of The Department of Phthisiology and Pulmonology of the Bogomolets National Medical University (on the Occasion of the 100th Anniversary of the Founding of the Department)

Department of Phthisiology and Pulmonology of O.O. Bogomoletsa was founded in the distant past (1924). The department was initially established as an associate professorship in tuberculosis at the Kyiv Medical Institute (KMI), later became a course on tuberculosis, and eventually developed into a full department of tuberculosis. During its existence, the department changed its name several times (Department of Phthisiology, Department of Phthisiology with a Course of Pulmonology, Department of Phthisiology and Pulmonology).The direction of the work of the associate professorship on tuberculosis of the KMI (head A.I. Sobkevych) is the scientific analysis of the symptoms of tuberculosis and the development of recommendations for the rational nutrition of patients. The direction of the tuberculosis course (head D.Ya. Epshtein) is to improve the method of treating tuberculosis with the help of an artificial pneumothorax.The field of work of the Department of Tuberculosis (head V.P. Rudin) is the analysis of age-related reactivity of the body of tuberculosis patients, features of pathogenesis, clinic, diagnosis and treatment of tuberculosis in young people and the elderly; study of tuberculous meningitis and new methods of climate therapy for tuberculosis.The field of work of the Department of Phthisiology (head M.S. Pylypchuk) is the development of methods of diagnosis and improvement of treatment of patients with tuberculosis and non-specific lung diseases (use of heparin, donors of sulfhydryl groups, galascorbin and proteolytic enzymes; establishment of hemosorption, endolymphotherapy, aerosol therapy and intravenous administration of antituberculosis drugs drugs, lung resection with pneumoperitoneum) and treatment of tuberculosis patients with chronic alcoholism. Study of the surfactant system of the lungs, the mucociliary apparatus and the aerogematic barrier; animal lung transplantation experiments.The field of work of the department of phthisiology and pulmonology since 1997 (head — V.I. Petrenko) — improvement of existing and development of new methods of antimycobacterial and pathogenetic therapy (Tri-vi-plus, Dufalak®, Kagocel®, Glutargin, ademethionine, Livolin Forte and Immunofan) in patients with pulmonary tuberculosis; application of biocorrective technologies in emergency conditions in pulmonology and the latest technologies in diagnostics (dopplerography) and treatment (information-wave therapy «IHT-Threshold») of tuberculosis; environmental problems in phthisiology and pulmonology (cigarette smoking, ionizing radiation).The student circle at the Department of Phthisiology and Pulmonology has been operating since 1960. Students have been actively engaged in scientific research. They take part in the implementation of the Department’s National Development Program and make presentations at scientific and practical conferences, congresses and forums (they receive diplomas and certificates). Active student participation is noted during the «April Student Scientific Sessions» (Ukraine) and Olympiads (Ukraine, Uzbekistan).

An evidence-based assessment of the nutritional recommendations for thepreventionof diabetes mellitus.

Thissystematic review presents the most recent scientific knowledge concerningdietary recommendations for T2DM published in the English language by various scientific societies during the past 10years. The recommendations are herein presented and discussed in the light of a critical, evidence-based appraisal aiming to provide a comprehensive guide for the clinician in daily practice. In the case of overweight or obesity, the cornerstone of the primary prevention of T2DM is the combination of a healthy body weight (body mass index < 25kg/m2) or a reduction of fat byat least 7% and the implementation of at least 150min of moderate physical activity per week. Restriction of calories and of dietary fat is recommended, the latter as well as several dietary patterns providing a holistic approach to dieting andall havingbeen correlated with decreased risk of T2DM. Among these dietary patterns are the Mediterranean diet, the DASH diet (Dietary Approaches to Stop Hypertension), the low-glycemic diet, and the HEI-Healthy Eating Index and AHEI-Alternative Healthy Eating Index. Micronutrient deficiencies of, for example, vitamin D, chromium and magnesium, may be associated with insulin resistance in T2DM. Overall, the combination of nutrition through dietary patterns that are mainly plant-based and which emphasize wholegrains, legumes, nuts, fruits, and vegetables and that include only small percentages of refined and processed foods, together with physical activity, has been associated with decreased T2DM risk.

DEVELOPING MENU PLANNING SOFTWARE USING OPTIMIZATION AND ARTIFICIAL INTELLIGENCE ALGORITHM

In today's world, awareness of health and nutrition is growing, emphasizing the need for personalized nutrition recommendations and reducing food waste. This study collected demographic data and food preferences from users and analyzed them using artificial intelligence models. A model developed with the Random Forest algorithm was trained to predict users' future preferences and guide menu planning. Tests showed that combining AI with optimization techniques successfully creates user-focused menus, enhancing satisfaction and reducing food waste. The study also highlighted challenges related to the dataset's size, pointing to a need for more qualitative data. The developed model provides innovative solutions for catering companies and institutions offering mass dining, improving employee satisfaction while minimizing waste. Future research aims to refine the model for broader applications.

Estimation of efficacy of a home monitoring and communication platform to prevent frailty among older adults in Sweden- a pilot study with a randomized controlled trial design

BackgroundThe aging population of the world is increasing. Aging leads to risks for frailty and other chronic diseases and health systems must focus more on prevention to guarantee healthy aging. The primary objective was to estimate the efficacy of the POSITIVE-(The Maintaining and imPrOving the intrinSIc capaciTy Involving Primary Care and caregiVErs) system in improving frailty during a 6-month follow-up period. MethodA randomized controlled, assessor-blinded pilot study (RCT) with 50 individual < 70 years, pre-frail or frail was recruited from a primary care center in Stockholm Region. All participants received a drug review, nutritional recommendations, and a Vivifrail physical exercise program. In addition, the intervention group received POSITIVE including a tablet, an application, and portable measurement devices. The intervention group was monitored remotely by a primary care nurse at the primary health care centre during a six-month follow-up period. ResultsAt baseline there was a significance between the groups regarding the FTS-5 scale, and significantly more obese participants in the intervention group. The drug reviews showed that three of 43 participants got a review and new diseases were discovered. The test of interactions showed a tendency for significant differences over time between the groups in frailty measured by Fried Frailty Phenotype's and FTS-5 scales. ConclusionFrailty status over time in the intervention group not differed significantly from the controls. Including individuals to the project even through a pandemic showing that the design is possible for future studies to show effects of new ways of preventing frailty at home. Trial RegistrationClinicalTrials.gov. Registration number: NCT04592146. October 19, 2020. https://clinicaltrials.gov/ct2/show/NCT04592146?term=positive&draw=2&rank=7

In vitro protein digestive properties and peptidomic characterization of five whole component plant protein beverages using a pepsin-pancreatin model

Plant protein has received great attention for its potential nutrition and health benefits. In this study, the digestive properties and peptidomics of whole component plant protein beverages from soybean, chick pea, pea, oat, and quinoa were characterized using an in vitro pepsin-pancreatin digestion model. The study found that quinoa beverage had a higher in vitro protein digestibility (80.49 %), followed by pea, soybean, chick pea, and oat beverage (79.25–70.89 %). Additionally, quinoa and soybean beverage showed comparably higher in vitro digestible indispensable amino acid score (DIAAS) of 81–97, while chick pea and pea beverage had lower in vitro DIAAS of 58–79 due to low concentration of sulfur-containing AA (SAA). Meanwhile, peptides with molecular weight (MW) below 1 kDa occupied more than 93 % of the digested fraction in quinoa beverage, which might result in its higher DPPH scavenging activity, ABTS scavenging activity and ACE inhibitory activity with the IC50 value of 2.80, 0.20 and 0.90 mg/mL, respectively. Peptidomics characterization combined with rapid screening by PeptideRanker and BIOPEP database further suggested that cereals, especially oat and quinoa, released potentially bioactive peptides with a higher percentage (30.89 % and 22.81 %, respectively) compared to legumes like soybean and chick pea (13.30–18.52 %). Additionally, the identified active peptides were more likely to be derived from globular proteins. The methods and data here provided a reference for a better understanding of the digestive properties and nutritional recommendations of whole component plant protein product.

Successful weaning from parenteral nutrition in a short bowel syndrome patient with high-output stoma through restricted oral diet: a case report.

A restricted oral diet plays a significant role in the nutritional management of patients with Short Bowel Syndrome (SBS). SBS patients often experience increased intestinal output, especially if they are classified as net "secretors" (typically having less than 100 cm of residual jejunum). This means they lose more water and sodium from their stoma than they take in by mouth. In this report, we present the case of an SBS patient with 80 cm of remaining bowel, no colon in continuity, and a high-output stoma. The patient was managed with a restrictive oral diet in combination with parenteral nutrition, pharmacological treatment, and high patient compliance. Following this regimen, the patient's condition improved significantly, leading to a reduction in stoma output and an improvement in nutritional status, including stabilization and weight gain. Upon discharge from the hospital, the patient was maintaining an oral diet with specific nutritional recommendations and receiving parenteral saline. This case report suggests that the combined use of restricted oral intake and parenteral nutrition (PN), alongside appropriate pharmacological management and high patient compliance, can effectively manage high-output stomas and improve nutritional status, even in cases where the small bowel is less than 100 cm in length.

Spatial distribution of antioxidant activity in baguette and its modulation of proinflammatory cytokines in RAW264.7 macrophages

Baguette is a globally acclaimed bakery staple, composed by a crispy crust and soft crumb, both containing Maillard reaction products (MRPs) with potential bioactivities. However, MRPs’ impacts on the nutritional and health attributes of baguette, particularly in terms of cellular and biological functions, are yet to be clearly elucidated. This study chemically characterizes the crust and crumb of baguettes and investigates the influence of the Maillard reaction on baguette’s nutritional profile, especially in the antioxidant and anti-inflammatory effects. The findings indicate an increase in browning intensity and advanced glycation end products (AGEs) from the baguette’s interior to its exterior, alongside a significant rise in the antioxidant capacity of the crust, suggesting the Maillard reaction’s role in boosting antioxidative properties. Both the crust and crumb demonstrated strong cytocompatibility with immune cells, capable of reducing cellular oxidative stress and regulating intracellular free radical levels. The crust effectively countered peroxyl radical-induced cell membrane hyperpolarization by 91% and completely neutralized the suppression of oxygen respiration in mitochondria, displaying higher efficacy than the crumb. In contrast, crumb extracts were more potent in inhibiting lipopolysaccharide-induced expression of proinflammatory cytokines, such as interleukins-1β (IL-1β) and IL-6, in macrophages. It could provide the fundamental data and cell-based approach for investigating the biological impacts of bread on immune responses, contributing to the refinement and supplementation of nutritional recommendations.

Show me the evidence to guide nutrition practice: Scoping review of macronutrient dietary treatments after metabolic and bariatric surgery.

Clinical practice recommendations for macronutrient intake in Metabolic and Bariatric Surgery (MBS) are insufficiently grounded in the research, possibly due to a paucity of research in key areas necessary to support macronutrient recommendations. An initial scoping review, prior to any systematic review, was determined to be vital. To identify topical areas in macronutrients and MBS with a sufficient evidence base to guide nutrition recommendations. PubMed, Cochrane, Ovid Medline, and Embase were initially searched in January 2019 (updated November 1, 2023) with terms encompassing current bariatric surgeries and macronutrients. Out of 757 records identified, 98 were included. A template was created. Five types of outcomes were identified for extraction: dietary intake, anthropometrics, adverse symptoms, health, and metabolic outcomes. All stages of screening and extraction were conducted independently by at least two authors and disagreements were resolved via team discussion. Macronutrient-related dietary treatments were classified as either innovative or standard of care. Descriptions of dietary arms were extracted in detail for a qualitatively generated typology of dietary or nutritional treatments. Heatmaps (treatments by outcomes) were produced to identify promising topics for further systematic analyses. We identified protein supplementation and "food-focused" (e.g., portion-controlled meals, particular foods in the diet, etc.) topical areas in MBS nutrition care with potentially sufficient evidence to create specific MBS Macronutrients guidelines and identified topical areas with little research. Clinical practice regarding macronutrient intake remains guided by consensus and indirect evidence. We detail ways that leadership at the profession level may remedy this.