Abstract Objectives Personalized and evidenced-based nutritional interventions are needed to overcome the burden of type 2 diabetes (T2D) epidemic. The aim of this study was to describe the implementation and impact on glycemic control of an intervention based on Nutritional Care Process Terminology (NCPT) within a T2D comprehensive care program in Mexicans. Methods This is a single-arm study of a 2-years follow-up. We evaluated 258 individuals of the CAIPaDi program across six visits. The program seeks to achieve metabolic goals and provide self-efficacy to recently T2D-diagnosed patients. The customized nutritional intervention was implemented for all participants based on an NCPT model. The intervention was implemented by two dietitians, following the NCPT program. Each participant engaged in a 30-minutes session each visit. The main outcome is the achievement of treatment goals defined by the National Committee for Quality Assurance criteria (NCQA). Results The program was effective to reduce the prevalence of subjects with poor glycemic control from 85% to 57% (P < .0001) after 2 years. Nutritional diagnoses were grouped into the three main domains, 1) ingestion, 2) clinical, and 3) Behavioral/Environmental. At baseline, the most prevalent diagnostic was behavioral diagnostics (44%), followed by ingestion (39%), and clinical (17%). The majority of individuals with behavioral diagnostics migrated to ingestion, whereas individuals with ingestion diagnoses at baseline migrated to the non-diagnostic at the final visit. At the end of the follow-up, the most frequent diagnostic was ingestion (45%), with 29% of the subjects with good glycemic control, contrasting with 79% of the non-diagnostic individuals (p = .0001). Subjects in the category the non-diagnostic nutritional in one previous visit, were 89% more likely to reach a good glycemic control in the last visit (HR 1.89; 95CI% 1.17–3.05) even after adjusting by confounders: age, sex, body fat, years of onset and HbA1c at baseline. Conclusions An intervention based on NCPT can help provide individualized nutritional interventions and prioritize clinical attention to improve the effectiveness of a T2D comprehensive care program. Funding Sources Consejo Nacional de Ciencia y Tecnología project 214,718.