Nutraceutical Market Research Articles

A GENERAL REVIEW ON NUTRACEUTICALS: ITS GOLDEN HEALTH IMPACT OVER HUMAN COMMUNITY

Nutraceutical is the hybrid of Nutrition and Pharmaceutical. Nutraceuticals, in broad, are food or part of food playing a significant role in modifying and maintaining normal physiological function that maintains healthy human beings. The principal reasons for the growth of the nutraceutical market worldwide are the current population and the health trends. The food products used as nutraceuticals can be categorized as dietary fibre, prebiotics, probiotics, polyunsaturated fatty acids, antioxidants and other different types of herbal/ natural foods. These nutraceuticals help in combating some of the major health problems of the century such as obesity, cardiovascular diseases, cancer, osteoporosis, arthritis, diabetes, cholesterol etc. In whole, Nutraceutical has led to the new era of medicine and health, in which the food industry has become a research-oriented sector.

Omega-3 nutraceuticals, climate change and threats to the environment: The cases of Antarctic krill and Calanus finmarchicus

The nutraceutical market for EPA (eicosapentaenoic acid) and DHA (docosahexaenoic acid) is promoting fishing for Euphasia superba (Antarctic krill) in the Southern Ocean and Calanus finmarchicus in Norwegian waters. This industry argues that these species are underexploited, but they are essential in their ecosystems, and climate change is altering their geographical distribution. In this perspective, we advocate the cessation of fishing for these species to produce nutraceuticals with EPA and DHA. We argue that this is possible because, contrary to what this industry promotes, the benefits of these fatty acids only seem significant to specific population groups, and not for the general population. Next, we explain that this is desirable because there is evidence that these fisheries may interact with the impact of climate change. Greener sources of EPA and DHA are already available on the market, and their reasonable use would ease pressure on the Arctic and Antarctic ecosystems.

Safety and Quality of Nutraceuticals: Have FSSAI Guidelines been Able to Blaze the Trail?

The nutraceutical industry has three main segments, including herbal/- natural products, dietary supplements and functional foods. The dietary supplements market is preliminarily driven by the paradigm shift towards preventive health management practices, amid rising healthcare costs and increasing burden of lifestyle diseases. Rise in healthcare expenditure, increased usage of nutraceuticals product as a substitute to prescription and OTC drugs and augmented demand for the nutritional diet are the major factors driving the global nutraceuticals market. Many individual laws were devised to govern its manufacturing and sale. However, increasing regulatory formalities from multiple agencies and laws, complicate the development, testing and marketing of these substances and hamper the growth of the nutraceutical market. Globally, the regulatory authorities are aware of the changing needs of consumers and proactively protect consumers by amending existing laws to accommodate changes. Market entry requirements of nutraceuticals, functional foods and supplements vary from country to country. The global regulatory guidelines aim at regulating various aspects of the nutraceutical and dietary supplements market, focusing on its manufacture, testing, labeling, sale and registration to assure safety and quality of the product. The major change that was introduced was the ban on marketing Nutraceuticals as medicinal products. This review has been performed to provide a comprehensive understanding of the global regulatory requirements with critical analysis of the Indian regulatory guidelines to explore the lacunae and suggest the need of further amendments in the form of recommendations that can be incorporated into regulatory body guidelines to make it more competitive for national & international trade.

Nutraceuticals and their Nanotechnology-Based Therapeutic Applications in Different Diseases

Nanotechnology today is growing very rapidly and has infinite applications in almost everything we do, in the medicine we take, food we eat, chemicals we use, car we drive and much more. Nanoparticles could help make more compelling clinical medicines. The point is to improve regions going from drug conveyance to the discovery of infections. One of the expected advantages of nanoparticles is the chance of creating focused on treatments, so that medications go precisely where they are required in the body Nutraceuticals, up today, today, don't have a particular definition unmistakable from those of other food-inferred classes, for example food supplements, natural items, pre and probiotics, useful nourishments, and so on They have, be that as it may, a pharmacological useful impact on wellbeing. Numerous investigations have been as of late routed to survey their wellbeing, adequacy, and guideline since they are getting developing consideration by market and examination, with the plan to clear the contrast among them and other market accessible food-determined items that guarantee gainful impact on wellbeing. Additionally, nutraceuticals have been widely explored for promoting overall health outcomes and in management of various diseases since they are considered to be neutral. They play a vital role in modifying and maintaining normal body physiological functions. Nonetheless, the bioactive mixes present in nutraceuticals can't accomplish their possible results because of restricted watery solvency prompting helpless bioavailability profile and collaboration with gastro-intestinal liquids. Greater part of traditional items in market are unable to show their therapeutic outcome. Nanotechnology has tremendous potential to revolutionize the nutraceutical market. Recent progress in field of nutraceutical delivery has incorporated nanotechnology to overcome the drawbacks accompanying nutraceuticals. This review focuses on issues associated with nutraceuticals and various nanoscale formulation approaches like liposomes, nano emulsions, nanocrystals, lipid and polymeric nanoparticles to obtain an insight to recent developments in nutraceuticals segment. Keywords: Nanoparticles; Nutraceutical; Nutraceutical delivery; Dietary supplements

Assessment and management of new and emerging risks for Europe's dietary supplement companies operating with botanicals

AbstractThis study identifies new and emerging risks in the botanicals sector with the aim of fostering the success of nutraceutical and dietary supplement companies based on quality, product safety, and consumer trust. Focusing on the Italian nutraceutical market, an analysis was conducted based on interviews with experts. The outcomes of the analysis and the resulting guidelines on how to manage safety and quality by preventing risk at firms commercializing botanical‐based nutraceuticals and dietary supplements are of direct relevance to industry practitioners and to bioeconomy and biotechnology scholars. © 2020 Society of Industrial Chemistry and John Wiley & Sons Ltd

Profiling phenolic compounds in underutilized mango peel by-products from cultivars grown in Spanish subtropical climate over maturation course

Nutraceutical market has undergone an exponential growth worldwide due to its health link-up. With the purpose of evaluating nutraceutical value, the phenolic composition of underutilized mango peel by-products of three cultivars (‘Keitt’, ‘Kent’ and ‘Osteen’) grown in Spanish subtropical climate was monitored at three maturation stages (green, ripe and overripe). Tracking the total phenol content, mango peels were figured out to have until twenty-seven fold higher than edible fraction. Mango peels comprised a wide range of phenolic compounds such as mono- and di-galloyl compounds, gallotannins, phenolic acids, benzophenones and flavonoids. The influence of both factors, cultivar and maturation degree, on the phenolic composition was the main outcome of the research. ‘Keitt’ mango peel was revealed as the cultivar with the highest phenolic content mainly due to the great quantities of galloyl glucose, 5-galloylquinic acid, digalloylquinic acid, hexagalloyl glucose and macluring galloyl glucoside detected. Regarding to the effect of maturation degree, green mango peels showed the highest amounts of polyphenols, although this behaviour could be dependent on the mango cultivar. Therefore, mango peels resulted to be a promising and low-cost resource of phenolic compounds to be exploited in food industry, but to enhance the nutraceutical value, factors such as cultivar and maturation degree should be taken into account.

Nutraceuticals: A Comparative Analysis of Regulatory Framework in Different Countries of the World.

Nutraceutical is a term that is a combination of nutrition and pharmaceutical. They are believed to improve physical and mental health and provide therapeutic benefit in disease conditions. Nutraceuticals are claimed to be beneficial in several disease conditions which include cardiovascular disorder, neurodegenerative disorders, metabolic disorders and cancer prevention. In the current review, we will study the current regulatory framework in some of the major countries of the world by comparing different parameters of these regulations. Global nutraceutical market is currently expanding at a rapid pace but there are some restraints to the market growth which include poor quality manufacturing and unharmonized regulations leading to trade barriers across the globe. Although there are laws and regulations in place which govern nutraceutical products in different countries, these regulations lack harmonization and differ from country to country. Some of the countries follow stringent regulations, whereas, in some of the countries, well-structured and stern regulations for nutraceuticals are lacking. The development of a well regulated, harmonized and research-driven approach can help boost the confidence of consumers in nutraceutical products in the world thereby driving the nutraceutical market.

Establishment and optimization of a hemp (Cannabis sativa L.) agroinfiltration system for gene expression and silencing studies

Industrial hemp (Cannabis sativa L.) is a high-yielding annual crop primarily grown for fiber, seeds, and oil. Due to the phytochemical composition of hemp, there has been an increased interest in the market for nutraceuticals and dietary supplements for human health. Recent omics analysis has led to the elucidation of hemp candidate genes involved in the syntheses of specialized metabolites. However, a detailed study of these genes has not been undertaken due to the lack of a stable transformation system. We report for the first time an agroinfiltration system in hemp utilizing vacuum infiltration, which is an alternative method to stable transformation. A combination of 0.015% Silwett L-77, 5 mM ascorbic acid, and thirty second sonication followed by a 10-minute vacuum treatment resulted in the highest β-glucuronidase expression in the leaf, male and female flowers, stem, and root tissues. The phytoene desaturase gene was silenced with a transient hairpin RNA expression, resulting in an albino phenotype in the leaves and the male and female flowers. This agroinfiltration system would be useful for overexpression and silencing studies of target genes to regulate the yield of specialized metabolites in hemp.

Trends in use, pharmacology, and clinical applications of emerging herbal nutraceuticals.

The nutraceuticals market is vast, encompassing many different products with inconsistent levels of evidence available to support their use. This overview represents a Western perspective of the nutraceuticals market, with a brief comparison with that in China, as an illustration of how individual health supplements increase and decrease in popularity in regional terms. Recent changes in sales patterns, mainly taken from the US market, are summarized and a selection of five newer products, which have not been subject to extensive recent review are profiled: astaxanthin, a carotenoid found in red algae, seafood, salmon and trout, as an antioxidant; cannabidiol, a non-euphoric marijuana ingredient used as mood enhancer and for painful/inflammatory conditions; modified extracts of ginseng used in new indications including dementia and space travel; monk fruit, a non-sugar high intensity sweetener and nigella seed, a popular food ingredient and Asian medicine, which has experienced an extraordinary rise in sales recently. LINKED ARTICLES: This article is part of a themed section on The Pharmacology of Nutraceuticals. To view the other articles in this section visit http://onlinelibrary.wiley.com/doi/10.1111/bph.v177.6/issuetoc.

Nutraceutical regulations: An opportunity in ASEAN countries.

In today's era of increased standards of lifestyle and life expectancy, there has been a constant demand for supplements by consumers. Nutraceuticals are among the supplements in demand. Although there is a big opportunity for the nutraceutical business, there are no uniform regulatory requirements in different regions. Nations are looking to the nutraceutical sector to help keep their populations healthy and safe by introducing certain rules and regulations. Generally, developed countries have regulations in place, but there are some countries, such as those in the Asia Pacific regions or in Association of Southeast Asian Nations (ASEAN) countries, that have not yet fine-tuned their regulations for nutraceutical products. The ASEAN countries involve highly commercialized markets such as Singapore, Thailand, Malaysia, and the Philippines. The overall nutraceutical market of ASEAN countries is growing at a compound annual growth rate of ∼8.4%. About 40% of the ASEAN population consumes nutraceuticals on a daily basis. ASEAN countries are forming harmonized regulations for dietary supplements. This could be a big opportunity for manufacturers to introduce their products into the ASEAN market. A special unit of the Traditional Medicine and Health Supplements Product Working Group (TMHA PWG) helps manufacturers understand the regulatory procedures of these countries. Despite countries' own special requirements, manufacturers can follow the standards and harmonized guidelines put forth by TMHA PWG. The aim of this review is to introduce the regulatory procedure and requirements for international business developers to launch any new nutraceutical products into the ASEAN market.

Inflammation response after the cessation of chronic arsenic exposure and post-treatment of natural astaxanthin in liver: potential role of cytokine-mediated cell-cell interactions.

Ongoing groundwater arsenic contamination throughout China was first recognized in the 1960s. Groundwater arsenic contamination is a high risk for human and animal health worldwide. Apart from drinking water, diet is the second pathway for arsenic to enter the human body and eventually cause liver injury. Natural astaxanthin extracted from the green algae Haematococcus pluvialis has dominated the nutraceutical market for potential health benefits. Nevertheless, the molecular mechanism underlying the protective effect post astaxanthin against arsenic-induced hepatotoxicity remains largely obscure. In this study, we investigate the effect of natural astaxanthin (derived from Haemotococcus pluvialis) on oxidative stress and liver inflammatory response in rats after the cessation of chronic arsenic exposure. Wistar rats were given astaxanthin (250 mg kg-1) daily for 2 weeks after the cessation of exposure to sodium arsenite (300 μg L-1, drinking water, 24 weeks) by intragastric administration. The results showed that post treatment with astaxanthin attenuated liver injury induced by long-term exposure to arsenic in rats. Most importantly, post treatment with astaxanthin decreased the increasing of inflammatory cytokine NF-κB, tumor necrosis factor-α, interleukin-1β, oxidative stress level, and total arsenic content in livers of rats exposed to arsenic. In addition, post treatment with astaxanthin reversed the increasing of protein levels of alpha-smooth muscle actin and collagen Iα1, which are the activation markers of hepatic stellate cells (HSCs). Collectively, these data demonstrate that post astaxanthin treatment attenuates inflammation response in the liver after the cessation of chronic arsenic exposure via inhibition of cytokine-mediated cell-cell interactions. Daily ingestion of natural astaxanthin might be a potential and beneficial candidate for the treatment of liver damage after the cessation of chronic exposure to sodium arsenite.

Gamma-aminobutyric acid and probiotics: Multiple health benefits and their future in the global functional food and nutraceuticals market

Abstract Probiotics have attracted growing interest in recent decades due to their multiple health benefits. The synergistic relationship between probiotics and prebiotics can enhance the production of metabolites called postbiotics, which are gaining increasing importance because of their beneficial functions in the gastrointestinal tract and their influence on different organs and tissues. Notable among the postbiotics is gamma-aminobutyric acid, which plays an essential role in the prevention of neural disease, type 1 diabetes, cancer, immunological disorders and asthma. Generally, gamma-aminobutyric acid is produced by lactic acid bacteria, which under certain conditions can produce a high amount of this amino acid. The food industry has leveraged this capacity to develop functional foods enriched with gamma-aminobutyric acid.

Engineered nano scale formulation strategies to augment efficiency of nutraceuticals

Abstract Nutraceuticals have been widely explored for promoting health outcomes and in management of various diseases. They are considered to be neutral and safe and are extensively used to promote overall health. They play a vital role in modifying and maintaining normal body physiological functions. However, the bioactives present in nutraceuticals are unable to achieve their potential outcomes due to limited aqueous solubility leading to poor bioavailability profile and interaction with gastro-intestinal fluids. Majority of conventional products in market are unable to show their therapeutic outcome. Nanotechnology has tremendous potential to revolutionize the nutraceutical market. Recent progress in field of nutraceutical delivery has incorporated nanotechnology to overcome the drawbacks accompanying nutraceuticals. This review focuses on issues associated with nutraceuticals and various nanoscale formulation approaches like liposomes, nanoemulsions, nanocrystals, lipid and polymeric nanoparticles to obtain an insight to recent developments in nutraceuticals segment.

Nutraceuticals: One more step towards good health

The term "nutraceutical" is used to describe any food, or part of a food supplements, that offers a medical or health benefit beyond simple nutrition. They play significant role in modifying and maintaining normal physiological function that is required for today’s busy and stressful life style. The principal reasons for the growth of the nutraceutical market worldwide are the current population and their health trends. The food products used as nutraceuticals can be categorized as dietary fibre, prebiotics, probiotics, polyunsaturated fatty acids, antioxidants and other different types of herbal/ natural or functional foods. These nutraceuticals help in countering some of the serious health problems such as obesity, cardiovascular diseases, cancer, osteoporosis, arthritis, diabetes, atherosclerosis etc. Thus, nutraceutical has lead to the new era of health protector in which the food and pharmaceutical industries has become a research oriented sector.

Structural Modification of Styrene Maleic Anhydride Copolymers for Plant Bioactive Compound Extraction

Ability of poly (styrene-alt-maleic anhydride) (PSMA) to undergo a conformational transition into an amphipathic α-helix coil offers one possible mechanism by which PSMA surface activity can be switched on or off in response to the pH change. This behaviour allows it to be useful in membrane solubilization for extraction technology. Bioactive compounds are recovered from plant tissues for different reasons. One of the most important reasons is due to the increased demand in nutraceuticals market and modern therapeutics. Despite this, aqueous-based extraction of these compounds has been reported to give low extraction yield. A development of new green extraction protocol is still a challenging task for all researchers nowadays. This study demonstrated, for the first time, possible use of PSMA as a lysis agent for plant bioactive compound extraction. To enhance its membrane affinity at physiological pH, the polymer was esterified with methanol. Both PSMA and its derivative (ePSMA) were characterized in terms of their membrane binding affinity through a combined use of both surface characterization and physical techniques. Analysis of the ternary phase diagrams suggested that ePSMA could facilitate stronger hydrophobically-driven interactions with the lipid. This was convinced by the reduced critical PSMA/lipid mass ratio from 7:1 (PSMA) to 1:1 (ePSMA), as observed in the ternary phase diagrams. Last but not the least, the crude extracts of Coffea robusta leaves obtained from ePSMA-based extraction showed a total phenolic content of 20.32±0.75 mg/g sample, significantly higher than that from the PSMA- (14.24±1.27 mg/g sample) and aqueous-based (16.33±1.03 mg/g sample) extractions. A structural manipulation of PSMA is thus a key to tailor its membrane solubilization and so, the extraction efficacy of bioactive compounds from plant cells.

Influence of unit operations on immunoglobulins and thermal stability of colostrum fractions

Colostrum-based ingredients are gaining significance in the global nutraceutical market as dietary supplements, but compositional variation, bioactive heat sensitivity and lack of appropriate preservation technologies hamper commercial colostrum processing. The effect of commonly employed unit operations on the physicochemical and nutraceutical components of skim colostrum was determined, and effects of membrane processing on its thermal gelation temperature, key to further liquid processing, were monitored. Homogenisation and high-shear mixing did not alter immunoglobulin content. However, commercial thermal pasteurisation (72 °C, 15 s) and batch pasteurisation (63 °C, 30 min) led to 56.4% and 24.6% denaturation of IgG, respectively. Microfiltration eliminated microbial load of diluted skim colostrum to render it practically sterile, while ultrafiltration concentrated the proteins of colostrum fractions. Concentration of protein, particularly immunoglobulins, resulted in lowering of thermal gelation temperature. Skim colostrum and colostrum whey can, therefore, be preserved by employing microfiltration and concentrated with simultaneous purification by ultrafiltration.

The emergence of India as a blossoming market for nutraceutical supplements: An overview

BackgroundIn today's world where chronic lifestyle diseases are on a rapid ascent among the masses, nutraceuticals have firmly established themselves as key to human health owing to their disease prevention advantages. India, in particular, has witnessed an upswing in the acceptance of nutraceuticals as a viable option for maintaining optimum health. Nutraceutical market in IndiaIn the last five years, the nutraceutical market here has flourished into a $3 bn industry and is expected to grow to a $6.1bn by the year 2022. Until the turn of the century, the existence of innumerable laws with respect to the nutraceutical industry created a state of uncertainty in the minds of nutraceutical manufacturers in India. The regulationsHowever, the introduction of the Food Safety and Standards Act (FSSA) has reinforced regulations with respect to nutraceuticals, creating a regulated space for manufacturers to conduct their business in. ConclusionToday, the Food Safety and Standards Authority of India (FSSAI) ensures that regulations for nutraceuticals in India are at par with the international standards.

Biological mechanisms of glycan- and glycosaminoglycan-based nutraceuticals.

A nutraceutical is defined as a standardized pharmaceutical-grade nutrient. Among hundreds of nutraceuticals, polysaccharide or glycan-based products such as those containing chondroitin sulfate glycosaminoglycan isolated from animal cartilage have been on the top nutraceutical selling list for many years. It is expected that the nutraceutical market will reach $250 billion dollars worldwide by 2018. Glycans are most abundant biopolymers on earth those are synthesized by bacteria, fungi, plants, insects, and animals. Glycans that are synthesized by animals or from all marine sources can be modified with covalently linked sulfates or containing acidic monosaccharides whereas glycans that are synthesized by terrestrial plants or fungi usually do not contain sulfates. Glycans such as starch are common sources of energy for animals, therefore they are on the nutrient-side of nutraceuticals. Undigestible polysaccharides from plants could serve as dietary fiber for humans that change the contents of the gastrointestinal tract and affect how other nutrients and chemicals are absorbed, thus dietary fibers could be called nutraceuticals. Other intra- and extracellular glycans from different sources serve as biological active components that regulate a myriad of physiological functions. The reported biological functions for such glycans are not limited to immune system regulatory, anti-coagulating, anti-tumor, anti-viral, anti-oxidant, anti-aging, and lipid-lowing activities, which make them pharmaceutical-side nutraceuticals. This review will present the full spectrum of glycan-based nutraceuticals and summarize current knowledge (published data from 1960s to current) of the structure, biological function, and mechanisms of glycans from both terrestrial and marine sources.

Need of Nutraceuticals / Functional Food Products for Health Benefits to World-Wide People

Improved economic and developed people with their lifestyle have created many challenges of health issues (obesity, osteoporosis, cancer, diabetes, allergies and dental problems), due to selection of different food habits (such as consumption of manifold junk foods). It has created number of health problem (development of many diseases) related to nutritional deficiencies food. Nowadays, people have developed the habit for shifting of synthetic food ingredients to organic foods and ingredients, obtained from natural sources. In this regards, nutraceuticals food or its food products can perform important role in controlling the diseases via fulfilling all the health benefits to many people at worldwide. Incredible dietary supplements as nutraceuticals food (involvement in nutritional, immunologic and physiological functions) can help in prevention or treatment of many diseases (mitigating of gastrointestinal (GI) tract problem), as it is synthesized from raw herbals and lots of rapidly growing industries are reported to synthesize these natural products. And around 100 million people are found to take these products (power of plant based materials) for getting health benefits. It can work as drugs as health benefit of nutraceuticals via regulation/ control for diseases. Global nutraceuticals market had been valued for US$ 165.62 billion in 2014 and it would be grow the value of US$ 278.96 billion by 2021 with compound annual growth rate of 7.3%. This proposed paper will discuss the different types of nutraceuticals food or its functional components involved in prevention or treatment of diseases.

Current Regulatory requirements for Registration of Nutraceuticals in India and USA

There is growing recognition of the potential role for nutraceuticals and dietary supplements in helping to reduce health risks and improve health quality. Pharmaceutical and nutritional companies are aware of the monetary success taking advantage of the nutraceuticals and dietary supplements. Nutraceuticals has proven health benefits and their Consumption will keep disease at bay and allow humans to maintain an overall good health. Functional foods and internationally products represent a value added growth opportunity both domestically and internationally. Development of better characterized and research proven products will help enhance consumer confidence in nutraceutical and functional food products in the world. Regulatory aspects of such products were in a state of confusion in 20th century. Till date the regulations are not harmonized for the globe and change from country to country. But now it is clearly understood that the regulations for clinical evidence and safety of such products cannot be less stringent than rules for modern medicines and thus the science of nutraceutical is progressing. The global nutraceutical market will reach $285.0 billion by 2021 from $198.7 billion in 2016 at CAGR of 7.5% from 2016-2021. The present research has been devoted towards better understanding of the nutraceuticals and its regulation in India and USA.