Abstract The objective of this study was to examine the effects of ego state on the interpersonal skills of nursing students. The targets of this study were the nursing students in D city. The questionnaires were administered to one hundred forty-four nursing students between March 15 and March 30 in 2015. For ego state, the study used Egogram checklist, developed by Bernes and standardized by Korea Transactional Analysis Association, and for interpersonal skills, it used Relationship Change Scale, developed by Schlein and Guerney and revised to suit the conditions in Korea. The collected data were analyzed using t-test, Pearson's correlation, and hierarchical regression. The study results showed that the variables that had significant explanatory power (33.8%) for interpersonal skills were the nurturing parent ego, adapted child ego, and free child ego. The study suggests convergent implications on a transactional analysis programs for nursing students to improve interpersonal skills as the findings showed that the ego state of nursing students affected the interpersonal skills.