Background Currently, worldwide nursing experts have been inspiring nurses to pursue innovation in nursing in order to improve nursing outcomes. As a consequence, practicing nurses ought to have the capability to be receptive to the innovation in their practice environment; therefore, a new specialty called ‘nursing informatics’ (NI) has emerged to keep pace with these emerging innovations. Aim The aim of this study was to measure the relationship between innovation behavior levels and TIGER-based NI competencies among critical care nurses. Participants and methods A descriptive correlational design was used in carrying out this study. This study was conducted in a Critical Care Unit at an International Private Hospital in Egypt. The convenience sampling method was used to select 30 participants who met the inclusion criteria to join the study. Data were collected using a three-section questionnaire as follows: (i) demographic data sheet; (ii) Innovation Behavior Questionnaire; and (iii) Nursing Informatics Competency Assessment Tool. Results More than half of the participants had a moderate level of innovation behavior. Moreover, more than one-third of the studied sample rated themselves as competent in NI. In addition, a significant positive relationship was found between innovation behavior and overall NI competency levels as perceived by the participants. Conclusion This study contributes to the identification of informatics competency levels that are pertinent to the role of critical care nurses. Moreover, this study signifies that the innovative behavior of critical care nurses would help in generating proactive approach concerning developing a NI competency level in the future. Recommendation Future studies should relate the demonstrated and perceived NI competency levels in critical care units and other work settings. Moreover, integration of the NI and nursing innovation courses as one of the core courses, and not as an elective, in the nursing curriculum is recommended.