Background: Reiki is a universal life-force energy that promotes healing and relaxation. Reiki requires no equipment or technology, is noninvasive, does not interfere with conventional treatments, is appropriate for all ages, and has no known medical contraindications. There is an emerging preference for nonopioid therapies for symptom management. Within an integrative person-centered holistic care model, nursing care plans include a patient's whole narrative with physical, mental, emotional, and spiritual elements. The Evidence-Based Practice PICOT Question: Will hospitalized patients of any age (population) receiving one 20-minute session of Reiki (intervention) compared with usual care (comparison) report a change from prerating symptom score (outcome) at the completion of the 20-minute session (time frame)? Method: A total of 1,278 patients received a 20-minute Reiki session with volunteer, certified Reiki practitioners from September 2017 through October 2019. Results: The average symptom prescore was 5.52 and postscore was 2.25, thus showing an average change of -3.17. Conclusions: The authors presented the results that were consistent with research findings from the literature review suggesting that Reiki can decrease pain, general discomfort, anxiety, insomnia, and nausea.