Objective To explore the effects of nurse-physician collaboration model on anxiety, depression and quality of life (QOL) of patients undergoing concurrent chemo-radiotherapy. Methods A total of 180 eligible patients from December 2013 to December 2014 were randomly divided into study group (n=96) and control group (n=84). The patients of study group received nurse-physician collaboration nursing, while the patients of control group received routine nursing. The self-rating anxiety scale (SAS), self-rating depression scale (SDS) and European organization for research and treatment of cancer quality of life questionnaire-3.0 (EORTC QLQ-C30) were used to investigate the differences between groups before and after intervention. Results Anxiety and depression in study group were better than those in control group after treatment, and the difference was statistically significant (P<0.05). Overall health, emotional function, social function, cognitive function, role function, pain, insomnia and breathing difficulties were better in study group than those in control group after treatment (P<0.05). Conclusions Nurse-physician collaboration model can improve the anxiety, depression and QOL of patients receiving chemoradiotherapy. Key words: Anxiety; Depression; Quality of life; Nurse-physician collaboration model; Chemo-radiotherapy