The majority of NLCs are managed autonomously by nurses, with the assistance of a multidisciplinary team with advanced training and expertise. In these clinics, nurses perform thorough physiological assessments, arrange the patient's care accordingly, administer therapies, monitor the patient's condition, administer medication, educate patients about their health, and refer patients to other colleagues as needed. The purpose of this systematic study was to determine the extent, viability, and cost-effectiveness of nurse-led clinics. The review's goal is to give the best available data on nurse-led clinics so that it may assess if adopting NLCs with a standardized structure is necessary to deliver rigorous treatment and support future attempts to establish nurse-led clinical services. A literature search was conducted using electronic databases such as Medline, Pubmed, Pubmed Central, CINAHL, and Google Scholar to gather information on the impact of Nurse-Led Clinics with respect to scope, feasibility, and cost effectiveness. The search was conducted in accordance with the preferred reporting items for systematic reviews and meta-analyses (PRISMA) guidelines. Two standards were used to evaluate the 117 articles that were found in the search results. First, papers that have been published and are readily available for peer review should be considered substantial information. Second, studies that focused just on the effects of NLC in respect to scope, practicability, and affordability. Studies on the breadth, viability, and cost-effectiveness of NLC were included in the search, whereas research publications published in languages other than English were disregarded. Following screening and the removal of duplicates, 13 papers were found to be eligible, and 10 studies were included in this review. The analysis indicates that access to healthcare has improved dramatically in nurse-led clinics across many specialized areas. Because NLCs are easily accessible, primary care settings are not as burdened and fewer needless emergency visits occur. Strong patient-provider relationships are fostered by nurses' all-encompassing, patient-centered approaches, which raise patient satisfaction and engagement in the healthcare process. The focus of effective nurse-led clinics is on interprofessional treatment and teamwork. Cooperation amongst nurses, doctors, pharmacists, and other medical professionals promotes collaborative decision-making, coordinated treatment, and better patient outcomes. The collaborative model, in which nurses play a crucial role as care coordinators, guarantees that patients receive thorough and seamless care.