Orifice injector plates are widely used in hybrid rocket motors (HRM), but little work has been done on the influences of their design parameters on combustion performances of HRM. The effects of orifice diameter, injection pressure drop and orifices distribution of the orifice injector plate on combustion efficiency of HRM are investigated by experimental and numerical methods in this paper. The hydrogen peroxide (H2O2) and hydroxyl terminated polybutadiene (HTPB) with tube grain are selected as propellant. Firstly, 5 kinds of orifice injector plates with different orifice diameter and orifices distribution are designed, and 7 fire experiments are carried out. The experimental results show that the combustion efficiency of HRM increases with the decrease of orifice diameter and injection pressure drop. Moreover, the combustion efficiency of motor with plat using single-ring distribution is the highest, while the one using three-ring distribution is the lowest. Secondly, 36 orifice injector plates with different design parameters are calculated by three-dimensional numerical simulation of two-phase flow. The liquid oxidizer evaporation, solid-gas interaction, gaseous phase combustion, and turbulence are considered in the simulation model. The conclusions draw from simulation results agree with the experimental data, which illustrates the validity of numerical simulation model. The conclusions based on experimental and numerical results can provide guidance for designing high-performance orifice injector plate in HRMs.