The thermal and velocity profiles of various nanofluid systems on a rotating disk are simulated. Finite difference method, the orthogonal collocation method, and the differential quadrature method (DQM) of numerical approaches are used to solve the governing equations and are compared to determine the faster and more accurate solution procedure. Five nanoparticles Al, Al2O3, Cu, CuO, and TiO2 solved in three base fluids water, ethylene glycol, and engine oil are considered to be used on the disk at different volume fractions. A new general algorithm is presented for solving equations of a rotating‐disk problem quickly and accurately and it is found that the DQM method is the best approach for this numerical simulation. Heat transfer performance of a rotating disk would be much better enhanced with water based Al nanofluid. A wide range of results for different base–fluid combinations with nanoparticles is presented with untransformed 3D results and effects of the variation of different parameters provides comprehensive insight and prevents inaccurate deductions.