OCCUPATIONAL APPLICATIONS The application of ergonomics principles can reduce the number, severity, and costs of work-related musculoskeletal disorders. Increasingly, academic and practitioner research demonstrates that ergonomic improvements also contribute to manufacturing operating efficiency and a company's profitability. This article examines whether it is possible to identify business benefits achieved through ergonomics interventions via an ergonomics award process. The projects, conducted independently at numerous manufacturing locations and submitted to a global company's internal ergonomics award process, were reviewed for effect upon both work-related musculoskeletal disorders and operational efficiency. The results suggest the award process was successful in gathering relevant information about the projects, and that a macroergonomics program methodology along with a participatory approach supported successful results. A cost-benefit estimation showed positive effects in operational efficiency and work-related musculoskeletal disorders reduction. Possible improvements to the award submission process were identified.TECHNICAL ABSTRACT Background: As documented by academics and practitioners, and generally accepted by the popular media, application of ergonomics principles can reduce the number, severity, and costs of work-related musculoskeletal disorders. Research increasingly demonstrates that ergonomic improvements also contribute to manufacturing operating efficiency and a company's profitability. Purpose: To expand the body of practitioner-based knowledge related to the benefits that may be realized through implementing an ergonomics program in industry, focusing on the physical aspects of work. Specifically considered is the importance of a macroergonomic, company-wide process to define how risk assessments are conducted, how interventions are chosen and measured, and how results are summarized. Method: Eighteen case studies, selected from among 166 submitted to a global manufacturing company's internal ergonomics award process were reviewed. Results: A macroergonomics program methodology, in combination with a participatory approach, supported success in terms of reduced work-related musculoskeletal disorder risk and operational efficiency. Specifically, information about how projects were identified and who participated as team members demonstrates the importance of a participatory approach to achieve positive results. Conclusion: The case study results, based upon a practitioner perspective, suggest that operational efficiency and work-related musculoskeletal disorder reduction are often both improved by ergonomic interventions in the workplace, which is consistent with similar findings in earlier research. However, requiring more specific and standardized cost and benefit information in an award submission process is likely to provide more complete information about project results in a manner of value to practitioners, academia, and business. A future challenge is to gain more specific information in a manner that does not significantly add to the workload of individuals leading the projects who, in these case studies, have many responsibilities beyond ergonomics. A collaborative effort between practitioners and researchers to create and test such a method would be of value to both.