This paper systematically reviews the geomorphological and geochronological evidence of the last glacial cycle (∼115-11.7 ka) south of 52°S in southernmost Patagonia. We review the extent and timing of glaciation, compile geochronometric data from published studies into an open-access database and present an updated empirical reconstruction of ice-sheet evolution. The extent and timing of the local Last Glacial Maximum is ambiguous and we review the data that indicate that the local Last Glacial Maximum occurred during Marine Isotope Stage (MIS) 3/MIS 4 versus during MIS 2 at the time of the global Last Glacial Maximum. These contrasting scenarios differ by ∼100 km in lateral ice extent and 10s of thousands of years in timing, implying drastically different past environmental conditions, and therefore drivers. All of the major ice lobes were extensive until at least 18 ka and the onset of deglaciation occurred at ∼18-17 ka. The southernmost Patagonian Ice Sheet rapidly collapsed to the Fuegian fjords in <1000 years, likely due to the lower altitude of the Andes in this region, lower slopes of the glacier surfaces and through ice calving within the deep fjords into which the ice sheet retreated. During the Antarctic Cold Reversal (∼14.7-13 ka), glaciers readvanced only a few kilometres, restricted to the Fuegian fjords, and not ∼100 km to a ‘Stage E’ moraine, as previously hypothesised. This review highlights the disparity of dating constraints across southernmost Patagonia and suggests possible approaches for further study. More work is required to understand and resolve the discrepancy in the geochronological data and to determine a robust empirical reconstruction for the maximum last glacial extent in southernmost Patagonia, which is imperative for making climate inferences and comparing to numerical ice-sheet models.