The ultra-low permeability, thin layer and low abundance GLN area is developed by waterinjection with horizontal and straight combined well pattern. With the extension of development time, the water appears in multiple sections and directions in horizontal Wells, and the well area gradually enters the stage of medium and high water cut, which shows the characteristics of rising when water is injected, falling when liquid is stopped, and limiting the profile control pressure in multiple rounds of Wells. Therefore, developing the “note when mining, mining without note” asynchronous injection-production adjustment of horizontal well technology, make full use of the artificial fracture of high permeability channel and matrix suction effect between low permeable formation permeability, increase the crack near the matrix suction swept volume, to achieve the purpose of the horizontal well steady liquid water control, up to the level of the special low permeability thin layer low abundance wellblock improve recovery factor. Through the mechanism of injection-production, the use of pore throat boundaries, the respect such as injection-production timing and parameter optimization research, combined with the reservoir numerical simulation and theoretical formula, conduct asynchronous injection-production field practice, improved the development effect of horizontal well, and have achieved good economic benefits, for the next class of reservoir level wellblock middle and high water cut stage to explore a new way of governance.