Number Of Pt Research Articles

Translationally controlled tumor protein interacts with TaCIPK23 to positively regulate wheat resistance to Puccinia triticina.

Hypersensitive response-programmed cell death (HR-PCD) regulated by Ca2+ signal is considered the major regulator of resistance against Puccinia triticina (Pt.) infection in wheat. In this study, the bread wheat variety Thatcher and its near-isogenic line with the leaf rust resistance locus Lr26 were infected with the Pt. race 260 to obtain the compatible and incompatible combinations, respectively. The expression of translationally controlled tumor protein (TaTCTP) was upregulated upon infection with Pt., through a Ca2+-dependent mechanism in the incompatible combination. The knockdown of TaTCTP markedly increased the area of dying cell and the number of Pt. haustorial mother cells (HMCs) at the infection sites, whereas plants overexpressing the gene exhibited enhanced resistance. The interaction between TaTCTP and calcineurin B-like protein-interacting protein kinase 23 (TaCIPK23) was also investigated, and the interaction was found occurred in the endoplasmic reticulum. TaCIPK23 phosphorylated TaTCTP in vitro. The expression of a phospho-mimic TaTCTP mutant in Nicotiana benthamiana promoted HR-like cell death. Silencing TaCIPK23 or TaCIPK23/TaTCTP co-silencing resulted in the same results as silencing TaTCTP. This suggested that TaTCTP is a novel phosphorylation target of TaCIPK23, and both participate in the resistance of wheat to Pt. in the same pathway.

Confined Pt and M (M = Fe, Co) nanoparticles on NC with ultralow Pt loading for oxygen reduction reaction

In this work, we have prepared Pt and M nanoparticles on nitrogen-doped carbon catalysts (Pt&M/NC, M = Fe, Co) with an ultralow Pt loading (<3 wt%) from room reduction of Pt and 3d transition metals by sodium borohydride on NC, where NC is firstly from pyrolysis of carbon black together with melamine. In Pt&M/NC (M = Fe, Co), Pt and 3d transition metals are in the individual nanoparticles with the size < 2 nm, where M is conducive to create the spatial confinement effect to anchor Pt nanoparticles. Meanwhile, Pt&M/NC (M = Fe, Co) has more internal defects than those of Pt/NC and M/NC. Owing to the synergistic effect of Pt and M together with NC, electrochemical results show that Pt&Co/NC has the ORR peak potential and half wave potential of 0.863 and 0.840 V vs. RHE, respectively, where they are 0.848 and 0.827 V vs. RHE for Pt&Fe/NC, more positive than that of Pt/NC. The average electron transfer number of Pt&M/NC (M = Fe, Co) is more than 3.8, close to the four-electron transfer way. This work provides a new method to reduce Pt use for ORR catalysts.

Synthesis, spectroscopic, DFT, anticancer evaluation and enzyme inhibition studies of platinum(II) complexes with 1-methyl-1H-1,2,3,4-tetrazole-5-thiol and phosphine ligands: Crystal structure of [Pt(mtzt)2(dppe)]

A number of Pt(II) complexes of 1-methyl-1H-1,2,3,4-tetrazole-5-thiol (Hmtzt) with phosphine ligands have been prepared and characterized and then evaluated as potential anti-cancer and ALP enzyme inhibitor agents. The complex [Pt(mtzt)2]2 was prepared by the reaction of 1-methyl-H1-tetrazole-5-thiol (Hmtzt) with K2PtCl4. This complex was treated with equivalent molar amounts of diphosphine ligands to afford complexes of the type [Pt(mtzt)2(PPh2(CH2)nPPh2)] in good yield, {PPh2(CH2)nPPh2, where n = 1 (dppm), n = 2 (dppe), n = 3 (dppp), n = 4 (dppb) and (PPh2((C5H4)2Fe)PPh2) (dppf)}. The prepared complexes were characterized by elemental analysis, IR, 1H-{31P} and 31P-{1H} NMR spectroscopy. The resulting data suggested that the prepared complexes were mononuclear with chelating diphosphines while the mtzt ligands were monodentate coordinating via the sulfur atom to give a square planner arrangement around the Pt(II) ion. This was confirmed by a single crystal structural analysis of the [Pt(mtzt)2(dppe)] complex. The Pt(II) complexes underwent structural optimization through the utilization of the DMol3 tool within the material studio package. A comparison of the results of molecular modelling with those of the X-ray structural analysis indicated that the structures were almost identical. The free ligand and two selected complexes were tested for inhibition activity against an alkaline phosphatase (ALP) enzyme, which was found to be active inhibitors, and the inhibition rate (37–88 %) range. Furthermore, the anticancer activity of the complexes (1, 3, and 6) was tested against human liver cancer (HepG2). The results showed that the prepared complexes have moderate activity but are lower than cis-platin. Complex 1 has the highest activity with an IC50 of 34.78 ± 1.75 M against the HepG2 cell line..

120 A Review of Certified Burn Therapist’s Involvement in JBCR

Abstract Introduction Burn therapist certification (BT-C) was introduced in 2018 to recognize therapists with specialized skill in burn rehabilitation and promote quality burn therapy. There are currently 32 BT-Cs, representing a small fraction of therapists who rehabilitate burn patients. Barriers to certification described in a Letter to the Editor by O’Neil in 2022 included an indifference to therapy research and program development. Despite efforts to call for additional support of therapy advancement and research, therapist publications continue to be sparse. This review analyzed BT-C therapists involved in publications as one indicator of a positive impact on the field. Methods A review of therapist-authored manuscripts and abstracts published in the Journal of Burn Care and Research from 2018-2022 was performed. Therapy authored publications included any manuscript or abstract with a therapist listed as a lead or contributing author. Publications with only SLP, PTA, or OTA credentials were excluded. Therapists were only considered to be certified if they had achieved BT-C at the time of publication. Results BT-C make up not more than 15% of therapists practicing in burns, yet the percentage of therapy-authored manuscripts published from 2018-2022 with a BT-C credited author is 50%. When examining supplemental editions, 31% of accepted therapy-authored submissions from 2018-2022 included a BT-C therapist. The table compares the percentage of therapy-authored manuscripts and therapy-authored submissions from BT-C versus the percentage of BT-C using the 215 identified PT and OT members from 2008 as a conservative estimate of the floor of the number of PT and OT providing routine burn care, with the current count of BT-C at 32. Conclusions Estimations of the number of PT and OT working in burn rehabilitation are difficult to determine. It is assured that therapists providing care to burn patients routinely are larger in number than those who are active members in the American Burn Association in any given year. One publication revealed 215 active PT and OT members in 2008. Despite BT-C therapists making up a small percentage of the therapy community working in burn rehabilitation, BT-C therapists contributed to half of therapy publications and almost a third of abstract submissions in each area respectively, indicating that certified burn therapists have a profound, and disproportionately large, impact on formal investigation and research. Applicability of Research to Practice Currently there is a lack of objective information that can be presented to administrators to validate support of the burn therapist certification. Supporting certification may promote quality care through involvement in research furthering best practice.

Abstract WP68: Rehabilitation Therapy Doses Are Low After Stroke And Predicted By Clinical Factors

Background: Stroke is a leading cause of disability. Greater rehabilitation therapy after stroke improves functional outcomes but is often not provided. This study examined amount of rehabilitation therapy during the first year after stroke in the U.S. and identified factors that predict rehabilitation therapy dose. Methods: Adults with new radiologically confirmed stroke were enrolled in the STRONG Study 2-10 days after stroke onset at 28 acute care hospitals in the U.S. Following initial assessment during acute hospitalization, the number of PT, OT, and ST sessions was measured at 3-, 6-, and 12-months post-stroke. The 3-month visit included a live exam. Negative binomial regression was used to investigate relationships that clinical and demographic factors had with therapy dose. False discovery rate was used to correct for multiple comparisons. Results: Of 763 patients enrolled during the acute stroke admission, 510 were seen for follow-up. Rehabilitation therapy doses were overall low, with most therapy delivered within the first 3 months; 35.0% of patients received no PT; 48.8%, no OT, and 61.7%, no ST. Discharge destination was significantly related to cumulative therapy; the percentage of patients discharged to an inpatient rehabilitation facility varied from 0-71%. Most demographic factors did not predict therapy dose, though Hispanic patients received lower cumulative amounts of PT and OT. Acutely, severity of clinical factors (grip strength, NIHSS score, and NIHSS subscores for aphasia and neglect) predicted higher subsequent therapy doses. At 3 months post-stroke, measures of impairment and function (FM-UE, mRS, and SIS-ADL) predicted further therapy doses. ConclusionS: Rehabilitative therapy doses during the first year of stroke recovery are low in the U.S. Patients with more severe deficits receive higher doses. Multiple factors, particularly clinical measures assessed as early as acute stroke admission, predict rehabilitation doses. These findings suggest directions to address this unmet need.

Pengaruh Limbah Cair terhadap Kualitas Air dan Penyakit yang Timbul di Masyarakat Kelurahan Sei. Merbau Kecamatan Teluk Nibung Kota Tanjungbalai

&#x0D; &#x0D; Water is a source of life for the community and is a basic need that is used by the community every day for their daily needs. However, due to the increasingly dense population and the number of PT in Sei Merbau Village, Teluk Nibung District, the water is polluted by Liquid Waste. And people in Sei Merbau Village, Teluk Nibung District, feel the impact of the water such as water that is not suitable for consumption and the emergence of various diseases. This study aims to find out how the effect of liquid waste on water quality and diseases that arise in the community in Sei Village. Merbau, Teluk Nibung District. The research method used is descriptive qualitative research method in which data collection is carried out using interviews and field observations of 10 respondents aged between 25 - 40 years. The results of this study indicate that liquid waste causes changes in water quality and causes various skin diseases to occur in the community in Sei Village. Merbau, Teluk Nibung District.&#x0D; Keywords: Water, Liquid Waste, Society, Disease and Sei Merbau

Atomically Precise Platinum Carbonyl Nanoclusters: Synthesis, Total Structure, and Electrochemical Investigation of [Pt27(CO)31]4- Displaying a Defective Structure.

The molecular Pt nanocluster [Pt27(CO)31]4– (14–) was obtained by thermal decomposition of [Pt15(CO)30]2– in tetrahydrofuran under a H2 atmosphere. The reaction of 14– with increasing amounts of HBF4·Et2O afforded the previously reported [Pt26(CO)32]2– (32–) and [Pt26(CO)32]− (3–). The new nanocluster 14– was characterized by IR and UV–visible spectroscopy, single-crystal X-ray diffraction, direct-current superconducting quantum interference device magnetometry, cyclic voltammetry, IR spectroelectrochemistry (IR SEC), and electrochemical impedance spectroscopy. The cluster displays a cubic-close-packed Pt27 framework generated by the overlapping of four ABCA layers, composed of 3, 7, 11, and 6 atoms, respectively, that encapsulates a fully interstitial Pt4 tetrahedron. One Pt atom is missing within layer 3, and this defect (vacancy) generates local deformations within layers 2 and 3. These local deformations tend to repair the defect (missing atom) and increase the number of Pt–Pt bonding contacts, minimizing the total energy. The cluster 14– is perfectly diamagnetic and displays a rich electrochemical behavior. Indeed, six different oxidation states have been characterized by IR SEC, unraveling the series of 1n– (n = 3–8) isostructural nanoclusters. Computational studies have been carried out to further support the interpretation of the experimental data.

An effective method of applying octahedral Pt-Ni/C to membrane electrode assembly and related in-situ X-ray absorption fine structures study

To further promote the commercialization of fuel cells, it is essential to develop high-performance catalysts and apply them to the membrane electrode assembly (MEA). Here, the octahedral Pt-Ni/C is successfully used in MEA by a double-layer structure to obtain a higher performance than commercial Pt/C. The design of double-layer catalyst layer structure effectively hinders the diffusion of non-noble metals and improves the durability of MEA. Meanwhile, the catalytic and failure mechanism in proton-exchange membrane fuel cells (PEMFCs) is also directly reflected by the in-situ X-ray absorption fine structure (XAFS) for the first time. Compared to commercial Pt/C, the addition of Ni can effectively protect Pt by significantly reducing the valence change of Pt. Besides, the variation of coordination number of Pt in the Pt-Ni/C is smaller than that in Pt/C when the potential rises. This proves that the synergistic effect between different metals can improve the stability of Pt and reduce the adsorption capacity of oxygen on the surface of Pt atoms. It can provide a theoretical reference for putting the shape-controlled catalysts into practical application in the future.

Proposed Business Strategy to Increase the Number of Customers for a Conveyor Belt Company

PT. XYZ is a company that provides conveyor belt needs for its clients with an office location in Central Java. PT. XYZ is currently getting a profit that is deemed not high enough for its shareholders even though it has established business relationships with leading companies. Some of the causes that make the low profit are the lack of a number of clients to work with, the limited company resources, and the high cost of packaging goods. This research will focus on the problem of the lack of a number of PT. XYZ's customers. Using the Five (5) Whys method, it was found the root cause analysis of the PT. XYZ is because of the number of industrial areas surrounding company is currently not much. Solutions that can be done in overcoming these problems are to apply market strategies such as market expansion, market development, diversification, or product development. In solving these problems, the SWOT Analysis method and research studies of previous studies are used. The results showed that market expansion was the chosen solution. This research approach can be used by companies that have similar problems.

Early Physical and Occupational Therapy and Discharge Disposition in Patients with Sepsis

<h3>Research Objectives</h3> To explore whether implementing an early mobility protocol conducted by professionals from PT and or occupational therapy (OT) is associated with discharge location for a group of patients with sepsis, septic shock, or severe sepsis. <h3>Design</h3> A quasi-experimental study design was used with a non-equivalent post-test design. The data were collected for 3 months. <h3>Setting</h3> Mid-sized Midwestern hospital. <h3>Participants</h3> The population of the usual care group were 117 adult patients admitted to any unit with a diagnosis of sepsis, septic shock, or severe sepsis from February 1, 2019, through April 30, 2019. The early rehabilitation group were 96 patients admitted May 6, 2019 through July 31, 2019. <h3>Interventions</h3> The usual care group received PT and OT when an order was received from the hospital medicine provider. The experimental group were treated with PT and OT per an early rehabilitation protocol. <h3>Main Outcome Measures</h3> The dependent variables were number of PT and OT visits and discharge disposition. <h3>Results</h3> There was no statistically significant (p < 0.05) difference found between the groups for PT treatments (t(131) = -0.307, p = 0.760) nor for the OT treatments (t (104) = 0.925, p = 0.357). The mean number of PT and OT visits in each group were approximately the same as well (PT visits 3.86, SD = 3.83 vs. 4.05 visits, SD = 3.302; OT visits, 3.85, SD = 3.764 vs. 3.25, SD = 2.855; Table 2). The data demonstrated that the patients who received PT and OT were significantly more likely to be discharged to home/home health care (p = 0.029 for PT, p = 0.047 for OT) rather than to inpatient healthcare services (See Table 3). <h3>Conclusions</h3> This study demonstrates that the inclusion of PT and OT treatment in the care of patients with sepsis-related illness admitted to the hospital may influence their discharge disposition. The majority of the patients in this study were able to discharge to home. <h3>Author(s) Disclosures</h3> The author, Karen Clark, does not have any conflicts of interest in regards to this study.

Adult patient perceptions on the effectiveness of scoliosis specific exercises.

There is a paucity of research focusing on adults with scoliosis, yet many of these individuals suffer from pain and disability. Recent literature has demonstrated that for this patient population general physical therapy is no better than other non-operative treatment options.[1-3] This study assessed the perceptions of the effectiveness of Physiotherapeutic Scoliosis Specific Exercises (PSSE) on adult scoliosis. The purpose of this study is to present the results of a retrospective analysis of how adults with scoliosis perceive that physical therapy utilizing PSSE has impacted their quality of life (QoL), function, and pain. A 10 question survey was sent via a secure server (Qualtrics) to all PSSE participating patients ≥ 18 years old from one PSSE specialty clinic from the beginning of the PSSE program, 7 years. Survey responses were anonymous, collected by someone other than the primary investigator, and statistics were calculated with SPSS 24 (IBM Corp., Armonk, NY). Results: Fifty-seven adults (88.9% female) responded to the survey (55% response rate) with 67.2% being over the age of 55 years. The majority (61.9%) felt that PT had moderately or significantly positively impacted their QoL. The most common number of PT visits ranged from 5-10, after which 71.9% of participants were either somewhat or very confident in their ability to perform their PSSE program unsupervised at home. The most common frequency of home exercise program (HEP) performance was 1-2 times per week (46.0%) for a duration of 5-40 minutes. Quantitative analysis of exercise adherence using a Spearman's rho (rs) revealed positive associations between confidence in correctly performing the HEP with the perceived positive impact of the exercises (rs = .45, p < .001), the greater frequency of performing the HEP (rs = .30, p = .024) and greater time performing the HEP (rs = .33, p = .004). This retrospective analysis showed that 61.9% of adults with scoliosis felt that PT utilizing PSSE had moderately or significantly positively impacted their QoL. Adherence to a HEP is critical to the success of the program. Greater confidence in correctly performing the HEP was positively correlated with perceived impact, frequency and time spent exercising. The sample was limited to adults from one clinic that specializes in scoliosis and may not be generalizable to other clinics.

Structure–Property Relationships of Pt–Sn Nanoparticles Supported on Al2O3 for the Dehydrogenation of Methylcyclohexane

The structure–catalytic property relationships of Al2O3-supported Pt–Sn nanoparticles (Pt–Sn/Al2O3) in the dehydrogenation of methylcyclohexane (MCH) were investigated by varying the Sn/Pt ratios of the catalysts. The initial activity and the deactivation rate of the Pt–Sn/Al2O3 catalysts in the MCH dehydrogenation decreased in line with an increase in the Sn/Pt ratio from 0 to 3. The Pt–Sn/Al2O3 catalyst with a Sn/Pt ratio of 2 showed good activity, durability, and toluene selectivity in the MCH dehydrogenation among the series of catalysts. The dispersion of Pt in the Pt–Sn/Al2O3 catalysts was observed to decrease with an increase in the Sn/Pt ratio. Structural changes in the catalysts from Pt–Sn clusters to intermetallic Pt3Sn and PtSn nanoparticles were also observed using scanning transmission electron microscopy and X-ray diffraction. According to structural analysis using X-ray absorption fine-structure spectroscopy and infrared spectroscopy using carbon monoxide as a probe, the electron density of Pt increased, and the fraction of Pt–Pt adjacent sites decreased with an increase in the Sn/Pt ratio. Comparing the catalytic properties and the structures of the Pt–Sn/Al2O3 catalysts, their initial activities were correlated with the dispersion of Pt. In addition, the durability and selectivity of the catalysts were enhanced due to an increase in the electron density of Pt and a decrease in the number of Pt–Pt adjacent sites. Overall, the properties of the catalysts in the MCH dehydrogenation are determined by the local structure of Pt atoms rather than the crystal structure of the Pt–Sn alloy nanoparticles on Al2O3.

Electrochemical Reduction of CO2 Using Carbon-Based Materials Modified with 3d-Metal Atoms As Electrocatalysts

For the reductive CO2 fixation using solar energy, photo-generated electrons and/or holes must be captured and utilized for chemical reactions that generate products beneficial to humans. To construct the artificial photosynthesis systems, electron transfer catalysts designed to promote electrochemical CO2 reduction reactions (CO2RR) are a critical requirement. Previous studies have shown that precise tuning of adsorption energies of key intermediates is critical for obtaining high activity and reaction selectivity. There are two important factors that determine the adsorption energy of the intermediate on electrocatalysts. First, the metal species in the catalyst, i.e., the transition metals at the active sites with a higher number of d-electrons, tend to reduce the adsorption energy. Previous works have investigated the effects of metal species on the CO2RR using organometallic complexes as platforms to support various metals via coordination bonds. For example, cobalt-modified tetraphenylporphyrin (TPP) is known to exhibit efficient CO2RR activity due to its proper binding strength to COOH*, whereas nickel (Ni) and copper (Cu) modified TPP are known to have low catalytic activity due to the low binding energy of COOH*. The second critical factor is the coordination structure of the metal. First-principles calculations have revealed that a decrease in the coordination number of Pt and Cu in the bulk increases the bond strength of CO* and affects the activity of the CO2RR. Thus, it can be expected that the coordination number can be a control parameter to improve the performance of metal species that were previously thought to have no CO2RR activity. We have investigated the effects of metal species and the coordination structure on CO2RR using graphene and covalent triazine frameworks (CTF)[1,2]. CTF consisting of microporous conjugated polymers with 1,3,5-triazine linker units, are suitable for investigating the above issue due to the high design flexibility. Through the studies, we have revealed that Ni-modified graphene and CTF can work as efficient electrocatalysts for CO2RR due to the unsaturation nature of the Ni atoms on the substrate. In this talk, we report our systematic studies on CO2RR using carbon-based materials with 3d metal atoms, focusing on the effects of metal species and coordination structures.[1] P. Su, K. Iwase, S. Nakanishi, K. Hashimoto, K. Kamiya, Small, 12, 6083-6089 (2016).[2] P. Su, K. Iwase, T. Harada, K. Kamiya, S. Nakanishi, Chem. Sci., 9, 3941-3947 (2018). Figure 1

Regulating Electronic Status of Platinum Nanoparticles by Metal–Organic Frameworks for Selective Catalysis

Selective hydrogenation of alkynes to alkenes remains challenging in the field of catalysis due to the ease of over-hydrogenated of alkynes to alkanes. Favorably, the incorporation of metal nanopar...

Insight into the Effect of the Continuous Testing and Aging on the so2 Sensing Characteristics of a YSZ (Yttria-stabilized Zirconia)-Based Sensor Utilizing ZnGa2O4 and Pt Electrodes

Insight into the Effect of the Continuous Testing and Aging on the so2 Sensing Characteristics of a YSZ (Yttria-stabilized Zirconia)-Based Sensor Utilizing ZnGa2O4 and Pt Electrodes

Web-Based Self-Directed Exercise Program Is Cost-Effective Compared to Formal Physical Therapy After Primary Total Knee Arthroplasty

BackgroundWeb-based physical therapy (WBPT) is a potential means to reduce costs following total knee arthroplasty (TKA). Although outcomes data support the use of self-directed therapy after TKA, there is a paucity of literature evaluating its cost-effectiveness. This study aimed to determine utilization trends of either outpatient physical therapy (OPPT) or WBPT after TKA, assess the outcomes of patients based on their use of WBPT, OPPT, or both, and evaluate OPPT costs based on the amount of WBPT used. MethodsA retrospective review of 701 patients (731 TKAs) was performed. Patients were given a prescription for OPPT and access to a self-directed WBPT program. Functional scores were obtained preoperatively and 6 months postoperatively, and the rate of manipulation under anesthesia (MUA), range of motion, and PT costs were recorded. ResultsAbout 49.8% of patients utilized WBPT, 34.7% of patients utilized WBPT and OPPT, and 23% of patients utilized neither source of therapy. Patients that utilized both WBPT and OPPT demonstrated the lowest rates of MUA. There were no differences in postoperative outcomes based on the number of WBPT logins. Overall, PT cost was 3.4× higher for those that underwent MUA. Subgroup analysis of patients that utilized WBPT revealed that the cost and number of PT visits decreased as the number of logins increased. Patients younger than 65 utilized more WBPT and OPPT while demonstrating worse outcomes (lower Knee Injury and Osteoarthritis Outcome Score for Joint Replacement postoperative scores and more MUAs). ConclusionWBPT can be an effective option to offset costs associated with OPPT, without compromising outcomes.

Revealing Sintering Kinetics of MoS2-Supported Metal Nanocatalysts in Atmospheric Gas Environments via Operando Transmission Electron Microscopy.

The decoration of two-dimensional (2D) substrates with nanoparticles (NPs) serve as heterostructures for various catalysis applications. Deep understanding of catalyst degradation mechanisms during service conditions is crucial to improve the catalyst durability. Herein, we studied the sintering behavior of Pt and bimetallic Au-core Pt-shell (Au@Pt core-shell) NPs on MoS2 supports at high temperatures under vacuum, nitrogen (N2), hydrogen (H2), and air environments by in situ gas-cell transmission electron microscopy (TEM). The key observations are summarized as effect of environment: while particle migration and coalescence (PMC) was the main mechanism that led to Pt and Au@Pt NPs degradation under vacuum, N2, and H2 environments, the degradation of MoS2 substrate was prominent under exposure to air at high temperatures. Pt NPs were less stable in H2 environment when compared with the Pt NPs under vacuum or N2, due to Pt-H interactions that weakened the adhesion of Pt on MoS2. Effect of NP composition: under H2, the stability of Au@Pt NPs was higher in comparison to Pt NPs. This is because H2 promotes the alloying of Pt-Au, thus reducing the number of Pt at the surface (reducing H2 interactions) and increasing Pt atoms in contact with MoS2. Effect of NP size: The alloying effect promoted by H2 was more pronounced in small size Au@Pt NPs resulting in their higher sintering resistance in comparison to large size Au@Pt NPs and similar size Pt NPs. The present work provides key insights into the parameters affecting the catalyst degradation mechanisms on 2D supports.

A coassembled peptide hydrogel boosts the radiosensitization of cisplatin.

We constructed a novel supramolecular hydrogel by carrying out a coassembly of cisplatin and short naproxen-capped peptides. This procedure boosted the radiosensitization effect of cisplatin by increasing the number of Pt-DNA adducts, arresting the cell cycle, and inhibiting cyclooxygenase-2.

Tuning of interfacial perpendicular magnetic anisotropy and domain structures in magnetic thin film multilayers

We investigate the magnetic domain structures and the perpendicular magnetic anisotropy (PMA) arising in CoFeB films interfaced with selected heavy metal (HM) layers with large spin Hall angles in HM/CoFeB/MgO (HM = W, Pt, Pd, WxTa1−x) stacks as a function of CoFeB thickness and composition for both as-deposited and annealed materials stacks. The coercivity and the anisotropy fields of annealed material stacks are higher than for the as-deposited stacks due to crystallisation of the ferromagnetic layer. Generally a critical thickness of MgO > 1 nm provides adequate oxide formation at the top interface as a requirement for the generation of PMA. We demonstrate that in stacks with Pt as the HM, the PMA depends crucially on the alloy composition of the ferromagnet requiring a Co rich alloy to achieve PMA, i.e. it is important to have a large number of Pt–Co hybrid bonds at the interface compared to Pt–Fe hybrid bonds. In Pd/CoFeB/MgO layers, we observe for appropriate PMA a special stripe domain configuration that also includes circular skyrmion-like spin structures. Three different means of selective tuning of the PMA are discussed apart from the conventional FM thickness variation: Changing the number of repetitions of a multilayer stack is shown to change the PMA and strong PMA is found for certain compositions of WxTa1−x that also result in very low coercive fields (<1 mT) of the CoFeB. The PMA has also been shown to be tuned via annealing, very strong anisotropy fields of up to 1 T and low pinning of domain structures were measured in W/CoFeB/MgO, making these multilayers stacks a promising candidate for MRAM development.

Reporting of patient (pt) characteristics (c) and use of stratification factors (SF) in phase III trials for metastatic colorectal cancer (mCRC): Urgent need for standardization.

e15055 Background: An increasing number of pt and tumor c have predictive and prognostic implications in mCRC. However, there is no consensus on their reporting in trial results. Methods: Pt c and SF from 136 phase III trials of systemic therapies (Rx) in mCRC published between 1988 and 2018 (68,326 pts) were collected. Trials were also grouped per publication date (G1: 1988-97; G2: 98 – 2007; G3: 08-18). Patterns of reporting and trends across G were evaluated. Results: Pt c consistently reported were performance status, PS (98.5%), age (92.6%) and gender (90.4%); race (20.6%) &amp; weight/BMI/BSA were not (13.2%). Tumor c frequently reported were metastatic (met) spread (70.6%) while time intervals related to disease course (25%) and synchronous met vs not (19.1%) were omitted. Of note, primary site was largely reported as colon vs rectum (69%) and sidedness or anatomical location was discernable only in 10.3%. Prior Rx reporting focused on chemo (58.5%) with radiation and surgery and reported in 34% &amp; 28.7%. Reporting of prognostic factors was variable and limited: histology grade CEA, alk phos, LDH (range 10.3-15.4%). Only 11.8% of trials reported genomic factors - KRAS MT was included in all with BRAF MT in 4.4%. Of 140 trials used for SF analysis, 115 had ≥ 1 (range 1-7). Common SF were PS (60%), geography /institution (55.7%). Prior Rx (27%), met spread (24.3%) were sometimes used while primary site (7.8%), genomic factors (6.1%) rarely were. Trends across G are per Table. Conclusions: There is marked inconsistency in pt c &amp; SF reporting in mCRC trials. Consensus guidelines will aid in standardization of trial interpretation and future meta-analyses; and will need to be updated based on emerging data. [Table: see text]