Flat grooved heat pipes (HPs) have become essential in advanced thermal management solutions across various engineering applications. Modeling these devices, especially multichannel flat grooved HPs, involves significant challenges due to complex phenomena such as phase-change heat transfer and free-surface flow, requiring substantial computational resources, time and expertise. These constraints often limit the full exploration and optimization of HPs’ potential in diverse applications. To address this gap, an accelerated 3D computational fluid dynamics (CFD) modeling approach is presented in this study. This novel method begins with a detailed 3D modeling of a single groove, developed using kinetic theory and facilitated by CFD software. The results from this model are then applied as boundary conditions to simulate the entire HP in a multichannel configuration. The importance of this methodology is further highlighted by the alignment of simulation results with experimental observations. The approach significantly enhances computational efficiency by reducing the number of iterations by 10% and computational time by 80%, resulting in a five-fold speed-up. The methodology enables accelerated, comprehensive modeling of multichannel variations and delivers critical insights for optimizing the design of multichannel flat grooved HPs for various engineering applications.