The application of computer devices equipped with video monitors both in clinical practice and human vision research has become widespread. These devices offer great advantages over other traditional methodologies (such as printed tests) because they facilitate the variation of the experimental parameters or the design of new psychophysical experiences. The aim of this paper is to determine the degree to which spatial inhomogeneity affects the generation of sinusoidal gratings on a video display. Knowing this degree of tolerance will enable us to determine the minimum demands that can be made on the graphic board and the video screens for their implementation in assessing contrast sensitivity in clinical practice. The importance of contrast deviation—due to sampling and discrete number of gray levels—exceeds that of spatial inhomogeneities. Therefore, correct stimulus generation should not be expressed in location space but in frequency space, as then we will ensure both the stimulus spatial frequency and contrast.