In order to study the failure characteristics and mechanism of red clay slope under dry-wet cycling conditions, a model slope similar to engineering slope was established. The test slope was monitored by testing elements, and the variation laws of moisture content, temperature, pore water pressure, soil pressure and displacement were analyzed respectively under the alternating conditions of dry-wet cycling. The failure characteristics and mechanism of slope are obtained. With the increase of dry-wet cycles, the overall water content of slope increases, pore water pressure decreases, lateral displacement increases, and vertical displacement remains unchanged to a certain extent. After five dry-wet cycles, the water content of the top and top of the slope is the largest, the water content of the bottom and foot of the slope is the smallest, the horizontal displacement of the slope is the largest, and the horizontal displacement of the top of the slope is the smallest. The range of temperature change increases with the number of dry-wet cycles, and tends to be stable after the third dry-wet cycle. The earth pressure is the largest at the top of the slope, followed by the foot of the slope and the smallest at the slope surface, and the first two dry-wet cycles have the greatest impact on the earth pressure. In the process of dry-wet cycling, the surface cracks of slope undergo the cyclic process of cracking, healing and re-cracking. The width and depth of cracks increase gradually. The surface failure characteristics represented by gully weathering and spalling gradually change into shallow failure characteristics represented by collapse and slump.