Number Of Detected Photons Research Articles

Emerging Synthetic Bioluminescent Reactions for Non-Invasive Imaging of Freely Moving Animals.

Bioluminescence imaging (BLI) is an indispensable technique for visualizing the dynamics of diverse biological processes in mammalian animal models, including cancer, viral infections, and immune responses. However, a critical scientific challenge remains: non-invasively visualizing homeostatic and disease mechanisms in freely moving animals to understand the molecular basis of exercises, social behavior, and other phenomena. Classical BLI relies on prolonged camera exposure to accumulate the limited number of photons that traveled from deep tissues in anesthetized or constrained animals. Recent advancements in synthetic bioluminescence reactions, utilizing artificial luciferin-luciferase pairs, have considerably increased the number of detectable photons from deep tissues, facilitating high-speed BLI to capture moving objects. In this review, I provide an overview of emerging synthetic bioluminescence reactions that enable the non-invasive imaging of freely moving animals. This approach holds the potential to uncover unique physiological processes that are inaccessible with current methodologies.

Construction of a Nearly Unbiased Statistical Estimator of Sinogram to Address CT Number Bias Issues in Low-Dose Photon Counting CT.

Photon counting detector (PCD)-CT has demonstrated promise to reduce ionizing radiation exposure further and improve spatial resolution. However, when the radiation exposure or the detector pixel size is reduced, image noise is elevated, and the CT number becomes more inaccurate. This exposure level-dependent CT number inaccuracy is referred to as statistical bias. The issue of CT number statistical bias is rooted in the stochastic nature of the detected photon number, N, and a log transformation used to generate the sinogram projection data. Due to the nonlinear nature of the log transform, the statistical mean of the log-transformed data is different from the desired sinogram, the log transform of the statistical mean of N. Consequently, when a single instance of N is measured, as in clinical imaging, the log-transform leads to an inaccurate sinogram and statistically biased CT numbers after reconstruction. This work presents a nearly unbiased and closed-form statistical estimator of sinogram as a simple yet highly effective method to address the statistical bias issue in PCD-CT. Experimental results validated that the proposed approach addresses the CT number bias problem and improves the quantification accuracy of both non-spectral and spectral PCD-CT images. Additionally, the process can slightly reduce noise without adaptive filtering or iterative reconstruction.

Ultra-high-precision detection of single microwave photons based on a hybrid system between a Majorana zero mode and a quantum dot

The ability to detect single photons has become increasingly essential due to the rise of photon-based quantum computing. In this theoretical work, we propose a system consisting of a quantum dot (QD) side-coupled to a superconducting nanowire. The coupling opens a gap in both the QD mode and the Majorana zero mode (MZM) at the nanowire edge, enabling photon absorption in the system. We show that the absorbed photoelectron decays via rapid (subnanosecond to nanosecond) nonradiative heat transfer to the nanowire phonon modes rather than by spontaneous emission. Furthermore, we calculate the temperature increase and associated resistance increase induced by the absorption of a photon for a given appropriate set of material and environmental parameters, yielding a temperature increase in the millikelvin range and a resistance increase in the kiloohm range, vastly exceeding the photon-absorption-induced temperature and resistance increases for competing 2D-3D hybrid systems by 5 and 9 orders of magnitude, respectively. Last, we determine the detector efficiency and discuss the system density required for deterministic photon number measurement, demonstrating that a photon absorption probability of over 99.9 percent can be achieved for an integrated system consisting of an array of nanowire-QD complexes on-chip inside a cavity. Our results thus provide a basis for a deterministic microwave photon number detector with an unprecedented photon-number-detection resolution.

Thin-Film-Based Multifunctional System for Optical Detection and Thermal Treatment of Biological Samples.

In this work, we present a multifunctional Lab-on-Chip (LoC) platform based on hydrogenated amorphous silicon sensors suitable for a wide range of application in the fields of biochemical and food quality control analysis. The proposed system includes a LoC fabricated on a 5 cm × 5 cm glass substrate and a set of electronic boards for controlling the LoC functionalities. The presented Lab-on-Chip comprises light and temperature sensors, a thin film resistor acting as a heating source, and an optional thin film interferential filter suitable for fluorescence analysis. The developed electronics allows to control the thin film heater, a light source for fluorescence and absorption measurements, and the photosensors to acquire luminescent signals. All these modules are enclosed in a black metal box ensuring the portability of the whole platform. System performances have been evaluated in terms of sensor optical performances and thermal control achievements. For optical sensors, we have found a minimum number of detectable photons of 8 × 104 s-1·cm-2 at room temperature, 1.6 × 106 s-1·cm-2 in presence of fluorescence excitation source, and 2.4 × 106 s-1·cm-2 at 90 °C. From a thermal management point of view, we have obtained heating and cooling rates both equal to 2.2 °C/s, and a temperature sensor sensitivity of about 3 mV/°C even in presence of light. The achieved performances demonstrate the possibility to simultaneously use all integrated sensors and actuators, making promising the presented platform for a wide range of application fields.

Multicopy observables for the detection of optically nonclassical states

Distinguishing quantum states that admit a classical counterpart from those that exhibit nonclassicality has long been a central issue in quantum optics. Finding an implementable criterion certifying optical nonclassicality (i.e, the incompatibility with a statistical mixture of coherent states) is of major importance as it often is a prerequisite to quantum information processes. A hierarchy of conditions for detecting whether a quantum state exhibits optical nonclassicality can be written based on some matrices of moments of the optical field [Phys. Rev. A 72, 043808 (2005)]. Here, we design optical nonclassicality observables that act on several replicas of a quantum state and whose expectation value coincides with the determinant of these matrices, hence providing witnesses of optical nonclassicality that overcome the need for state tomography. These multicopy observables are used to construct a family of physically implementable schemes involving linear optical operations and photon number detectors.

Detecting entanglement between modes of light

We consider a subgroup of unitary transformations on a mode of light induced by a Mach-Zehnder Interferometer and an algebra of observables describing a photon-number detector preceded by the interferometer. We explore the uncertainty principles between such observables and their usefulness in performing a Bell-like experiment to show the violation of the Clauser-Horne-Shimony-Holt (CHSH) inequality under the physical assumption that the detector distinguishes between only zero photons and a nonzero number of photons. We show the local settings of the interferometer which lead to a maximal violation of the CHSH inequality.

Single-photon sources based on asymmetric spatial multiplexing with optimized inputs

We develop a statistical theory describing the operation of multiplexed single-photon sources equipped with photon-number-resolving detectors that includes the potential use of different input mean photon numbers in each of the multiplexed units. This theory accounts for all relevant loss mechanisms and allows for the maximization of the single-photon probabilities under realistic conditions by optimizing the different input mean photon numbers unit-wise and the detection strategy that can be defined in terms of actual detected photon numbers. We apply this novel description to analyze periodic single-photon sources based on asymmetric spatial multiplexing realized with general asymmetric routers. We show that optimizing the different input mean photon numbers results in maximal single-photon probabilities higher than those achieved by using optimal identical input mean photon numbers in this setup. We identify the parameter ranges of the system for which the enhancement in the single-photon probability for the various detection strategies is relevant. An additional advantage of the unit-wise optimization of the input mean photon numbers is that it can result in the decrease of the optimal system size needed to maximize the single-photon probability. We find that the highest single-photon probability that our scheme can achieve in principle when realized with state-of-the-art bulk optical elements is 0.935. This is the highest one to our knowledge that has been reported thus far in the literature for experimentally realizable single-photon sources.

Efficient Backcasting Search for Optical Quantum State Synthesis.

Non-Gaussian states are essential for many optical quantum technologies. The so-called optical quantum state synthesizer (OQSS), consisting of Gaussian input states, linear optics, and photon-number resolving detectors, is a promising method for non-Gaussian state preparation. However, an inevitable and crucial problem is the complexity of the numerical simulation of the state preparation on a classical computer. This problem makes it very challenging to generate important non-Gaussian states required for advanced quantum information processing. Thus, an efficient method to design OQSS circuits is highly desirable. To circumvent the problem, we offer a scheme employing a backcasting approach, where the circuit of OQSS is divided into some sublayers, and we simulate the OQSS backwards from final to first layers. Moreover, our results show that the detected photon number by each detector is at most 2, which can significantly reduce the requirements for the photon-number resolving detector. By virtue of the potential for the preparation of a wide variety of non-Gaussian states, the proposed OQSS can be a key ingredient in general optical quantum information processing.

Amplification of optical Schrödinger cat states with an implementation protocol based on a frequency comb

We proposed and analyzed a scheme to generate large-size Schr\"odinger cat states based on linear operations of Fock states, squeezed vacuum states, and conditional measurements. By conducting conditional measurements via photon number detectors, two unbalanced small-amplitude Schr\"odinger kitten states combined by a beam splitter can be amplified to a large-size cat state with the same parity. According to simulation results, two Schr\"odinger odd kitten states with amplitudes of $|\ensuremath{\beta}|=1.06$ and $|\ensuremath{\beta}|=1.11$ generated from one-photon-subtracted 3 dB squeezed vacuum states, are amplified to an odd cat state of $|\ensuremath{\beta}|=1.73$ with a fidelity of $F=99%$. A large-size Schr\"odinger odd cat state with $|\ensuremath{\beta}|=2.51$ and $F=97.30%$ is predicted when 5.91 dB squeezed vacuum states are employed. According to the analysis on the impacts of experimental imperfections in practice, Schr\"odinger odd cat states of $|\ensuremath{\beta}|>2$ are available. A feasible configuration based on a quantum frequency comb is developed to realize the large-size cat state generation scheme we proposed.

Quantum statistics of Schrödinger cat states prepared by logical gate with non-Gaussian resource state

A measurement-induced continuous-variable logical gate is able to prepare Schrödinger cat states if the gate uses a non-Gaussian resource state, such as cubic phase state (I.V. Sokolov (2020) [21]). Our scheme provides an alternative to hybrid circuits which use photon subtraction and (or) Fock resource states and photon number detectors. We reveal the conditions under which the gate conditionally prepares quantum superposition of two undistorted “copies” of an arbitrary input state that occupies a finite area in phase space. A detailed analysis of the fidelity between the gate output state and high-quality Schrödinger cat state is performed. A clear interpretation of the output state quantum statistics in terms of Wigner function in dependence on the gate parameters and measurement outcome is presented for a representative set of input Fock states.

Microwave photon number resolving detector using the topological surface state of superconducting cadmium arsenide

The authors propose a microwave photon number detector with single-photon resolution using cadmium arsenide at low temperature, with the graphene-like surface state acting as the absorber and the superconducting bulk as the bolometer.

Superconducting Nanowire Photon-Number-Resolving Detectors Integrated with Current Reservoirs

Photon-number-resolving detectors (PNRDs) play pivotal roles in many quantum-photonic applications; and intrinsic and multiplexed PNRDs have been reported previously. However, for intrinsic PNRDs, the maximum resolvable photon number is limited to a few photons; for the multiplexed PNRDs, the fidelity generally decreases when the to-be-resolved photon number becomes large. Here, to resolve more photons with high fidelity, we report on combined PNRDs, based on a spatial multiplexing configuration of multiple elements, each capable of resolving a few photons. After setting up a model and calculating the fidelity, we propose a possible physical system to realize the combined PNRDs. The proposed detectors are based on the superconducting nanowire multiphoton detectors integrated with current reservoirs that we recently reported, but are designed and configured into PNRDs. Specifically, information about the detected photon numbers is stored in the format of the supercurrent in the current reservoir and then readout by an integrated yTron. We present in detail the operating principle and show a design that can resolve up to 11 photons with high fidelity.

Retrieval of multiple scattering contrast from x-ray analyzer-based imaging* *Project supported by the National Natural Science Foundation of China (Grant Nos. 11475170, U1532113, and 11905041) and the Fundamental Research Funds for the Central Universities, China (Grant No. PA2020GDKC0024).

We present a moment-based alternative approach to retrieve multiple scattering contrasts from x-ray analyzer-based imaging. By use of the properties of moments of convolutions, the multiple-image radiography approach is theoretically validated. Furthermore, higher order moments of the object scattering distribution, inaccessible in multiple-image radiography, are simultaneously provided by this alternative approach. It is experimentally demonstrated that the skew and kurtosis information related to the distribution of sub-pixel features within the object can be obtained from those complementary contrasts. Finally, the sensitivity of the retrieved multiple scattering contrasts is investigated experimentally. The finding that the sensitivity is inversely proportional to the square root of the detected photon number essentially indicates that the retrieval of moments with an order higher than two can be achieved without increasing exposure time or dose. The presented alternative approach provides an access to the exploitation of multiple scattering contrasts, which is expected to be useful in biomedical research, materials science, security screening, etc.

Contrast resolution of few-photon detectors

We investigate the minimum acquisition time, expressed as the number of image frames, and the minimum number of absorbed photons per pixel required to achieve a predefined contrast resolution in a monochromatic, pixelated image acquisition system at low light intensities (from well below one photon, to several hundred photons per pixel and frame). Primarily we compare systems based on the pixels of the photon-number-resolving (PNR) type of detectors and detectors that discriminate, in a binary fashion, between zero and non-zero photon numbers (so-called click detectors). We find that our model can seamlessly interpolate between the two. We also model detectors with intrinsic PNR capabilities and integrating detectors with a simple saturation model, derive the probability of errors in assigning the correct intensity (or ‘gray level’) and finally discuss how the estimated levels, which need to be based on threshold levels due to the stochastic nature of the detected photon number, should be assigned. Overall, we find that non-ideal PNR-detector-based systems offer advantages even over ideal click-detector-based systems when the incident mean photon number is sufficiently large, which is guaranteed to occur around ten photons per pixel and frame.

Optimization of multiplexed single-photon sources operated with photon-number-resolving detectors

Detectors inherently capable of resolving photon numbers have undergone a significant development recently, and this is expected to affect multiplexed periodic single-photon sources where such detectors can find their applications. We analyze various spatially and time-multiplexed periodic single-photon source arrangements with photon-number-resolving detectors, partly to identify the cases when they outperform those with threshold detectors. We develop a full statistical description of these arrangements in order to optimize such systems with respect to maximal single-photon probability, taking into account all relevant loss mechanisms. The model is suitable for the description of all spatial and time multiplexing schemes. Our detailed analysis of symmetric spatial multiplexing identifies a particular range of loss parameters in which the use of the new type of detectors leads to an improvement. Photon number resolution opens an additional possibility for optimizing the system in that the heralding strategy can be defined in terms of actual detected photon numbers. Our results show that this kind of optimization opens an additional parameter range of improved efficiency. Moreover, this higher efficiency can be achieved by using less multiplexed units, i.e., smaller system size as compared to threshold-detector schemes. We also extend our investigation to certain time-multiplexed schemes of actual experimental relevance. We find that the highest single-photon probability is 0.907 that can be achieved by binary bulk time multiplexers using photon-number-resolving detectors.

Photonic-Crystal Scintillators: Molding the Flow of Light to Enhance X-Ray and γ-Ray Detection.

Scintillators are central for detection of γ-ray, x-ray, and high energy particles in various applications, all seeking higher scintillation yield and rate. However, these are limited by the intrinsic isotropy of spontaneous emission of the scintillation light and its inefficient outcoupling. We propose a new design methodology for scintillators that exploits the Purcell effect to enhance their light emission. As examples, we show 1D photonic crystals from scintillator materials that achieve directional emission and fivefold enhancement in the number of detectable photons per excitation.

Benchmarking photon number resolving detectors.

Photon number resolving detectors are the ultimate measurement of quantum optics, which is the reason why developing the technology is getting significant attention in recent years. With this arises the question of how to evaluate the performance of the detectors. We suggest that performance of a photon number detector can be evaluated by comparing it to a multiplex of on-off detectors in a practical scenario: conditional preparation of a photon number state. Here, both the quality of the prepared state and the probability of the preparation are limited by the number of on-off detectors in the multiplex, which allows us to set benchmarks that can be achieved or surpassed by the photon number resolving detectors.

Injection Locking and Parametric Locking in a Superconducting Circuit

When a signal is injected in a parametric oscillator close enough to its resonance, the oscillator frequency and phase get locked to those of the injected signal. Here, we demonstrate two frequency locking schemes using a Josephson mixer in the parametric down-conversion regime, pumped beyond the parametric oscillation threshold. The circuit then emits radiation out of two spectraly and spatially separated resonators at frequencies determined by the locking schemes that we choose. When we inject the signal close to a resonance, it locks the oscillator emission to the signal frequency by injection locking. When we inject the signal close to the difference of resonances, it locks the oscillator emission by parametric locking. We compare both schemes and investigate the dependence of the parametric locking range on the pump and the injection signal power. Our results can be interpreted using Adler's theory for lasers, which makes a new link between laser physics and superconducting circuits that could enable better understanding of pumped circuits for quantum information applications such as error correction, circulators and photon number detectors.

Optimized MPGD-based Photon Detectors for high momentum particle identification at the Electron-Ion Collider

Particle IDentification (PID) is a central requirement of the experiments at the future EIC. Hadron PID at high momenta by RICH techniques requires the use of low density gaseous radiators, where the challenge is the limited length of the radiator region available at a collider experiment. By selecting a photon wavelength range in the far UV domain, around 120 nm, the number of detectable photons can be increased. Ideal sensors are gaseous Photon Detectors (PD) with CsI photocathode, where the status of the art is represented by the MPGD-based PDs at COMPASS RICH. Detector optimization is required for the application at EIC. Here we report about a dedicated prototype where the sensor pad-size has been reduced to preserve the angular resolution. A new DAQ system based on the SRS readout electronics has been developed for the laboratory and test beam studies of the prototype.

Limits to remote molecular detection via coherent anti-Stokes raman spectroscopy using a maximal coherence control technique

ABSTRACTThe demand for remote molecular detection has been rising in recent years. The technique of coherent anti-Stokes Raman spectroscopy (CARS) has become one of the most optimal methods due to its high efficiency, fast response time and ease of use. In this article, we estimate the number of detectable photons from a CARS signal by using a semiclassical nonlinear optics approach. Several key parameters and their effect on the signal are studied in the following discussion. We also provide a method to prepare the maximum coherence between vibrational states in an effective two level system.