The purpose of this study was to identify longitudinal heterogeneous trajectories of sleep status, adjusted for the effect of pain over time, among patients who had surgery forlung cancerand to quantify how disturbed sleep in the hospital affects functional recovery after discharge. We included patients from a surgical cohort (CN-PRO-Lung 1). All patients reported symptoms using the MD Anderson Symptom Inventory-Lung Cancer (MDASI-LC) daily during postoperative hospitalization. Group-based dual trajectory modeling was used to investigate trajectories of disturbed sleep and pain during the first 7days of postoperative hospitalization. Cox regression was used to compare the recovery of walking ability between the different sleep trajectories. Among 421 patients, disturbed sleep trajectories comprised low (31%),moderate (52%), and high (17%) groups. The surgical approach and number of chest tubes were associated with pain, and the number of chest tubes was also associated with sleep disturbances (OR = 1.99; 95% CI: 1.08-3.67). Recovery of walking ability after discharge was significantly slower in the high (median days = 16; 95% CI: 5-NA) and moderate disturbed sleep trajectory groups (median days = 5; 95%CI: 4-6) than in the low group (median days = 3; 95% CI: 3-4). Changes in disturbed sleep among patients withlung cancer followed three distinct trajectories over the first 7days of hospitalization after surgery. Dual trajectory analyses highlighted the high concordance between specific trajectories of disturbed sleep and pain. Patients at high sleep disturbance and high levels ofpain may benefit from appropriate interventions for both symptoms in combination with the patient's surgical approach and the number of chest tubes.
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