Number Of Centenarians Research Articles

GETTING BETTER OR GETTING WORSE: MARKERS OF LONGEVITY ACROSS COHORTS AND COUNTRIES

Abstract The expansion of life expectancy and the lengthening of the human life span are extraordinary achievements observed over the last century. Among those accomplishments is the increasing number of centenarians in many countries. However, it is not clear whether new cohorts of centenarians are in better health when compared to earlier born cohorts of centenarians. The purpose of this symposium is to compare centenarian cohorts across different countries. Two centenarian cohorts each from Hong Kong, Japan, and the United States are included in the analyses. Results provide different perspectives across countries. The Hong Kong Centenarian Studies compared current centenarians to those who participated at an earlier time and noted that proxies in the second study rated centenarians in worse health when compared to centenarian self-ratings. The Kyotango study assessed living conditions, care need level, ADL, IADL, and cognitive function by gender and noted cognitive improvement for men. Finally, later cohorts of the U.S. Health and Retirement Study were in worse health when compared to the earlier born cohort. The results provide an indication for policy makers and practitioners who will prepare for a larger number of centenarians in need of additional support. Although some improvement for later born cohorts is noticeable, it is obvious that more care provision will also be needed as centenarians around the world will survive with more health conditions. Additional research should evaluate centenarians in other parts of the world.

IMPROVING COGNITIVE FUNCTION IN THE NEW COHORT—BUT ONLY FOR MEN. FINDINGS FROM THE KYOTANGO CENTENARIAN STUDY

Abstract The Kyotango Centenarian Cohort Study was established with the aim of tracing long-term changes in the overall functioning of centenarians. This study started in 2014 in Kyotango City. Since then, new centenarians and those who were expected to be 100 years old the following April were invited to the study every year in September. Eligible centenarians were invited by the city, and centenarians and their families agreed to participate to answer questions either by mail or face-to-face interviews, according to their preference. For the non-participants, anonymized living conditions and care need levels were provided by the city. The number of centenarian candidates varied by year (24-55). However, the number of woman centenarians had increased through the 8-year surveyed period (31 and 42 for women, 10 and 9 for men in 2014 and 2021). On average, every year 40 new centenarians were invited and 80% of them participated in the survey. Among the functional variables, cognitive function was estimated by proxies, which had a high correlation with MMSE. No clear improving trend for nursing care level in Japanese long-term care insurance, as measured by activities of daily living and cognitive function rating, was observed. Meanwhile, an improving trend for cognitive function was observed among men but not among women. This might be caused by the gender difference in the survival ratio that frail women were more likely to survive. Future research should investigate possible reasons for a cohort improvement in Japanese centenarian men, and cognitive intervention programs should particularly target women.

WHO ARE THE PORTUGUESE WHO REACH 100 YEARS OF AGE? A DEMOGRAPHIC ANALYSIS USING 2021 CENSUS DATA

Abstract Portugal is considered one of the oldest countries of Europe as a conjugation of low birth rates and high life expectancy. The age group of 100+ is one of the fastest growing, with 270 centenarians in 1990 to 1961 centenarians in 2020 (Teixeira et al., 2020). In this study we present the profile of centenarians based on real data of the last Portuguese Census 2021. There are 2801 centenarians, showing a significant increase in relation to the previous censuses (589 centenarians in 2001, and 1526 centenarians in 2011). Most centenarians are women (82.0%), widowed (84.6%), attended school (61.0%), have social pension as main income source (96.3%), are catholic (93.9%) and were born in Portugal (98.6%). The average number of reported difficulties in vision, hearing, mobility, self-care, memory/concentration, and communication is of 5.12, meaning that the current cohort of centenarians face high constrains in their daily living and most probably depend on any sort of care support. Overall, Portugal follows the longevity phenomenon of a growing number of centenarians as verified in USA, Japan, and other European countries (United Nations, 2022). Profiling centenarians’ main characteristics with reliable data is a starting point for outlining the specific social, medical, and financial needs of those reaching very advanced ages, and for defining government policies and age-sensitive interventions.

HEALTH PROFILE OF PORTUGUESE CENTENARIANS FROM 2011 TO 2021: AN UPDATE BASED ON NATIONAL CENSUS

Abstract According to the Portuguese National Census, the number of centenarians increased from 1526 (82.1% women) in 2011 to 2801 (82.0% women) in 2021. Along with a description of main sociodemographic characteristics, this paper provides an updated health profile of this population based on their perceived difficulties in six functional domains of basic actions (seeing, hearing, walking, cognition, self-care, and communication) as assessed by a set of questions developed by the Washington Group on Disability Statistics that is consistent with the International Classification of Functioning, Disability, and Health (ICF). Sex differences are also presented, as well as comparisons between data from Census 2011 and Census 2021. Most centenarians show major constraints in their mobility and personal care (76.3% cannot/have great difficulties in walking/climbing stairs, and 72.8% cannot/have great difficulties in bathing/dressing), and a better outcome is reported in communication (64.2% report no/reduced difficulty for understanding/being understood). This profile globally follows the pattern observed in 2011, but with fewer centenarians reporting such level of difficulties. The percentage of centenarians reporting no/reduced difficulties in seeing and hearing increased from 32.6% and 27.7% in 2011, to 54.4% and 44.8% in 2021, respectively. In both censuses, women presented a higher percentage of difficulties in all health-related variables. Globally, this comparative perspective shows improvements in the perceived health profile of the later born cohort of Portuguese centenarians and features the continued need for addressing gender-specific and gender-sensitive interventions that acknowledge older women’s care needs.

Centenary Personality: Are There Psychological Resources that Distinguish Centenarians?

The number of centenarians is increasing year by year. Considering that happier people are likely to live longer, we asked ourselves whether healthy centenarians share psychological resources or positive personality characteristics that have enabled them to face traumatic situations and the challenges life more successfully. To our knowledge this is an issue that has not been sufficiently researched. Mixed methodology was applied. Qualitative Study 1: Nineteen centenarians participated between 100 and 107 years old of which 16 were women. Semi-structured, in-depth interviews about their life story were done. Quantitative Study 2: The purpose was to control the results of Study 1. Fifteen proxies for the centenarians participated. Results: In Study 1, 35 psychological resources were identified, of which 19 were central or identifying resources of the centenarians, and 16 peripheral or the product of individual differences. The central resources were grouped into six categories: vitality, taking pleasure in interaction, commitment, control, intellectually motivated and positivity, with resilience and intelligence added. The results in Study 2 were completely concordant. In conclusion, analysis of the lives of healthy centenarians provides us with knowledge that could help in achieving a healthy old age. Additionally, the study opens up new lines of research.

ДОЛГОЖИТЕЛИ В ДЕМОГРАФИЧЕСКОЙ СТРУКТУРЕ НАСЕЛЕНИЯ РОССИИ

The subject of the study is a cohort of the Russian population aged 90+ (centenarians). The purpose of the work is to conduct a theoretical study of the place of the cohort of centenarians in the demographic structure of the country's population. The relevance of the study is due to the fact that longevity is still a fairly rare phenomenon, attracting the attention of many specialists. The iden- tification of its determining factors remains an important medical, social, and state problem. Today there is no universal answer to the question "what determines the level of longevity?". In light of the search for an answer to it, it is necessary at least to give an accurate picture of longevity in Russia, both on the national scale and in the context of its regions. The scientific novelty consists in identifying the level of longevity in Russia and the spatial pattern of the spread of this phenomenon on the territory of the country. The statistical data of the Federal State Statistics Service, as well as analytical publications in periodicals, served as the information base of the study. The research methods include general logical, analytical, statistical, and cartographic methods. To measure the level of longevity, such indicators were used (including calculated) as the absolute number of centenarians (persons aged 90+); the proportion of centenarians (aged 90+) in the total population; the index of longevity or longevity for groups aged 90+. In the course of the study, the authors obtained the following results: indicators of the level of longevity in Russia and in its regions were determined. In order to visualize the obtained regional data, their mapping was carried out. Factors influencing spatial differences in the level of longevity in the country have been identified. The authors conclude about the positive dynamics of the longevity level of the population of Russia in 1990-2021. Among the macro-regions of Russia, the Central Federal District is the leader in terms of the absolute number of cen tenarians, their share in the total population, and the value of the longevity index. The Far Eastern Federal District is an outsider according to these parameters. At the same time, the territories that in Russia are traditionally considered “hotbeds” of longevity – the North Caucasus and Siberia – do not show high values of longevity indicators. Outsider regions in terms of the longevity of the population are mainly “areas of new development”.

SWISS CENTENARIANS: PRELIMINARY FINDINGS FROM THE SWISS100 PHONE STUDY

Abstract Increase in very old individuals is observed in all developed countries around the world. The number of centenarians has also been rising, requiring the investigation of the characteristics of these exceptionally long-lived individuals as well as their experience of life at age 100. In the present study, we present findings from the first nation-wide Swiss centenarian study SWISS100. Given the ongoing COVID-19 pandemic, we conducted a telephone study with centenarians and a family member as proxy informant, using a mixed-methods approach to investigate specific characteristics, their life circumstances and their experience during the pandemic. Recruitment was conducted with the help of the national address registry. A total of 64 centenarians and 62 family members participated, leading to data for 119 centenarians. Centenarians were on average 102 years old, with a range of 100 to 108 years. In line with higher survival rates in females, 76% were women and 24% were men. Most centenarians had received basic education and had completed an apprenticeship. Concerning their residence, 43% lived in private homes and 57% lived in institutions. Of those living in private, half lived alone, one fourth lived with their spouse and one fourth lived with a child. The majority was widowed. Over 80% had children. Although over 70% of the centenarians reported health restrictions, 60% reported good to excellent subjective health. Over 90% of the sample were aware of COVID-19. Despite substantial COVID-19-related restrictions, life-satisfaction was high. Overall, Swiss centenarians show health-related vulnerability but also psychological resilience.

1365 Analysis of Outcomes Pre- and Post-Physiotherapy Protocol for Centenarian Patients Presenting with Neck of Femur Fractures

Abstract Aim The number of centenarians has quadrupled over the last 2 decades with an increase in the number presenting with proximal femur fractures. Very little is known about mortality and morbidity in this age group. There is a subjective assumption that they are too frail and may not do well with surgery. This audit aims to outline improved outcomes of surgery in centenarian patients with NOF fractures following dedicated modified physiotherapy intervention. Method Data reviewing centenarian NOF outcomes over a two-year period (2015-2016) was compared with outcomes following a dedicated post-operative physiotherapy trust protocol for centenarian NOF patients. 16 patients (15 female, 1 male) from Jan 2017- August 2019 were identified. Data was analysed for patient demographics, surgical details including anaesthesia, post-operative complications, physiotherapy outcomes and mortality. Results 10 patients had dynamic hip screws and 6 patients had hemiarthroplasties. Inpatient mortality was 0% compared to previous audit of 8.3%. The average length of stay had reduced from 23.3 days in previous audit to 18.5 days in current. 82% of patients could transfer with frame in the post-operative period. Conclusions Positive surgical outcomes are demonstrated even in centenarians particularly when given tailored post-operative physiotherapy with reduced length of stay, mortality, and high levels of physiotherapy compliance. Comparisons with younger elderly patients will help guide future management.

What do we learn from the clinical and biological evaluation of the oral cavity in centenarians?

The number of centenarians is rapidly increasing worldwide and so are the studies on this segment of the population. A general consensus in the literature is that healthy longevity is an outcome of multiple factors, but the interrelationship between good oral health and healthy aging remains not fully understood. As part of the “CaT: Centenari a Trieste” study, a population-based cohort study set in Trieste, Italy, we report here the results of subjective self-reported oral health parameters and objective clinical and biological oral variables and their association with cognitive impairment in 25 centenarians enrolled in the study from September 2017 to May 2019. Oral health-related variables were recorded by means of a self-evaluation questionnaire and a comprehensive oral examination of teeth, prostheses and mucosae conducted by a trained dentist. In addition, 6-n-propylthiouracil (PROP) taste perception and salivary oxidative stress markers, specifically the Total Oxidative Status and Ferric Reducing Ability of Saliva, were measured. Finally, the oral data obtained were compared with the presence or absence of dementia in the enrolled subjects. The centenarians included in our study were generally satisfied with their oral health. Among the causes of discomfort, the most prevalent were difficulties in chewing and biting, with few subjects describing a correlation between their oral health and psycho-social issues. We evaluated possible relations of clinical and biological variables to the likelihood of being demented and did not find significant associations. We found a higher though not statistically significant mean salivary flow and antioxidant capacity of saliva in non-demented subjects. When evaluating the PROP taste perception profile, we found a higher proportion of supertasters compared with previous studies and different taste perception profiles according to dementia. Despite the relatively small number of participants, we believe that our study contributes to a better understanding of the clinical and biological profile of the oral cavity in subjects aged over 100 years, encouraging the inclusion of a comprehensive evaluation of the oral cavity in centenarian studies performed worldwide.

Aging and the hypothalamic-pituitary-thyroid axis.

The world's population is increasingly aging, this noted particularly in the Western world where there are ever greater numbers of centenarians and those over 85 years. Given the immense importance of the thyroid gland for optimal health and the fact that morphological and functional changes in the hypothalamic-pituitary-thyroid (HPT) axis take place as a natural adaptation to the aging process, a clear distinction must be made in older individuals between these and the onset of disease. However, this is problematic since, frequently, subtle differences exist between them, making diagnosis a challenging task, especially as concerns subclinical disease. The newly emerging interdisciplinary field of geroscience offers the prospect of being used as a platform to investigate the effect of disrupted HPT function on functional capacity and cognitive ability among the aged, as well as the risk or onset of age-associated diseases, thus enhancing healthspan and lifespan. Because optimal functioning of the thyroid gland is a prerequisite for longevity as well as for mental and physical wellbeing, this review summarizes the recent scientific data regarding HPT and aging while discussing alternative and personalized treatment approaches to maintaining a healthy thyroid as a means to ensuring a long, active, and healthy life.

A comparison of general versus regional anesthesia in patients over 100 years old: A retrospective cohort study

Aim: As the life expectancy maintains to rise, the number of centenarians applied for surgery is increasing. Functional and anatomical changes in elderly patients may cause postoperative morbidity and mortality. The aim of this retrospective cohort study is to analyze and compare general and regional anesthesia in centenarians underwent different surgeries. Material and Methods: Patients aged over 100 years (American Society of Anesthesiology scores of II–IV) were included in our study. The centenarians were divided into two study groups: general anesthesia (Group GA, n=20) and regional anesthesia (Group RA, n=18). The demographic characteristics, procedure, and hospital data were evaluated. Results: There were no significant differences betveen two groups with regards to gender, height, weight, body mass index, ASA scores, perioperative colloid and crystalloid fluid consumptions. Duration of anesthesia and procedure in Group RA was shorter than that in Group GA. The requirement for invasive arterial monitorization, central venous catheterisation, and nasogastric tube in Group GA was higher than that in Group RA. Postoperative delirium was similar in both groups. Heart rate, mean arterial pressure, and peripheral oxygen saturation were similar. In-hospitality mortality was 26.3% in the entire group of centenarians. Conclusions: This study examined the role of different anesthetic methods in extremely elderly patients over 100 years old during different surgeries. Anesthetic agent preferences, long duration of anesthesia and surgery, and hemodynamic instability can cause serious complications. We therefore conclude that careful considerations are required in extremely elderly patients.

Implications of Exceeding the Age and Interventions to Extend Life Purpose: Perspectives From Asian Centenarians

Centenarians have often been regarded as living paradigms of exceptional longevity yet little is known from their perspective about the purpose, meaning and quality of living longer lives. In Singapore, the number of centenarians has multiplied 30-fold from 50 in 1990 to about 1500 in 2020. Although centenarians are respected as ‘national treasures’ – having witnessed Singapore’s transformation from British colony to global city state, their needs remain invisible in both the healthcare and social sectors. The tendency to romanticize exceptional longevity neglects a deeper understanding of (i) its consequence on the oldest old (85+ years) who may be impacted by severe functional and sensory deficits and (ii) their experience of social isolation in the family and communities. This paper discusses findings based on interviews with 15 Singapore centenarians (100 to 111 years old) and their family carers. Diverse experiences of longevity are shaped by these factors: health status; personal disposition; strength of family and social networks; exposure to adversity and coping resources; spiritual beliefs; role loss; and changes in the lived environment. Appropriate health and psychosocial interventions could have been delivered earlier in the life trajectory to enable better quality of life and continued social engagement. Learning from the challenges (eg. social withdrawal; extensive functional and sensory losses) of existing centenarians contributes to a more precise understanding of how best to harness the productive capacities of our oldest old.

Caregiving adult children's perceptions of challenges relating to the end of life of their centenarian parents.

The number of centenarians in Europe is increasing; many face health impairments. Adult children often play a key role in their care, but there is a lack of research into what it means for these caregiving relatives to be confronted for many years with their parents' end of life (EOL), dying and death as well as their own advancing age. This study aims to analyse the challenges of caregiving adult children regarding their parents' end of life and the related burdens and barriers they report. Semi-structured interviews were conducted with 13 caregivers following a theory-based and tested guideline. The computer-aided coding and evaluation followed the structured content analysis approach. The analysis showed three main themes: 'Confronting EOL', 'Communicating about death and dying' and 'Assisting in the terminal phase'. The respondents commented on burdensome demands and concerns about the future. Further, a strong underlying presence of intra- and interpersonal conflicts relating to EOL became apparent. The results indicate several potential burdens for centenarians' caregiving offspring. They are confronted with a double challenge resulting from the combination of their own advanced age and experiencing the burdens of their parents' very old age. Further, some participants struggled with their own unclear perspective on the future because of the relative but unclear proximity of the parent's death. Multiple conflicts and overlapping conflict dimensions emphasise the potential of the EOL topic to influence the well-being of family caregivers and care recipients. The convenience sample used for the study may cause limitations, for example, the fact that persons with a formally lower educational status are not represented. The findings suggest that interventions designed for family-related care situations should include topics like 'Finiteness and grief', 'Communicating about dying and death' and 'Decisions and dispositions at EOL'.

Immunosenescence is both functional/adaptive and dysfunctional/maladaptive.

Alterations in the immune system with aging are considered to underlie many age-related diseases. However, many elderly individuals remain healthy until even a very advanced age. There is also an increase in numbers of centenarians and their apparent fitness. We should therefore change our unilaterally detrimental consideration of age-related immune changes. Recent data taking into consideration the immunobiography concept may allow for meaningful distinctions among various aging trajectories. This implies that the aging immune system has a homeodynamic characteristic balanced between adaptive and maladaptive aspects. The survival and health of an individual depends from the equilibrium of this balance. In this article, we highlight which parts of the aging of the immune system may be considered adaptive in contrast to those that may be maladaptive.

The Population of Centenarians in Brazil: Historical Estimates from 1900 to 2000

AbstractSince the nineteenth century, the census has provided the number of 100‐year‐olds in Brazil, one of the most populous countries worldwide. In 1900, 4,438 individuals reported themselves to be centenarians, a figure that increased about fivefold by the 2000 census. However, due to data quality issues, we are skeptical about the real size of the recorded population in the Brazilian census. We offer alternative estimates of the most likely number of centenarians during the twentieth century by combining variable‐r relations with different mortality models. Our results indicate there was virtually no centenarian at the beginning of the twentieth century. The population has become larger than 1,000 individuals only in the 1990s, suggesting there has been an extensive, although diminishing, overenumeration of centenarians in the census records. Our results can help policymakers to plan the demands of a growing old age population in places that face stricter family and public budget constraints.

Centanarians of Moscow: functional, cognitive and emotional state

The long-livers of Moscow: functional, cognitive and emotional status. Aim: To evaluate the functional, cognitive and emotional state of long-livers for determining the amount of necessary assistance from social services and medical personnel.Methods: According to the register of super-long-livers of Moscow, 82 people aged from 95 to 105 years were recruited. Participants looked around at home. When visiting, the comprehensive geriatric assessment were performed for each paitent, including an assessment of the overall level of physical and instrumental activity, mental status and cognitive functions. The following questionnaires were used for the assessment: a brief scale of mental status assessment (MMSE), a geriatric scale of depression, the Barthel index (activity in everyday life), IADL (assessment of instrumental activity), to assess the quality of life, a visual assessment scale (VAS) was used.Result: The study showed that, on average, people who reached or were approaching the 100th anniversary had a high level of instrumental (15.6 +/–5.4) and daily activity (72 +/–27.8). In general, no significant decrease in cognitive functions (21.8 +/–5.6) and emotional level (6.3 +/–4.1) was detected in the study participants.Conclusion: The first data showed the uniqueness and fragility of people in this age group. Future work using a similar integrated and multidimensional approach is necessary for a better understanding of aging processes and risk factors worsening the condition of patients, ensuring an increase in the number of centenarians with a high level of life satisfaction.

Стареющее общество: перспективы повышения качества жизни

The article is devoted to the issues related to the phenomenon of “aging society”. The relevance of creating a barrier-free environment for the elderly is dictated by the current demographic trend towards an increase in life expectancy, an increase in its quality. The number of centenarians with functional impairments (senile dementia, Parkinson’s and Alzheimer’s) who require care at a qualitatively new level is increasing. Innovative form of organizing the leisure of the elderly «Kindergarten for the elderly people» is considered as one of the ways to solve the problem. Based on the data of a study conducted by the Federal state budgetary educational institution of higher education of the Far-Eastern state medical university of the Ministry of Health of Russia in 2020, identified the need to create a social institution «Kindergarten for the elderly people». The article notes the need for older people to adapt to the changing conditions of their life in the society saturated with gadgets and information.

Ageing badly: indicators of old-age structure in Australia and New Zealand.

INTRODUCTION Until 2050, Australia and New Zealand will experience continuing increase in the population aged >65 years. Studying differences in indicators of old-age structure between these countries can inform policymakers. AIM To calculate and analyse indicators of old-age structure for Australia and New Zealand. METHODS Five indicators of old-age structure were calculated: centenarian ratio (number of centenarians per 100,000 people), longevity index (proportion of people aged ≥90 and ≥65 years in the population), longevity level (proportion of 80+/60+ years population), ageing tendency (proportion of people aged ≥60 years in the population) and centenarity index (ratio between the centenarians and the total population ≥90 years). RESULTS All indicators of old-age structure demonstrated an advantageous ageing structure in Australia compared with New Zealand. In addition, the New Zealand Māori and Australian Aboriginal indicators of old-age structure demonstrated a significant disadvantage to these ethnic groups compared with the general population. DISCUSSION Public health policy needs to target ageing in New Zealand as a major goal in advancing the 'Ageing Well' policy advocated by the government.

129 To Examine the Factors Affecting the Health and Wellbeing of Centenarians Living in Ireland

Abstract Background The notable increases in life expectancies worldwide combined with advances in contemporary medicine, escalating healthcare costs and increased demands on social services has driven the interest in centenarians as a model for healthy ageing. According to the United Nations, the global number of centenarians is set to continue to climb, expecting to reach more than 25 million people in 2100 (Robine & Cubaynes, 2017). Though the role of genetics in the context of successful ageing is irrefutable, it is important to recognise that the determinants of ageing go beyond genetics alone and equal credence needs to be given to one’s social and economic circumstances, to their physical environment and finally, to one’s own individual characteristics and behaviours. Methods The study focused on selecting a subsample of participants who were 100 years or older until the saturation point was reached. This study employed story telling (one to one interviews) in order to give centenarians a voice. Stories help us to answer the “big” questions about the meaning of life in general and of our lives specifically. Results A number of key themes emerged from the study denoting the factors that affect the health and wellbeing of Irish centenarians including, social connectedness, resilience & robust personality, continued participation in life throughout the life course and spirituality. Conclusion This research demonstrates that the successful attainment of longevity goes beyond the maintenance of physical health and concludes that in order to promote optimum well-being among older people, it is necessary to take note of the experiences, views and values, of the older person themselves.

Abstract P119: Prevalence and Coincidence of Arterial Hypertension and Orthostatic Hypotension in Pre and Centenarians: Preliminary Results of Moscow Centenarian Study

Background: Orthostatic hypotension (OH) and Arterial Hypotension (AH) is commonly reported among older adults and is associated with an increased risk of mortality. The number of centenarians is, but they are still under-investigated population. The aim of the Moscow Centenarian Study (NCT02876809) was to perform a complex evaluation of centenarians living in Moscow. Preliminary results on arterial hypertension and orthostatic hypotension prevalence and blood pressure levels are reported in this abstract. Methods: Data was collected 82 participants aged 95 years and older (median 98 y.o) who participated in the Moscow centenarian study in 2016. Face-to-face interviews were conducted and data collected include blood pressure (BP) measurements and medical history. Results: The prevalence based on blood pressure measurements of AH was 78.1%. However, 2% were unaware of their high BP. Average supine systolic blood pressure (SBP) was 151 mmHg (with the range between 100 and 216 mmHg) and diastolic blood pressure - 74 mmHg (with a range between 44 and 197 mmHg). 33.8% had SBP between 140-159 mmHg, 17.6% - 160-179 mmHg and 22% had SBP equal or above 180 mmHg. Average supine DBS was 74 mmHg. 4.4% had DBP 50 mmHg or below, 22% - 90 or above mmHg. 80% of the patient took medication for AH. In average older adults took 2 medications to control blood pressure, 17% did not take any pills for hypertension.The prevalence of OH among pre- and centenarians in Moscow was 24.3% (29.2% were bad binders, and 46.1% did not have orthostatic hypotension). 95.6% who had OH took medication to control BP. The mean number of drugs was 2.The coincidence of AH and OH was 18.3%. However, 4.9% had isolated OH, and 21.4% had AH without evidence of OH. Conclusions: The coincidence of AH and OH are common in pre and centenarians and reach almost 20%. The preliminary results of the Moscow centenarian Study demonstrate wide ranges of systolic and diastolic BP in centenarians. BP impact on physical status and cognitive functions should be evaluated for a better understanding of health status in centenarians.