Abstract P119: Prevalence and Coincidence of Arterial Hypertension and Orthostatic Hypotension in Pre and Centenarians: Preliminary Results of Moscow Centenarian Study

Abstract

Background: Orthostatic hypotension (OH) and Arterial Hypotension (AH) is commonly reported among older adults and is associated with an increased risk of mortality. The number of centenarians is, but they are still under-investigated population. The aim of the Moscow Centenarian Study (NCT02876809) was to perform a complex evaluation of centenarians living in Moscow. Preliminary results on arterial hypertension and orthostatic hypotension prevalence and blood pressure levels are reported in this abstract. Methods: Data was collected 82 participants aged 95 years and older (median 98 y.o) who participated in the Moscow centenarian study in 2016. Face-to-face interviews were conducted and data collected include blood pressure (BP) measurements and medical history. Results: The prevalence based on blood pressure measurements of AH was 78.1%. However, 2% were unaware of their high BP. Average supine systolic blood pressure (SBP) was 151 mmHg (with the range between 100 and 216 mmHg) and diastolic blood pressure - 74 mmHg (with a range between 44 and 197 mmHg). 33.8% had SBP between 140-159 mmHg, 17.6% - 160-179 mmHg and 22% had SBP equal or above 180 mmHg. Average supine DBS was 74 mmHg. 4.4% had DBP 50 mmHg or below, 22% - 90 or above mmHg. 80% of the patient took medication for AH. In average older adults took 2 medications to control blood pressure, 17% did not take any pills for hypertension.The prevalence of OH among pre- and centenarians in Moscow was 24.3% (29.2% were bad binders, and 46.1% did not have orthostatic hypotension). 95.6% who had OH took medication to control BP. The mean number of drugs was 2.The coincidence of AH and OH was 18.3%. However, 4.9% had isolated OH, and 21.4% had AH without evidence of OH. Conclusions: The coincidence of AH and OH are common in pre and centenarians and reach almost 20%. The preliminary results of the Moscow centenarian Study demonstrate wide ranges of systolic and diastolic BP in centenarians. BP impact on physical status and cognitive functions should be evaluated for a better understanding of health status in centenarians.