22MnMoB hot-stamping quenched steel sheets were well welded together by power frequency spot welder with optimization of relevant welding parameters in this paper. According to the experiment results of welding spatter, maximum shearing force and the size of nugget, the effects of welding current, welding time and electrode pressure on weld property were advanced. The results show that while welding current, welding time and electrode pressure are respectively set as 6.0~6.5kA, 0.5~0.7s and 4~7kN, the weld exhibits good mechanical property. The nugget diameter appears approximate linear relationship with mechanical property of weld and determines the fracture model of welds. The novel hot stamping steel sheets exhibit good welding property. The optimizing welding parameters can be used to instruct the practical production.